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Combination Therapy for Pancreatic Cancer
Study Summary
This trial is testing a new combination of chemotherapy drugs and immunotherapy to see if it's effective in treating pancreatic cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have skin conditions like eczema or psoriasis but only on my skin.My cancer is not endocrine or acinar pancreatic carcinoma.My liver tests are normal or slightly elevated due to a blockage that can be treated.I have had surgery for pancreatic cancer.I do not have endocrine or acinar pancreatic cancer.I have been tested for blood clots and am receiving treatment if any were found.My heart's pumping ability is below normal or less than 50%.I have never had lung conditions like pulmonary fibrosis or pneumonitis, except for radiation-related issues.Men who are able to father a child must agree to use birth control.My pancreatic cancer diagnosis has been confirmed by a biopsy.My blood thinner medication has been stable for 2 weeks, and the study lead agrees it's okay despite my high clot risk.I have been hospitalized for severe depression or attempted suicide in the last two years.My side effects from cancer treatment are mild, except for hair loss and some nerve pain.I do not have uncontrolled skin, muscle, nerve disorders or a rare blood disorder.I have fluid buildup needing frequent drainage.I haven't had major surgery or significant injury in the last 2 weeks.I haven't had a severe infection needing antibiotics in the last 2 weeks, except for a treated bile duct infection.I haven't had a live vaccine in the last 4 weeks and don't plan to during or within 5 months after my treatment.I am fully active or can carry out light work.My cancer is confirmed as metastatic pancreatic adenocarcinoma.My stage IV cancer is confirmed by a biopsy and cannot be surgically removed.The researcher thinks that you have a medical condition that makes it unsafe for you to participate in the study.I am not on cancer treatment, except for hormone therapy.You are currently taking experimental drugs for other medical studies.I have had a stem cell or organ transplant before.I haven't had any cancer except for low-risk types in the past two years.I have stable thyroid issues or controlled Type 1 diabetes, but no other immune conditions.I had radiation therapy for pancreatic cancer less than 2 weeks ago.I have had cancer spread to my brain or its coverings.I have high calcium levels that aren't managed without ongoing treatment.I have or had hepatitis B.I have a significant liver condition.I have active tuberculosis.I haven't had major heart issues, seizures, uncontrolled high blood pressure, or unstable heart rhythm recently.I have not had severe bleeding in the last 28 days.My pancreatic cancer diagnosis has been confirmed by a pathologist.My blood clotting tests are within normal limits, or I've been on stable blood thinners for 2 weeks.I have had treatment for pancreatic cancer before.I haven't had immunosuppressive treatment in the last 2 weeks, except for a one-time approved dose.I have not received any blood transfusions in the last 4 weeks.I have been taking more than 10 mg of prednisone daily for over five days within the last month.I am 18 years old or older.My white blood cell count is healthy without needing medication.My biopsy confirms I have stage IV cancer that cannot be surgically removed.I am fully active or can carry out light work.My recent blood and organ function tests are within normal ranges.My bilirubin levels are within the normal range, or slightly higher if I have Gilbert's disease or a blockage that can be treated.My kidney function, measured by creatinine levels or CrCl, is within the normal range.My cancer can be measured and biopsied.I have cancer pain not controlled without changing pain meds in the last 2 weeks.
- Group 1: Motixafortide, Cemiplimab, Gemcitabine, Nab-Paclitaxel
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many participants is this study seeking to recruit?
"Affirmative. The information on clinicaltrials.gov elucidates that this investigation is currently soliciting participants. This research effort, which was initially published on November 9th 2020, needs 10 patients from 2 different medical centres to complete the trial."
Has Motixafortide been evaluated in other investigations?
"Currently, there are 1169 investigations into Motixafortide which have been initiated. Of these ongoing trials, 325 reside in their third and final phase of development. Although the majority of research is based out of Shanghai, 61006 sites support studies for this medication worldwide."
What medicinal applications is Motixafortide employed for?
"Motixafortide can be employed to treat those with a previous history of anthracycline-based therapies, metastatic cutaneous squamous cell carcinoma, and cancerous metastases."
Could you please elucidate the risks of Motixafortide usage?
"Our team at Power assigned Motixafortide a rating of 2 as it is currently in Phase 2 clinical trials, with some safety data gathered but none indicating its efficacy."
Are volunteers being enlisted for this experiment?
"Yes, the information available on clinicaltrials.gov reveals that this research effort is in search of participants. The trial was first made visible to the public on November 9th 2020 and has since been updated as recently as November 7th 2022; it requires 10 volunteers from 2 different medical centres."
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