Ditropan Xl

Nocturia, Urinary Bladder, Overactive, Neurological Disorders + 8 more

Treatment

20 Active Studies for Ditropan Xl

What is Ditropan Xl

Oxybutynin

The Generic name of this drug

Treatment Summary

Oxybutynin, sold under the brand name Ditropan XL, is a medication used to treat the symptoms of overactive bladder (OAB) such as urgency, frequency, and nocturia. It has been used since 1975 and is a safe and effective first-line treatment for OAB. Oxybutynin helps improve quality of life for people with OAB by reducing the embarrassing and inconvenient symptoms associated with the condition.

Ditropan

is the brand name

image of different drug pills on a surface

Ditropan Xl Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Ditropan

Oxybutynin

1975

256

Effectiveness

How Ditropan Xl Affects Patients

Oxybutynin helps to relieve the symptoms of an overactive bladder, such as frequent and urgent urination, by blocking certain receptors (muscarinic receptors). Angioedema (swelling) is a possible side effect of taking this drug and should be monitored for. Other possible side effects include hallucinations, confusion, agitation, and drowsiness. It is important to assess the response to oxybutynin before operating heavy machinery or driving. Dose adjustments may also be necessary.

How Ditropan Xl works in the body

Oxybutynin relaxes the bladder muscles by blocking the effects of acetylcholine. This increases the bladder's capacity, reducing the urge to urinate and making it easier to control when going to the bathroom. The active ingredient in oxybutynin is N-desethyloxybutynin, which works by preventing the muscarinic receptors in your bladder from being activated.

When to interrupt dosage

The prescribed dose of Ditropan Xl is contingent upon the diagnosed condition, such as Neurological Disorders, Foley Catheterization and Nocturia. The amount of dosage can be found in the table below, contingent upon the mode of delivery (e.g. Tablet, extended release or Patch).

Condition

Dosage

Administration

Spinal Dysraphism

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Urinary Bladder, Overactive

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Neurological Disorders

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

increased frequency of urination

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Foley Catheterization

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Longterm Indwelling Ureteral Stent

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Nocturia

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Bladder Spasms

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Urinary Urgency

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Urinary Incontinence, Urge

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Overactive Bladder Syndrome

, 5.0 mg/mL, 10.0 mg, 15.0 mg, 5.0 mg, 0.39 mg/hour, 0.28 mg/mg, 0.1 mg/mg, 2.5 mg, 0.0907 mg/mg, 10.0 %, 1.0 mg/mL

, Syrup, Oral, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Gel, Gel - Transdermal, Transdermal, Topical, Gel - Topical, Solution, Solution - Oral, Patch, Spray, metered, Spray, metered - Topical, Patch - Transdermal

Warnings

Ditropan Xl has four contraindications, thus it should not be utilized when dealing with any of the conditions noted in the following table.

Ditropan Xl Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Oxybutynin may interact with Pulse Frequency

Urinary Retention

Do Not Combine

uncontrolled narrow-angle glaucoma

Do Not Combine

Gastric Retention

Do Not Combine

There are 20 known major drug interactions with Ditropan Xl.

Common Ditropan Xl Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Oxybutynin.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Oxybutynin.

Aclidinium

Major

The risk or severity of adverse effects can be increased when Oxybutynin is combined with Aclidinium.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Oxybutynin.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Oxybutynin.

Ditropan Xl Toxicity & Overdose Risk

The most toxic dose of oxybutynin in rats is 460 mg/kg. Overdosing on this drug can lead to symptoms such as confusion, fever, rapid heartbeat, difficulty urinating, breathing problems, paralysis, and coma. If an overdose is suspected, supportive care and activated charcoal should be administered immediately. Two cases of overdose from a 100 mg dose of oxybutynin have been reported in the past, both involving simultaneous alcohol consumption. Both patients were able to recover after receiving supportive treatment.

image of a doctor in a lab doing drug, clinical research

Ditropan Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Ditropan Xl?

79 active trials are presently being conducted to assess the potential of Ditropan Xl to ameliorate Overactive Bladder Syndrome, Foley Catheterization and Neurological Disorders.

