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Duexis vs Mobic
Introduction
For patients suffering from conditions like osteoarthritis and rheumatoid arthritis, certain drugs that reduce inflammation and provide relief from pain are often essential. Duexis and Mobic are two such medications prescribed for these conditions. Both drugs work by inhibiting the production of chemicals in the body responsible for inflammation and associated symptoms.
Duexis is a combination drug consisting of ibuprofen, an NSAID (Non-Steroidal Anti-Inflammatory Drug), which reduces inflammation, and famotidine, a type of medication known as H2 blockers that helps to reduce stomach acid production thereby preventing ulcers.
On the other hand, Mobic or meloxicam also belongs to the group of NSAIDs but it's more selective in its action focusing mainly on COX-2 enzyme which results in less gastrointestinal side effects compared to non-selective NSAIDs. The choice between Duexis and Mobic would depend on patient-specific factors including their risk profile for gastric issues.
Duexis vs Mobic Side By Side
| Attribute | Duexis | Mobic |
|---|---|---|
| Brand Name | Duexis | Mobic |
| Contraindications | Should not be taken with anticoagulants like warfarin or corticosteroids such as prednisone. Not recommended for individuals with kidney disease without regular monitoring. | Should not be taken with anticoagulants like warfarin or corticosteroids such as prednisone. Not recommended for individuals with kidney disease without regular monitoring. |
| Cost | Around $3000 for 90 tablets (800 mg/26.6 mg) | Around $140-$170 for a month's supply (30 tablets of 15mg) |
| Generic Name | Ibuprofen and Famotidine | Meloxicam |
| Most Serious Side Effect | Signs of an allergic reaction, liver problems, and severe skin reactions. | Signs of an allergic reaction, heart issues, stroke symptoms, liver problems, and kidney problems. |
| Severe Drug Interactions | Anticoagulants and corticosteroids. | Anticoagulants and corticosteroids. |
| Typical Dose | 800 mg/26.6 mg three times a day | 7.5 mg per day, can be increased to 15 mg per day |
What is Duexis?
Duexis (a combination of ibuprofen and famotidine) represents a unique drug class, designed to alleviate pain and inflammation while simultaneously reducing the risk of stomach ulcers. It was first approved by the FDA in 2011. Duexis acts by inhibiting prostaglandin synthesis via non-selective inhibition of cyclooxygenase enzymes, which helps with managing pain and inflammation, whereas famotidine reduces gastric acid secretion, mitigating potential gastrointestinal side effects.
On the other hand, Mobic (generic name Meloxicam), an NSAID like ibuprofen but with selective COX-2 inhibitor properties, gained FDA approval in 2000. Its primary use is to manage painful symptoms from osteoarthritis or rheumatoid arthritis. The selectivity for COX-2 over COX-1 gives Mobic a better gastrointestinal safety profile than non-selective NSAIDs; however, it may not protect against ulcer formation as effectively as Duexis does due to its incorporated antacid component.
What conditions is Duexis approved to treat?
Duexis is approved for the treatment of several conditions, including:
- Osteoarthritis and rheumatoid arthritis symptoms
- Gastric ulcers caused by prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs)
- Reducing the risk of developing gastric ulcers in patients at risk
Mobic, on the other hand, is used to relieve:
- Pain and inflammation from various forms of arthritis including osteoarthritis and rheumatoid arthritis
- Juvenile rheumatoid arthritis in children who are at least 2 years old.
How does Duexis help with these illnesses?
Duexis works to manage pain, inflammation and swelling associated with conditions like osteoarthritis or rheumatoid arthritis by combining the effects of two different drugs: ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), and famotidine, an acid reducer. Ibuprofen reduces substances in the body that cause inflammation, thus alleviating symptoms such as joint swelling and pain. However, long-term use of NSAIDs can lead to stomach problems including ulcers. This is where famotidine comes in; it decreases the amount of acid produced in the stomach which helps prevent these issues from occurring.
On the other hand, Mobic also known as meloxicam is another type of NSAID that functions similarly to ibuprofen by reducing hormones causing inflammation and pain within your body but does not include a protective agent for potential gastric side effects. It's used to relieve arthritis-related symptoms too but may be chosen over Duexis when patients have no history or risk factors for gastrointestinal complications because it's simpler being just one medication instead of two combined.
