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Lyumjev vs Humalog
Introduction
For diabetic patients dealing with type 1 or type 2 diabetes, insulin analogs that mimic the body's natural insulin response can help control blood sugar levels and manage symptoms. Lyumjev and Humalog are two such drugs that are often prescribed for this purpose. Both of these medications act on glucose metabolism, but they have different onset times and durations of action in controlling blood sugar.
Lyumjev is an ultra-rapid acting insulin analog designed to work faster than other rapid-acting insulins like Humalog, aiming to better match the speed at which natural insulin is released in people without diabetes after meals. On the other hand, Humalog is classified as a rapid-acting human insulin analog used to lower levels of glucose in the blood; it starts working about 15 minutes after injection and continues working evenly for approximately two hours.
These differences can influence when a patient takes their doses relative to meal timings - something crucially important for effective management of blood sugar levels throughout the day.
Lyumjev vs Humalog Side By Side
| Attribute | Lyumjev | Humalog |
|---|---|---|
| Brand Name | Lyumjev | Humalog |
| Contraindications | Episodes of hypoglycemia, allergy to insulin lispro products, interactions with certain drugs like beta-blockers and clonidine, effects of corticosteroids and thyroid hormones on blood glucose levels | Episodes of hypoglycemia, allergy to insulin lispro, interactions with certain drugs affecting glucose levels, effects of physical activity and stress on insulin need |
| Cost | Around $280 for a single vial | Around $275 for one vial |
| Generic Name | Insulin lispro-aabc | Insulin lispro |
| Most Serious Side Effect | Signs of allergic reactions, low potassium levels, severe hypoglycemia, hyperglycemia | Severe hypoglycemia, allergic reactions, potassium levels fluctuation, lipodystrophy, swelling hands/feet |
| Severe Drug Interactions | Beta-blockers, clonidine, corticosteroids, thyroid hormones | Not specifically mentioned, but similar considerations as Lyumjev regarding drugs that affect blood glucose levels |
| Typical Dose | 0.5–1 unit/kg/day, starting dose typically 0.5 units/kg/day | Based on individual's blood sugar levels and insulin requirements, adjusted to maintain optimal glycemic control |
What is Lyumjev?
Lyumjev and Humalog are both insulins used to control blood sugar in people with diabetes. Lyumjev (also known as insulin lispro-aabc) is an ultra-rapid-acting insulin analog, a newer development compared to the rapid-acting Humalog (or insulin lispro). Eli Lilly Company introduced Humalog first in 1996, while Lyumjev got its approval from the FDA more recently in 2020. Both these insulins work by replacing the insulin that would normally be produced by your pancreas, thus helping move sugar from your bloodstream into other body cells where it's used for energy. However, Lyumjev has been designed to absorb and act faster than Humalog due to its added ingredients: treprostinil and citrate. This feature makes it particularly beneficial for controlling post-meal glucose spikes. While side effects can occur with any medication use, both of these medications have similar profiles; however, they may differ slightly based on individual response or sensitivity.
What conditions is Lyumjev approved to treat?
Lyumjev is approved for the treatment of diabetes mellitus in adults and children:
- Type 1 Diabetes Mellitus: Lyumjev is used to improve glycemic control in patients with type 1 diabetes.
- Type 2 Diabetes Mellitus: It's also utilized as an aid to manage blood sugar levels in individuals with type 2 diabetes. Please note that it should always be used together with a longer-acting insulin or oral medications meant for managing blood sugar levels.
How does Lyumjev help with these illnesses?
Lyumjev and Humalog are both insulin lispro products used to manage blood glucose levels in individuals with type 1 or type 2 diabetes. Just like the natural hormone, they allow cells in the body to absorb and use glucose for energy by facilitating its transport across cell membranes. The primary difference comes down to speed of action: Lyumjev has been designed to work faster than Humalog.
The rapid-acting effect is achieved by including an additive in Lyumjev that increases blood flow at the injection site, allowing the insulin to be absorbed more quickly. This means that Lyumjev begins working within minutes of administration which can help better control spikes in blood sugar levels immediately after meals.
