Ditropan Xl

Nocturia, Urinary Bladder, Overactive, Neurological Disorders + 8 more
Treatment
20 Active Studies for Ditropan Xl

What is Ditropan Xl

OxybutyninThe Generic name of this drug
Treatment SummaryOxybutynin, sold under the brand name Ditropan XL, is a medication used to treat the symptoms of overactive bladder (OAB) such as urgency, frequency, and nocturia. It has been used since 1975 and is a safe and effective first-line treatment for OAB. Oxybutynin helps improve quality of life for people with OAB by reducing the embarrassing and inconvenient symptoms associated with the condition.
Ditropanis the brand name
image of different drug pills on a surface
Ditropan Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ditropan
Oxybutynin
1975
256

Effectiveness

How Ditropan Xl Affects PatientsOxybutynin helps to relieve the symptoms of an overactive bladder, such as frequent and urgent urination, by blocking certain receptors (muscarinic receptors). Angioedema (swelling) is a possible side effect of taking this drug and should be monitored for. Other possible side effects include hallucinations, confusion, agitation, and drowsiness. It is important to assess the response to oxybutynin before operating heavy machinery or driving. Dose adjustments may also be necessary.
How Ditropan Xl works in the bodyOxybutynin relaxes the bladder muscles by blocking the effects of acetylcholine. This increases the bladder's capacity, reducing the urge to urinate and making it easier to control when going to the bathroom. The active ingredient in oxybutynin is N-desethyloxybutynin, which works by preventing the muscarinic receptors in your bladder from being activated.

When to interrupt dosage

The prescribed dose of Ditropan Xl is contingent upon the diagnosed condition, such as Neurological Disorders, Foley Catheterization and Nocturia. The amount of dosage can be found in the table below, contingent upon the mode of delivery (e.g. Tablet, extended release or Patch).
Condition
Dosage
Administration
Urinary Bladder, Overactive
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Neurological Disorders
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
increased frequency of urination
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Spinal Dysraphism
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Foley Catheterization
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Longterm Indwelling Ureteral Stent
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Nocturia
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Bladder Spasms
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Urgency
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Urinary Incontinence, Urge
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered
Overactive Bladder Syndrome
, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL
, Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Transdermal, Patch, Patch - Transdermal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Spray, metered - Topical, Spray, metered

Warnings

Ditropan Xl has four contraindications, thus it should not be utilized when dealing with any of the conditions noted in the following table.Ditropan Xl Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Oxybutynin may interact with Pulse Frequency
Urinary Retention
Do Not Combine
uncontrolled narrow-angle glaucoma
Do Not Combine
Gastric Retention
Do Not Combine
There are 20 known major drug interactions with Ditropan Xl.
Common Ditropan Xl Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Oxybutynin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Oxybutynin.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Oxybutynin is combined with Aclidinium.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Oxybutynin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Oxybutynin.
Ditropan Xl Toxicity & Overdose RiskThe most toxic dose of oxybutynin in rats is 460 mg/kg. Overdosing on this drug can lead to symptoms such as confusion, fever, rapid heartbeat, difficulty urinating, breathing problems, paralysis, and coma. If an overdose is suspected, supportive care and activated charcoal should be administered immediately. Two cases of overdose from a 100 mg dose of oxybutynin have been reported in the past, both involving simultaneous alcohol consumption. Both patients were able to recover after receiving supportive treatment.
image of a doctor in a lab doing drug, clinical research

Ditropan Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Ditropan Xl?

79 active trials are presently being conducted to assess the potential of Ditropan Xl to ameliorate Overactive Bladder Syndrome, Foley Catheterization and Neurological Disorders.
Condition
Clinical Trials
Trial Phases
Nocturia
3 Actively Recruiting
Phase 4, Not Applicable
Bladder Spasms
1 Actively Recruiting
Phase 2
Spinal Dysraphism
0 Actively Recruiting
Urinary Incontinence, Urge
6 Actively Recruiting
Not Applicable, Phase 4
Foley Catheterization
0 Actively Recruiting
Urinary Urgency
2 Actively Recruiting
Not Applicable
Urinary Bladder, Overactive
0 Actively Recruiting
Overactive Bladder Syndrome
29 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2
Longterm Indwelling Ureteral Stent
0 Actively Recruiting
Neurological Disorders
7 Actively Recruiting
Not Applicable, Phase 2
increased frequency of urination
3 Actively Recruiting
Not Applicable

Ditropan Xl Reviews: What are patients saying about Ditropan Xl?