Condition

Clinical Trials

Trial Phases

Nocturia

4 Actively Recruiting

Not Applicable, Phase 4

Bladder Spasms

1 Actively Recruiting

Phase 2

Spinal Dysraphism

0 Actively Recruiting

Urinary Incontinence, Urge

5 Actively Recruiting

Not Applicable, Phase 4

Foley Catheterization

0 Actively Recruiting

Urinary Urgency

2 Actively Recruiting

Not Applicable

Urinary Bladder, Overactive

0 Actively Recruiting

Overactive Bladder Syndrome

26 Actively Recruiting

Not Applicable, Phase 4, Phase 1, Phase 2, Phase 3

Longterm Indwelling Ureteral Stent

0 Actively Recruiting

Neurological Disorders

7 Actively Recruiting

Not Applicable, Phase 2

increased frequency of urination

3 Actively Recruiting

Not Applicable

Ditropan Xl Reviews: What are patients saying about Ditropan Xl?

4.7

Patient Review

11/20/2012

Ditropan Xl for Needing to Urinate Immediately

I find this medication really keeps me up at night.

4.7

Patient Review

7/23/2013

Ditropan Xl for Problems with Bladder Control

I've been taking this medication for a while, and it's been working great. Recently, I had to up my dosage from 10mg to 15mg, but it's still doing the job.

4.7

Patient Review

11/20/2012

Ditropan Xl for Needing to Urinate Immediately

I find that this treatment helps me stay up at night.

4.7

Patient Review

7/23/2013

Ditropan Xl for Problems with Bladder Control

I've been taking this for a while now, and it's been doing great things for me. Recently had to up the dosage from 10mg to 15mg, but other than that no complaints!

4.3

Patient Review

2/3/2018

Ditropan Xl for Problems with Bladder Control

I take a 5mg tablet when I don't want to use the restroom as often. It generally decreases my trips to 7 or 8 times per day, which is amazing. However, I do experience extreme fatigue and stomach pain after taking it, as well as constipation.

4.3

Patient Review

5/30/2015

Ditropan Xl for Overactive Bladder

I've used this medication for years, and I find that the generic oxybutynin chloride ER 10 is just as effective as ditropan. I hate having to take medication, but this stuff is really necessary so I've just placed my refill order.

4.3

Patient Review

5/1/2013

Ditropan Xl for Needing to Urinate Immediately

My husband's been taking this medication since he had a stroke, but unfortunately it hasn't helped significantly with his nocturia. We're hoping his primary doctor will have some more ideas.

4.3

Patient Review

5/1/2013

Ditropan Xl for Needing to Urinate Immediately

My husband has had to wake up every two hours at night to urinate since his stroke. The medication prescribed to him in rehab hasn't changed anything. We'll have to bring it up with his primary doctor at his next appointment.

4.3

Patient Review

2/3/2018

Ditropan Xl for Problems with Bladder Control

I find that this medication really helps to cut down on the number of times I have to go to the bathroom. However, the side effects can be pretty harsh. I get very tired and often have stomach pain and constipation. I also wet the bed once after taking it, so now I make sure not to take it before bedtime.

4.3

Patient Review

5/30/2015

Ditropan Xl for Overactive Bladder

I've been taking this for over five years and I don't think the generic oxybutynin chloride ER 10 is any less effective. I would rather not have to take medication at all, but unfortunately it's necessary in my case.

4

Patient Review

1/26/2016

Ditropan Xl for Needing to Urinate Immediately

I've been taking this medication for over six months. It's been working very well, but I have experienced some negative side effects like dry mouth and a decreased sense of taste.

4

Patient Review

9/17/2016

Ditropan Xl for Frequent Urination

I was really surprised at how much this drug helped me after just one pill. My doctor prescribed it to me to help with my bladder issues until they figure out what's going on. It takes the edge off the pain and discomfort I constantly feel. The only downside is that it's very expensive.

4

Patient Review

1/15/2019

Ditropan Xl for Overactive Bladder

The generic oxybutynin ER has been a total game-changer for me. I can actually sleep through the night now, and don't have to worry about accidents during the day. The only downside is that it made my hair fall out, but that was with the CL ER version originally prescribed.

4

Patient Review

1/26/2016

Ditropan Xl for Needing to Urinate Immediately

I've been taking this daily for six months and it's helped me a lot. The only downside is that I have dry mouth and decreased taste, but those are minor problems in comparison to what this medication has helped me with.

4

Patient Review

9/17/2016

Ditropan Xl for Frequent Urination

I was really surprised at how well this medication worked. My doctor prescribed it to me to help with my bladder issues and it has definitely taken the edge off the pain. The only downside is that it's quite expensive.

