Benazepril Hydrochloride

Congestive Heart Failure, Primary Hypercholesterolemia, Coronary Disease + 13 more

Treatment

5 FDA approvals

20 Active Studies for Benazepril Hydrochloride

Treatment for

Congestive Heart Failure

What is Benazepril Hydrochloride

AmlodipineThe Generic name of this drug

Treatment SummaryBenazepril, brand name Lotensin, is a medication used to treat high blood pressure, congestive heart failure, and chronic renal failure. Benazepril is converted into its active form benazeprilat in the liver, which is an angiotensin-converting enzyme (ACE) inhibitor that helps reduce blood pressure.

Norvascis the brand name

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Benazepril Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Norvasc

Amlodipine

1992

1199

Approved as Treatment by the FDA

Amlodipine, also known as Norvasc, is approved by the FDA for 5 uses like Coronary Disease and Coronary Artery Disease (CAD) .

Coronary Disease

Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin

Coronary Artery Disease (CAD)

Used to treat Coronary Artery Disease (CAD) in combination with Atorvastatin

Coronary Artery Disease

Used to treat angiographically documented disease in combination with Atorvastatin

Vasospastic Angina

Used to treat Vasospastic Angina in combination with Atorvastatin

Angina, Stable

Used to treat Chronic Stable Angina Pectoris in combination with Atorvastatin

Effectiveness

How Benazepril Hydrochloride Affects PatientsBenazepril is a drug used to treat high blood pressure, heart failure, and other conditions. It works by blocking an enzyme in the body called angiotensin-converting enzyme (ACE). This enzyme helps produce a hormone called angiotensin II, which can cause blood vessels to tighten and raise blood pressure. By blocking ACE, Benazepril reduces blood pressure, prevents stroke, and helps protect the kidneys from damage.

How Benazepril Hydrochloride works in the bodyBenazeprilat works by blocking the enzyme that helps create angiotensin, a hormone that narrows blood vessels. This prevents angiotensin from forming, which in turn lowers blood pressure and stops the body from producing as much of it. This leads to relaxed blood vessels and a decrease in stress hormones, allowing the body to regulate its blood pressure more easily.

When to interrupt dosage

The suggested dose of Benazepril Hydrochloride is contingent upon the diagnosed ailment, including Kidney Diseases, Diabetic Nephropathy and previous treatment. The quantity of dosage varies, as per the method of delivery (e.g. Capsule or Tablet - Oral) outlined in the table hereunder.

Condition

Dosage

Administration

High Cardiovascular Risk

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Kit, Suspension, Suspension - Oral, Solution - Oral, Solution

Dyslipidemias

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Pharmacotherapy

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Homozygous Familial Hypercholesterolemia

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Vasospastic Angina

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

inadequate response to diet

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Congestive Heart Failure

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Primary Hypercholesterolemia

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Coronary Disease

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Cardiovascular Events

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Lifestyle Modification

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Hypertensive disease

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Hypertensive disease

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Angina, Stable

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Coronary Artery Disease

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Dyslipidemias

10.0 mg, 5.0 mg, , 2.5 mg, 1.0 mg/mL

Warnings

Benazepril Hydrochloride has two contraindications and ought not to be utilized for the conditions in the following table.Benazepril Hydrochloride Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Amlodipine may interact with Pulse Frequency

There are 20 known major drug interactions with Benazepril Hydrochloride.

Common Benazepril Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Amifostine

Major

Amlodipine may increase the hypotensive activities of Amifostine.

Hydroxyzine

Major

The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Hydroxyzine.

Mobocertinib

Major

The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Mobocertinib.

Ziprasidone

Major

The risk or severity of QTc prolongation can be increased when Amlodipine is combined with Ziprasidone.

Abafungin

Minor

The therapeutic efficacy of Abafungin can be increased when used in combination with Amlodipine.

Benazepril Hydrochloride Toxicity & Overdose RiskPossible side effects from taking Metoprolol include headache, dizziness, tiredness, sleepiness, dizziness when standing up, nausea, and cough. Overdosing on Metoprolol is likely to cause dangerously low blood pressure.

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Benazepril Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Benazepril Hydrochloride?

325 active clinical trials are analyzing the potential of Benazepril Hydrochloride in treating previously managed Kidney Diseases and Diabetic Nephropathy.