Thus, while both insulins serve a similar role in managing diabetes, patients might prefer Lyumjev if they desire quicker onset of action around meal times.
What is Humalog?
Humalog is a brand name for insulin lispro, which is a rapid-acting human insulin analogue that works by lowering levels of glucose (sugar) in the blood. It has a faster onset and shorter duration of action than regular human insulin. Humalog was first approved by the FDA in 1996.
Unlike traditional insulins, Humalog does not inhibit the reabsorption of glucose in your body. Its unique way of functioning means its side-effect profile is different from other types of insulin. Specifically, it's less likely to cause weight gain - a common concern with many diabetes medications.
The effects on rapidly decreasing blood sugar can be beneficial for managing mealtime blood sugar spikes, particularly useful for patients who struggle to control their post-meal blood sugars with other slower-acting insulins.
What conditions is Humalog approved to treat?
Humalog is a fast-acting insulin that's approved for the treatment of both type 1 and type 2 diabetes. It's typically used to control blood sugar levels during meals and snacks, sudden rises in blood sugar, and around the time of exercise. Here are some conditions it can be used for:
- Type 1 diabetes (a condition where the body does not produce any insulin)
- Type 2 diabetes (a condition where the body either doesn't produce enough insulin or resists its effects)
How does Humalog help with these illnesses?
Humalog is an insulin analog that works to lower levels of glucose in the blood, a critical function for those with diabetes. It acts as a hormone and plays roles in many processes in the body, affecting energy storage and usage, glucose regulation, and satiety signals. In individuals with diabetes where natural insulin production or sensitivity is impaired, Humalog provides an external source of this necessary hormone. Its rapid onset allows it to quickly handle post-meal surges of blood sugar levels. While Lyumjev also serves this purpose, Humalog has been a standard choice due to its established safety profile over years of use by patients around the world. Just like Wellbutrin doesn't significantly affect serotonin levels but rather focuses on norepinephrine; Humalog doesn't have significant effects on other hormones but specifically targets insulin-related mechanisms.
How effective are both Lyumjev and Humalog?
Both insulin lispro-aabc (Lyumjev) and insulin lispro (Humalog) have been successful in managing blood sugar levels in patients with diabetes, both type 1 and type 2. The FDA approved these drugs several years apart; Humalog first came to market in 1996, while Lyumjev was approved more recently, in 2020.
Similarities between the two can be traced back to their main component: insulin lispro. Both are rapid-acting insulins that help control blood sugar spikes after meals. However, studies show that Lyumjev acts slightly faster than Humalog at reducing blood sugar levels due to its modified formulation designed for quicker absorption.
In a clinical trial conducted during the approval process of Lyumjev, it demonstrated similar efficacy and safety profiles as Humalog but offered additional advantages such as lower post-meal glucose spikes and less risk of late postprandial hypoglycemia when compared directly with Humalog.
Despite being newer on the market, Lyumjev has gathered positive reactions from health professionals due to its fast onset of action -- starting within approximately 13 minutes versus around half an hour for most other rapid-acting insulins like Humalog.
However, just like any medication choice made by doctors or individuals dealing with diabetes care management should consider multiple factors such as lifestyle habits including meal patterns & physical activity routine along with individual’s medical history before initiating treatment since there could be variations in response rates among different individuals.
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At what dose is Lyumjev typically prescribed?
Dosages of Lyumjev range from 0.5–1 unit/kg/day, but research has shown that a starting dose of 0.5 units/kg/day is typically sufficient for managing type 1 diabetes in most patients. Children and adolescents may be started on lower doses depending on their weight and overall health status. In any patient group, if blood glucose control isn't achieved after several weeks, the dosage can be gradually increased under medical supervision. It's crucial to remember that there isn't an absolute maximum daily dose as it varies based on individual insulin requirements; however, exceeding prescribed dosages without consulting your healthcare provider should always be avoided.
At what dose is Humalog typically prescribed?
