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Flonase vs Allegra
Introduction
For individuals suffering from allergic reactions such as rhinitis or other forms of seasonal allergies, certain medications can aid in managing symptoms and providing relief. Flonase and Allegra are two such drugs that are commonly prescribed for these conditions. They each function differently to combat allergy symptoms, but both have proven effectiveness in providing relief. Flonase is a corticosteroid nasal spray that works by reducing inflammation in the nasal passages, primarily treating congestion, sneezing, and runny nose caused by allergies. On the other hand, Allegra (Fexofenadine) is classified as an antihistamine which blocks the action of histamine - a substance in your body involved in allergic reactions - thus relieving symptoms like itching eyes/nose/ throat, running nose and watery eyes.
Flonase vs Allegra Side By Side
| Attribute | Flonase | Allegra |
|---|---|---|
| Brand Name | Flonase | Allegra |
| Contraindications | Should not be taken with certain antifungal drugs (such as ketoconazole), antibiotics (like erythromycin) or HIV medications due to negative interactions. Avoid alcohol to prevent intensification of side effects. | Should not be taken with certain antifungal drugs, antibiotics, or HIV medications due to negative interactions. Avoid alcohol to prevent intensification of side effects. Inform healthcare provider about liver disease. |
| Cost | The price of 120 sprays averages around $22, which works out to $0.18–$0.37/day, depending on your dose. Generic versions are significantly cheaper, costing just over $.10 to $.25 per day depending on usage. | The price of 30 tablets (180 mg) is about $20, working out to approximately $0.67/day. Generic versions average around $.40-.60 per day depending on purchase location and quantity. |
| Generic Name | Fluticasone Propionate | Fexofenadine |
| Most Serious Side Effect | Vision problems, rapid heartbeat, unusual fatigue and weakness, severe nervous system reaction. | Symptoms of an allergic reaction, rapid heartbeat, severe dizziness, difficulty urinating, persistent fatigue and dry mouth. |
| Severe Drug Interactions | Antifungal drugs, antibiotics, HIV medications. | Antifungal drugs, antibiotics, HIV medications. |
| Typical Dose | 1–2 sprays per nostril once daily. For children aged between 4 and 11, it may start with one spray in each nostril per day. Dosage can be increased if there is no response; however, exceeding two sprays in each nostril daily is not recommended. | 60 mg twice daily or 180 mg once daily for adults and children ages 12 years and older. For children aged 6 to 11 years, usually 30mg twice daily. Dosage can be increased as per doctor's advice. |
What is Flonase?
Fluticasone (the generic name for Flonase) is a type of medication known as a corticosteroid, which was approved by the FDA in 1994. It works by reducing inflammation and swelling in the nasal passages, providing relief from symptoms such as congestion, sneezing, and runny nose. It is prescribed for the treatment of allergic rhinitis and non-allergic rhinitis.
On the other hand, Fexofenadine (the generic name for Allegra) is an antihistamine that blocks histamines – substances that cause allergy symptoms. Allegra was first introduced to the market in 1996. Unlike Flonase which targets inflammation specifically within nasal passages, Allegra works on allergy symptoms throughout your body including itchy/watery eyes or hives.
Both medications have their unique advantages depending on specific symptoms one may be experiencing. However, since Flonase reduces overall inflammation rather than simply blocking histamines like Allegra does its effects might offer broader symptom relief but could also yield more side effects.
What conditions is Flonase approved to treat?
Flonase is approved for the treatment of various allergic reactions, including:
- Seasonal and perennial allergic rhinitis, commonly known as hay fever
- Non-allergic (vasomotor) rhinitis
- Its use can also help decrease nasal symptoms caused by allergens, dust mites, pet dander or pollen.
How does Flonase help with these illnesses?
Flonase helps manage allergy symptoms by decreasing the inflammation caused by allergens in your nasal passages. It does this by acting as a glucocorticoid receptor agonist, which means it binds to receptors in cells and activates them to produce an anti-inflammatory response. Inflammation is one of the body's responses to harmful stimuli such as allergens, and it results in symptoms like swelling, redness, heat, pain or loss of function. Histamines play crucial roles in allergic reactions causing these symptoms. So when Flonase reduces inflammation, it can alleviate these negative effects of allergies and help patients better manage their condition.
