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Radiation Therapy

Group 1: 10 Gy Low-KV IORT for Pancreatic Cancer (IORT Trial)

Phase 1
Waitlist Available
Research Sponsored by Loyola University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 52 weeks
Awards & highlights

IORT Trial Summary

This trial is testing whether adding radiation therapy to surgery helps people with pancreatic cancer live longer.

Eligible Conditions
  • Pancreatic Cancer

IORT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~52 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 52 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Maximum Tolerated Dose
Secondary outcome measures
Diet Surveys

IORT Trial Design

3Treatment groups
Experimental Treatment
Group I: Group 3: 20 GY Low-KV IORTExperimental Treatment1 Intervention
20 GY Low Kilovoltage Intraoperative Radiation: intraoperative low-kV IORT will be delivered as a single dose of 20 Gy at 2 millimeter depth. Patients will be accrued to this group until the DLT is reached and MTD is realized.
Group II: Group 2: 15 Gy Low-KV IORTExperimental Treatment1 Intervention
15 Gy Low Kilovoltage Intraoperative Radiation: intraoperative low-kV IORT will be delivered as a single dose of 15 Gy at 2 millimeter depth. Doses will be escalated in increments of 5 Gy until completion of 20 Gy dose level or the DLT is reached and MTD is realized.
Group III: Group 1: 10 Gy Low-KV IORTExperimental Treatment1 Intervention
10 Gy Low Kilovoltage Intraoperative Radiation: intraoperative low-kV IORT will be delivered as a single dose of 10 Gy at 2 millimeter depth. Doses will be escalated in increments of 5 Gy until completion of 20 Gy dose level or the DLT is reached and MTD is realized.

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Who is running the clinical trial?

Loyola UniversityLead Sponsor
156 Previous Clinical Trials
30,922 Total Patients Enrolled
~1 spots leftby Jun 2025
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