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Ultrasound-assisted Chemotherapy for Glioblastoma (SC9/ABX Trial)
SC9/ABX Trial Summary
This trial will test a new way of giving the chemotherapy drug paclitaxel to people with glioblastoma that has come back after surgery. In this trial, they will give the drug through a device that uses ultrasound to open the blood brain barrier for a short time so that the drug can get into the brain.
SC9/ABX Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSC9/ABX Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.SC9/ABX Trial Design
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Who is running the clinical trial?
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- It has been over 12 weeks since I finished my radiation therapy.I cannot take Abraxane or carboplatin due to health reasons.I am allergic to or have had reactions to drugs similar to paclitaxel or carboplatin.You have problems with controlling your body temperature or feeling changes in temperature caused by a medical device.I am mostly able to care for myself and carry out daily activities.I have epilepsy that isn't well-controlled or need specific epilepsy drugs.My cancer can be measured or seen on tests.I am eligible for surgery to remove part of my tumor.I am on a stable or decreasing dose of dexamethasone under 6 mg for mass effect.My glioblastoma does not have the IDH1 mutation and is grade 4.I do not have severe heart or lung conditions.My liver, kidney, and bone marrow are functioning well, as shown by recent tests.My tumor is 70 mm or smaller on an MRI before surgery.My cancer has grown despite 1-2 previous treatments.You have a risk of the wound in your head opening up.I need to keep taking my blood thinner medication.I am allergic to ingredients in the Definity ultrasound contrast agent.I agree to use birth control during and up to 6 months after the study.My tumor is located in the back part of my brain.You have taken any experimental medications within the past month.I have had cancer within the last 3 years.I am 18 years old or older.Your disease is spread out in different areas of your body and cannot be fully seen in ultrasound images if the areas are more than 70 millimeters apart.
- Group 1: SC9/ABX (phase 1); SC9/ABX/Carboplatin (phase 2)
- Approved for 5 Other Conditions - This treatment demonstrated efficacy for 5 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Have any other studies been conducted with Chemotherapy, albumin-bound paclitaxel?
"At present, 856 clinical trials are being conducted to research Chemotherapy, albumin-bound paclitaxel. Of these active studies, 231 are in the third phase of development. Although a majority of them originate from Westmead, New South Wales, there is a total of 45936 sites that oversee this medication's testing."
Are there still opportunities for volunteers to join this clinical trial?
"Per information available on clinicaltrials.gov, this medical experiment is actively in search of participants. The initial announcement was made October 29th 2020 and the trial details were last revised on November 11th 2022."
What maladies is Chemotherapy, albumin-bound paclitaxel typically administered for?
"Chemotherapy, albumin-bound paclitaxel is typically used to address hypoalbuminemia. Additionally, this medication can be employed in the treatment of apn, shock states, hypovolemic episodes and locally advanced non-small cell lung cancer."
How many participants can join this experiment?
"Affirmative. Clinicaltrials.gov reports that this research initiative, which was first published on October 29th 2020, is still accepting patients. 57 participants need to be enrolled from a single medical centre."
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