On the other hand, Allegra (fexofenadine) works differently from Flonase; instead of reducing inflammation directly like Flonase does, Allegra prevents histamine — a substance produced by the body during an allergic reaction — from having an effect on the cells. This blocking action inhibits sneezing, itching and runny nose that come with hay fever.
What is Allegra?
Allegra is a brand name for fexofenadine, an antihistamine drug that reduces the effects of histamines in your body. Histamines can produce symptoms such as sneezing, itching, watery eyes, and runny nose which are common in allergic reactions. Fexofenadine was first approved by the FDA in 1996 and has since become one of the most commonly used over-the-counter allergy medications.
Unlike Flonase (a nasal spray corticosteroid), Allegra does not work by reducing inflammation but instead blocks histamine activity to relieve allergy symptoms. This means its side-effect profile is different from corticosteroids like Flonase; it does not cause dryness or stinging in the nose and does not have a risk of nosebleeds. However, unlike Flonase which works directly on inflamed tissues in the nasal passages, Allegra may take longer to take effect as it must be absorbed into your bloodstream after oral ingestion.
What conditions is Allegra approved to treat?
Allegra (fexofenadine) is an antihistamine that has been approved by the FDA for the treatment of:
- Seasonal allergic rhinitis, also known as hay fever
- Chronic idiopathic urticaria or hives caused by unknown sources.
Its non-drowsy formula makes it a popular choice among patients who want to relieve their allergy symptoms without feeling sleepy during the day.
How does Allegra help with these illnesses?
Histamine is a compound released by cells in response to injury and allergic or inflammatory reactions, causing contraction of smooth muscle and dilation of capillaries. Allegra (fexofenadine) works by blocking the histamine receptors in the body, thereby reducing typical allergy symptoms like sneezing, itching, watery eyes, and runny nose. It's an antihistamine that doesn't cross the blood-brain barrier as much as older medications do; this means it doesn't cause drowsiness or affect cognition significantly - a benefit for those who need to remain alert. Unlike Flonase which is a nasal spray corticosteroid designed to reduce inflammation locally in your nasal passages, Allegra can be taken orally and has effects throughout the entire body making it potentially more effective at relieving widespread itchiness or hives associated with allergies. As such, it may be prescribed when a patient does not respond well to localized treatments such as Flonase.
How effective are both Flonase and Allegra?
Both Flonase (fluticasone propionate) and Allegra (fexofenadine) are effective treatments for the symptoms of allergic rhinitis, also known as hay fever. They were approved by the FDA in 1994 and 1996 respectively, making them relatively contemporary options. While they work through different mechanisms - Flonase is a nasal steroid while Allegra is an antihistamine - they both aim to reduce inflammation and relieve allergy symptoms.
The effectiveness of Flonase and Allegra was directly studied in several clinical trials; these two drugs exhibited similar efficacy in managing symptoms such as sneezing, itchy or watery eyes, runny nose, and itchy throat. One study from 2002 showed that patients receiving either treatment experienced comparable relief from their allergy symptoms.
A review article published in 2003 highlighted that fluticasone has been shown to be effective at reducing all major nasal symptoms associated with hay fever including congestion which many oral antihistamines struggle with. The same report noted that Flonase rarely causes side effects due to its local application but can cause occasional nosebleeds.
As per a meta-analysis conducted in 2011 regarding fexofenadine's performance demonstrated it to be more effective than placebo at treating allergic rhinitis while causing less drowsiness compared to other first-generation antihistamines like diphenhydramine(Benadryl). However, despite being well tolerated generally by users there have been reports of headaches and nausea among some individuals using this medication. It must be noted though that this happens quite infrequently.
While both medications are considered first-line treatments for allergies each one has specific situations where they might prove more beneficial: For instance, if you experience significant nasal congestion along with your allergies then Flonase would likely provide better symptom control due its anti-inflammatory action within the nasal passages whereas if you're looking for quick acting systemic relief without concern over possible sleepiness then Allegra could suit your needs better given its swift action once taken orally.
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At what dose is Flonase typically prescribed?
Fluticasone Propionate (Flonase) nasal spray dosages vary from 1–2 sprays per nostril once daily, but studies have shown that for most people the relief of allergic rhinitis symptoms typically begins within 12 hours after the first dose. Children aged between 4 and 11 may be started on one spray in each nostril per day. In either population, dosage can be increased after a few days if there is no response; however, exceeding two sprays in each nostril daily is not recommended under any circumstances.
