Permapen

Gas Gangrene, Botulism, Anthrax + 20 more

Treatment

20 Active Studies for Permapen

Treatment for

Gas Gangrene

What is Permapen

BenzylpenicillinThe Generic name of this drug

Treatment SummaryBenzylpenicillin (Penicillin G) is a common antibiotic used to treat infections caused by susceptible bacteria. It is injected into a muscle or vein because it cannot be absorbed through the stomach. Penicillin G is typically used to treat streptococcal infections, staphylococcal infections, and some bacterial infections caused by gram-positive aerobic bacilli. It may also be used to prevent certain bacterial infections in some cases. Penicillin G is not effective against gram-negative bacteria or anaerobic bacteria, and its effectiveness can vary depending on the region.

Bicillin L-Ais the brand name

image of different drug pills on a surface

Permapen Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bicillin L-A

Benzylpenicillin

1952

Effectiveness

How Permapen Affects PatientsPenicillin G is an antibiotic used to treat bacterial infections caused by certain bacteria. It works by stopping the bacteria from building a protective wall around itself, which eventually kills the bacteria. Penicillin G is effective against both gram-positive and gram-negative bacteria, and is resistant to a variety of beta-lactamases, including penicillinases, cephalosporinases, and extended spectrum beta-lactamases.

How Permapen works in the bodyPenicillin G works by attaching to proteins inside bacteria cells that help build the cell wall. This prevents the bacteria's cell wall from forming properly, leading to its destruction. Penicillin G may also interfere with a tool the bacteria use to stop its own destruction.

When to interrupt dosage

The measure of Permapen is based on the identified disorder, such as rat bite fever, Haverhill fever and Actinomycosis. The dosage is contingent upon the administration approach (e.g. Intramuscular; Intravenous or Injection, suspension) listed in the table below.

Condition

Dosage

Administration

Sepsis

, 5000000.0 [iU], 20000000.0 [iU], 5000000.0 [USP'U], 1200000.0 [iU]/mL, 5000000.0 units, 1000000.0 units, 10000000.0 units, 500000.0 units, 600000.0 [iU]/mL, 2400000.0 [iU]/mL, 100000.0 [iU]/mL, 200000.0 [iU]/mL, 300000.0 [iU]/mL, 1000000.0 [iU], 900000.0 [iU]/mL, 500000.0 units/mL, 1200000.0 units/mL, 250000.0 units/mL, 900000.0 units/mL, 300000.0 units/mL

, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, suspension, Injection, suspension - Intramuscular, Intramuscular, Intramuscular; Intrapleural; Intrathecal; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intrapleural; Intrathecal; Intravenous, Intravenous, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intravenous; Topical, Powder, for solution - Intramuscular; Intravenous; Topical, Oral, Tablet - Oral, Tablet, Suspension - Intramuscular, Suspension, Suspension - Oral, Powder, for solution - Intramuscular, Injection, solution, Injection, solution - Intravenous, Injection, powder, for solution - Intravenous

Acute Rheumatic Fever

Endocarditis

Bacterial Meningitis

Botulism

Haverhill fever

Diphtheria

Meningitis, Meningococcal

Endocarditis

Anthrax

Syphilis

rat bite fever

Empyema

Gram-Negative Bacterial Infections

Gas Gangrene

Lockjaw

Pericarditis

Pneumonia

Gonorrhea

Actinomycosis

Warnings

Permapen has one contraindication, so it should be avoided when confronting any of the circumstances specified in the accompanying table.Permapen Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Benzylpenicillin may interact with Pulse Frequency

There are 20 known major drug interactions with Permapen.

Common Permapen Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Benzylpenicillin.

Adefovir dipivoxil

Minor

The excretion of Adefovir dipivoxil can be decreased when combined with Benzylpenicillin.

Chlormadinone

Minor

The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Benzylpenicillin.

Cidofovir

Minor

The excretion of Cidofovir can be decreased when combined with Benzylpenicillin.

Cloprostenol

Minor

The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Benzylpenicillin.

