Your session is about to expire
Duexis vs Ibuprofen
Introduction
For patients experiencing pain from conditions such as arthritis, certain medications that reduce inflammation and provide relief can greatly improve their quality of life. Duexis and Ibuprofen are two such drugs often prescribed for pain management. Both act by inhibiting enzymes involved in the production of prostaglandins - compounds that contribute to inflammation, fever, and pain signals. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) widely used to relieve various types of pain including headaches, toothache and menstrual cramps. On the other hand, Duexis is actually a combination medication, containing ibuprofen for its anti-inflammatory effects along with famotidine which helps to prevent stomach ulcers -- a common side effect associated with prolonged NSAID use. The choice between these two options would depend on individual patient needs and risk factors.
Duexis vs Ibuprofen Side By Side
| Attribute | Duexis | Ibuprofen |
|---|---|---|
| Brand Name | Duexis | Ibuprofen |
| Contraindications | Should not be taken with aspirin for heart protection without consulting a physician. Not recommended for use by children under 18 unless directed by a healthcare provider. | Should not be taken with aspirin for heart protection without consulting a physician. Increased risk of serious cardiovascular thrombotic events. |
| Cost | Around $2515 for 90 tablets | Around $10 for 100 tablets (200 mg each) |
| Generic Name | Ibuprofen and Famotidine | Ibuprofen |
| Most Serious Side Effect | Unusual bleeding or bruising, signs of allergic reaction, severe stomach pain, rapid weight gain, jaundice, chest pain, kidney problems. | Symptoms of an allergic reaction, intense skin reactions, unusual weight gain, blood in the stool or urine, difficulty focusing vision, rapid heartbeat. |
| Severe Drug Interactions | Increased risk of serious cardiovascular thrombotic events, ulcers, and bleeding in the stomach and intestines. | May increase the risk of heart attack or stroke, especially if used long term at high doses. |
| Typical Dose | One tablet three times per day, each tablet contains ibuprofen 800 mg and famotidine 26.6 mg. | 200–400 mg every 4 to 6 hours as needed, not to exceed 3200 mg under medical supervision. |
What is Duexis?
Duexis, containing ibuprofen and famotidine, is a combination medication that was uniquely developed to target two major issues simultaneously. The key component of Duexis is ibuprofen, which belongs to the class of NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) used for pain relief and inflammation reduction. This substance was first approved by FDA in 1974 and has been widely used since then. Ibuprofen works by inhibiting enzymes that produce prostaglandins - substances responsible for inducing pain and inflammation in our bodies.
The second ingredient of Duexis—famotidine—is an H2 blocker designed to reduce stomach acid production thus preventing potential ulcers caused by the long-term use of ibuprofen alone. It acts as a kind of protective agent providing extra safety layer for those who need regular intake of NSAIDs but have risks or history related to gastrointestinal problems.
Comparatively speaking, while generic ibuprofen can treat symptoms like fever, body pains or minor swelling effectively on its own; Duexis with its additional component targets not only these ailments but also takes preventive measures against possible side effects such as peptic ulcers that may occur from prolonged usage.
What conditions is Duexis approved to treat?
Duexis is approved for the treatment of various types of pain and inflammation:
- Osteoarthritis
- Rheumatoid arthritis It can also help to reduce the risk of developing stomach ulcers in patients at risk for these conditions, due to its combination with another drug, famotidine.
How does Duexis help with these illnesses?
Duexis helps to manage pain and inflammation by inhibiting the enzyme cyclooxygenase, which is involved in the production of prostaglandins. Prostaglandins play a key role in processes such as inflammation, fever, and pain signals. By blocking their production, Duexis can effectively relieve symptoms associated with conditions like arthritis. Unlike traditional ibuprofen however, Duexis also contains famotidine. Famotidine is a histamine-2 blocker that reduces the amount of gastric acid produced by the stomach. This added component makes Duexis less likely than regular ibuprofen to cause gastrointestinal side effects such as ulcers or stomach bleeding. Thus by combining anti-inflammatory action with protective measures for the digestive system, Duexis offers an improved solution for patients requiring long-term management of inflammatory conditions.
What is Ibuprofen?