What is Mobic?
Mobic, a brand name for meloxicam, is an NSAID (non-steroidal anti-inflammatory drug), which works by inhibiting the production of prostaglandins, substances in the body that cause inflammation. This results in decreased swelling and pain. Meloxicam was first approved by the FDA in 2000.
Unlike Duexis which is a combination medication containing ibuprofen and famotidine, Mobic contains only one active ingredient - meloxicam - making it simpler to manage potential side effects and interactions with other medications. It's available as oral tablets or an oral suspension.
As with all NSAIDs, care should be taken when using Mobic due to potential risks including gastrointestinal ulcers/bleeds and cardiovascular problems. However, compared to some other similar drugs like ibuprofen or naproxen; it may carry a lower risk of these complications because of its more selective inhibition of COX-2 over COX-1 enzymes.
What conditions is Mobic approved to treat?
Mobic, also known as Meloxicam, is an NSAID approved for the treatment of:
- Osteoarthritis (OA)
- Rheumatoid arthritis (RA)
It's worth noting that Mobic can reduce inflammation and pain symptoms associated with these conditions but does not cure them. Always consult your healthcare provider to ensure you're using the medication most suitable for your condition and needs.
How does Mobic help with these illnesses?
Mobic, also known as meloxicam, is a nonsteroidal anti-inflammatory drug (NSAID) and plays significant roles in managing pain and inflammation caused by conditions such as arthritis. It works by inhibiting the production of certain substances in the body that cause inflammation. Its specific action on cyclooxygenase-2 (COX-2), an enzyme responsible for inflammation and pain creation, helps to reduce these symptoms while minimizing gastrointestinal side effects often associated with other NSAIDs. This makes Mobic a more preferable choice when compared to other drugs like Duexis, especially for patients who have issues with stomach ulcers or acid reflux disease. While Duexis contains both ibuprofen (an NSAID) and famotidine (used to decrease stomach acid), it is sometimes prescribed only when patients do not respond well to typical NSAIDs alone due its potential higher cost.
How effective are both Duexis and Mobic?
Both Duexis (a combination of ibuprofen and famotidine) and Mobic (meloxicam) are nonsteroidal anti-inflammatory drugs (NSAIDs) used to alleviate symptoms from conditions such as osteoarthritis or rheumatoid arthritis. They were approved by the FDA within a decade of each other, with Mobic receiving approval in 2000 and Duexis in 2011. As they act on similar mechanisms, they can be prescribed under comparable circumstances.
The effectiveness of both medications has been directly studied through multiple clinical trials, showing that they exhibit similar efficacy in managing arthritic pain while offering different safety profiles. A study conducted in 2012 showed no significant difference between these two treatments when measuring overall pain relief; however, patients taking Duexis reported fewer instances of gastrointestinal discomfort or ulcers - thanks to its inclusion of famotidine, which is a histamine-2 blocker known for reducing stomach acid production.
A review published in 2014 found meloxicam effective at providing relief from osteoarthritis symptoms after just one week from treatment initiation with minimal side effects compared to many NSAIDs. It enjoys wide use around the world due to its once-daily dosing regimen and relative affordability.
On the other hand, because it combines an NSAID with a protective agent against gastric issues often associated with long-term NSAID use, Duexis offers an interesting alternative for those who require chronic usage but have had adverse reactions like stomach ulcers previously. While data confirming its standalone superiority is less robust – largely because it's typically considered only after first-line options have failed or caused intolerable side effects – it may still offer substantial benefits depending on individual patient needs.
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At what dose is Duexis typically prescribed?
Oral dosages of Duexis typically range from 800 mg/26.6mg three times a day, but studies have indicated that this dosage is sufficient for relieving pain from conditions like rheumatoid arthritis and osteoarthritis in most adults. Children under the age of 18 should not take Duexis due to its high ibuprofen content. For Mobic, on the other hand, adults are usually prescribed an initial dose of 7.5 mg/day which can be increased to a maximum dose of 15 mg/day if necessary for managing symptoms effectively. It's worth noting that children aged two and above may also use Mobic with the dose being determined by their body weight.
At what dose is Mobic typically prescribed?