Permapen Toxicity & Overdose RiskThe lowest toxic dose of this drug for rats has been measured at 8900mg/kg. Taking too much of this drug may cause seizures, and long-term use of high doses can lead to a decrease in white blood cells.

image of a doctor in a lab doing drug, clinical research

Permapen Novel Uses: Which Conditions Have a Clinical Trial Featuring Permapen?

85 active studies are being conducted to assess the potential of Permapen in treating Pneumonia, Acute Rheumatic Fever and Gram-Negative Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Pneumonia

21 Actively Recruiting

Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 1

Lockjaw

1 Actively Recruiting

Phase 4

Bacterial Meningitis

0 Actively Recruiting

Botulism

2 Actively Recruiting

Phase 1, Phase 2

Communicable Diseases

0 Actively Recruiting

Acute Rheumatic Fever

0 Actively Recruiting

Fusospirochetosis

0 Actively Recruiting

Meningitis, Meningococcal

0 Actively Recruiting

Anthrax

1 Actively Recruiting

Phase 2

Gram-Negative Bacterial Infections

1 Actively Recruiting

Phase 2

Gas Gangrene

0 Actively Recruiting

Empyema

0 Actively Recruiting

Listeriosis

0 Actively Recruiting

Actinomycosis

0 Actively Recruiting

Diphtheria

1 Actively Recruiting

Phase 4

rat bite fever

0 Actively Recruiting

Endocarditis

0 Actively Recruiting

Pericarditis

0 Actively Recruiting

Endocarditis

1 Actively Recruiting

Not Applicable

Sepsis

1 Actively Recruiting

Not Applicable

Permapen Reviews: What are patients saying about Permapen?

5Patient Review

8/4/2022

Permapen for Anxious

I was given this medication during my autism re-evaluation last week, and it has helped to reduce my anxiety and itching much better than Zoloft did about 6 years ago. I would highly recommend this drug to anyone who needs help with anxiety.

5Patient Review

10/7/2022

Permapen for Feel Like Throwing Up

This medication has been a godsend for my eating disorder. Not only does it help with anxiety, but it also helps immensely with the nausea I experience after eating.

5Patient Review

3/30/2022

Permapen for Itching

This treatment was very effective for me in relieving the itching associated with my pityriasis rosea. I didn't experience any negative side effects, and it made me feel much better overall as I waited for the rash to go away on its own.

5Patient Review

10/25/2022

Permapen for Inducing of a Relaxed Easy State

This has been an amazing addition to my routine. I was struggling with anxiety and insomnia after being hospitalized for Covid, but this medication has helped me get a full night's sleep without any side effects.

5Patient Review

3/30/2022

Permapen for Itching

Hydroxyzine was very effective at quelling the itch and making me feel more comfortable. I didn't experience any major negative side effects, just some drowsiness. All in all, it was a very positive experience.

5Patient Review

8/4/2022

Permapen for Anxious

I was given this medication during my re-evaluation for autism last week, and it has helped with my anxiety and itchiness much better than Zoloft did about six years ago. I would highly recommend this to anyone who needs help in those areas.

5Patient Review

10/25/2022

Permapen for Inducing of a Relaxed Easy State

I started taking this to help me sleep at night due to anxiety after being hospitalized for Covid. It's been amazing- I'm finally able to get a full night's sleep without any side effects.

5Patient Review

10/7/2022

Permapen for Feel Like Throwing Up

This medication has been a lifesaver for me. I have an eating disorder and it's helped me immensely with both my anxiety around food and the nausea I experience when I do eat.

5Patient Review

3/30/2022

Permapen for Itching

Hydroxyzine was very effective for me in managing the itchiness associated with pityriasis rosea. I only experienced drowsiness, which was to be expected, and it didn't cause any problems. All in all, a very positive experience.

5Patient Review

8/4/2022

Permapen for Anxious

This medicine has helped my anxiety much better than Zoloft did to me about 6 years ago. I would highly recommend it to anyone who needs help with anxiety.