4

Patient Review

1/15/2019

Ditropan Xl for Overactive Bladder

The generic oxybutynin ER has helped me be able to control my urination, empty my bladder completely, and only get up once at night. However, the oxybutynin CL ER originally prescribed made my hair fall out.

3.7

Patient Review

11/25/2010

Ditropan Xl for Needing to Urinate Immediately

3.7

Patient Review

4/30/2011

Ditropan Xl for Problems with Bladder Control

3.7

Patient Review

8/9/2019

Ditropan Xl for A Condition of Bladder Dysfunction from Nerve Disorder

Overall, this works really well! The only downside is that it can cause dry mouth.

3.7

Patient Review

11/25/2010

Ditropan Xl for Needing to Urinate Immediately

3.7

Patient Review

4/30/2011

Ditropan Xl for Problems with Bladder Control

3.7

Patient Review

8/9/2019

Ditropan Xl for A Condition of Bladder Dysfunction from Nerve Disorder

Works great, but unfortunately leaves my mouth really dry.

3.3

Patient Review

6/21/2010

Ditropan Xl for Frequent Urination

3.3

Patient Review

6/21/2010

Ditropan Xl for Frequent Urination

3

Patient Review

9/24/2011

Ditropan Xl for Problems with Bladder Control

At first, this drug helped me to urinate less at night. But after a few weeks of continued use, I started experiencing dry mouth and changes to my sense of taste. Additionally, my gums and tongue became sore. So, I stopped taking the medication. Unfortunately, the nighttime urination has returned; however, I am hopeful that the other side effects will dissipate as well.

3

Patient Review

8/9/2019

Ditropan Xl for Overactive Bladder

I've found that this treatment is slowly becoming less effective.

3

Patient Review

8/9/2019

Ditropan Xl for Overactive Bladder

I found that this treatment was less and less effective the longer I took it.

3

Patient Review

9/24/2011

Ditropan Xl for Problems with Bladder Control

After taking this for a few days, I found that I had to urinate less frequently at night. However, after a few weeks I started to experience dry mouth and changes in how food tasted. These side effects continued even after discontinuing use, so be wary before starting this medication.

2.3

Patient Review

9/26/2010

Ditropan Xl for Frequent Urination

2.3

Patient Review

11/21/2012

Ditropan Xl for Problems with Bladder Control

The dry mouth is the worst experience. And a funny taste in my mouth.

2.3

Patient Review

10/21/2013

Ditropan Xl for Difficult or Painful Urination

My doctor prescribed this to me after surgery, because I would start leaking urine when I stood up or walked. I waited the three months they suggested, and then started taking the pills. Unfortunately, the generic extended release form hasn't helped at all. If anything, it's made things worse with side effects like drowsiness, dry mouth, and an upset stomach after eating. Not sure if I should tell my doctor or just keep going for a bit longer.

2.3

Patient Review

9/26/2010

Ditropan Xl for Frequent Urination

2.3

Patient Review

11/21/2012

Ditropan Xl for Problems with Bladder Control

The dry mouth is the worst experience. And a funny taste in my mouth.

2.3

Patient Review

10/21/2013

Ditropan Xl for Difficult or Painful Urination

I was given this medication after bladder surgery to help with incontinence. However, even after waiting the suggested three months post-op, I saw no improvement while taking the pills. Additionally, I experienced bothersome side effects like dry mouth and drowsiness. Overall, not a great experience.

2

Patient Review

7/23/2010

Ditropan Xl for Frequent Urination

2

Patient Review

7/23/2010

Ditropan Xl for Frequent Urination

1

Patient Review

9/24/2012

Ditropan Xl for Needing to Urinate Immediately

Though this medication did work, it took a while for the effects to be felt. I'm going to try taking it earlier in the morning from now on.

1

Patient Review

9/24/2012

Ditropan Xl for Needing to Urinate Immediately

Though this drug does work, it takes a few hours to start seeing results. I'm going to experiment with taking it earlier in the morning.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ditropan xl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the best time of the day to take oxybutynin?

"You should take oxybutynin two to four times a day, usually at regular intervals. The extended-release tablet is usually taken once a day, with or without food."

Answered by AI

What are the side effects of Ditropan?

"The following side effects may occur: dry mouth, dizziness, drowsiness, blurred vision, dry eyes, nausea, vomiting, upset stomach, stomach pain, constipation, diarrhea, headache, unusual taste in mouth, dry/flushed skin, and weakness. If you experience any of these effects, notify your doctor or pharmacist."

