Your session is about to expire
← Back to Search
Reduced Intensity BMT for Solid Cancer
Study Summary
This trial is testing a new, less intense chemotherapy treatment followed by a bone marrow transplant from a donor with a partial match, and then lower doses of immunosuppressive drugs.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
Find a Location
Who is running the clinical trial?
Media Library
- My family and I prefer a specific donor for my treatment.I have been diagnosed with neuroblastoma or ganglioneuroblastoma.I have recovered from the side effects of my previous cancer treatments.I don't need my cancer to be measurable or, if it is, it hasn't grown in the last 6 weeks.I do not have any uncontrolled infections.I am a male and will choose a male donor.My donor and I match in at least one gene at five specific genetic locations.My organs are functioning well.I am a woman who could get pregnant and am not using effective birth control or am currently pregnant.I am older than 6 months.My donor has a KIR Haplotype B.My donor is HLA-mismatched to maximize treatment benefits.I will choose the youngest donor available.My cancer did not respond to initial standard chemotherapy treatments.I have high-risk disease and cannot undergo intense treatment due to my organ function.My condition is stage 4 rhabdomyosarcoma.My cancer is metastatic Ewing Sarcoma.My osteosarcoma has spread beyond my lungs or to areas in my lungs that cannot be surgically removed.My tumor has less than a 10% survival estimate and will be reviewed individually.My lung function tests are above 50% of what's expected, or my oxygen levels are above 92% without assistance.I am mostly able to carry out daily activities.My sex, race, or ethnicity does not affect my eligibility.I have received the standard initial treatment for my condition.My cancer returned more than 6 months after my last bone marrow transplant.My liver function tests are within the required range.My kidney function is normal or meets the minimum required level.My diagnosis is high risk with an expected survival rate of less than 10%.I have a family member who is a match for a bone marrow donation.My donor's blood type does not match mine, but a matching donor is available.I'm sorry, but it seems like some information is missing. Could you please provide examples of the criteria you would like me to rewrite?I don't have harmful antibodies against a donor's tissue.My donor and I share at least one HLA haplotype.My heart's pumping ability is within the required range.I have been diagnosed with desmoplastic small round cell tumor.My donor's CMV status matches mine.My cancer did not respond well to my first chemotherapy treatment.
- Group 1: Reduced intensity conditioning
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Which type of patient would be ideal for this clinical trial?
"To participate in this study, patients must have cancer and be between the ages of 1 year old to 50 years old. Currently, the clinical trial is looking for 60 total patients."
How many people will be given the chance to participate in this clinical trial?
"Yes, according to the most recent update on clinicaltrials.gov, this trial is still looking for patients. The study was first posted almost 9 years ago on March 27th, 2013 and is seeking a total of 60 participants at 5 different locations."
Is the age limit for this experiment set at 70 years or below?
"This particular clinical trial requires that potential participants are aged between 1 year and 50 years old."
What is the standard function of Tacrolimus?
"Tacrolimus is an immunosuppressant medication that can be used to manage dermatitis, atopic conditions, multiple sclerosis, and acute myelocytic leukemia."
Where are patients able to participate in this trial?
"At the moment, investigators are looking for volunteers at 5 different study sites. If you live near Valhalla, Charlotte or Baltimore, it might be easier for you to participate because travel would be minimal."
Are there any more open slots for this research study?
"The listed information on clinicaltrials.gov suggests that this study is looking for more participants. The original posting was on March 27th, 2013 with the most recent edit being on August 12th, 2022."
When did the FDA approve the use of Tacrolimus?
"There is some data indicating that Tacrolimus is safe, but none yet supporting that it effective. Consequently, it received a score of 2."
What other scientific investigations have utilized Tacrolimus?
"At the moment, there are 1065 separate clinical trials researching tacrolimus. Out of those, 190 are in Phase 3. Most of the tacrolimus trials are based out of Philadelphia, Pennsylvania; however, 30089 different locations worldwide are running some form of trial for this medication."
Share this study with friends
Copy Link
Messenger