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CD34-Selected Stem Cell Transplant for Bone Marrow Transplant (EXCESS Trial)
EXCESS Trial Summary
This trial is for people with a disease that requires a stem cell transplant, but don't have a perfect match. A close relative has been identified whose stem cells are not a perfect match, but can be used. The donor's blood cells are treated to minimize cells that are most likely to attack the patient's tissues.
EXCESS Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowEXCESS Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.EXCESS Trial Design
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Who is running the clinical trial?
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- I do not have a severe or life-threatening infection.My bone marrow is not functioning well.I have severe graft-versus-host disease.I need considerable assistance and medical care.My condition has come back or hasn't improved.I can understand and sign the consent form myself or have someone who can.My lung function is significantly below normal.My heart's pumping ability is severely reduced.My liver is not severely damaged.You are pregnant.I received a stem cell transplant from a donor and need more cell therapy.I am eligible for a CD34+ topoff.I need a stem cell transplant from a donor.I am younger than 70 years old.You have a mental health condition that may affect your ability to participate in the study.I am HIV positive.
- Group 1: Cohort 1: CD34+ Cells for transplant
- Group 2: Cohort 2: CD34+ cells as a top off
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is this investigation currently enrolling participants?
"Indeed, the information on clinicaltrials.gov affirms that this medical trial is actively recruiting participants. Initially posted on October 1st 2010 and last updated January 5th 2022, 144 patients need to be recruited at two separate sites."
To what extent is this medical study being populated by participants?
"Affirmative. Clinicaltrials.gov lists this medical trial as actively seeking participants since its first posting on October 1st, 2010 and last update on January 5th 2022. 144 individuals must be sourced from two different locations for successful completion of the study."
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