Ibuprofen, often sold under the brand names Advil and Motrin, is a non-steroidal anti-inflammatory drug (NSAID) that works by reducing hormones causing inflammation and pain in the body. It was first approved by the FDA in 1984. Unlike Duexis, which combines ibuprofen with famotidine to decrease stomach acid production, Ibuprofen alone doesn't protect against potential gastric side effects associated with NSAIDs. Its singular action on prostaglandins means that its side-effect profile is also different from combination drugs like Duexis; specifically, it's more likely to cause gastrointestinal issues such as ulcers or bleeding. The effectiveness of Ibuprofen can be beneficial for treating various conditions ranging from minor aches and pains to severe joint pain seen in conditions like rheumatoid arthritis. However, patients who are at risk for gastric complications may benefit more from combined medications like Duexis.
What conditions is Ibuprofen approved to treat?
Ibuprofen, a key component of Duexis, is approved by FDA for the treatment and management of various conditions including:
- Minor to moderate pain resulting from different medical conditions
- Inflammatory diseases such as rheumatoid arthritis and osteoarthritis
- Fever reduction
- Menstrual cramps
It's important to note that Ibuprofen should be used under proper guidance due to its potential side effects.
How does Ibuprofen help with these illnesses?
Ibuprofen, a common nonsteroidal anti-inflammatory drug (NSAID), is known for its ability to alleviate pain and reduce inflammation by inhibiting the synthesis of prostaglandins. This makes it particularly effective in managing conditions like arthritis, menstrual cramps, headaches and other forms of acute or chronic pain. Duexis, on the other hand, combines ibuprofen with famotidine – an acid reducer commonly used to prevent stomach ulcers. The presence of famotidine doesn't influence the action of ibuprofen directly but helps protect against gastrointestinal side effects that can sometimes be associated with long-term NSAID use. Hence Ibuprofen continues to be a first-line choice for many due to its effectiveness and accessibility unless there's specific concern about potential gastric complications where combination therapy like Duexis may provide an added level of protection.
How effective are both Duexis and Ibuprofen?
Both Duexis and ibuprofen are effective nonsteroidal anti-inflammatory drugs (NSAIDs) that have been widely used to relieve pain, inflammation, and fever. They were approved by the FDA several years apart, with ibuprofen gaining approval in the 1970s and Duexis being approved more recently in 2011. Although they both contain the same active ingredient of ibuprofen, Duexis also includes famotidine, a substance known to reduce stomach acid.
The effectiveness of these two medications was directly studied in clinical trials before their approval; each has demonstrated efficacy at managing symptoms like arthritis pain while maintaining promising safety profiles. In one study comparing patients receiving pure ibuprofen vs those taking Duexis (ibuprofen/famotidine), no significant differences were observed regarding its effect on arthritis pain relief.
However, clinical reviews indicate benefits for combining ibuprofen with famotidine as seen in Duexis – primarily protecting against gastric ulcers that may arise from long-term NSAID use. This makes it an attractive choice over plain ibuprofen for patients who need prolonged treatment or have a history of gastro-intestinal issues.
In summary, while both medications can effectively manage similar conditions due to their common component - ibuprophen; deciding between them often comes down to individual patient needs. For instance: those prone to stomach issues might find better results using combination therapy found in Deuxies.
Related trials for duexis and ibuprofen
Find Top Clinical Trials
Choose from over 30,000 active clinical trials.
At what dose is Duexis typically prescribed?
Oral dosages of Duexis typically involve taking one tablet three times per day. Each tablet contains ibuprofen 800 mg and famotidine 26.6 mg. This drug is mainly used for the relief of rheumatoid arthritis and osteoarthritis while also preventing stomach ulcers. It's important to note that it should not be used by children under the age of 18, unless specifically directed by a healthcare provider due to potential risks and side effects. The dosage can be adjusted based on patient response, but exceeding the prescribed dose is not recommended as it could lead to serious gastrointestinal complications.
At what dose is Ibuprofen typically prescribed?
Ibuprofen therapy typically begins with a dosage ranging from 200–400 mg every 4 to 6 hours as needed. The dose can then be increased if necessary, but should not exceed the maximum daily limit of 1200 mg for over-the-counter use or 3200 mg under medical supervision. For chronic conditions such as osteoarthritis and rheumatoid arthritis, a regular intake may be recommended by your healthcare provider in divided doses throughout the day. It is also important to note that higher dosages or prolonged usage of ibuprofen could lead to potential side effects and hence it's crucial to follow your doctor’s instructions carefully while on this medication regimen.