At what dose is Allegra typically prescribed?
Allegra (fexofenadine) treatment typically begins with a dosage of 60 mg twice daily or 180 mg once daily for adults and children ages 12 years and older. For children aged between 6 to 11 years old, Allegra is usually started at a dose of 30mg, administered twice daily. This can be increased as per your doctor's advice if the symptoms persist or are not well controlled. Importantly, one should never exceed the maximum recommended dosage of Allegra within a span of 24 hours without professional medical guidance. The therapeutic effect usually starts within an hour after administration but could vary based on individual health conditions.
What are the most common side effects for Flonase?
Common side effects of Flonase and Allegra can include:
- Headache
- Back pain
- Minor nosebleed
- Sore throat, cough
- Nausea, vomiting or stomach upset
- Menstrual problems (cramps)
- Sinus pain, congestion or fullness
- Fever (feeling feverish) -Dizziness, tired feeling or sleep problems(insomnia) -Mild rash
Remember to contact your healthcare provider if any of these side effects are persistent or particularly bothersome.
Are there any potential serious side effects for Flonase?
Although generally considered safe, Flonase and Allegra can exhibit some side effects in rare cases. Keep an eye out for these potentially severe reactions:
- Signs of allergic reaction such as hives, difficulty breathing, swelling of your face or throat
- Vision problems including blurred vision, pain or swelling in the eye
- Rapid heartbeat or fluttering feeling in your chest
- Unusual fatigue and weakness which might be a sign of low sodium levels - this could present with other symptoms like headache, confusion, slurred speech, vomiting and loss coordination
- Severe nervous system reaction: rigid muscles, high fever sweating confusion rapid heartbeats tremors
If you observe any unusual symptoms after using either Flonase or Allegra it's crucial to seek immediate medical attention. However remember that every individual is unique & not everyone will experience these side effects. Always consult with a healthcare professional before starting any new medication regimen.
What are the most common side effects for Allegra?
Allegra, as an antihistamine medication, has its own list of potential side effects:
- Headache or dizziness
- Nausea
- Diarrhea or upset stomach
- Menstrual cramps
- Cough, hoarseness or deepened voice from throat irritation
- Muscle or back pain
While some side effects are similar to Flonase such as headache and nausea, others like coughing due to a sore throat and muscle pain are more specific to Allegra. It's also important to note that unlike Flonase which is administered through the nose, Allegra is taken orally which may cause gastrointestinal discomfort in some patients.
Are there any potential serious side effects for Allegra?
While Allegra is widely recognized for its effectiveness in treating allergy symptoms, it's crucial to understand potential serious side effects. These could include:
- Symptoms of an allergic reaction: trouble breathing; hives; swelling of your face, lips, tongue or throat
- Rapid heartbeat or fluttering in your chest
- Headaches or migraines that don't go away
- Severe dizziness and feeling like you might pass out
- Difficulty urinating (especially older men)
- Persistent fatigue and dry mouth
If any of these conditions occur while taking Allegra, discontinue use immediately and seek medical attention. As always, consult with a healthcare professional before starting any new medication regimen.
Contraindications for Flonase and Allegra?
Both Flonase and Allegra are commonly used for managing allergy symptoms, but they may have different effects on people. If you notice your symptoms worsening or experience any adverse reactions like difficulty breathing, swelling of the face or throat, rash, itching, severe dizziness or trouble swallowing while taking these medications, please seek immediate medical help.
Neither Flonase nor Allegra should be taken if you're already using certain antifungal drugs (such as ketoconazole), antibiotics (like erythromycin) or HIV medications which can interact with them negatively. Always inform your doctor about all the medicines and supplements that you are currently taking; some of these drugs might require a clearance period to prevent harmful interactions with either Flonase or Allegra.
Furthermore, avoid drinking alcohol while using these medications because it could intensify potential side effects such as drowsiness and cause impairment in thinking and judgment. It is also important to tell your healthcare provider about any existing health conditions (like liver disease for those considering Allegra use) before starting treatment.
How much do Flonase and Allegra cost?
For the brand name versions of these drugs:
- The price of 120 sprays of Flonase (50 mcg/spray) averages around $22, which works out to $0.18–$0.37/day, depending on your dose.
- The price of 30 tablets of Allegra (180 mg) is about $20, working out to approximately $0.67/day.
