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Bempedoic acid 180 mg tablet for Cardiovascular Disease (CLEAR Outcomes Trial)

Phase 3
Waitlist Available
Research Sponsored by Esperion Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 68 months
Awards & highlights

CLEAR Outcomes Trial Summary

This trial will test if bempedoic acid can help people who can't tolerate statins by reducing their risk of cardiovascular events.

Eligible Conditions
  • Cardiovascular Disease
  • Statin Adverse Reaction Syndrome

CLEAR Outcomes Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 68 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 68 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants With First Occurrence of Four Component Major Adverse Cardiovascular Events (MACE)
Secondary outcome measures
Number of Participants With First Occurrence of Myocardial Infarction
Number of Participants With First Occurrence of Three Component MACE
Number of Participants With Time to All-cause Mortality
+3 more

Side effects data

From 2022 Phase 3 trial • 13970 Patients • NCT02993406
11%
Hyperuricaemia
11%
Hypertension
10%
COVID-19
8%
Urinary tract infection
8%
Arthralgia
7%
Diabetes mellitus
7%
Headache
6%
Blood uric acid increased
6%
Myalgia
6%
Back pain
5%
Nasopharyngitis
1%
Cholelithiasis
1%
Pneumonia
1%
Angina pectoris
1%
Non-cardiac chest pain
1%
Osteoarthritis
1%
COVID-19 pneumonia
1%
Angina unstable
1%
Transient ischaemic attack
1%
Atrial fibrillation
1%
Cardiac failure congestive
100%
80%
60%
40%
20%
0%
Study treatment Arm
Bempedoic Acid 180 mg
Placebo Comparator

CLEAR Outcomes Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Bempedoic Acid 180 mgExperimental Treatment1 Intervention
Bempedoic acid 180 mg tablet taken orally, once daily.
Group II: Placebo ComparatorPlacebo Group1 Intervention
Matching placebo tablet taken orally, once daily
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bempedoic acid
FDA approved

Find a Location

Who is running the clinical trial?

Esperion Therapeutics, Inc.Lead Sponsor
25 Previous Clinical Trials
7,948 Total Patients Enrolled
The Cleveland ClinicOTHER
1,034 Previous Clinical Trials
1,351,455 Total Patients Enrolled
Michael Louie, MDStudy DirectorEsperion Therapeutics, Inc.
2 Previous Clinical Trials
74 Total Patients Enrolled
~1660 spots leftby Jun 2025
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