5Patient Review

10/25/2022

Permapen for Inducing of a Relaxed Easy State

Since taking this medication, I have been able to sleep through the night without any issues. I am a light sleeper by nature, but this has really helped me out.

5Patient Review

10/7/2022

Permapen for Feel Like Throwing Up

This medication has been instrumental in my battle against anorexia. Not only does it help with the anxiety I experience around food, but it also helps immensely with the nausea that comes from eating.

5Patient Review

3/30/2022

Permapen for Itching

I was pleased with how well hydroxyzine worked to ease my itching and make me feel more comfortable as I waited for my pityriasis rosea rash to go away. I would definitely recommend it to others in a similar situation.

5Patient Review

8/4/2022

Permapen for Anxious

I was given this medication during my autism re-evaluation last week, and it has helped my anxiety much better than Zoloft did about 6 years ago. I would highly recommend this to anyone who needs help with anxiety.

5Patient Review

10/25/2022

Permapen for Inducing of a Relaxed Easy State

This medication has allowed me to get a full night's sleep for the first time in years. I highly recommend it for anyone struggling with anxiety or insomnia.

5Patient Review

10/7/2022

Permapen for Feel Like Throwing Up

This medication has been a godsend. It's not only helped my anxiety and eating habits, but it's also relieved the nausea I experience after eating.

4.3Patient Review

4/28/2022

Permapen for Anxious

I take it for anxiety before bed it works just fine and helps me sleep.

4.3Patient Review

4/28/2022

Permapen for Anxious

This medication works well for me in terms of reducing anxiety and helping me sleep at night.

4.3Patient Review

4/28/2022

Permapen for Anxious

I take this before bed to help with my anxiety and it does the job perfectly. I sleep soundly through the night.

4.3Patient Review

4/28/2022

Permapen for Anxious

This medication has been working well for me in terms of reducing anxiety and promoting sleep.

4Patient Review

7/31/2022

Permapen for Anxious

I've found this treatment to be effective, though it can make me feel like a bit of a robot during the day. I have some short-term memory problems and confusion, which can be annoying, but overall this medication has helped me immensely.

4Patient Review

7/31/2022

Permapen for Anxious

I'm a tall man, and this treatment worked well for me. The main downside is that I feel pretty zoned out during the day. It's confusing and frustrating at times, but it helps with anxiety tenfold.

4Patient Review

7/31/2022

Permapen for Anxious

I'm a tall man and this treatment worked well for me. The main downside is that I feel like a robot on it-- very confused and out of sorts. This can be really annoying, especially when mixed with things like shorter term memory loss (I once waited in the wrong line at the store for 30 minutes). Overall though, I would recommend it to anyone struggling with anxiety or stress.

4Patient Review

7/31/2022

Permapen for Anxious

I'm a tall guy and this medication worked great for me. The only downside is that I feel like a robot on it and get confused easily about things. I would recommend taking it before bed or as needed, but it really helped me out when I was going through a lot.

3.7Patient Review

5/5/2022

Permapen for Hives

This medication quickly and effectively got rid of my chronic hives. However, it caused me to feel very sleepy and groggy afterwards, so I'm looking for another option now.

3.7Patient Review

2/28/2022

Permapen for Inducing of a Relaxed Easy State

This medication prescribed to me for insomnia does work in the sense that it has a calming effect. However, I find that I wake up feeling groggy and then later in the day feel like I've been drugged and need to sleep again. Not very helpful overall.

3.7Patient Review

4/15/2022

Permapen for Anxious

I've been taking this medication for two years now, but I don't take it every day like I'm supposed to. It was originally prescribed to me for anxiety and panic attacks; however, I noticed that my body began to build a tolerance to it and it stopped working as well as it was supposed to. Definitely not a long-term solution.

3.7Patient Review

2/28/2022

Permapen for Inducing of a Relaxed Easy State

I was prescribed this medication for my insomnia and it does help me fall asleep. I wake up feeling groggy but after some tea, I'm doing well. However, about 10 hours later I feel drugged again and have to go back to sleep. So while it does help with falling asleep, it's not very helpful in terms of staying awake and functional during the day.