Thus, if you are in the higher dosage range for Flonase (i.e., two sprays in each nostril daily), then brand-name Allegra is more expensive on a per-day treatment basis. Please note that cost should not be a primary consideration in determining which of these drugs is right for you.
For the generic versions of Flonase (fluticasone propionate) and Allegra (fexofenadine), costs are significantly lower:
- Generic fluticasone propionate nasal spray is available at similar dosages as its branded counterpart with approximate costs ranging from just over $.10 to $.25 per day depending on usage.
- Fexofenadine can be found in packs starting from 15 up to 100 capsules/tablets with prices varying but typically costing less than it's branded version - averaging around $.40-.60 per day depending upon where purchased and quantity bought.
Popularity of Flonase and Allegra
Fluticasone, or Flonase as it's widely known, is a nasal spray used to treat seasonal and perennial allergy symptoms. In 2020, this medication was prescribed roughly 3.2 million times in the United States. It has been steadily increasing in prevalence since becoming available over-the-counter in 2014.
Fexofenadine, commercially known as Allegra, is an antihistamine that also treats allergy symptoms. It was estimated to have been prescribed about 2 million times in the US during 2020. Fexofenadine accounts for nearly 10% of overall antihistamine prescriptions in the US and its use remained relatively steady throughout the past decade.
While both medications are effective at treating allergies, they work differently: Flonase reduces inflammation and swelling in your nasal passages thereby alleviating congestion while Allegra blocks histamines which reduce itching and sneezing often associated with allergies.
Conclusion
Both Flonase (fluticasone) and Allegra (fexofenadine) have proven track records in the treatment of allergy symptoms, with numerous clinical trials validating their effectiveness over placebo. In certain cases, these medications might be used together under careful physician supervision as they work differently to control allergies. Flonase is a corticosteroid nasal spray that primarily works by reducing inflammation in the nasal passages while Allegra, an antihistamine, prevents histamines from causing allergic reactions.
Flonase can be considered a first-line therapy for persistent or severe seasonal allergies where symptoms are localized to the nose and eyes due to its potent anti-inflammatory action. On the other hand, Allegra may be preferred in patients with body-wide symptoms like hives or itching since it acts systemically.
Both are available over-the-counter now which represents potential savings especially for those without insurance coverage. However, both drugs may require some time before their full effects become apparent.
The safety profiles of both Flonase and Allegra are generally good but differ slightly; side effects associated with Flonase largely concern local irritation such as nosebleeds whereas Allegra has minimal sedation unlike older antihistamines but could occasionally cause headache or nausea. As always when starting new medication for allergies or otherwise, individuals should monitor how they respond to ensure optimum relief.
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Refrences
- Nelson, H. S., Reynolds, R., & Mason, J. (2000, May). Fexofenadine HCl is safe and effective for treatment of chronic idiopathic urticaria. Annals of Allergy, Asthma & Immunology. Elsevier BV.http://doi.org/10.1016/s1081-1206(10)62515-x
- Meltzer, E. O., Casale, T. B., Nathan, R. A., & Thompson, A. K. (1999, October). Once-daily fexofenadine HCl improves quality of life and reduces work and activity impairment in patients with seasonal allergic rhinitis. Annals of Allergy, Asthma & Immunology. Elsevier BV.http://doi.org/10.1016/s1081-1206(10)62671-3
- Sakairi, T., Suzuki, K., Makita, S., Wajima, T., Shakuto, S., Yoshida, Y., & Yaguchi, M. (2005). Effects of Fexofenadine Hydrochloride in a Guinea Pig Model of Antigen-Induced Rhinitis. Pharmacology. S. Karger AG.http://doi.org/10.1159/000087124
- Meltzer, E. O., Rickard, K. A., Westlund, R. E., & Cook, C. K. (2001, March). Onset of therapeutic effect of fluticasone propionate aqueous nasal spray. Annals of Allergy, Asthma & Immunology. Elsevier BV.http://doi.org/10.1016/s1081-1206(10)63300-5
- Takahashi, G., Matsuzaki, Z., Okamoto, A., Ito, E., Matsuoka, T., Nakayama, T., & Masuyama, K. (2012). A Randomized Control Trail of Stepwise Treatment with Fluticasone Propionate Nasal Spray and Fexofenadine Hydrochloride Tablet for Seasonal Allergic Rhinitis. Allergology International. Japanese Society of Allergology.http://doi.org/10.2332/allergolint.11-oa-0342