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Ibuprofen vs Voltaren
Introduction
For patients dealing with inflammation and pain, certain drugs that inhibit the production of compounds in the body associated with inflammation and pain - known as prostaglandins - can assist in managing symptoms. Ibuprofen and Voltaren are two such medications frequently prescribed for these conditions. They both work on reducing levels of prostaglandins, but their mechanisms are slightly different. Ibuprofen is a non-selective non-steroidal anti-inflammatory drug (NSAID), affecting widespread areas of inflammation throughout the body. Voltaren, on the other hand, contains diclofenac which also belongs to NSAIDs class but has shown higher potency than ibuprofen at equal doses, effectively targeting sites of specific muscle or joint pains.
Ibuprofen vs Voltaren Side By Side
| Attribute | Advil motrin | Voltaren |
|---|---|---|
| Brand Name | Advil, Motrin | Voltaren |
| Contraindications | Should not be taken with anticoagulants like warfarin without medical advice due to increased risk of bleeding. Increased risk of heart attack or stroke. | Should not be taken with anticoagulants like warfarin without medical advice due to increased risk of bleeding. Increased risk of heart attack or stroke. |
| Cost | Averages around $10 for a 100-tablet bottle of 200 mg, pennies per tablet for generic | Approximately $60 for 30 grams of gel (1%), less for generic forms |
| Generic Name | Ibuprofen | Diclofenac |
| Most Serious Side Effect | Cardiovascular issues like heart attack or stroke, digestive system problems, liver function disorders, kidney issues | Cardiovascular issues like heart attack or stroke, severe stomach pain or cramps, liver function disorders |
| Severe Drug Interactions | Anticoagulants (blood thinners) like warfarin | Anticoagulants (blood thinners) like warfarin |
| Typical Dose | 200-800 mg per dose, up to four times daily | 75–150 mg/day, divided into two or three doses |
What is Ibuprofen?
Ibuprofen, the active ingredient in popular brands like Advil and Motrin, is a nonsteroidal anti-inflammatory drug (NSAID) that was first approved by the FDA in 1974. It works by reducing hormones that cause inflammation and pain in the body, making it a common choice for relief from symptoms of arthritis, fever, toothache, headache among other conditions. On the other hand we have Diclofenac which is marketed under several brand names including Voltaren. This medication also falls under NSAIDs but it has more pronounced anti-inflammatory effects compared to ibuprofen making it suitable for treating severe forms of inflammatory diseases such as rheumatoid arthritis or osteoarthritis. However due to its potency diclofenac tends to have more side effects especially on prolonged usage and higher dosages when compared with ibuprofen which also has its own set of potential side effects such as stomach ulcers if used frequently over an extended period.
What conditions is Ibuprofen approved to treat?
Ibuprofen and Voltaren (generic name diclofenac) are both approved for the treatment of several pain-related conditions:
- Mild to moderate acute pain
- Rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis
- Primary dysmenorrhea, or menstrual cramps In addition, ibuprofen is also indicated for the reduction of fever. Meanwhile, Voltaren has specific approval for treating migraines and actinic keratosis, a type of skin condition caused by sun damage.
How does Ibuprofen help with these illnesses?
Ibuprofen helps to manage pain and inflammation by decreasing the production of prostaglandins, chemicals in the body that cause inflammation and increase pain sensation. It does this by inhibiting an enzyme called cyclooxygenase (COX), which is involved in prostaglandin synthesis. Prostaglandins play key roles in processes like inflammation, fever, and tissue repair. By blocking COX enzymes, ibuprofen lowers prostaglandin levels, reducing inflammatory symptoms.
On the other hand, Voltaren (diclofenac) acts similarly but has a stronger affinity for COX-2 than COX-1. This means it more specifically targets inflammation-causing processes rather than general functions of prostaglandins such as protecting stomach lining or promoting platelet aggregation. Because they work on similar pathways with slightly different focuses, choosing between these two medications depends on individual patient needs including their pain level severity and risk factors for gastrointestinal side effects.
What is Voltaren?
Voltaren is a brand name for diclofenac, which is a non-steroidal anti-inflammatory drug (NSAID), similar to ibuprofen. However, it works by inhibiting both COX-1 and COX-2 enzymes responsible for producing prostaglandins that cause inflammation in the body. As such, Voltaren is able to reduce pain and swelling associated with conditions like arthritis or injury. Diclofenac was first approved by the FDA in 1988.
Unlike ibuprofen, Voltaren does not inhibit platelet aggregation as significantly and therefore has less potential for causing stomach bleeding. Its side effect profile can also differ from that of other NSAIDs: while it may still potentially cause gastrointestinal discomfort or rare cardiovascular events as do all NSAIDs, it doesn't have common issues associated with ibuprofen such as renal impairment risk in long-term use.
The effects of diclofenac on inflammation make it beneficial especially for those suffering from chronic pain conditions who may not find sufficient relief from regular over-the-counter drugs like ibuprofen.
What conditions is Voltaren approved to treat?
