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Exercise and Prehabilitation for Kidney Failure

N/A
Recruiting
Led By Christopher Nguan, MD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Has been fully worked up for suitability for renal transplantation
Age = to or > 19 and any gender
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to 1 week prior to renal transplantation. again, change from 1 month post transplant to 6 month post transplant.
Awards & highlights

Study Summary

This trial is testing whether an exercise intervention prior to kidney transplantation can improve post-operative outcomes. The study will look at outcomes including walking speed, strength, endurance, quality of life and fatigue.

Who is the study for?
This trial is for adults aged 19 or older with chronic kidney failure who are able to do a home-based exercise program and have been cleared for kidney transplantation. They must be patients at Vancouver General Hospital or St. Paul's Hospital, able to read and write in English, and have physician clearance.Check my eligibility
What is being tested?
The study tests if exercising before a kidney transplant can help improve walking speed, strength, endurance, quality of life, fatigue levels pre-operatively and lead to better recovery outcomes post-transplantation such as fewer complications and shorter hospital stays.See study design
What are the potential side effects?
Since the intervention involves an exercise program designed for individuals awaiting kidney transplants, side effects may include typical exercise-related issues like muscle soreness or strain but will vary based on individual health conditions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been evaluated and considered suitable for a kidney transplant.
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I am 19 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from 1 week following kidney transplant to 30 and 90 days post operatively.
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from 1 week following kidney transplant to 30 and 90 days post operatively. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in 30-second timed sit to stand.
Change in 6-minute walk test (6-MWT).
Change in Fried Frailty Score.
+6 more
Secondary outcome measures
Participant adherence to a tailored home-based exercise program.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Exercise GroupExperimental Treatment1 Intervention
All participants who are allocated to the exercise group will be asked to complete 4-5 days per week of mixed modality exercise incorporating aerobic, resistance, and flexibility training. The exercise intervention is prescribed based on the FITT principle: frequency, intensity, time and type. The 10-point Rating of Perceived Exertion (RPE) scale, which has been well correlated to target HR levels, will be used to monitor exercise intensity levels throughout the intervention, with participants instructed to maintain their intensity level at 3-5 during exercise sessions. Participant progression will be individualized and based on their subjective perceived intensity level using the RPE scale. In person instruction, from a member of the research team with standard first aid and CPR-C training, and an instructional handout and exercise log will be provided, as well as exercise resistance bands to perform resistance exercises.
Group II: Control GroupActive Control1 Intervention
This will consist of regular care, which is standard procedure.

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,422 Previous Clinical Trials
2,468,112 Total Patients Enrolled
Christopher Nguan, MDPrincipal InvestigatorUniversity of British Columbia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
The Effect of a Prehabilitation Exercise Program on Physical Functioning for Patients Undergoing Kidney Transplantation
Christopher Nguan 2019. "The Effect of a Prehabilitation Exercise Program on Physical Functioning for Patients Undergoing Kidney Transplantation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04044963.
All > Kidney Transplant
~37 spots leftby Jan 2026
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