Condition

Clinical Trials

Trial Phases

Congestive Heart Failure

184 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1

Hypertensive disease

3 Actively Recruiting

Not Applicable, Phase 3

inadequate response to diet

0 Actively Recruiting

Dyslipidemias

1 Actively Recruiting

Phase 2

Homozygous Familial Hypercholesterolemia

2 Actively Recruiting

Phase 3

Vasospastic Angina

1 Actively Recruiting

Phase 2, Phase 3

Dyslipidemias

0 Actively Recruiting

Primary Hypercholesterolemia

8 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Coronary Disease

1 Actively Recruiting

Not Applicable

Lifestyle Modification

2 Actively Recruiting

Not Applicable

Angina, Stable

0 Actively Recruiting

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Coronary Artery Disease

0 Actively Recruiting

High Cardiovascular Risk

2 Actively Recruiting

Phase 2, Phase 3

Cardiovascular Events

4 Actively Recruiting

Not Applicable

Pharmacotherapy

0 Actively Recruiting

Benazepril Hydrochloride Reviews: What are patients saying about Benazepril Hydrochloride?

5Patient Review

3/31/2016

Benazepril Hydrochloride for High Blood Pressure

My blood pressure has gone down significantly since I started taking this medication, and my pulse is much lower too.

5Patient Review

10/23/2012

Benazepril Hydrochloride for High Blood Pressure

5Patient Review

11/18/2012

Benazepril Hydrochloride for High Blood Pressure

4.7Patient Review

6/27/2013

Benazepril Hydrochloride for High Blood Pressure

I find that this treatment makes me have to urinate more frequently, especially at night.

4Patient Review

11/23/2016

Benazepril Hydrochloride for High Blood Pressure

This medication was successful in lowering my blood pressure for the most part; however, I recently had to go to the ICU because it caused kidney failure. This is after 5 years of use with no other adverse effects, save for occasional lightheadedness. Now, I'm having issues with blood pressure bottoming out suddenly, urinary difficulties, dehydration, severe nausea and vomiting. My doctor has me still taking 10mg per day, but if I don't take it for a couple days I seem to do better.

4Patient Review

2/14/2013

Benazepril Hydrochloride for High Blood Pressure

4Patient Review

4/7/2014

Benazepril Hydrochloride for High Blood Pressure

This treatment effectively lowered my blood pressure.

3.7Patient Review

8/14/2013

Benazepril Hydrochloride for High Blood Pressure

I'm a little concerned about this dry cough I've had since starting the medication. Some say it's called a "cardiac cough", but my doctor disagrees with that diagnosis. Help!

3.7Patient Review

9/10/2013

Benazepril Hydrochloride for High Blood Pressure

I'm a new user and I haven't been able to maintain a lower blood pressure with this medication.

3.7Patient Review

2/25/2013

Benazepril Hydrochloride for High Blood Pressure

Nausea developed after years of successful treatment.

3.7Patient Review

3/31/2013

Benazepril Hydrochloride for High Blood Pressure

This treatment really helped me relax.

3.7Patient Review

6/15/2022

Benazepril Hydrochloride for High Blood Pressure

I've been on this medication for about six months. The 5mg-a-day tablet doesn't seem to be helping as much as I'd hoped. My blood pressure has been in the normal range most of the time, but there are occasional high readings—especially before a doctor's appointment. I was told that it could help your kidneys if taken daily, but I'm not sure about that.

3.3Patient Review

1/4/2017

Benazepril Hydrochloride for High Blood Pressure

I'm a 62 year old woman who started taking this medication four months ago. I was on 5mg, but my blood pressure gradually started to increase until it was out of control. I'll be starting a new regimen of 5mg twice a day to see if that helps.

3Patient Review

2/21/2014

Benazepril Hydrochloride for Prevention of Recurrent Atrial Fibrillation

I recently started taking this medication and I am Black. I'm wondering if the fact that the pharmacy printout says not to use in Black people is something to be concerned about?

2.3Patient Review

1/30/2017

Benazepril Hydrochloride for High Blood Pressure

The medicine lowered my blood pressure but I had a really annoying dry cough. Also, if I caught sunlight or blue LED lights just right it would give me a migraine. These effects went away when I stopped taking the medicine for two months, and then came back when I started again. So far the new medication (Lozartan) is working well!

1.7Patient Review

12/16/2013

Benazepril Hydrochloride for High Blood Pressure

I'm not satisfied because my doctor increased my dosage without monitoring my blood work, and as a result my creatinine level was raised to 3.7. I'm still not back to normal numbers five weeks later.

1.3Patient Review

11/19/2013

Benazepril Hydrochloride for High Blood Pressure

My blood pressure is consistently high when I'm not on this medication, often reading over 200/100. Even with the meds, my BP usually hovers around 140/90, which is still too high in my opinion.