Voltaren, also known as diclofenac, is a potent medication approved for the treatment of:
- Mild to moderate pain and inflammation caused by conditions like osteoarthritis or rheumatoid arthritis
- Acute migraine attacks (in certain formulations) This makes it an option for individuals seeking relief from more severe pain that ibuprofen might not effectively manage.
How does Voltaren help with these illnesses?
Diclofenac, the active ingredient in Voltaren, works by inhibiting cyclooxygenase (COX), an enzyme that plays a key role in the production of prostaglandins. These substances are responsible for inflammation and pain responses within the body. By reducing their production, Voltaren helps to alleviate symptoms such as swelling, stiffness and joint pain associated with conditions like osteoarthritis or rheumatoid arthritis. It may have more potent anti-inflammatory effects compared to ibuprofen due to its more pronounced COX-2 selectivity. This means it might be prescribed when a patient does not respond well enough to other over-the-counter NSAIDs like ibuprofen, or it could be used in combination with these drugs under medical supervision for better symptom control.
How effective are both Ibuprofen and Voltaren?
Both Ibuprofen and Diclofenac (Voltaren) have established histories of success in treating patients with pain, inflammation, and fever. They were initially approved by the FDA within a decade apart, ibuprofen in 1974 and diclofenac in 1988. Since they belong to the same class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs), they may be prescribed under similar circumstances but act differently on their target enzymes.
The efficacy of ibuprofen and diclofenac was directly studied in several clinical trials for different conditions such as osteoarthritis, rheumatoid arthritis, dental pain among others; both drugs showed comparable effectiveness at managing symptoms along with similar safety profiles. In these studies, no significant differences were observed between patients receiving ibuprofen or diclofenac regarding relief from pain or reduction in inflammation.
A review study comparing NSAIDs published in 2000 demonstrated that both agents are effective at providing symptomatic relief starting from the first dose. Both have been shown to possess a relatively well-tolerated side effect profile when used appropriately for short periods. The same study also reports that Ibuprophen is one of the most commonly used over-the-counter analgesic worldwide due its favorable safety profile.
Diclofenac is often seen as more potent than other common NSAIDs including ibuprophen especially when it comes to reducing inflammation which makes it an excellent choice for inflammatory conditions like arthritis. However this potency comes at a cost - gastrointestinal side effects are more common with Diclophenac compared to Ibroprohen according to multiple meta-analysis studies.
It's important though that individual response varies significantly implying doctors should consider patient-specific factors before prescribing either medication.
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At what dose is Ibuprofen typically prescribed?
Oral dosages of Ibuprofen typically range from 200-800 mg per dose, taken up to four times daily. However, for many minor aches and pains, a single dose of 200-400 mg is often sufficient. Dosage for children depends on their weight and the specific product being used. Voltaren (Diclofenac), on the other hand, is usually administered in doses of 50-150 mg per day in divided doses for adults depending on the condition being treated. Children's dosage should be determined by a healthcare provider as it can depend on both weight and condition being treated. In either case with either medication, dosage can be adjusted based upon efficacy and tolerance but should not exceed the maximum recommended daily limits: generally 3200 mg/day for ibuprofen or 150mg/day for diclofenac.
At what dose is Voltaren typically prescribed?
Voltaren treatment usually begins with a dosage of 75–150 mg/day, divided into two or three doses, which can be spaced out evenly throughout the day. The dose can then be increased to 200 mg/day if required, also divided into smaller doses for administration at regular intervals during the day. The maximum recommended daily dose is 225 mg; this may be tested if there is no response to treatment after several weeks at a lower dose. As always, it's important not to exceed the prescribed dosage and follow your doctor's instructions carefully when taking Voltaren.
What are the most common side effects for Ibuprofen?
Common side effects of Ibuprofen include:
- Stomach pain, heartburn or nausea
- Headache
- Dizziness and nervousness
- Mild rash or itching skin
- Bloating, gas, diarrhea or constipation
On the other hand, Voltaren (diclofenac) has its own set of possible side effects such as:
- Indigestion, gas, stomach pain or bloating
- Diarrhea vs. constipation
- Headache or dizziness
- Itching and mild skin rash
Remember that these are potential side effects - not everyone who takes these medications will experience them. If any of these symptoms persist while taking either medication, do consult your healthcare provider for advice.
Are there any potential serious side effects for Ibuprofen?
Ibuprofen and Voltaren (generic name diclofenac) are both nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and reduce inflammation, but they can have different potential side effects:
-
Allergic reactions: Both medications can cause allergic reactions, including hives, difficulty breathing, swelling in your face or throat. If you experience these symptoms after taking either medication, seek immediate medical attention.
-
Cardiovascular issues: NSAIDs may increase the risk of heart attack or stroke. Symptoms like chest pain leading to the neck, jaw or arm; shortness of breath; sudden dizziness; rapid weight gain without a clear reason must be addressed immediately.
-
Digestive system problems: These can include nausea, vomiting blood or dark-colored stool indicating bleeding in your stomach or intestines.
-
Liver function disorders: Signs may include jaundice (yellowing skin), darker urine coloration than usual coupled with severe fatigue.
-
Kidney issues: Reduced urination amounts paired with puffiness around eyes/lower extremities might indicate kidney trouble induced by NSAID use.
