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Targeted Therapy for Cancer
Study Summary
This trial uses genomic testing to direct cancer treatment. Patients with cancer that has progressed after standard treatment or for which there is no agreed-upon treatment may benefit.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- It's been over 4 weeks since my last cancer treatment or major surgery, and any side effects are mild.I finished treatment for brain cancer or metastases more than 4 weeks ago.I have started my menstrual periods.I do not have any of the excluded medical conditions or treatments.You have abnormal blood test results.My heart function is within the normal range.I have not had certain types of cancer before.I have a confirmed diagnosis of cancer that needs treatment and has shown progression.I can provide a tumor sample for testing.You must use effective birth control or avoid sex before and during the study, and for 4 months after the study ends. If you or your partner become pregnant during the study, tell your doctor right away.You can still participate if you have HIV, but you need to meet certain requirements.Patients must have certain blood and chemistry test results within a specific range.I am not taking any medications that are not allowed in this study.I can do light work and my doctor expects me to live at least 3 more months.I stopped taking steroids at least a week ago and haven't taken any since.I don't have conditions that could cause abnormal heart rhythms.My cancer has not responded to standard treatments, and no other effective options are available.I had an ECG test within the last 8 weeks and my heart meets the study's criteria.Requirements for the initial biopsy used to determine if you are eligible for the clinical trial.I have had treatment for skin cancer that is not melanoma.I have been cancer-free from another type for 5 years.I do not have any conditions that increase my risk of heart rhythm problems.I have not had a hysterectomy or both ovaries removed and have had a menstrual cycle in the last 2 years.
- Group 1: Subprotocol Z1C (CDK4 or CDK6 amplification and Rb protein)
- Group 2: Subprotocol Z1M (LAG-3 expression >= 1%)
- Group 3: Subprotocol C2 (MET exon 14 deletion/mutation)
- Group 4: Subprotocol V (cKIT exon 9, 11, 13, or 14 mutation)
- Group 5: Subprotocol Z1A (NRAS mutation in codon 12, 13, or 61)
- Group 6: Subprotocol I (PIK3CA mutation)
- Group 7: Subprotocol A (EGFR activating mutation)
- Group 8: Subprotocol C1 (MET amplification)
- Group 9: Subprotocol B (HER2 activating mutation)
- Group 10: Subprotocol E (EGFR T790M or rare activating mutation)
- Group 11: Subprotocol K1 (FGFR amplification)
- Group 12: Subprotocol T (SMO or PTCH1 mutation)
- Group 13: Subprotocol F (ALK translocation)
- Group 14: Subprotocol P (PTEN loss)
- Group 15: Subprotocol H (BRAF V600E/R/K/D mutation)
- Group 16: Subprotocol L (mTOR mutation)
- Group 17: Subprotocol M (TSC1 or TSC2 mutation)
- Group 18: Subprotocol W (FGFR pathway aberrations)
- Group 19: Subprotocol G (ROS1 translocation or inversion)
- Group 20: Subprotocol J (HER2 amplification >= 7 copy numbers)
- Group 21: Subprotocol R (BRAF fusion or BRAF non-V600 mutation)
- Group 22: Subprotocol Z1F (PIK3CA mutation)
- Group 23: Subprotocol Q (HER2 amplification)
- Group 24: Subprotocol K2 (FGFR mutation or fusion)
- Group 25: Subprotocol Z1K (AKT mutation)
- Group 26: Subprotocol U (NF2 inactivating mutation)
- Group 27: Subprotocol N (PTEN mutation or deletion and PTEN expression)
- Group 28: Subprotocol Z1D (Loss of MLH1 or MSH2 by IHC)
- Group 29: Subprotocol S1 (NF1 mutation)
- Group 30: Subprotocol Y (Akt mutation)
- Group 31: Subprotocol Z1E (NTRK1, NTRK2 or NTRK3 gene fusion)
- Group 32: Subprotocol S2 (GNAQ or GNA11 mutation)
- Group 33: Subprotocol X (DDR2 S768R, I638F, or L239R mutation)
- Group 34: Subprotocol Z1B (CCND1, 2, or 3 amplification with Rb by IHC)
- Group 35: Subprotocol Z1G (PTEN loss)
- Group 36: Subprotocol Z1H (PTEN mutation)
- Group 37: Subprotocol Z1L (BRAF fusion, aberration or non-V600 mutation)
- Group 38: Subprotocol Z1I (BRCA1 or BRCA2 gene mutation)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What prior investigations have included Subprotocol R considerations of BRAF union or non-V600 mutation?
"Presently, 1594 clinical trials are underway to evaluate Subprotocol R (BRAF fusion or BRAF non-V600 mutation), 237 of those being in the last phase. Most studies for this therapy take place in Seattle, Washington but there exist 890 other sites running these experiments."
What is the intake capacity for this clinical research?
"To fulfill the requirements of this trial, 6452 eligible participants must enroll. These patients can join from various medical facilities such as Saint Jude Medical Center in Fullerton, Colorado and Providence Saint Joseph Medical Center/Disney Family Cancer Center situated in Burbank, Idaho."
Are there any vacancies for individuals interested in participating in this research?
"Affirmative. According to the data on clinicaltrials.gov, this medical trial is currently recruiting patients and has been since August 12th 2015. The last update was made on November 30th 2022, with a total of 6452 participants needed from across 100 locations."
How many healthcare establishments are administering this experiment?
"This research is recruiting patients from Saint Jude Medical Center in Fullerton, Colorado, Providence Saint Joseph Medical Center/Disney Family Cancer Center in Burbank, Idaho and Southwest Oncology PC in Durango, Connecticut as well as other 100 sites."
What medical conditions are typically treated through Subprotocol R (BRAF fusion or BRAF non-V600 mutation)?
"Subprotocol R (BRAF fusion or BRAF non-V600 mutation) is primarily used to address renal failure but can also be applied for the management of metastatic basal cell carcinoma, inoperable melanoma, and squamous cell carcinomas."
Is Subprotocol R (BRAF fusion or BRAF non-V600 mutation) sanctioned by the FDA?
"Subprotocol R of this trial (BRAF fusion or BRAF non-V600 mutation) was assessed at a score 2 on the safety scale, as there is clinical data confirming its safety but no evidence to back up efficacy yet."
Who else is applying?
What state do they live in?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
What site did they apply to?
Why did patients apply to this trial?
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