4.7Patient Review
11/20/2012
Ditropan Xl for Needing to Urinate Immediately
I find this medication really keeps me up at night.
4.7Patient Review
7/23/2013
Ditropan Xl for Problems with Bladder Control
I've been taking this medication for a while, and it's been working great. Recently, I had to up my dosage from 10mg to 15mg, but it's still doing the job.
4.7Patient Review
11/20/2012
Ditropan Xl for Needing to Urinate Immediately
I find that this treatment helps me stay up at night.
4.7Patient Review
7/23/2013
Ditropan Xl for Problems with Bladder Control
I've been taking this for a while now, and it's been doing great things for me. Recently had to up the dosage from 10mg to 15mg, but other than that no complaints!
4.3Patient Review
2/3/2018
Ditropan Xl for Problems with Bladder Control
I take a 5mg tablet when I don't want to use the restroom as often. It generally decreases my trips to 7 or 8 times per day, which is amazing. However, I do experience extreme fatigue and stomach pain after taking it, as well as constipation.
4.3Patient Review
5/30/2015
Ditropan Xl for Overactive Bladder
I've used this medication for years, and I find that the generic oxybutynin chloride ER 10 is just as effective as ditropan. I hate having to take medication, but this stuff is really necessary so I've just placed my refill order.
4.3Patient Review
5/1/2013
Ditropan Xl for Needing to Urinate Immediately
My husband's been taking this medication since he had a stroke, but unfortunately it hasn't helped significantly with his nocturia. We're hoping his primary doctor will have some more ideas.
4.3Patient Review
5/1/2013
Ditropan Xl for Needing to Urinate Immediately
My husband has had to wake up every two hours at night to urinate since his stroke. The medication prescribed to him in rehab hasn't changed anything. We'll have to bring it up with his primary doctor at his next appointment.
4.3Patient Review
2/3/2018
Ditropan Xl for Problems with Bladder Control
I find that this medication really helps to cut down on the number of times I have to go to the bathroom. However, the side effects can be pretty harsh. I get very tired and often have stomach pain and constipation. I also wet the bed once after taking it, so now I make sure not to take it before bedtime.
4.3Patient Review
5/30/2015
Ditropan Xl for Overactive Bladder
I've been taking this for over five years and I don't think the generic oxybutynin chloride ER 10 is any less effective. I would rather not have to take medication at all, but unfortunately it's necessary in my case.
4Patient Review
1/26/2016
Ditropan Xl for Needing to Urinate Immediately
I've been taking this medication for over six months. It's been working very well, but I have experienced some negative side effects like dry mouth and a decreased sense of taste.
4Patient Review
9/17/2016
Ditropan Xl for Frequent Urination
I was really surprised at how much this drug helped me after just one pill. My doctor prescribed it to me to help with my bladder issues until they figure out what's going on. It takes the edge off the pain and discomfort I constantly feel. The only downside is that it's very expensive.
4Patient Review
1/15/2019
Ditropan Xl for Overactive Bladder
The generic oxybutynin ER has been a total game-changer for me. I can actually sleep through the night now, and don't have to worry about accidents during the day. The only downside is that it made my hair fall out, but that was with the CL ER version originally prescribed.
4Patient Review
1/26/2016
Ditropan Xl for Needing to Urinate Immediately
I've been taking this daily for six months and it's helped me a lot. The only downside is that I have dry mouth and decreased taste, but those are minor problems in comparison to what this medication has helped me with.
4Patient Review
9/17/2016
Ditropan Xl for Frequent Urination
I was really surprised at how well this medication worked. My doctor prescribed it to me to help with my bladder issues and it has definitely taken the edge off the pain. The only downside is that it's quite expensive.
4Patient Review
1/15/2019