3.7Patient Review

4/15/2022

Permapen for Anxious

I've been taking this medication for two years now, but I don't take it every day like I'm supposed to. I originally started taking it for anxiety and panic attacks; however, I noticed that my body began to build a tolerance to it and it no longer worked as well as it did before. Definitely not a long-term medication.

3.7Patient Review

5/5/2022

Permapen for Hives

This medication quickly got rid of my hives where Benedryl failed. Though I still breakout occasionally, the itching is gone--which is a huge plus. The only downside is that it leaves me feeling drowsy and tired long after I should be awake and alert. So, I'm discussing other options with my doctor.

3.7Patient Review

2/28/2022

Permapen for Inducing of a Relaxed Easy State

I was prescribed this for insomnia. It helps me fall asleep but I wake up feeling groggy and then, about 10 hours later, I feel like I've been drugged and have to sleep again. Not very helpful.

3.7Patient Review

4/15/2022

Permapen for Anxious

I've been taking this medication for two years now, but I don't take it every day like I'm supposed to. It was prescribed to me for anxiety and panic attacks, but I noticed that my body began to build a tolerance to it and it no longer worked as well as it had before. Definitely not a long-term solution.

3.7Patient Review

5/5/2022

Permapen for Hives

This medication quickly got rid of my chronic hives, which Benedryl did nothing for. Although it does make me groggy, the itching is gone. I'm currently looking for another alternative with my doctor.

3.7Patient Review

2/28/2022

Permapen for Inducing of a Relaxed Easy State

I was prescribed this medication for my insomnia and it does help me fall asleep. I wake up feeling groggy, but after some tea I'm doing well. However, about 10 hours later I feel drugged again and have to go back to sleep. So while it does help me fall asleep, I don't think it's a very sustainable solution for my insomnia problem.

3.7Patient Review

5/5/2022

Permapen for Hives

This medication took care of my chronic hives immediately where Benedryl did nothing. ! I may still break out, but the itching is completely gone. However, it leaves me feeling drowsy and groggy even after I'm up for the day.

3.7Patient Review

4/15/2022

Permapen for Anxious

I've been taking this medication for two years now, but I don't take it every day like I'm supposed to. It's helped with my anxiety and panic attacks, but I noticed that my body started to build up a tolerance to it and it stopped working as well as it did at first. Definitely not a long-term solution.

3Patient Review

8/6/2022

Permapen for Anxious

I was prescribed this medication for my anxiety and it worked very well at first. I felt calm and normal again. However, the next day I experienced an elevated heart rate and felt out of it. I wish there was a pill that could provide the same relief without the side effects.

3Patient Review

8/6/2022

Permapen for Anxious

Hydroxyzine worked well in the beginning to calm my anxiety and it let me sleep through the night. However, I experienced an elevated heart rate the next day which was very uncomfortable.

3Patient Review

8/6/2022

Permapen for Anxious

This medication was very effective at treating my severe anxiety and panic attacks. I felt calm and normal again within 20 minutes of taking it, and slept through the night. However, the next day I experienced some side effects like an elevated heart rate and feeling out of it. Overall, this is a good medication but I would love to find one without the negative side effects.

3Patient Review

8/6/2022

Permapen for Anxious

Hydroxyzine helped me feel normal again after just 20 minutes, which I loved. However, I experienced some less-than-ideal side effects the next day that included an elevated heart rate and feeling "out of it." All things considered, this medication is good but not perfect.

2.3Patient Review

8/16/2022

Permapen for Itching

I was given this to help with my eczema and anxiety, but it actually made me more irritable and the itching didn't get any better. If you're struggling with depression, I would not recommend this medicine as it seems to make things worse.

2.3Patient Review

8/16/2022

Permapen for Itching

I was given this medication to help with eczema-induced itching, as well as anxiety. Unfortunately, the former got worse instead of better, and the latter turned me into an intolerable person. If you have depression, I would stay away from this drug altogether.

