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What is Oramorph Sr
MorphineThe Generic name of this drug
Treatment SummaryMorphine is an opioid medication derived from poppy seeds that was first discovered in 1805. It is a powerful pain reliever, but its usage is limited due to its potential for addiction, withdrawal, and abuse. Morphine is still used today, and it is often combined with other, less strong opioids like codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone. Morphine was approved by the FDA in 1941.
Morphine Sulfateis the brand name
Oramorph Sr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Morphine Sulfate
Morphine
1971
459
Approved as Treatment by the FDA
Morphine, also known as Morphine Sulfate, is approved by the FDA for 2 uses including Chronic Pain and Pain .Chronic Pain
Helps manage Pain, Chronic
Pain
Effectiveness
How Oramorph Sr Affects PatientsMorphine works by blocking the transmission of pain signals in the body, and it typically takes 6-30 minutes to start working. Taking too much morphine can cause long-term changes in the brain. Men and women respond differently to morphine, with women being more sensitive to its effects. Morphine-6-glucuronide is much weaker than regular morphine; it is 22 times less likely to cause pupil constriction.
How Oramorph Sr works in the bodyMorphine-6-glucuronide, a metabolite of morphine, is responsible for most of the drug's effects. It works by activating two types of opioid receptors: mu and kappa. The mu-opioid receptor is linked to the drug's ability to affect the reward pathway in the brain and to modify the respiratory system. The kappa-opioid receptor is associated with addiction disorders.
When to interrupt dosage
The prescribed amount of Oramorph Sr is contingent upon the specified condition, such as Therapeutic procedure, Pain and Chronic Pain. The quantity of dosage can be found in the table below, contingent upon the mode of administration.Condition
Dosage
Administration
Therapeutic procedure
10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL
, Oral, Solution, Solution - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal; Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository, Suppository - Rectal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Intrathecal; Intravenous, Injection, solution - Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution / drops, Solution / drops - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Epidural, Solution - Epidural, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Syrup, Solution - Intravenous, Liquid - Intravenous, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Intramuscular, Injection - Intramuscular, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Parenteral, Solution - Parenteral, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex - Epidural, Injection, lipid complex, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid
Pain
10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL
, Oral, Solution, Solution - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal; Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository, Suppository - Rectal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Intrathecal; Intravenous, Injection, solution - Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution / drops, Solution / drops - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Epidural, Solution - Epidural, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Syrup, Solution - Intravenous, Liquid - Intravenous, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Intramuscular, Injection - Intramuscular, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Parenteral, Solution - Parenteral, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex - Epidural, Injection, lipid complex, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid
Chronic Pain
10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL
, Oral, Solution, Solution - Oral, Capsule, extended release - Oral, Capsule, extended release, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal; Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository, Suppository - Rectal, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Intramuscular; Intravenous; Subcutaneous, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Capsule, coated, extended release, Capsule, coated, extended release - Oral, Tablet - Oral, Tablet, Tablet, extended release, Tablet, extended release - Oral, Intrathecal; Intravenous, Injection, solution - Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Capsule, Capsule - Oral, Solution / drops, Solution / drops - Oral, Solution - Intramuscular; Intravenous; Subcutaneous, Epidural, Solution - Epidural, Solution - Intravenous; Subcutaneous, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Liquid, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Syrup, Solution - Intravenous, Liquid - Intravenous, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Intramuscular, Injection - Intramuscular, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection - Epidural; Intrathecal; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Parenteral, Solution - Parenteral, Tablet, film coated, Tablet, film coated - Oral, Injection, lipid complex - Epidural, Injection, lipid complex, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid
Warnings
Oramorph Sr ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Mental Depression
Do Not Combine
Asthma
Do Not Combine
Gastrointestinal obstruction
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Morphine may interact with Pulse Frequency
Common Oramorph Sr Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Morphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Morphine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Morphine.
Eluxadoline
Major
The risk or severity of constipation can be increased when Morphine is combined with Eluxadoline.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Morphine.
Oramorph Sr Toxicity & Overdose RiskThe lethal dose of morphine for males is 0.78µg/mL and for females it is 0.98µg/mL. Overdosing on morphine can lead to slowed breathing, sleepiness, weak muscles, cold and clammy skin, constricted pupils, and dilated pupils. Symptoms can worsen to include fluid buildup in the lungs, slow heart rate, low blood pressure, and even death. Treatment for morphine overdose includes oxygen, medication to boost blood pressure, and medication to counteract the effects of morphine.
Oramorph Sr Novel Uses: Which Conditions Have a Clinical Trial Featuring Oramorph Sr?
24 active clinical trials are currently assessing the ability of Oramorph Sr to provide therapeutic benefit, relieve Pain and ease Chronic Pain.Condition
Clinical Trials
Trial Phases
Pain
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Chronic Pain
0 Actively Recruiting
Oramorph Sr Reviews: What are patients saying about Oramorph Sr?
5Patient Review
10/29/20075Patient Review
10/29/20075Patient Review
10/17/2008 In comparison to other drugs, this one did not work at all for me or the three other people I know who have tried it. I believe that pharmacies are switch patients to this cheaper version in order to save money, rather than provide effective care.
5Patient Review
8/6/2008 I found this to be a much better option than generic morphine.
4.3Patient Review
12/21/20074Patient Review
2/12/2009 This treatment was very effective in reducing my pain levels. It took a little bit of time to get used to, but it really helped me out.
3.7Patient Review
11/18/2008 This medication is very effective at reducing pain so that I can get on with my day. It's become a wonder drug for me and my back has never felt better.
3.3Patient Review
1/3/2009 I was pleased that this treatment alleviated my pain.
3Patient Review
10/9/20073Patient Review
2/8/2009 This treatment lowers the maximum pain level I experience from a 10 to more manageable 6 or 7. The side effects are also relatively mild.
2.3Patient Review
10/29/20072.3Patient Review
3/6/2008