Answered by AI

How long does it take Ditropan XL to start working?

"Oxybutynin works to relax the muscles around the bladder after 3-4 hours. However, it may take up to 4 weeks before the full effect is seen. If there is no improvement after 7 days, speak to your doctor. If symptoms worsen at any time, speak to your doctor."

Answered by AI

What is Ditropan XL used for?

"This drug is a long-acting form of oxybutynin, which is used to treat overactive bladder and urinary conditions. It relaxes the muscles in the bladder, helping to decrease urgency and frequency of urination. Oxybutynin belongs to a class of drugs called antispasmodics."

Answered by AI

Clinical Trials for Ditropan Xl

Image of Stanford Medicine Department of Obstetrics & Gynecology in Palo Alto, United States.

Detrusor Nerve Radiofrequency Ablation for Overactive Bladder

22 - 80
Female
Palo Alto, CA

The goal of this clinical trial is to learn if a vaginal radiofrequency (RF) device called MORPHEUSV works to treat overactive bladder (OAB) in women. Researchers also want to learn how safe the device is for this indication. This study will include women ages 22 to 80 who have had OAB symptoms for at least 6 months. The main questions it aims to answer are: Does the MORPHEUSV device lower the number of daily episodes of accidental urine leakage caused by urgency? Does it work better than a sham (placebo) treatment? Researchers will compare the MORPHEUSV device to a sham treatment to see how well it reduces symptoms of overactive bladder. Participants will: 1) Receive one session of either the MORPHEUSV or sham treatment. 2) Track their symptoms using a diary and questionnaires 3) Return for three to six follow-up visits over 12 months. This study is being conducted at multiple clinics in the United States.

Waitlist Available
Device

Stanford Medicine Department of Obstetrics & Gynecology (+10 Sites)

Mickey Karram, MD

InMode MD Ltd.

Have you considered Ditropan Xl clinical trials?

We made a collection of clinical trials featuring Ditropan Xl, we think they might fit your search criteria.
Go to Trials

Have you considered Ditropan Xl clinical trials?

We made a collection of clinical trials featuring Ditropan Xl, we think they might fit your search criteria.
Go to Trials
Image of Rossignol Medical Center in Phoenix, United States.

Photobiomodulation for Autism

4 - 12
All Sexes
Phoenix, AZ

For this study, the proposed intervention will be noninvasively delivered near infra-red (NIR) light - transcranial Photobiomodulation (tPBM) - to the brains of autistic children. This will occur, twice a week, for 10 weeks. The NIR light is delivered to specific brain areas by Cognilum, a wearable device developed by Jelikalite. The expected outcome is improved focus, improved eye contact, improved speech, improved behavior, and gains in functional skills. Cognilum may impact the clinical practice of treating autism. At the beginning, at five weeks, and at the end of study, the clinician will complete the CARS-2, SRS, CGI, and a caregiver interview; additionally, questionnaires will be administered to caregivers during one of the 1-hour weekly treatment sessions.

Phase 2
Recruiting

Rossignol Medical Center

Richard E Frye, M.D., Ph.D

Image of Mickey Karram MD in Corona Del Mar, United States.

Nerve Ablation for Overactive Bladder

21 - 80
Female
Corona Del Mar, CA

The goal of this Safety and efficacy of transvaginal Detrusor Nerve Ablation for treatment of overactive bladder symptoms, including refractory overactive bladder The main questions it aims to answer are: •Change from baseline to the end of treatment in a 3-day diary analysis to assess the reduction of urgency incontinence episodes. \[Time Frame: 3 months\] Subjects will undergo one treatment session and be reassessed at 4 weeks post-treatment. If less than a 50% improvement is noted, a second and third treatment session will be performed at 4-week intervals. If more than a 50% improvement is noted, patients will be followed longitudinally to assess the durability of the treatment. Investigators will have the ability to initiate a second and or third treatment on an individual basis. Follow-up will occur at 3- months, 6-months and 12 months after the subject's last treatment.

Waitlist Available
Has No Placebo

Mickey Karram MD (+2 Sites)

Mickey Karram, MD

InMode MD Ltd.

Have you considered Ditropan Xl clinical trials?

We made a collection of clinical trials featuring Ditropan Xl, we think they might fit your search criteria.
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