2.3Patient Review

3/15/2022

Permapen for Anxious

I took a 25mg dose of this medication last night as needed and experienced heart palpitations about two hours after taking it. I had no idea that the medication could cause this side effect until reading other reviews.

2.3Patient Review

8/16/2022

Permapen for Itching

I was given this for my eczema and anxiety. Unfortunately, it didn't help with the itching at all; if anything, it made me more irritable to the point where I couldn't stand being around myself. This medicine made my depression worse, so I had to stop taking it.

2.3Patient Review

3/15/2022

Permapen for Anxious

I took a 25mg dose of this medication last night and within about 2 hrs or so, I started experiencing heart palpitations. Didn’t realize it was from this medication until I read these reviews.

2.3Patient Review

3/15/2022

Permapen for Anxious

I took a 25mg dose of this medication last night and within about 2 hrs or so, I started experiencing heart palpitations. OMG!!! Didn’t realize it was from this medication until I read these reviews.

2.3Patient Review

8/16/2022

Permapen for Itching

I didn't find this to be helpful for my eczema or anxiety. If anything, it made me more irritable and depressed.

2.3Patient Review

3/15/2022

Permapen for Anxious

1.7Patient Review

6/20/2022

Permapen for Inducing of a Relaxed Easy State

I was prescribed this for my anxiety and depression. I was also hoping it would help me sleep better, but unfortunately it doesn't seem to work at all. In my opinion, it seems like doctors are prescribing this more as a placebo because they're afraid of lawsuits. This is really unfortunate because there are so many people suffering without any real help.

1.7Patient Review

6/20/2022

Permapen for Inducing of a Relaxed Easy State

I was really hoping this would help with my anxiety and depression, as well as promote better sleep. Unfortunately, I saw zero benefits from taking this medication. In my opinion, it's nothing more than a placebo that doctors are pushing because they're afraid of lawsuits.

1.7Patient Review

6/20/2022

Permapen for Inducing of a Relaxed Easy State

I was hoping this would help with my anxiety and depression, as well as improve my sleep. Unfortunately, I saw no benefits whatsoever. All it did was drain my wallet.

1.7Patient Review

6/20/2022

Permapen for Inducing of a Relaxed Easy State

I was prescribed this for my anxiety and depression. I was told it would also help me sleep, but it hasn't done anything at all. In my opinion, it's a placebo that doctors are overprescribing because they're afraid of lawsuits.

1Patient Review

11/10/2022

Permapen for Anxious

This medication made my blood pressure go really high, which was especially dangerous when I had to go to the dentist. Overall, not a great experience.

1Patient Review

11/10/2022

Permapen for Anxious

This medication made my blood pressure go sky high, which was especially dangerous when I had to go to the dentist.

1Patient Review

11/10/2022

Permapen for Anxious

Do not take this medication if you're planning on going to the dentist anytime soon. It made my blood pressure go sky-high and was incredibly dangerous.

1Patient Review

11/10/2022

Permapen for Anxious

Be aware that this medication can cause a significant rise in blood pressure, which can be dangerous in certain situations such as at the dentist.

Patient Q&A Section about permapen

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How much is benzathine penicillin?

"Bicillin L-A is a penicillin antibiotic that treats some infections caused by bacteria. However, it will not work for colds, the flu, or other viruses. The average retail price for the most common version of Bicillin L-A is $3,080.23, but it is currently available for 36% off at $1,956.80."

Answered by AI

What is benzathine penicillin used for?

"Penicillin G benzathine injection is used to treat bacterial infections such as mild to moderate infections of the upper respiratory tract, syphilis, yaws, bejel, and pinta. It is also used to prevent rheumatic fever, chorea, rheumatic heart disease, or acute glomerulonephritis. This medicine is an antibiotic."

Answered by AI

How many units is 2ml of bicillin?

"Please see prescribing information for the Penicillin G Sodium brand of sterile powder for intramuscular use.

The size of the syringe is 2 mL and it contains 1,200,000 units of penicillin G. The needle is 21 gauge, thin-wall and 1-1/2-inches long. The syringe has 0.22 mEq of sodium per 1,200,000 units of penicillin G."