1Patient Review

3/11/2014

Benazepril Hydrochloride for Nondiabetic Proteinuric Nephropathy

I used this medication for six months and saw no benefits. In fact, I developed a number of undesirable side effects, like a dry cough and digestive problems. I'll be trying a different medication now.

1Patient Review

5/18/2015

Benazepril Hydrochloride for High Blood Pressure

I would recommend monitoring your blood pressure closely while taking this medication, as it caused my numbers to skyrocket.

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Patient Q&A Section about benazepril hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is benazepril hydrochloride used for?

"Benazepril is a medication used to treat high blood pressure. Hypertension puts extra strain on the heart and arteries, and if left unchecked, can lead to serious health problems."

Answered by AI

What are the side effects of benazepril HCL?

"The person has the following symptoms: a cough, a headache, dizziness, fatigue, dizziness upon standing, an increased serum creatinine level, drowsiness, and nausea."

Answered by AI

What is the difference between benazepril and benazepril hydrochloride?

"Benazeprilat inhibits ACE, preventing the conversion of angiotensin I (AT-I) to angiotensin II (AT-II); AT-II is a potent vasoconstrictor.

Benazepril Hydrochloride is a substance that inhibits the conversion of angiotensin I to angiotensin II. As a prodrug, it is metabolized to its active form, benazeprilat, which inhibits ACE. AT-II is a vasoconstrictor, and by preventing its formation, benazeprilat reduces hypertension."

Answered by AI

Is benazepril hydrochloride a diuretic?

"Generic Name: benazepril-hydrochlorothiazide

Benazepril works by relaxing blood vessels, causing them to widen. This action lowers blood pressure and also reduces the workload on the heart. The hydrochlorothiazide diuretic increases the amount of urine you make, which decreases excess water and salt in your body. This diuretic effect also helps to lower blood pressure by reducing the amount of fluid in the blood vessels."

Answered by AI

Clinical Trials for Benazepril Hydrochloride

Have you considered Benazepril Hydrochloride clinical trials? We made a collection of clinical trials featuring Benazepril Hydrochloride, we think they might fit your search criteria.

Explore trials for Benazepril Hydrochloride

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Supportive Management for Heart Failure and Methamphetamine Addiction

18+

All Sexes

Los Angeles, CA

Heart failure (HF) affects over 6 million people in the US and is a major cause of both hospital admissions and death. HF has many causes and contributing factors. One of the most aggressive forms of HF is associated with methamphetamine abuse, which has become its own epidemic in the US over the past twenty years. People who use methamphetamine tend to develop HF at a much younger age, with more severe disease and more serious consequences. A recent analysis using nationwide data, methamphetamine use doubled the risk of death or hospitalizations compared to non-users in patients with HF. Thus, methamphetamine users with HF represent a very high-risk group of patients from a healthcare perspective. HF may be reversible in some patients who use methamphetamine if patients can achieve 1) abstain from further methamphetamine use and 2) consistently take all the medications that can improve HF. These two goals are very difficult to achieve in practice, as the care of both methamphetamine addiction and HF requires specialized medical expertise and intensive regular follow up of patients. In general, achievement of one goal is not possible without the other. Patients who use methamphetamine have poor adherence to medical follow-up and therapies, and abstinence from methamphetamine is difficult to maintain. This is further complicated because the current model of HF care does not incorporate treatment for methamphetamine use. The current study proposes to launch a multidisciplinary clinic that treats both HF and methamphetamine use disorder at the same time. The HF care will be led by a cardiologist while the methamphetamine use treatment will be led by a psychiatric clinical pharmacist trained in addiction medicine. State-of-the-art HF care will include optimization of four pillar HF medications. Methamphetamine use treatment will include counseling and incentivized abstinence known as contingency management (CM). The investigators will manage the patients in the clinic for 6 months total. The investigators are interested in demonstrating that this integrated clinic model will result in improved delivery of care for these patients by reporting the rates of successful abstinence from methamphetamine, improved optimization of the four HF medications, and enhanced patient reported quality of life over the 6 months of follow up. The investigators will also collect data on the costs associated with providing this level of care and estimate a range of potential cost-savings.

Waitlist Available

Has No Placebo

Los Angeles General Medical Center (+1 Sites)Tien Ng, PharmD

Have you considered Benazepril Hydrochloride clinical trials? We made a collection of clinical trials featuring Benazepril Hydrochloride, we think they might fit your search criteria.