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Radiation Therapy + Chemotherapy for Cervical Cancer
Study Summary
This trial compares radiation therapy with chemotherapy to radiation therapy alone to see which is more effective in treating patients with early cervical cancer who have already undergone surgery.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have a severe infection or septicemia.My cancer has spread to areas near the uterus or I have positive surgical margins.My cervical cancer was initially treated with surgery to remove the uterus and pelvic lymph nodes.The condition has spread deeply into the third layer.I have a blockage in my intestines or bleeding in my digestive tract.I have cervix cancer and have had radiation or chemotherapy before.My tumor is at least 5 cm and not deeply embedded.My tumor is at least 4 cm and has grown deep into the tissue.My kidney function is normal or nearly normal.My kidney condition requires special adjustments for radiation therapy.I have a fistula following surgery.I can take care of myself but may not be able to do heavy physical work.My tumor is at least 2 cm and located in the middle third of the affected area.I had surgery between 3 to 8 weeks ago.I have not had any cancer other than non-melanoma skin cancer in the last 5 years.
- Group 1: Arm I (EBRT, IMRT)
- Group 2: Arm II (cisplatin, EBRT, IMRT)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are Canadian medical facilities part of this research project?
"There are 100 hospitals and other medical facilities participating in this trial, including Comprehensive Cancer Centers of Nevada in Columbus, OptumCare Cancer Care at Fort Apache in Portsmouth, Riverside Methodist Hospital in Toledo."
What diseases or conditions is Cisplatin used to treat?
"While most commonly used to treat neoplasm metastasis, Cisplatin can also be administered to patients with advanced ovarian cancer that has not responded well to other treatments."
Are there any severe side effects that have been associated with Cisplatin?
"Cisplatin has received a safety score of 3. This is based on the fact that it is Phase 3 trial, meaning there have been multiple rounds of data supporting its efficacy and safety."
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