Answered by AI

What is bicillin used to treat?

"Bicillin L-A should never be given intravenously.

The antibiotic penicillin G benzathine is the best choice to treat syphilis. It is given as two injections, one into each hip or buttock muscle. They must be given at the same visit. Bicillin L-A must never be given through a vein."

Answered by AI

Clinical Trials for Permapen

Image of The University of Texas Health Science Center at Houston in Houston, United States.

Have you considered Permapen clinical trials? We made a collection of clinical trials featuring Permapen, we think they might fit your search criteria.

Image of Geisinger 65-Forward, Buckhorn in Bloomsburg, United States.

Osteopathic Manipulative Therapy for Respiratory Diseases

65 - 100

All Sexes

Bloomsburg, PA

This trial aims to investigate whether Osteopathic Manipulative Therapy (OMT) can help patients with respiratory illnesses and their symptoms. The study will see if adding OMT to standard care can reduce symptoms

Waitlist Available

Has No Placebo

Geisinger 65-Forward, BuckhornMargaret Moore, DO

Image of Boston Medical Center in Boston, United States.

Recovery Management Checkups for Opioid Use Disorder

18 - 65

All Sexes

Boston, MA

This trial is testing a new version of a treatment program for opioid use disorder (OUD) called Recovery Management Checkups (RMC) that is tailored for people who have been hospitalized with serious injection

Waitlist Available

Has No Placebo

Boston Medical CenterSimeon Kimmel, MD

Antibody Test for Syphilis

Any Age

All Sexes

Ottawa, Canada

"This trial is testing a new syphilis antibody test called the Multiplo Complete Syphilis Antibody Test in an urban STI clinic. They will be using a finger-prick blood sample to

Waitlist Available

Has No Placebo

Sexual Health ClinicPatrick O'Byrne, PhDMedMira Laboratories Inc.

Image of Boston Children's Hospital in Boston, United States.

Clinical Stability Assessment for Pneumonia in Children

2 - 25

All Sexes

Boston, MA

This trial aims to see if doctors can safely give less antibiotics to children with complex medical conditions who have pneumonia by adjusting the duration of antibiotics based on how stable the child is clinically. "This trial investigates

Recruiting

Has No Placebo

Boston Children's Hospital

Have you considered Permapen clinical trials? We made a collection of clinical trials featuring Permapen, we think they might fit your search criteria.

Image of California Department of Public Health in Richmond, United States.

Botulinum Vaccine for Botulism

18 - 69

All Sexes

Richmond, CA

This trial will test safety, tolerability, and effectiveness of a botulinum vaccine in healthy participants, with a 6-month follow-up.

Phase 2

Waitlist Available

Has No Placebo

California Department of Public Health

Image of University of Utah in Salt Lake City, United States.

Antibiotic Stewardship at Discharge for Pneumonia

18+

All Sexes

Salt Lake City, UT

This trial will test if an antibiotic stewardship approach tailored to a hospital's needs can reduce antibiotic overuse at discharge in hospitalized patients with CAP or UTI.

Waitlist Available

Has No Placebo

University of UtahValerie M Vaughn, MD

Image of University of Michigan in Ann Arbor, United States.

Motivational Interviewing for STI Screening

18+

All Sexes

Ann Arbor, MI

This trial will investigate if gay/bi men w/ HIV are willing to collect & return bacterial STI specimens for testing when combined with live AV conferencing support, to prevent health complications & reduce transmissions.

Waitlist Available

Has No Placebo

University of MichiganAkshay Sharma, PhD

Image of Duke University in Durham, United States.

Cefiderocol for Bacterial Infections in Newborns and Infants

< 18

All Sexes

Durham, NC

This trial studies the effectiveness of cefiderocol in treating bacterial infections in newborns & babies under 3 months.

Phase 2

Recruiting

Has No Placebo

Duke University (+1 Sites)Medical DirectorShionogi

Have you considered Permapen clinical trials? We made a collection of clinical trials featuring Permapen, we think they might fit your search criteria.