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Study Summary
This trial is testing whether simvastatin can help treat ovarian cancer. 20 patients will be given the drug and monitored for effects on their cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- You drink more than 5 alcoholic drinks every day.I do not have any unmanaged ongoing illnesses.I have taken statin medication before or am currently taking it.I am currently taking medications that interact with statins.I have been treated with doxorubicin or liposomal doxorubicin before.I have a long-term muscle disease.I have had cancer before, but it wasn't ovarian cancer or a non-melanoma skin cancer.I have an active HIV infection.Your hemoglobin A1C level is higher than 8.0%.I have active liver disease or cirrhosis.My ovarian cancer has returned but responds to platinum treatment.I am not allergic or unable to take carboplatin, liposomal doxorubicin, or simvastatin.
- Group 1: Simvastatin
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is this pioneering clinical trial the first of its kind?
"Since 2005, Simvastatin 40mg has been the subject of numerous drug trials. The first trial was conducted by Merck Sharp & Dohme LLC in 2005 and included 80 participants. Subsequently, it received its Phase 4 approval and today there are 37 active clinical trials being carried out across 31 nations encompassing 239 cities."
To what medical issues is Simvastatin 40mg usually prescribed as a remedy?
"Simvastatin 40mg is commonly used as a remedy for high cholesterol levels, but it can also be beneficial for diabetes mellitus, cardiovascular event prevention and hypercholesterolemia."
What is the current sample size for this research trial?
"Affirmative. Data hosted on clinicaltrials.gov supports that this medical study, which was initially announced on January 25th 2021, is actively recruiting patients. Approximately 20 individuals need to be admitted from 1 site."
Have any additional experiments been conducted utilizing Simvastatin 40mg?
"At present, there are 37 active trials for Simvastatin 40mg, 7 of which being in the final phase. These studies primarily take place at Pontyclun, Wales; however, they can be found across 480 other locations worldwide."
Is this research experiment currently recruiting participants?
"Affirmative. The details published on clinicaltrials.gov demonstrate that this medical study is enlisting participants at present. It was made public on January 25th 2021 and recently updated in April of 2022."
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