Ditropan Xl for Overactive Bladder
The generic oxybutynin ER has helped me be able to control my urination, empty my bladder completely, and only get up once at night. However, the oxybutynin CL ER originally prescribed made my hair fall out.
3.7Patient Review
11/25/2010
Ditropan Xl for Needing to Urinate Immediately
3.7Patient Review
4/30/2011
Ditropan Xl for Problems with Bladder Control
3.7Patient Review
8/9/2019
Ditropan Xl for A Condition of Bladder Dysfunction from Nerve Disorder
Overall, this works really well! The only downside is that it can cause dry mouth.
3.7Patient Review
11/25/2010
Ditropan Xl for Needing to Urinate Immediately
3.7Patient Review
4/30/2011
Ditropan Xl for Problems with Bladder Control
3.7Patient Review
8/9/2019
Ditropan Xl for A Condition of Bladder Dysfunction from Nerve Disorder
Works great, but unfortunately leaves my mouth really dry.
3.3Patient Review
6/21/2010
Ditropan Xl for Frequent Urination
3.3Patient Review
6/21/2010
Ditropan Xl for Frequent Urination
3Patient Review
9/24/2011
Ditropan Xl for Problems with Bladder Control
At first, this drug helped me to urinate less at night. But after a few weeks of continued use, I started experiencing dry mouth and changes to my sense of taste. Additionally, my gums and tongue became sore. So, I stopped taking the medication. Unfortunately, the nighttime urination has returned; however, I am hopeful that the other side effects will dissipate as well.
3Patient Review
8/9/2019
Ditropan Xl for Overactive Bladder
I've found that this treatment is slowly becoming less effective.
3Patient Review
8/9/2019
Ditropan Xl for Overactive Bladder
I found that this treatment was less and less effective the longer I took it.
3Patient Review
9/24/2011
Ditropan Xl for Problems with Bladder Control
After taking this for a few days, I found that I had to urinate less frequently at night. However, after a few weeks I started to experience dry mouth and changes in how food tasted. These side effects continued even after discontinuing use, so be wary before starting this medication.
2.3Patient Review
9/26/2010
Ditropan Xl for Frequent Urination
2.3Patient Review
11/21/2012
Ditropan Xl for Problems with Bladder Control
The dry mouth is the worst experience. And a funny taste in my mouth.
2.3Patient Review
10/21/2013
Ditropan Xl for Difficult or Painful Urination
My doctor prescribed this to me after surgery, because I would start leaking urine when I stood up or walked. I waited the three months they suggested, and then started taking the pills. Unfortunately, the generic extended release form hasn't helped at all. If anything, it's made things worse with side effects like drowsiness, dry mouth, and an upset stomach after eating. Not sure if I should tell my doctor or just keep going for a bit longer.
2.3Patient Review
9/26/2010
Ditropan Xl for Frequent Urination
2.3Patient Review
11/21/2012
Ditropan Xl for Problems with Bladder Control
The dry mouth is the worst experience. And a funny taste in my mouth.
2.3Patient Review
10/21/2013
Ditropan Xl for Difficult or Painful Urination
I was given this medication after bladder surgery to help with incontinence. However, even after waiting the suggested three months post-op, I saw no improvement while taking the pills. Additionally, I experienced bothersome side effects like dry mouth and drowsiness. Overall, not a great experience.
2Patient Review
7/23/2010
Ditropan Xl for Frequent Urination
2Patient Review
7/23/2010
Ditropan Xl for Frequent Urination
1Patient Review
9/24/2012
Ditropan Xl for Needing to Urinate Immediately
Though this medication did work, it took a while for the effects to be felt. I'm going to try taking it earlier in the morning from now on.
1Patient Review
9/24/2012
Ditropan Xl for Needing to Urinate Immediately
Though this drug does work, it takes a few hours to start seeing results. I'm going to experiment with taking it earlier in the morning.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ditropan xl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the best time of the day to take oxybutynin?