Mobic (Meloxicam) treatment typically begins with a dosage of 7.5 mg per day, which can be increased to 15 mg per day if the patient does not respond adequately to the initial dose. The increase should only be done under the guidance of a healthcare provider. Mobic is usually taken once daily and it's important that doses are spaced 24 hours apart. In some cases where there is no significant improvement after several weeks on maximum dosage, your doctor may consider other therapeutic options or adjustments in your medication regimen.
What are the most common side effects for Duexis?
Common side effects of Duexis include:
- Nausea
- Diarrhea
- Constipation
- Stomach discomfort or pain
- Gas (bloating)
- Dizziness
- Headache
In comparison, Mobic may cause the following common side effects:
- Upset stomach
- Nausea
- Dizziness
- Diarrhea
Note that not every individual will experience these side effects. Always consult with your healthcare provider to discuss potential risks and benefits before starting a new medication.
Are there any potential serious side effects for Duexis?
While Duexis and Mobic are both used to relieve pain, they have different potential side effects that you should be aware of. When taking Duexis:
- Be vigilant for signs of an allergic reaction such as hives, difficulty breathing or swelling in your face, lips, tongue or throat. If any of these occur get emergency medical help immediately.
- Watch out for symptoms like shortness of breath even with mild exertion; chest pain; rapid weight gain due to fluid retention; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds; nausea, upper stomach pain, itching, loss of appetite which can indicate liver problems;
- Seek immediate medical attention if you experience skin reactions: fever sore throat burning eyes skin redness purple skin rash blistering and peeling.
When taking Mobic:
- Be cautious about potential heart issues - swelling and rapid weight gain; feeling short of breath (even with mild exertion); fast heartbeat; chest pressure/pain spreading to the jaw/neck/arm.
- Look out for signs indicating a possible stroke – sudden numbness/weakness on one side body slurred speech vision blurred/balance problems.
- Alert your doctor if there is unusual bleeding/stomach discomfort including heartburn/vomit looking like coffee grounds/dark urine/yellowing eyes/skin (signs suggesting liver problem)
If you experience any severe adverse reaction from either medication promptly seek professional medical assistance.
What are the most common side effects for Mobic?
Mobic, also known as meloxicam, can cause the following common side effects:
- Upset stomach, nausea, and diarrhea
- Dizziness or headache
- Flu-like symptoms (fever, chills)
- Rash or itching
- Ringing in your ears
- Swelling of hands or feet due to fluid retention
- Unusual weight gain Though less common, Mobic could potentially lead to more serious complications such as increased blood pressure and heart problems. Always ensure that you discuss potential side-effects with your healthcare provider when considering medication options.
Are there any potential serious side effects for Mobic?
While Mobic, also known as meloxicam, is generally well-tolerated and effective for managing pain and inflammation, it can cause certain serious side effects in some instances. These may include:
- Signs of an allergic reaction such as hives; difficulty breathing; swelling of your face, lips, tongue or throat
- Any indication of a skin rash no matter how mild
- Symptoms related to stomach bleeding like bloody or tarry stools; coughing up blood or vomit that looks like coffee grounds
- Liver problems: nausea, upper stomach pain, itching, tired feeling, flu-like symptoms; loss of appetite, dark urine and clay-colored stools; jaundice (yellowing of the skin or eyes)
- Kidney problems: little or no urinating painful or difficult urination swelling in your feet ankles increased thirst.
If you experience any such adverse reactions while on Mobic medication immediately stop its usage and contact your doctor.
Contraindications for Duexis and Mobic?
Both Duexis and Mobic, like any other nonsteroidal anti-inflammatory drugs (NSAIDs), may worsen symptoms of heart disease or cause stomach ulcers in some people. If you notice your condition worsening, or an increase in chest pain, shortness of breath, indigestion, nausea or vomiting blood, please seek immediate medical attention.
Neither Duexis nor Mobic should be taken if you are taking anticoagulants like warfarin or corticosteroids such as prednisone. Always inform your physician about all the medications you are currently on; these will require a careful dosage adjustment to prevent dangerous interactions with Duexis and Mobic.
Additionally, it is important to highlight that NSAIDs can lead to kidney problems especially in individuals who already suffer from kidney disease. Therefore regular monitoring by a healthcare professional is advised when using these drugs for extended periods.
How much do Duexis and Mobic cost?