What are the most common side effects for Duexis?
Common side effects of Duexis can include:
- Nausea
- Diarrhea or constipation
- Gas, bloating, indigestion
- Dizziness, weakness, feeling tired
- Back pain
- Swelling in hands or feet.
Whereas Ibuprofen has some similar side effects as well as a few different ones including:
- Stomach upset (most common)
- Nervousness
- Dizziness or drowsiness
- Mild itching or rash.
The risk of heart attack and stroke may increase with use of both medications especially if you have heart disease. Always consult your healthcare provider before starting any new medication regimen.
Are there any potential serious side effects for Duexis?
While Duexis is generally considered safe for most patients, it's important to be aware of potential serious side effects. These could include:
- Unusual bleeding or bruising
- Signs of allergic reaction such as difficulty breathing, hives, swelling in your face or throat
- Severe stomach pain, nausea and vomiting (especially if the vomit looks like coffee grounds)
- Bloody or black stools
- Rapid weight gain due to fluid retention; shortness of breath; bloating
- Jaundice - yellowing of the skin and eyes due to liver problems.
Additionally, more severe reactions may occur including:
- Symptoms related to heart issues: chest pain spreading to jaw or shoulder, sudden numbness/weakness on one side of body, slurred speech
- Kidney problems: little or no urination, painful urination
If you experience any of these symptoms while taking Duexis seek immediate medical attention. It's critical that you also inform your healthcare provider about any other medications you're currently using as drug interactions can increase these risks further.
What are the most common side effects for Ibuprofen?
Ibuprofen, compared to Duexis, can often lead to the following side effects:
- Stomach upset or pain
- Diarrhea or constipation
- Mild heartburn
- Nausea and vomiting
- Dizziness or drowsiness
- Headache In rare cases, it may cause:
- Ringing in the ears
- Serious allergic reactions including rash and swelling
While more serious side effects are less common, they may include: -Fast heartbeat -Anxiety or nervousness
It's important to monitor for these symptoms when starting a new medication like ibuprofen. Always consult with your healthcare provider if you experience any of these symptoms after taking Ibuprofen.
Are there any potential serious side effects for Ibuprofen?
Ibuprofen, a component of Duexis, is generally well-tolerated by most individuals. However, in some instances it can lead to severe side effects that should be promptly addressed:
- Symptoms indicative of an allergic reaction such as hives, difficulty breathing or swallowing, and swelling particularly around the face or throat
- Intense skin reactions characterized by redness, peeling or blistering
- Unusual weight gain along with signs of fluid retention like swollen ankles
- Blood in the stool or urine
- Difficulty focusing vision or any other changes in sight
- Rapid heartbeat
If you experience any of these symptoms while taking ibuprofen-containing medications like Duexis discontinue use and immediately consult your healthcare provider.
Contraindications for Duexis and Ibuprofen?
Both Duexis and ibuprofen, along with many other nonsteroidal anti-inflammatory drugs (NSAIDs), may increase the risk of serious cardiovascular thrombotic events such as heart attack or stroke. If you notice severe chest pain, shortness of breath, weakness in one part or side of your body, slurred speech, etc., please seek immediate medical attention.
Neither Duexis nor ibuprofen should be taken if you are taking aspirin for heart protection without talking to your physician first. Always inform your doctor about all medications you are currently taking; aspirin can interfere with the effectiveness of both Duexis and ibuprofen.
Also note that NSAID medicines like these can also cause ulcers and bleeding in the stomach and intestines at any time during treatment which could turn out fatal especially for elderly people. Therefore it's vital to communicate any unusual discomfort or symptoms immediately to a healthcare provider.
How much do Duexis and Ibuprofen cost?
For the brand name versions of these drugs:
- The price of 90 tablets of Duexis (800 mg ibuprofen and 26.6 mg famotidine) averages around $2515, which works out to approximately $28/day.
- The price for a bottle of 100 ibuprofen tablets (200 mg each) is about $10, working out to roughly $0.30 per day if taking the maximum over-the-counter dose.
