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What is Penlac
CiclopiroxThe Generic name of this drug
Treatment SummaryCiclopirox olamine is an antifungal medication used to treat certain types of skin fungal infections, such as Tinea versicolor. It is available in several brand-name products, including Batrafen, Loprox, Mycoster, Penlac, and Stieprox.
Loproxis the brand name
Penlac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Loprox
Ciclopirox
1982
77
Effectiveness
How Penlac Affects PatientsCiclopirox is a medication that fights fungal infections, bacteria, and inflammation. It works by blocking certain enzymes to stop them from working properly. It is effective against a wide range of fungal organisms, as well as many Gram-positive and Gram-negative bacteria. It also reduces inflammation by preventing the formation of certain compounds that can cause inflammation.
How Penlac works in the bodyCiclopirox works differently than other antifungal medications. It binds to metal ions like iron and aluminum, which can make it hard for the fungus to use energy. It also changes the membrane of the fungus, making it harder for the fungus to keep its internal structures in order. Ciclopirox also works to reduce inflammation by blocking enzymes like 5-lipoxygenase and cyclooxygenase. Finally, it may also disrupt the DNA repair process and cell division signals.
When to interrupt dosage
The recommended measure of Penlac is based on the determined condition, including Seborrheic dermatitis of the scalp, Cellulitis and mild Onychomycosis. The dose fluctuates as per the technique of delivery featured in the table below.Condition
Dosage
Administration
Tinea Pedis
0.0077 mg/mg, , 7.7 mg/mL, 100.0 mg/mL, 0.08 mg/mg, 71.3 mg/mL, 0.077 mg/mL, 80.0 mg/mL, 2280.0 mg/mL, 1.0 %, 1.5 %, 8.0 %, 10.0 mg/mL, 40.0 mg/mL, 0.01 mg/mg, 0.03 mg/mg
, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Solution, Solution - Topical, Kit, Suspension, Suspension - Topical, Shampoo - Oral, Kit - Topical
Cellulitis
0.0077 mg/mg, , 7.7 mg/mL, 100.0 mg/mL, 0.08 mg/mg, 71.3 mg/mL, 0.077 mg/mL, 80.0 mg/mL, 2280.0 mg/mL, 1.0 %, 1.5 %, 8.0 %, 10.0 mg/mL, 40.0 mg/mL, 0.01 mg/mg, 0.03 mg/mg
, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Solution, Solution - Topical, Kit, Suspension, Suspension - Topical, Shampoo - Oral, Kit - Topical
cutaneous candidiasis
0.0077 mg/mg, , 7.7 mg/mL, 100.0 mg/mL, 0.08 mg/mg, 71.3 mg/mL, 0.077 mg/mL, 80.0 mg/mL, 2280.0 mg/mL, 1.0 %, 1.5 %, 8.0 %, 10.0 mg/mL, 40.0 mg/mL, 0.01 mg/mg, 0.03 mg/mg
, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Solution, Solution - Topical, Kit, Suspension, Suspension - Topical, Shampoo - Oral, Kit - Topical
Dermatitis, Seborrheic
0.0077 mg/mg, , 7.7 mg/mL, 100.0 mg/mL, 0.08 mg/mg, 71.3 mg/mL, 0.077 mg/mL, 80.0 mg/mL, 2280.0 mg/mL, 1.0 %, 1.5 %, 8.0 %, 10.0 mg/mL, 40.0 mg/mL, 0.01 mg/mg, 0.03 mg/mg
, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Solution, Solution - Topical, Kit, Suspension, Suspension - Topical, Shampoo - Oral, Kit - Topical
Candidiasis, Vulvovaginal
0.0077 mg/mg, , 7.7 mg/mL, 100.0 mg/mL, 0.08 mg/mg, 71.3 mg/mL, 0.077 mg/mL, 80.0 mg/mL, 2280.0 mg/mL, 1.0 %, 1.5 %, 8.0 %, 10.0 mg/mL, 40.0 mg/mL, 0.01 mg/mg, 0.03 mg/mg
, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Solution, Solution - Topical, Kit, Suspension, Suspension - Topical, Shampoo - Oral, Kit - Topical
Tinea Versicolor
0.0077 mg/mg, , 7.7 mg/mL, 100.0 mg/mL, 0.08 mg/mg, 71.3 mg/mL, 0.077 mg/mL, 80.0 mg/mL, 2280.0 mg/mL, 1.0 %, 1.5 %, 8.0 %, 10.0 mg/mL, 40.0 mg/mL, 0.01 mg/mg, 0.03 mg/mg
, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Solution, Solution - Topical, Kit, Suspension, Suspension - Topical, Shampoo - Oral, Kit - Topical
mild Onychomycosis
0.0077 mg/mg, , 7.7 mg/mL, 100.0 mg/mL, 0.08 mg/mg, 71.3 mg/mL, 0.077 mg/mL, 80.0 mg/mL, 2280.0 mg/mL, 1.0 %, 1.5 %, 8.0 %, 10.0 mg/mL, 40.0 mg/mL, 0.01 mg/mg, 0.03 mg/mg
, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Solution, Solution - Topical, Kit, Suspension, Suspension - Topical, Shampoo - Oral, Kit - Topical
moderate Onychomycosis
0.0077 mg/mg, , 7.7 mg/mL, 100.0 mg/mL, 0.08 mg/mg, 71.3 mg/mL, 0.077 mg/mL, 80.0 mg/mL, 2280.0 mg/mL, 1.0 %, 1.5 %, 8.0 %, 10.0 mg/mL, 40.0 mg/mL, 0.01 mg/mg, 0.03 mg/mg
, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Solution, Solution - Topical, Kit, Suspension, Suspension - Topical, Shampoo - Oral, Kit - Topical
Tinea cruris
0.0077 mg/mg, , 7.7 mg/mL, 100.0 mg/mL, 0.08 mg/mg, 71.3 mg/mL, 0.077 mg/mL, 80.0 mg/mL, 2280.0 mg/mL, 1.0 %, 1.5 %, 8.0 %, 10.0 mg/mL, 40.0 mg/mL, 0.01 mg/mg, 0.03 mg/mg
, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Solution, Solution - Topical, Kit, Suspension, Suspension - Topical, Shampoo - Oral, Kit - Topical
Tinea
0.0077 mg/mg, , 7.7 mg/mL, 100.0 mg/mL, 0.08 mg/mg, 71.3 mg/mL, 0.077 mg/mL, 80.0 mg/mL, 2280.0 mg/mL, 1.0 %, 1.5 %, 8.0 %, 10.0 mg/mL, 40.0 mg/mL, 0.01 mg/mg, 0.03 mg/mg
, Topical, Cream, Cream - Topical, Lotion, Lotion - Topical, Gel, Gel - Topical, Shampoo, Shampoo - Topical, Solution, Solution - Topical, Kit, Suspension, Suspension - Topical, Shampoo - Oral, Kit - Topical
Warnings
Common Penlac Drug Interactions
Drug Name
Risk Level
Description
Penlac Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is greater than 10ml/kg. Those who overdose may feel drowsy and have a headache.
Penlac Novel Uses: Which Conditions Have a Clinical Trial Featuring Penlac?
A single clinical trial is currently investigating the potential of Penlac to treat moderate Onychomycosis, Seborrheic Dermatitis of the Scalp and Tinea Pedis.Condition
Clinical Trials
Trial Phases
mild Onychomycosis
0 Actively Recruiting
Tinea Pedis
0 Actively Recruiting
cutaneous candidiasis
0 Actively Recruiting
Dermatitis, Seborrheic
0 Actively Recruiting
Tinea Versicolor
0 Actively Recruiting
Tinea
0 Actively Recruiting
Cellulitis
0 Actively Recruiting
moderate Onychomycosis
0 Actively Recruiting
Candidiasis, Vulvovaginal
0 Actively Recruiting
Tinea cruris
0 Actively Recruiting
Penlac Reviews: What are patients saying about Penlac?
5Patient Review
5/13/2011 Penlac finally cleared up the fungus on my toes after multiple rounds of other treatments that didn't work.
4Patient Review
1/25/2017 My doctor said this would take some time, and while it did help for a bit, the fungus came back. I had the fungus on my two big nails and Penlac cleared up the right toe but not the left. After one prescription renewal, I stopped using Penlac since it wasn't working--might as well try Vicks now.
3.7Patient Review
5/14/2014 While this treatment didn't completely transform my nails, it did make me take better care of them overall.
3Patient Review
8/2/2018 I've now been prescribed this treatment twice, and both times it has done nothing to improve my infection. In fact, it seems to have made it worse. I'll be asking my doctor for a new medication soon.
2.3Patient Review
6/5/20092Patient Review
4/19/2013 I've been using this treatment for about six weeks now, and it works great! I use a stiff file to grind down the nail and new growth looks healthy.
2Patient Review
5/9/2016 It was really tough to keep up with this treatment given that I had to remove it with nail polish remover every week, and it still didn't work for me. Such a waste of time and money.
2Patient Review
8/17/2009 I've been using Penlac for a year now, and I don't think it's made any difference in the appearance of my toenails.
1Patient Review
7/19/2017 Toenail fungus ALWAYS comes back. Right now, Penlac is keeping things from getting worse. Have not used it but a couple of months. Did use Lamasil 2x and it worked well, but it came back. Finally, a friend told me it always comes back. If you can get rid of it with Lamasil, then diligently use Penlac or another topical 1-2x week as a preventative measure to help keep the fungus at bay.
1Patient Review
3/15/2016 Vicks Vaporub was very effective, but I feel like I wasted a lot of time and money on this product.
Patient Q&A Section about penlac
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long should you use Penlac?
"It is considered that up to 48 weeks of daily applications of PENLAC® NAIL LACQUER (ciclopirox) Topical Solution, 8%, and professional removal of the unattached, infected nail, as frequently as monthly, are the full treatment needed to achieve a clear or almost clear nail (defined as 10% or less residual nail involvement)."
Answered by AI
Does Penlac work for toenail fungus?
"This medication is used to treat fungal infections of the fingernails and toenails. It can be used as part of a treatment program that may include the removal of unattached, infected nails by a health care professional. Ciclopirox works by preventing the fungus from growing."
Answered by AI
Can you get Penlac over the counter?
"You cannot buy ciclopirox (Penlac) over the counter in the United States, you need a prescription from a healthcare provider."
Answered by AI
What are the side effects of Penlac?
"The medication may cause blistering, swelling, or oozing at the application site."
Answered by AI