If you notice any unusual health changes while using ibuprofen or Voltaren/Diclofenac - especially those listed above - it's important that you contact a healthcare professional promptly.
What are the most common side effects for Voltaren?
Voltaren, a brand name for diclofenac sodium, can result in side effects such as:
- Nausea or vomiting
- Upset stomach and loss of appetite
- Diarrhea or constipation
- Headaches or dizziness
- Rashes on the skin
- Ringing in the ears
- Fluid retention leading to increased urination
- Sleep disturbances including insomnia.
In rare cases, it may also cause more serious side effects like fast heartbeat, blurred vision, weight changes (loss or gain), unusual sweating and agitation. Long-term use might lead to problems with liver function which could potentially manifest as yellowing of the eyes/skin (jaundice). Any muscle or joint pain could be an indication that Voltaren is not adequately managing your symptoms. Always consult your doctor if you encounter any adverse events while using this medication.
Are there any potential serious side effects for Voltaren?
Although Voltaren is a commonly used and well-tolerated anti-inflammatory medication, it can present some serious side effects in rare cases. These include:
- Signs of allergic reaction like skin rash, itching or hives, swelling of the face, lips or tongue
- Breathing problems
- Changes in vision
- Chest pain or chest tightness; uneven heartbeat
- High blood pressure: severe headache, blurred vision, trouble concentrating
- Severe stomach pain or cramps; extreme nausea or vomiting; bloody diarrhea
- Unusual weight gain (fluid retention)
Remember to stop taking Voltaren and consult your healthcare provider immediately if you experience any of these symptoms.
Contraindications for Ibuprofen and Voltaren?
Both Ibuprofen and Voltaren, along with most other non-steroidal anti-inflammatory drugs (NSAIDs), may increase the risk of heart attack or stroke in some people. If you notice any symptoms such as chest pain, shortness of breath, weakness on one side of your body or slurred speech, seek immediate medical attention.
Neither Ibuprofen nor Voltaren should be taken if you are already taking anticoagulants (blood thinners) like warfarin without discussing it with your physician. Concurrent use can lead to an increased risk of bleeding complications. Always inform your healthcare provider about all medications you are currently taking; blood thinners require careful monitoring while being used alongside NSAIDs like ibuprofen and Voltaren.
How much do Ibuprofen and Voltaren cost?
For the brand name versions of these drugs:
- The price of a 100-tablet bottle of Ibuprofen (200 mg) averages around $10, which works out to about $0.20 per tablet or $0.40-$0.80/day depending on your dose.
- The price for 30 grams of Voltaren gel (1%) is approximately $60, working out to roughly $2/day if applied twice daily.
Consequently, if you are using the higher dosage range for ibuprofen (i.e., up to 800mg/day), then brand-name Voltaren Gel is more expensive on a per-day treatment basis. However, cost should not be the primary consideration in determining which drug will give you optimal relief from pain and inflammation.
Now considering generic versions:
- Generic ibuprofen tablets are available at even lower costs than their branded counterparts with prices starting as low as pennies per tablet.
- Diclofenac - the active ingredient in Voltaren - also comes in less costly generic forms such as diclofenac sodium topical gel that can cost significantly less than brand-name Voltaren.
It's important to note that while both medications can be effective for pain management, they have different mechanisms and may work better for specific types of pain or inflammation. Always consult with a health care provider before starting any new medication regimen.
Popularity of Ibuprofen and Voltaren
Ibuprofen, both in its generic form and under various brand names, was estimated to have been prescribed about 21 million times in the US in 2020. Ibuprofen accounted for a significant percentage of non-steroidal anti-inflammatory drug (NSAID) prescriptions within this period. This medication has been widely used since it became available over-the-counter (OTC) in 1984.
On the other hand, Voltaren or diclofenac is another popular NSAID that was prescribed to approximately 6.5 million people in the USA during the same year. Although these figures seem smaller when compared to ibuprofen use, it's important to note that Voltaren had previously only been available through prescription but recently received approval for OTC use as well. The prevalence of diclofenac could potentially increase with greater accessibility moving forward.
Conclusion
Both ibuprofen and Voltaren (diclofenac) have been extensively used to manage pain, inflammation, and fever. Their effectiveness is supported by numerous clinical trials and meta-analyses indicating they are more effective than placebo treatments. Both drugs work by inhibiting cyclooxygenase enzymes involved in the production of prostaglandins, which cause pain and inflammation in the body.
Ibuprofen is commonly prescribed for short-term relief from mild to moderate acute pain or inflammation while Voltaren tends to be used for longer-term management of these symptoms because it has a less frequent dosing schedule due to its longer half-life.
Both ibuprofen and Voltaren come as generic medications representing significant cost savings especially for patients paying out-of-pocket. However, an adjustment period may not be needed since their effects are typically noticeable soon after administration.
The side effect profile is generally similar between the two drugs with gastrointestinal issues being most common but with diclofenac having a slightly higher risk of cardiovascular events compared to ibuprofen. For both drugs, patients must closely monitor any unusual physical discomforts or signs such as stomach upset or heartburn especially when starting treatment - if these become severe or persist, medical help should be sought immediately.
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Refrences
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