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Oxycodone vs Acetaminophen With Codeine
Introduction
For patients dealing with moderate to severe pain, certain drugs that inhibit the perception of pain can help in managing discomfort and improving quality of life. Oxycodone and Acetaminophen With Codeine are two such medications often prescribed for pain relief. They each impact different pathways in the brain, but both have significant effects in reducing patient's perceptions of pain. Oxycodone is a potent opioid analgesic medication which works by binding to mu-opioid receptors in the brain, blocking the feeling of pain. On the other hand, Acetaminophen with Codeine is a combination drug that utilizes both an opioid (codeine) and a non-opioid (acetaminophen) mechanism of action to provide comprehensive pain relief. The codeine component functions similarly to oxycodone by binding to opioid receptors while acetaminophen inhibits prostaglandin synthesis thereby reducing fever and minor pains.
Oxycodone vs Acetaminophen With Codeine Side By Side
| Attribute | Oxy contin roxicodone | Tylenol 3 |
|---|---|---|
| Brand Name | OxyContin, Roxicodone | Tylenol #3 |
| Contraindications | Should not be taken with MAO inhibitors or by individuals with severe respiratory depression or severe bronchial asthma. | Should not be taken with MAO inhibitors or by individuals with significant respiratory depression, acute or severe bronchial asthma, or known hypersensitivity to any of its components. |
| Cost | Prices start from as low as $14 for 120 capsules (~$0.12 per day) for the generic version. | Prices start from around $15 for 15 tablets (~$1 per day) for the generic version. |
| Generic Name | Oxycodone | Acetaminophen With Codeine |
| Most Serious Side Effect | Respiratory depression, addiction, and dependence. | Liver damage, severe allergic reactions, addiction, and dependence. |
| Severe Drug Interactions | MAO inhibitors, benzodiazepines, alcohol, other CNS depressants. | MAO inhibitors, alcohol, benzodiazepines, other opioids, drugs that cause drowsiness. |
| Typical Dose | 10–80 mg every 4 to 6 hours; starting dose around 5-15mg for moderate to severe pain. | 15-60 mg/day for codeine and not more than 4000 mg/day for acetaminophen; divided into four doses, spaced about 6 hours apart. |
What is Oxycodone?
Oxycodone (the generic name for OxyContin, amongst other brand names) is a powerful opioid medication used to treat severe pain. It was first approved by the FDA in 1950. Oxycodone works by changing the way your brain and nervous system respond to pain, effectively "numbing" the sensation for longer periods of time. It's typically prescribed for those suffering from intense acute or chronic pain conditions.
On the other hand, we have Acetaminophen with Codeine (also known as Tylenol #3), which is a combination drug that includes a non-opioid analgesic (acetaminophen) and an opioid analgesic (codeine). This blend provides moderate-to-severe pain relief. The acetaminophen component enhances codeine’s effects, thus making it more potent at lower doses.
While both medications are effective at relieving severe pain, they differ in their potency and side-effect profiles. Oxycodone has stronger effects on the central nervous system compared to codeine; this results in it having potentially more serious side effects than Acetaminophen with Codeine — including addiction and dependence due to its high potential for abuse.
What conditions is Oxycodone approved to treat?
Oxycodone is approved for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. It can be used in cases such as:
- Post-operative pain relief after major surgeries
- Chronic cancer-related pain
- Severe, chronic non-cancer related pain
On the other hand, Acetaminophen with Codeine is used to treat mild to moderately severe pain. This could involve situations like:
- Pain from dental procedures or tooth extraction
- Relief from minor surgeries or injuries
- Other conditions where over-the-counter medication doesn't provide sufficient relief
How does Oxycodone help with these illnesses?
Oxycodone is a potent opioid analgesic that works by binding to the mu-opioid receptors in the brain, blocking pain signals from reaching the nervous system. This results in a decrease in perception of pain and an increase in pain tolerance. Opioids like Oxycodone are particularly effective at managing moderate-to-severe acute or chronic pain but carry risks such as dependency and overdose.
On the other hand, Acetaminophen with Codeine combines two different types of analgesics: acetaminophen, which relieves mild-to-moderate pain by inhibiting prostaglandin synthesis; and codeine, an opioid that increases tolerance to pain. The combination provides more effective relief for moderate to moderately severe pain than either drug alone would provide. However, similar to oxycodone, long-term use can lead to substance dependence or abuse.
