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What is Xalatan
LatanoprostThe Generic name of this drug
Treatment SummaryLatanoprost is a medication used to reduce pressure inside the eyes and treat glaucoma. It was first approved by the FDA in 1998 and is the first topical prostaglandin F2 alpha analog used for glaucoma treatment. Latanoprost is generally very well-tolerated and does not cause any systemic side effects, like other drugs used for elevated intraocular pressure. Additionally, it can be administered once a day, making it easier to take than other glaucoma medications.
Xalatanis the brand name
Xalatan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Xalatan
Latanoprost
1995
30
Approved as Treatment by the FDA
Latanoprost, otherwise called Xalatan, is approved by the FDA for 7 uses including Open Angle Glaucoma and Ocular Hypertension .Open Angle Glaucoma
Used to treat Open Angle Glaucoma (OAG) in combination with Netarsudil
Ocular Hypertension
Used to treat Ocular Hypertension in combination with Netarsudil
Glaucoma
Ocular Hypertension
Used to treat Ocular Hypertension in combination with Netarsudil
Increased Intra Ocular Pressure (IOP)
Glaucoma, Angle-Closure
Open Angle Glaucoma (OAG)
Used to treat Open Angle Glaucoma (OAG) in combination with Netarsudil
Effectiveness
How Xalatan Affects PatientsLatanoprost helps reduce pressure in the eye by increasing the drainage of fluid from the eye. The effects are usually felt within a few hours and can last for up to a day. There is a risk of eye and periorbital changes, such as changes to the color of the iris, redness around the eyes, darkening of the eyelashes, extra hair growth around the eyes, and irritation in the eye. These changes can occur after taking latanoprost for as little as three months.
How Xalatan works in the bodyLatanoprost is used to treat high eye pressure, which can cause damage to the optic nerve and loss of vision. Latanoprost stimulates certain receptors in the eye, resulting in increased fluid drainage from the eye. This lowers the pressure and reduces the risk of damage to the optic nerve. The increased drainage is probably due to changes in the tissue surrounding the drainage pathways, which makes it easier for fluid to flow out.
When to interrupt dosage
The measure of Xalatan is dependent upon the diagnosed condition, including Ocular Hypertension, Open Angle Glaucoma and chronic angle-closure glaucoma with prior peripheral iridotomy or laser iridoplasty. Dosage likewise shifts as indicated by the technique of delivery (e.g. Solution - Ophthalmic or Ophthalmic) presented in the table beneath.Condition
Dosage
Administration
Glaucoma
0.05 mg/mL,
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical
Open Angle Glaucoma
0.05 mg/mL,
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical
Ocular Hypertension
0.05 mg/mL,
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical
Glaucoma, Angle-Closure
0.05 mg/mL,
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical
inadequate response to other therapeutic measures
0.05 mg/mL,
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution / drops - Ophthalmic; Topical, Ophthalmic; Topical
Warnings
Xalatan ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Latanoprost may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Latanoprost may interact with Pulse Frequency
Common Xalatan Drug Interactions
Drug Name
Risk Level
Description
Bimatoprost
Major
The risk or severity of intraocular pressure can be increased when Latanoprost is combined with Bimatoprost.
Baricitinib
Moderate
The serum concentration of Baricitinib can be increased when it is combined with Latanoprost.
Xalatan Toxicity & Overdose RiskThe lowest toxic dose of latanoprost in rats has been found to be greater than 50mg/kg. An overdose of latanoprost is not usually dangerous, but may cause redness in the eyes. However, a large overdose may lead to swelling in the macula, which can be treated with eye drops and oral medication. If you think you or someone else may have taken too much latanoprost, contact your local poison control center.
Xalatan Novel Uses: Which Conditions Have a Clinical Trial Featuring Xalatan?
34 active studies are being conducted to determine the potential of Xalatan to proffer Open Angle Glaucoma, Ocular Hypertension and counter inadequate reactions to other therapies.Condition
Clinical Trials
Trial Phases
Glaucoma, Angle-Closure
0 Actively Recruiting
Ocular Hypertension
13 Actively Recruiting
Phase 3, Phase 4, Phase 1, Phase 2, Not Applicable
inadequate response to other therapeutic measures
0 Actively Recruiting
Glaucoma
0 Actively Recruiting
Open Angle Glaucoma
13 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
Xalatan Reviews: What are patients saying about Xalatan?
5Patient Review
2/3/2017 I've been using this combination of Timolol and Xalatan for the past three years, and it has done an amazing job of restoring my IOPs to a healthy level. Not to mention, it has also prevented any further loss of visual field.
5Patient Review
8/8/2013 I've been using this medicine for years to manage my blood pressure and it's working great. However, in the past year I've developed severe cold hands and feet that can be quite painful at times. My doctor says there's nothing wrong with me medically, so I'm wondering if this could be an undocumented side effect of xalatan? Has anyone else had a similar reaction?
5Patient Review
12/28/2011 I experienced no negative side effects from this medication. It successfully lowered my blood pressure from 32 to 16 over the course of two years. I was recently switched to a generic version due to changes in my insurance, but it is not working as well for me.
4.7Patient Review
10/30/2014 I took this drug for a long time and it worked great, but sadly it stopped being effective about a year ago. My doctor has been trying to find a new combination of drugs that will work for me, but the side effects of all the other options have been really tough to deal with.
4Patient Review
10/31/2012 The price tag on this varies depending on where you look. I get "dry eye" from being on the computer frequently, so these help me out a lot. Make sure to ask your doctor about which kind would be best for you specifically, as they all have different purposes. Also, if you ever feel like there's something foreign in your eye(s), try using this medication alongside Azopt; it helped me control my eye pressure for over 10 years now. And a little tip: set an alarm or reminder of some sort to not forget taking theseeye drops!
Patient Q&A Section about xalatan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Xalatan used to treat?
"Latanoprost is used to lower eye pressure in patients with glaucoma or ocular hypertension. The drug works by increasing the outflow of fluid from the eye, which reduces intraocular pressure."
Answered by AI
Does Xalatan need to be refrigerated?
"Xalatan® should be stored in the refrigerator before it is opened. Once opened, it can be kept in the refrigerator for up to six weeks or at room temperature for the same amount of time."
Answered by AI
What type of drug is Xalatan?
"Latanoprost is a substance that is similar to a natural body chemical called prostaglandin. It is used as an eyedrop to treat increased pressure inside the eye. This increased pressure can be caused by open-angle glaucoma or ocular hypertension. These conditions can lead to blindness if they are not treated. Latanoprost reduces pressure in the eye by helping the fluid to drain out of the eye."
Answered by AI
What are the side effects of Xalatan?
"If you experience any of the following side effects after using the eye drops, call your doctor immediately: blurred vision, burning/stinging/itching/redness of the eye, feeling as if something is in the eye, changes in eyelash number/color/length/thickness, eyelid skin darkening, browning of the iris, watery eyes, dry eyes."
Answered by AI