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What is Declomycin
DemeclocyclineThe Generic name of this drug
Treatment SummaryChlortetracycline is an antibiotic that is similar to tetracycline, but stays in the body for longer periods of time. This allows it to keep a constant, effective level of medication in the blood.
Demeclocycline Hydrochlorideis the brand name
Declomycin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Demeclocycline Hydrochloride
Demeclocycline
2004
30
Approved as Treatment by the FDA
Demeclocycline, commonly known as Demeclocycline Hydrochloride, is approved by the FDA for 39 uses including Cholera (Disorder) and Listeria infection .Cholera (Disorder)
Listeria infection
Recurrent Upper and Lower Respiratory Tract Infections (RTIs)
Plague
Rickettsia Infections
Anthrax
Relapsing fever caused by Borrelia recurrentis
Chlamydial Infections
Campylobacter Infection
Sexually Transmitted Infections (STIs)
Tularemia
Anthrax disease
Severe Acne Vulgaris
Yaws
Brucellosis
Used to treat Brucellosis in combination with Streptomycin
Respiratory Tract Infections
Amebic colitis
Rickettsia Infections
Relapsing Fever
Gram-Negative Bacterial Infections
Conjunctivitis caused by chlamydia
Cat-Scratch Disease
Brucellosis
Used to treat Brucellosis in combination with Streptomycin
Plague
Chlamydia Infections
Acne Vulgaris
Yaws
Psittacosis
Chlamydia trachomatis
Urinary Tract Infections
Sexually Transmitted Diseases
Skin Infections caused by Staphylococcus Aureus
Disease
Actinomycosis
Listeriosis
Tularemia
CMC-CDI
Campylobacter Infections
Necrotizing ulcerative gingivostomatitis
Effectiveness
How Declomycin Affects PatientsDemeclocycline is an antibiotic used to treat a variety of illnesses caused by bacteria, including Rocky Mountain spotted fever, typhus fever, Q fever, chancroid, and brucellosis. It works by stopping the growth of bacteria and staying in the body for a long time. It does not directly kill the bacteria, but prevents it from reproducing.
How Declomycin works in the bodyDemeclocycline works by inhibiting protein production in cells. It binds to ribosomes, which are responsible for making proteins, and blocks the assembly of amino acids into proteins. This process is reversible, meaning that the effect can be reversed with time. Demeclocycline is also sometimes used to treat a condition called Syndrome of Inappropriate Antidiuretic Hormone (SIADH). It is thought to do this by blocking the binding of antidiuretic hormone to its receptor.
When to interrupt dosage
The quantity of Declomycin is contingent upon the diagnosed disorder, including Chlamydia trachomatis, Psittacosis and Respiratory Tract Infections. The measure of dosage is contingent upon the method of administration described in the accompanying table.Condition
Dosage
Administration
Yaws
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Plague
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Psittacosis
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Tularemia
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Amebic colitis
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Rickettsia Infections
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Respiratory Tract Infections
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Disease
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Cat-Scratch Disease
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Anthrax
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Brucellosis
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Actinomycosis
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Relapsing Fever
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Conjunctivitis caused by chlamydia
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Skin Infections caused by Staphylococcus Aureus
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Listeriosis
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Urinary Tract Infections
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Chlamydia trachomatis
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Necrotizing ulcerative gingivostomatitis
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Chlamydia Infections
150.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule - Oral, Capsule
Warnings
There are 20 known major drug interactions with Declomycin.Common Declomycin Drug Interactions
Drug Name
Risk Level
Description
Amdinocillin
Major
The therapeutic efficacy of Amdinocillin can be decreased when used in combination with Demeclocycline.
Amoxicillin
Major
The therapeutic efficacy of Amoxicillin can be decreased when used in combination with Demeclocycline.
Ampicillin
Major
The therapeutic efficacy of Ampicillin can be decreased when used in combination with Demeclocycline.
Aspoxicillin
Major
The therapeutic efficacy of Aspoxicillin can be decreased when used in combination with Demeclocycline.
Azidocillin
Major
The therapeutic efficacy of Azidocillin can be decreased when used in combination with Demeclocycline.
Declomycin Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 2372 mg/kg.
Declomycin Novel Uses: Which Conditions Have a Clinical Trial Featuring Declomycin?
43 active studies are presently evaluating the potential of Declomycin in providing relief from Chlamydia trachomatis, Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) and Necrotizing ulcerative gingivostomatitis.Condition
Clinical Trials
Trial Phases
Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)
0 Actively Recruiting
Necrotizing ulcerative gingivostomatitis
0 Actively Recruiting
Tularemia
0 Actively Recruiting
Amebic colitis
0 Actively Recruiting
Relapsing Fever
0 Actively Recruiting
Listeriosis
0 Actively Recruiting
Actinomycosis
0 Actively Recruiting
Gram-Negative Bacterial Infections
0 Actively Recruiting
Sexually Transmitted Diseases
7 Actively Recruiting
Not Applicable, Phase 4
Anthrax
1 Actively Recruiting
Phase 2
Conjunctivitis caused by chlamydia
0 Actively Recruiting
Cat-Scratch Disease
0 Actively Recruiting
Acne Vulgaris
0 Actively Recruiting
Brucellosis
0 Actively Recruiting
Respiratory Tract Infections
0 Actively Recruiting
Disease
0 Actively Recruiting
Psittacosis
0 Actively Recruiting
Chlamydia trachomatis
3 Actively Recruiting
Phase 2, Not Applicable
Campylobacter Infections
0 Actively Recruiting
Plague
0 Actively Recruiting
Patient Q&A Section about declomycin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Demeclocycline used for?
"Demeclocycline can be used to treat infections caused by different kinds of bacteria. These include infections of the lungs and other respiratory tract infections, certain skin infections, certain infections of the reproductive system, and certain other infections that are spread by ticks, lice, mites, or infected animals."
Answered by AI
What is another name for Demeclocycline?
"Demeclocycline is an antibiotic derived from a mutant strain of Streptomyces aureofaciens. It is used to treat infections caused by bacteria."
Answered by AI
Why is Declomycin used for Siadh?
"Demeclocycline, an antibiotic that belongs to a group of drugs known as tetracyclines, works by inhibiting the activation of adenylyl cyclase after AVP binds to the V2R in the kidney. This therapy is used to treat SIADH, a condition characterized by the body's inability to regulate the level of fluid in the blood."
Answered by AI
What is Declomycin used for?
"It will not work for virus infections (such as common cold, flu).
This medication is used to treat a wide variety of bacterial infections, including those that cause acne. It is a tetracycline antibiotic. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for virus infections (such as common cold, flu)."
Answered by AI