"You should take oxybutynin two to four times a day, usually at regular intervals. The extended-release tablet is usually taken once a day, with or without food."

Answered by AI

What are the side effects of Ditropan?

"The following side effects may occur: dry mouth, dizziness, drowsiness, blurred vision, dry eyes, nausea, vomiting, upset stomach, stomach pain, constipation, diarrhea, headache, unusual taste in mouth, dry/flushed skin, and weakness. If you experience any of these effects, notify your doctor or pharmacist."

Answered by AI

How long does it take Ditropan XL to start working?

"Oxybutynin works to relax the muscles around the bladder after 3-4 hours. However, it may take up to 4 weeks before the full effect is seen. If there is no improvement after 7 days, speak to your doctor. If symptoms worsen at any time, speak to your doctor."

Answered by AI

What is Ditropan XL used for?

"This drug is a long-acting form of oxybutynin, which is used to treat overactive bladder and urinary conditions. It relaxes the muscles in the bladder, helping to decrease urgency and frequency of urination. Oxybutynin belongs to a class of drugs called antispasmodics."

Answered by AI

Clinical Trials for Ditropan Xl

Image of Stanford Medicine Department of Obstetrics & Gynecology in Palo Alto, United States.

Detrusor Nerve Radiofrequency Ablation for Overactive Bladder

22 - 80
Female
Palo Alto, CA
The goal of this clinical trial is to learn if a vaginal radiofrequency (RF) device called MORPHEUSV works to treat overactive bladder (OAB) in women. Researchers also want to learn how safe the device is for this indication. This study will include women ages 22 to 80 who have had OAB symptoms for at least 6 months. The main questions it aims to answer are: Does the MORPHEUSV device lower the number of daily episodes of accidental urine leakage caused by urgency? Does it work better than a sham (placebo) treatment? Researchers will compare the MORPHEUSV device to a sham treatment to see how well it reduces symptoms of overactive bladder. Participants will: 1) Receive one session of either the MORPHEUSV or sham treatment. 2) Track their symptoms using a diary and questionnaires 3) Return for three to six follow-up visits over 12 months. This study is being conducted at multiple clinics in the United States.
Waitlist Available
Device
Stanford Medicine Department of Obstetrics & Gynecology (+10 Sites)Mickey Karram, MDInMode MD Ltd.
Have you considered Ditropan Xl clinical trials? We made a collection of clinical trials featuring Ditropan Xl, we think they might fit your search criteria.Go to Trials
Have you considered Ditropan Xl clinical trials? We made a collection of clinical trials featuring Ditropan Xl, we think they might fit your search criteria.Go to Trials
Image of Rossignol Medical Center in Phoenix, United States.

Photobiomodulation for Autism

4 - 12
All Sexes
Phoenix, AZ
For this study, the proposed intervention will be noninvasively delivered near infra-red (NIR) light - transcranial Photobiomodulation (tPBM) - to the brains of autistic children. This will occur, twice a week, for 10 weeks. The NIR light is delivered to specific brain areas by Cognilum, a wearable device developed by Jelikalite. The expected outcome is improved focus, improved eye contact, improved speech, improved behavior, and gains in functional skills. Cognilum may impact the clinical practice of treating autism. At the beginning, at five weeks, and at the end of study, the clinician will complete the CARS-2, SRS, CGI, and a caregiver interview; additionally, questionnaires will be administered to caregivers during one of the 1-hour weekly treatment sessions.
Phase 2
Recruiting
Rossignol Medical CenterRichard E Frye, M.D., Ph.D
Image of UConn Health in Farmington, United States.

MitoQ for Lower Urinary Tract Symptoms

50 - 75
Female
Farmington, CT
The goal of this clinical trial is to test the effect of a supplement called MitoQ (mitoquinol mesylate) on bladder symptoms such as urgency and frequency in women 50 years and older who have the metabolic syndrome. The main questions it aims to answer are: * Is the study design feasible and acceptable to participants? * Do participants taking the study drug get any improvement to their bladder symptoms compared to participants taking a placebo (a look-alike substance that contains no drug)? Participants will take 2 capsules of the study drug every morning for 4 months, answer many questions about their health including questions about their bladder health, perform physical and cognitive testing, give blood and urine samples, collect urine over 24 hour periods 3 times over the 4 months of the study, complete 3 day bladder diaries about how much they drink and void, undergo electrocardiograms, have their vitals and measurements (weight, height, waist circumference) taken, participate in 4 visits to the clinical research area and participate in many phone calls of varying length. Researchers will compare participants who were taking capsules containing MitoQ and participants taking capsules not containing MitoQ to see if MitoQ improves their bladder symptoms (urgency, frequency, nocturia, incontinence, etc.)
Phase 2
Recruiting
UConn HealthIman M Al-Naggar, PhD
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