Humalog treatment is typically initiated based on the individual's blood sugar levels and insulin requirements. The dosage can then be adjusted to maintain optimal glycemic control, generally divided into multiple doses administered before meals. There isn't a maximum dose per se for Humalog as it's tailored according to patient needs, however any substantial increase should be done under medical supervision. This personalization in dosing ensures that each individual receives the accurate amount of insulin to manage their diabetes effectively, with adjustments being made if there is no response to initial treatment after a few weeks.
What are the most common side effects for Lyumjev?
The common side effects associated with Lyumjev include:
- Hypoglycemia (low blood sugar)
- Injection site reactions such as redness, swelling, and itching
- Allergic reactions including rash and pruritus (itching)
- Weight gain
- Nasopharyngitis (inflammation of the nose and throat)
On the other hand, Humalog can cause:
- Hypoglycemia
- Lipohypertrophy or lipoatrophy at the injection site
- Allergic reactions including rash, hives, itching or difficulty breathing.
It's important to note that both these insulins should be used under medical supervision to manage diabetes effectively.
Are there any potential serious side effects for Lyumjev?
Lyumjev and Humalog are both insulin medications used to control blood sugar levels in people with diabetes. However, they can have different side effects. For Lyumjev, you should watch out for:
- Signs of allergic reactions: rash, itching or hives on the skin; shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body.
- Low potassium levels (hypokalemia) - muscle cramps or weakness, irregular heartbeat
- Hypoglycemia (low blood sugar level) – symptoms may include cold sweats; cool pale skin; headache; fast heartbeat; feeling sick; feeling very hungry; temporary changes in vision; drowsiness and tiredness.
- Hyperglycemia (high blood sugar level) – frequent urination and possibly increased thirst.
For severe cases like diabetic ketoacidosis where your body starts to break down fat too quickly causing ketones to build up in your bloodstream which could lead to coma if not treated immediately.
If you experience any of these symptoms while taking Lyumjev, it is important that you seek immediate medical attention.
What are the most common side effects for Humalog?
Humalog, a fast-acting insulin analog, can cause certain side effects including:
- Hypoglycemia (low blood sugar) which may result in trembling, sweating and rapid heartbeat
- Weight gain
- Local allergic reactions at the injection site such as redness, swelling or itching
- Systemic allergic reactions that could include rash over the whole body, shortness of breath or low blood pressure
- Changes in fat tissue around the injection site
- Fluid retention and heart failure with use of thiazolidinediones These side effects aren't exhaustive and it's important to discuss potential risks with your healthcare provider. Always consult a professional before making changes to your medication regimen.
Are there any potential serious side effects for Humalog?
While Humalog is generally well-tolerated, it can sometimes cause serious side effects. These may include:
- Signs of severe hypoglycemia: extreme hunger, blurred vision, trembling, sweating profusely and feeling weak or shaky
- Allergic reactions: rash or itching over the whole body; shortness of breath; wheezing; fast pulse rate; sweating and a feeling of impending doom
- Potassium levels fluctuation which might result in muscle cramps or weakness
- Lipodystrophy (changes in the appearance of body fat)
- Swelling hands/feet
These are not all potential side effects and others may occur. If you experience any unusual symptoms while using Humalog, you should contact your healthcare provider immediately.
Contraindications for Lyumjev and Humalog?
Both Lyumjev and Humalog, as with most other rapid-acting insulin analogs, can potentially cause hypoglycemia or low blood sugar in some patients. If you notice symptoms of hypoglycemia such as dizziness, confusion, irritability, hunger, fast heartbeat or sweating while on these medications please seek immediate medical help.
Lyumjev and Humalog should not be used if you are experiencing episodes of hypoglycemia or if you are allergic to insulin lispro products. Always inform your physician about any medications you're taking; certain drugs may affect the glucose lowering effect of Lyumjev and Humalog such as beta-blockers, clonidine among others. Some substances like corticosteroids and thyroid hormones might increase the blood glucose levels requiring more doses of insulin. Also remember that exercise and stress could also alter your need for insulin.