Thus, even at higher dosages, over-the-counter ibuprofen is significantly less expensive than Duexis on a per-day treatment basis. However, it's critical to remember that cost should not be your primary consideration in determining which drug is right for you.
Regarding generic versions:
- There isn't currently a generic version available for Duexis.
- Generic ibuprofen can cost as little as $0.04 per tablet or even less when bought in bulk packages.
As always with medication choices, patients are advised not only consider costs but effectiveness and potential side effects carefully under guidance from their healthcare provider before making any decisions.
Popularity of Duexis and Ibuprofen
Duexis, a combination drug of ibuprofen and famotidine, was prescribed to approximately 1.2 million people in the US in 2020. Duexis accounted for just under 5% of non-steroidal anti-inflammatory (NSAID) prescriptions in the US. However, it is one of the most common "combination" NSAIDs prescribed specifically to mitigate gastrointestinal side effects associated with prolonged use of ibuprofen alone.
Ibuprofen on its own was prescribed to about 22 million people in the USA throughout 2020. In terms of overall NSAID prescriptions across the country, Ibuprofen accounts for nearly half — making it an extremely prevalent choice amongst health care providers due to its efficacy and cost-effectiveness. The prevalence of ibuprofen has remained steady over the past decade as it continues being a go-to medication for various types inflammation-caused pains.
Conclusion
Both Duexis (a combination of ibuprofen and famotidine) and ibuprofen alone have long-standing records of usage in patients with conditions like osteoarthritis, rheumatoid arthritis or chronic pain due to inflammation. Numerous clinical studies back their effectiveness over placebo treatments. Famotidine is added to the formulation in Duexis primarily to counteract the potential gastrointestinal side effects, such as stomach ulcers that can be caused by prolonged use of NSAIDs like ibuprofen.
The choice between these two medications will depend largely on an individual's specific medical condition and their risk for developing gastrointestinal issues. If a patient has a history of stomach ulcers or is at high risk for them, then Duexis may be considered as it combines the anti-inflammatory action of ibuprofen along with famotidine’s acid-reducing capability.
While both drugs are generally well-tolerated, they do carry risks for certain side effects - common ones include dizziness, nausea, constipation and gas. With Duexis specifically designed to reduce some adverse GI events associated with NSAID use like Ibuprofen.
Ibuprofen is available over-the-counter while Duexis requires a prescription from your healthcare provider. Both options come in generic form which could offer cost savings particularly if you're paying out-of-pocket expense.
As always when starting new treatment regimens, patients should closely monitor any changes in symptoms or new occurrences and contact their healthcare professional immediately should any concerning issues arise.
Other Trials to Consider
Popular Categories
Popular Guides
Learn More About These Treatments
Refrences
- Deeks, E. D. (2013, July 24). Fixed-Dose Ibuprofen/Famotidine: A Review of Its Use to Reduce the Risk of Gastric and Duodenal Ulcers in Patients Requiring NSAID Therapy. Clinical Drug Investigation. Springer Science and Business Media LLC.http://doi.org/10.1007/s40261-013-0113-x
- KANTOR, T. G. (1979, December 1). Ibuprofen. Annals of Internal Medicine. American College of Physicians.http://doi.org/10.7326/0003-4819-91-6-877
- Faulkner, G., Prichard, P., Somerville, K., & Langman, M. J. (1988, November 19). Aspirin and bleeding peptic ulcers in the elderly. Bmj. BMJ.http://doi.org/10.1136/bmj.297.6659.1311
- Bello, A. E. (2012, April 25). DUEXIS<sup>®</sup> (ibuprofen 800 mg, famotidine 26.6 mg): a new approach to gastroprotection for patients with chronic pain and inflammation who require treatment with a nonsteroidal anti-inflammatory drug. Therapeutic Advances in Musculoskeletal Disease. SAGE Publications.http://doi.org/10.1177/1759720x12444710
- Taha, A. S., Hudson, N., Hawkey, C. J., Swannell, A. J., Trye, P. N., Cottrell, J., … Russell, R. I. (1996, May 30). Famotidine for the Prevention of Gastric and Duodenal Ulcers Caused by Nonsteroidal Antiinflammatory Drugs. New England Journal of Medicine. Massachusetts Medical Society.http://doi.org/10.1056/nejm199605303342204