What is Acetaminophen With Codeine?
Acetaminophen with Codeine, also known as Tylenol 3 among other brand names, is a combination of the non-opioid analgesic acetaminophen and the opioid codeine. It works by reducing pain signals in the brain and spinal cord while also increasing pain tolerance. Acetaminophen with Codeine was first approved by the FDA many years ago and remains a common choice for treating moderate to moderately severe pain.
As it contains an opioid, Acetaminophen with Codeine can cause drowsiness, constipation, and nausea - typical side effects associated with opioids like Oxycodone. However unlike Oxycodone which is purely an opioid medication, this drug includes acetaminophen which can be beneficial for its antipyretic (fever-reducing) properties but also brings along potential risks particularly related to liver toxicity if used excessively or improperly. The combined effect on both nociceptive (pain from tissue damage) and neuropathic (nerve-related) pain can make Acetaminophen with Codeine effective for a range of conditions where both types of pain are present.
What conditions is Acetaminophen With Codeine approved to treat?
Acetaminophen with Codeine is approved for the management of mild to moderate pain where treatment with an opioid is appropriate and for which alternative treatments are inadequate. Some conditions that Acetaminophen with Codeine can be used include:
- Postoperative pain control
- Pain due to injury
- Chronic conditions like cancer or arthritis pain when other non-opioid alternatives do not provide adequate relief.
How does Acetaminophen With Codeine help with these illnesses?
Acetaminophen with codeine is a combination medication that works in the nervous system to change how our bodies perceive and respond to pain. Acetaminophen, also known as paracetamol, is a non-opioid analgesic which helps reduce fever and mitigate mild-to-moderate pain. Codeine, on the other hand, is an opioid analgesic that acts on specific receptors in the brain to decrease discomfort from significant or severe pain. Its action on these receptors also produces feelings of relaxation and well-being - however there's a risk of addiction due to this euphoric effect.
Compared with oxycodone, another potent opioid medicine used for managing severe pain where other treatments may not work effectively, acetaminophen with codeine tends to cause less potential for abuse or dependency because it has less powerful opioid component (codeine) than oxycodone. Though acetaminophen with codeine might be considered when patients do not tolerate or fail to obtain sufficient relief from other opioids such as oxycodone.
How effective are both Oxycodone and Acetaminophen With Codeine?
Both oxycodone and acetaminophen with codeine have long histories of success in treating moderate to severe pain, and they were initially approved by the FDA several decades apart. Since they act on different opioid receptors, they may be prescribed under different circumstances. The effectiveness of oxycodone and acetaminophen with codeine in alleviating postoperative pain was directly studied in a double-blind clinical trial; the two drugs exhibited similar efficacy in managing pain symptoms as well as comparable safety profiles. In this study, none of the different metrics used to measure efficacy in controlling pain differed between patients receiving oxycodone and those receiving acetaminophen with codeine.
A 2010 review demonstrated that oxycodone is effective at relieving chronic cancer-related pain from the first week of treatment, its side effect profile is manageable compared to other strong opioids, and it is well-tolerated even in elderly populations or those with renal impairment. Oxycodone has become one of the most widely prescribed opioid analgesics worldwide due to its superior potency.
A 2009 meta-analysis indicated that combination therapy involving acetaminophen with low-dose codeine seems to be more effective than placebo for acute postoperative pain relief but less potent compared to stronger opioids like morphine or oxycodone. Nonetheless, acetaminophen/codeine combinations are typically considered a step-2 option on WHO’s Pain Ladder for mild/moderate pains where non-opioids alone insufficiently control symptoms. Despite having fewer studies supporting its use independently without co-prescription alongside paracetamol (acetaminophen), current evidence supports acetaminophen/codeine's role as an intermediate option when NSAIDs or simple analgesics fail but before resorting to stronger opioids such as morphines or higher dose-codeines.
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At what dose is Oxycodone typically prescribed?
Oral dosages of Oxycodone range from 10–80 mg every 4 to 6 hours, but typically a starting dose of around 5-15mg is used for treating moderate to severe pain in adults. For Acetaminophen with Codeine (Tylenol #3), the common initial dosage is usually one or two tablets every four to six hours as needed for pain. Each Tylenol #3 tablet contains 300 mg of acetaminophen and 30 mg of codeine. In either case, the dosage can be adjusted according to the severity of the pain and patient response. It should be noted that daily doses exceeding those recommended may result in serious liver damage due to acetaminophen content or opioid toxicity due to codeine/oxycodone content.
