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What is Vantas
HistrelinThe Generic name of this drug
Treatment SummaryHistrelin is a long-acting medication used to reduce the body’s production of hormones that control fertility. When used in children, it can help delay or prevent early puberty. In adults, it can be used to treat advanced prostate cancer. Histrelin works by stimulating the pituitary gland to produce a temporary increase in hormones like testosterone and dihydrotestosterone. This is followed by a decrease in these hormones due to a decrease in the sensitivity of the pituitary gland to histrelin. Histrelin is available under the brand names Supprelin LA and Vantas.
Vantasis the brand name
Vantas Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Vantas
Histrelin
2004
3
Effectiveness
How Vantas Affects PatientsHistrelin is a medicine used to suppress hormones in the body, which can help slow down puberty in children. It cannot be taken orally and is available as two different products, Vantas and Supprelin LA. Taking this medicine can cause a transient increase in certain hormones for the first week of treatment, such as estradiol in women and testosterone in both sexes. In order to monitor hormone levels, laboratory tests are recommended. It is important to note that using histrelin can lead to psychiatric events, convulsions, pseudotumor cerebri, spinal cord compression, urinary tract obstruction, an increased risk of
How Vantas works in the bodyHistrelin is a hormone-blocking drug. When used as an implant, it is released in the body in continual doses. At first, it increases the hormones that control sexual maturity and reproduction (like testosterone). But over time, it desensitizes the receptors that detect these hormones, reducing the levels of these hormones in the body. In children, it lowers the hormones that stimulate puberty, allowing them to remain at a normal height. In adults with prostate cancer, it stops the production of testosterone, preventing the cancer cells from growing.
When to interrupt dosage
The amount of Vantas is contingent upon the acknowledged ailment. The measure of dosage corresponds to the technique of delivery (e.g. Implant; Kit or Implant; Kit - Subcutaneous) provided in the table beneath.Condition
Dosage
Administration
Puberty, Precocious
50.0 mg,
, Subcutaneous, Implant, Implant - Subcutaneous, Implant; Kit, Implant; Kit - Subcutaneous
Prostatic Neoplasms
50.0 mg,
, Subcutaneous, Implant, Implant - Subcutaneous, Implant; Kit, Implant; Kit - Subcutaneous
Warnings
Vantas has one recognized contraindication, so it should not be taken for the conditions outlined in the following table.Vantas ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Vantas Drug Interactions
Drug Name
Risk Level
Description
Capromab pendetide
Major
Histrelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Corifollitropin alfa
Major
The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Histrelin.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Histrelin is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Histrelin is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Histrelin is combined with Ziprasidone.
Vantas Toxicity & Overdose RiskStudies on animals show no signs of serious toxicity when they were injected with up to 200 mcg/kg (rats and rabbits) or 2000 mcg/kg (mice) of histrelin acetate. This amount is much higher than the recommended maximum dose for humans of 10 mcg/kg/day. In clinical trials, no cases of overdose were reported. If an accidental or intentional overdose were to occur, it is unlikely due to the constant delivery of histrelin from the implants.
Vantas Novel Uses: Which Conditions Have a Clinical Trial Featuring Vantas?
4 active studies are investigating the potential of Vantas to combat Advanced Prostate Cancer.Condition
Clinical Trials
Trial Phases
Prostatic Neoplasms
0 Actively Recruiting
Puberty, Precocious
1 Actively Recruiting
Phase 3
Vantas Reviews: What are patients saying about Vantas?
5Patient Review
8/18/2011 The annual implant is extremely easy to use and maintain, and my PSA has stayed at an impressive 0.1 or lower.
5Patient Review
6/26/2009 I had hot flashes for a while, but this medication has really helped to alleviate that symptom.
5Patient Review
10/16/20084.7Patient Review
2/6/2010 The Vantas implant worked very well for me. My PSA fell from 36 to 2.9 in just two months.
3.7Patient Review
10/9/2011 The side effects of this treatment are very unpleasant.
3.7Patient Review
4/14/2012 This is a test from the drugs website
3.3Patient Review
9/13/2013 I've had this treatment for three years now, and during that time my dementia has progressed rapidly. I find it hard to concentrate or do anything I used to be able to do, and I experience a lot of other unpleasant symptoms like sweating, mood changes, stomach cramps, and feeling cold all the time.
3Patient Review
4/14/2012 This is a test from the core.
1.3Patient Review
10/4/2011 I have experienced several serious side effects from this implant, including but not limited to: enlarged breasts, 30% weight gain, erectile dysfunction.
Patient Q&A Section about vantas
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Vantas discontinued?
"· Endo International plc (NASDAQ: ENDP) (“Endo” or the “Company”), a global specialty pharmaceutical company focused on improving patients’ lives while creating shareholder value, today announced that it has discontinued the sale and marketing of Vantas in the United States
In September 2021, Endo will no longer sell or market Vantas in the United States."
Answered by AI
What is Vantas implant?
"The Vantas implant is a sterile, non-biodegradable drug delivery system that is designed to continuously deliver histrelin for 12 months after it is implanted subcutaneously. The Vantas implant contains 50 mg of histrelin acetate."
Answered by AI
How much is Vantas?
"Vantas was approved by the FDA in 2004 to treat late-stage prostate cancer. It has a list price of $4,400."
Answered by AI
What is Vantas for?
"Vantas contains histrelin acetate, which lowers the levels of male sex hormones like testosterone to help slow the growth of prostate cancer cells. Vantas comes as an implant that's inserted under the skin."
Answered by AI