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Exercise + Duloxetine for Knee Osteoarthritis
Study Summary
This trial will study whether adding duloxetine to aerobic exercise can help treat adults with symptomatic knee osteoarthritis and depression.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2012 Phase 4 trial • 291 Patients • NCT01118780Trial Design
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Who is running the clinical trial?
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- I cannot safely do supervised exercise due to my current health issues.I am 40 years old or older.I have been diagnosed with major depressive disorder.I do not plan to have knee surgery for osteoarthritis in the next 6 months.I am currently receiving treatment for my active cancer.I have been diagnosed with painful knee arthritis.I am currently taking medications like duloxetine, antipsychotics, benzodiazepines, or opioids.My current medications won't interfere with the study.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
- Group 1: Aerobic exercise plus Duloxetine
Frequently Asked Questions
What medical issues can be effectively treated with Duloxetine?
"Duloxetine is often prescribed to patients suffering from diabetic peripheral neuropathy (dpn). This medication has also been proven effective in managing knee pain, major depressive disorder (mdd), and issues with the musculoskeletal system."
Are there still opportunities to join this clinical trial?
"Affirmative. Per the information posted on clinicaltrials.gov, this healthcare study is currently recruiting eligible participants and was initially shared on October 7th 2021. The research team seeks to enroll thirty individuals from a single site for their investigation into the efficacy of this medical intervention."
Could you shed light on other research conducted using Duloxetine?
"Currently, 22 research trials for Duloxetine are underway with 4 in the critical Phase 3. Redwood City, California is home to a handful of these experiments but there are 781 locations globally participating in clinical trials involving this medication."
Has the FDA sanctioned Duloxetine for use?
"Duloxetine has been evaluated in Phase 2 clinical trials, showing some evidence to support safety but not efficacy. As such, we have rated its safety as a level 2 on our scale of 1-3."
How many participants are being monitored as part of this research protocol?
"Affirmative. Per the details published on clinicaltrials.gov, this research trial is currently looking for participants and was originally posted on October 7th 2021; with its most recent update being January 24th 2022. 30 people must be recruited from one medical facility to complete the study's requirements."
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