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Antibiotic Stewardship

Smart Prompt System vs Routine Care for Urinary Tract Infection

N/A
Waitlist Available
Led By Richard Platt, MD, MS
Research Sponsored by Harvard Pilgrim Health Care
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 15 month intervention
Awards & highlights

Study Summary

This trial will compare the effects of two different methods of treating UTIs in adults. One method is the standard antibiotic stewardship practices, and the other is a real-time precision medicine computerized physician order entry smart prompts.

Who is the study for?
The INSPIRE-ASP UTI Trial is for HCA hospitals that use MEDITECH electronic health record systems and admit non-critically ill adults with urinary tract infections. Individual patients are not directly enrolled; instead, the trial involves 59 hospitals.Check my eligibility
What is being tested?
This trial compares usual antibiotic stewardship practices against a new approach using smart prompts in the hospital's computerized order entry system to predict resistance to antibiotics in adult UTI patients.See study design
What are the potential side effects?
Since this trial focuses on hospital practices rather than direct patient interventions, it does not involve side effects in the traditional sense of medication or treatment-related adverse events.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~15 month intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and 15 month intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Extended-Spectrum Days Of Antibacterial Therapy (ES-DOT) per Empiric Day
Secondary outcome measures
Antipseudomonal Antibiotic Days Of Therapy (ES-DOT) per Empiric Day
Vancomycin Days of Antibacterial Therapy per Empiric Day
Other outcome measures
Antibacterial Escalations [Safety Outcome 1]
Empiric and Total Antibacterial Costs
Extended-Spectrum Days of Therapy with Inpatient Extended-Spectrum (ES) Antibacterial Treatment after Empiric Period
+5 more

Trial Design

2Treatment groups
Active Control
Group I: INSPIRE CPOE Smart PromptActive Control1 Intervention
Use of a computerized physician order entry (CPOE) smart prompt alert to guide empiric choice of antibiotics for UTI in non-ICU patients in the first 3 days of hospitalization.
Group II: Routine CareActive Control1 Intervention
Continued routine antibiotic stewardship strategies.

Find a Location

Who is running the clinical trial?

Brigham and Women's HospitalOTHER
1,622 Previous Clinical Trials
11,468,698 Total Patients Enrolled
Centers for Disease Control and PreventionFED
878 Previous Clinical Trials
22,479,565 Total Patients Enrolled
1 Trials studying Urinary Tract Infection
208 Patients Enrolled for Urinary Tract Infection
University of California, IrvineOTHER
546 Previous Clinical Trials
1,923,142 Total Patients Enrolled

Media Library

INSPIRE CPOE Smart Prompt (Antibiotic Stewardship) Clinical Trial Eligibility Overview. Trial Name: NCT03697096 — N/A
Urinary Tract Infection Research Study Groups: INSPIRE CPOE Smart Prompt, Routine Care
Urinary Tract Infection Clinical Trial 2023: INSPIRE CPOE Smart Prompt Highlights & Side Effects. Trial Name: NCT03697096 — N/A
INSPIRE CPOE Smart Prompt (Antibiotic Stewardship) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03697096 — N/A
Urinary Tract Infection Patient Testimony for trial: Trial Name: NCT03697096 — N/A
~0 spots leftby Jun 2024
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