How much do Lyumjev and Humalog cost?
For the brand name versions of these drugs:
- The price for a single vial of Lyumjev (insulin lispro-aabc) is around $280, which works out to between $9.30–$18.60/day, depending on your insulin needs.
- The price for one vial of Humalog (insulin lispro) averages at about $275, working out to approximately $9.15/day.
Thus, if you are in the higher dosage range for Lyumjev (i.e., 300 units/day or more), then Humalog could be less expensive on a per-day treatment basis. Please note that cost should not be a primary consideration in determining which of these insulins is right for you.
While there currently aren't generic versions available for either insulin variant due to patent protections and complex manufacturing processes, costs can sometimes be mitigated through insurance coverage or patient assistance programs offered by some pharmaceutical companies. Always remember it's essential to discuss with your healthcare provider which medication would best suit your individual health needs before making any decision based solely on cost differences.
Popularity of Lyumjev and Humalog
Insulin lispro, available under the brand name Humalog, was estimated to have been prescribed to about 6.5 million people in the US in 2020. Insulin lispro accounted for just over 22% of insulin prescriptions in the US. As a fast-acting insulin analog, it is often used for mealtime blood sugar control.
Lyumjev is a newer ultra-rapid acting form of insulin lispro that begins working more quickly than standard insulin lispro (Humalog). It was approved by the FDA only recently, in June 2020. Although specific prescription numbers aren't yet available due to its recent arrival on the market, Lyumjev is anticipated to become a popular choice among health providers and patients for its quicker onset of action and potential for improved post-meal blood sugar control.
Conclusion
Both Lyumjev and Humalog are rapid-acting insulin analogs with well-established records in managing blood sugar levels in patients with diabetes. They have been proven effective through numerous clinical studies and meta-analyses, showing they outperform placebo treatments. In some diabetic management plans, these drugs may be used together or alternated depending on the individual's glucose control needs.
Lyumjev is designed to work more quickly than Humalog due to its advanced formulation that allows for faster absorption. This makes it particularly suitable for controlling post-meal spikes in blood glucose levels.
Humalog has a longer history of use compared to Lyumjev and has been a reliable first-line option for mealtime insulin therapy. However, just like any medication regimen, adjustments may be needed over time based on metabolic control.
Both insulins come in various forms including vials and pens offering flexible administration options. The cost can vary significantly between the two medications so patients should explore all potential avenues of savings such as insurance coverage or patient assistance programs if paying out-of-pocket.
The side effect profiles are similar between the two insulins involving mostly hypoglycemia (low blood sugar), weight gain, allergic reactions at injection sites among others which generally tend to be mild but can be serious if not properly managed. For both drugs, close monitoring of blood glucose levels is essential especially when starting treatment or changing dosage regimens; medical help must be sought promptly if symptoms of severe hypoglycemia occur.
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Refrences
- Leohr, J., Dellva, M. A., LaBell, E., Coutant, D. E., Arrubla, J., Plum‐Mörschel, L., … Hardy, T. (2023, October 9). Ultra rapid lispro (Lyumjev®) shortens time to recovery from hyperglycaemia compared to Humalog® in individuals with type 1 diabetes on continuous subcutaneous insulin infusion. Diabetes, Obesity and Metabolism. Wiley.http://doi.org/10.1111/dom.15307
- Gale, E. A. (1997, September). Insulin lispro:a new quick-acting insulin analogue. Expert Opinion on Investigational Drugs. Informa Healthcare.http://doi.org/10.1517/13543784.6.9.1247
- Chico, A., Saigi, I., García-Patterson, A., Santos, M. D., Adelantado, J. M., Ginovart, G., … Corcoy, R. (2010, December). Glycemic Control and Perinatal Outcomes of Pregnancies Complicated by Type 1 Diabetes: Influence of Continuous Subcutaneous Insulin Infusion and Lispro Insulin. Diabetes Technology & Therapeutics. Mary Ann Liebert Inc.http://doi.org/10.1089/dia.2010.0111