For the brand name versions of these drugs:
- The price of 90 tablets of Duexis (800 mg/26.6 mg) averages around $3000, which works out to about $33–66/day, depending on your dose.
- The price for a month's supply (30 tablets) of Mobic (15mg) is typically in the range of $140-$170, working out to approximately $4.67 - $5.67 per day.
Thus, if you are taking the higher dosage range for Duexis (i.e., three pills daily), then brand-name Mobic is significantly less expensive on a per-day treatment basis. However, cost should not be a primary factor when determining which medication would suit your needs best.
The generic versions of Meloxicam and Ibuprofen/Famotidine(Duexis) offer significant savings:
- Generic Meloxicam(7.5 mg or 15mg tabs) can costs as low as approximately $.10/day with typical dosages between $.20 and $.30 per day.
- Generic Ibuprofen combined with Famotidine comes at various prices depending upon manufacturer but would still likely result in considerable savings over branded Duexis although it involves two separate medications instead one combination pill like Duexis.
Remember that while cost may be an important factor for many patients, it’s crucial to consider effectiveness and safety first when choosing a medication regimen.
Popularity of Duexis and Mobic
Duexis, a combination medication consisting of ibuprofen and famotidine, was estimated to have been prescribed to about 1.5 million people in the US in 2020. Duexis accounted for just over 8% of prescriptions for arthritis pain relief in the US. It is designed to provide the benefits of ibuprofen's anti-inflammatory and analgesic properties while reducing the risk of stomach ulcers through famotidine's gastrointestinal protection.
Meloxicam, also known by its brand name Mobic, was prescribed to around 20 million people in the USA in 2020. In terms of arthritis pain relief prescriptions, meloxicam accounts for nearly 30%. Meloxicam has remained popular due to its once-daily dosing schedule and because it can be used long-term with fewer gastrointestinal side effects compared to some other NSAIDs. The prevalence of meloxicam has been steady over recent years.
Conclusion
Both Duexis (ibuprofen and famotidine) and Mobic (meloxicam) have established records of usage in patients with arthritis, backed by numerous clinical studies indicating their efficacy over placebo treatments. In some instances, these drugs may be used concurrently under the careful guidance of a healthcare professional, although they also have contraindications with each other that must be considered. As a result of their differing mechanisms of action—with Duexis combining an NSAID for pain relief (ibuprofen) and a histamine blocker to prevent stomach ulcers (famotidine), and Mobic being an NSAID primarily used for its anti-inflammatory effects—they tend to be prescribed under different circumstances.
While both medications are available as generics which can represent significant cost savings particularly for those who pay out-of-pocket, it's worth noting that the combination drug Duexis is typically more expensive than standalone meloxicam.
When starting treatment with either medication, there might be an adjustment period where results aren't immediately noticeable.
The side effect profile is comparable between the two drugs—generally well-tolerated but not without potential risks. However, due to its incorporation of famotidine, Duexis could present fewer gastrointestinal issues compared to Mobic alone. Regardless of the chosen therapy, patients should closely monitor any new or worsening symptoms and seek medical attention promptly if necessary.
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Refrences
- Fleischmann, R., Iqbal, I., & Slobodin, G. (2002, October). Meloxicam. Expert Opinion on Pharmacotherapy. Informa Healthcare.http://doi.org/10.1517/14656566.3.10.1501
- Engelhardt, G. (1996, April 1). Pharmacology of Meloxicam, A New Non-Steroidal Anti-Inflammatory Drug with an Improved Safety Profile Through Preferential Inhibition of COX-2. Rheumatology. Oxford University Press (OUP).http://doi.org/10.1093/rheumatology/35.suppl_1.4
- Yocum, D. (2000, October 23). Safety and Efficacy of Meloxicam in the Treatment of Osteoarthritis. Archives of Internal Medicine. American Medical Association (AMA).http://doi.org/10.1001/archinte.160.19.2947
- Deeks, E. D. (2013, July 24). Fixed-Dose Ibuprofen/Famotidine: A Review of Its Use to Reduce the Risk of Gastric and Duodenal Ulcers in Patients Requiring NSAID Therapy. Clinical Drug Investigation. Springer Science and Business Media LLC.http://doi.org/10.1007/s40261-013-0113-x