At what dose is Acetaminophen With Codeine typically prescribed?
Treatment with Acetaminophen With Codeine generally starts at a dosage of 15-60 mg/day for codeine and not more than 4000 mg/day for acetaminophen. The dose can then be increased based on pain severity and patient response, typically divided into four doses, spaced about 6 hours apart. It is important to note that exceeding the maximum recommended daily dose of acetaminophen could lead to liver damage or other serious medical conditions. Even if there's no adequate response to treatment after a few days, do not increase the dose without consulting with your healthcare provider due to potential risks associated with high doses of this medication.
What are the most common side effects for Oxycodone?
For patients who need to choose between Oxycodone and Acetaminophen with Codeine, it's important to note the potential side effects. Both medications can cause some common side effects such as:
- Drowsiness or sleepiness
- Feeling dizzy or lightheaded
- Nausea or vomiting
- Constipation
- Dry mouth
Additionally, Oxycodone may also lead to feelings of relaxation and happiness which could potentially lead to misuse. It might cause a decrease in respiratory rate that could be harmful for those with breathing problems.
On the other hand, Acetaminophen with Codeine may occasionally result in shortness of breath, rash or itching, changes in vision and general weakness. The presence of acetaminophen means there is an added risk of liver damage if taken excessively over long periods.
Remember that everyone reacts differently to medication so while these are possible side effects they might not occur at all for many people. Always consult your healthcare provider before changing any medication regimen.
Are there any potential serious side effects for Oxycodone?
While taking Oxycodone or Acetaminophen with Codeine, it's crucial to monitor for the following serious side effects:
- Thoughts about suicide, self-harm or unusual changes in mood
- Signs of severe allergic reaction: hives, difficulty breathing, swelling in your face or throat
- Skin reactions such as rash, blistering and peeling accompanied by fever and sore throat
- Vision problems like blurred vision or tunnel vision; eye pain or swelling; appearance of halos around lights
- Cardiovascular abnormalities: rapid heartbeats, chest fluttering sensation; shortness of breath; sudden dizziness which might lead to fainting
- Symptoms indicating low sodium levels - headache, confusion, slurred speech, severe weakness/vomiting/loss of coordination/unsteady feeling -Severe nervous system reactions - overly stiff muscles; high temperature (fever); sweating heavily/confusion/rapid heartbeats/tremors/fainting spells. -Signs suggestive of serotonin syndrome – restlessness/agitation/hallucinations/high body temperature/excessive perspiration/shivering/increased heart rate/muscle stiffness/twitches/difficulty coordinating movements/upset stomach/vomiting bouts/diarrhea.
If any such symptoms are observed while taking either Oxycodone or Acetaminophen with Codeine it is highly advised to seek immediate medical attention.
What are the most common side effects for Acetaminophen With Codeine?
Acetaminophen with Codeine can lead to a range of side effects including:
- Nausea, vomiting, stomach pain
- Constipation
- Lightheadedness or dizziness
- Drowsiness and sleep problems (insomnia)
- A feeling of general discomfort or uneasiness
- Shortness of breath or shallow breathing
- Sweating and slight tremors
- Mood changes such as agitation, confusion, and feelings of fear or anxiety.
In rare instances, it may cause a skin rash. It's important to note that prolonged use may lead to dependency due to its opioid component. Users should always adhere to the prescribed dosage for safe administration.
Are there any potential serious side effects for Acetaminophen With Codeine?
Acetaminophen with codeine, while generally well-tolerated, may cause certain serious side effects in some instances. These can include:
- Signs of a severe allergic reaction such as hives; difficulty breathing; swelling of your face, lips, tongue or throat
- Feeling lightheaded and fainting
- Slow heart rate and weak pulse
- Confusion or unusual thoughts or behavior
- Severe constipation
- Pancreatitis (severe pain in your upper stomach spreading to your back)
If you experience any of these symptoms after taking acetaminophen with codeine, seek medical attention immediately. It's crucial not to exceed the recommended dose as it can lead to liver damage or death.
Contraindications for Oxycodone and Acetaminophen With Codeine?
Both Oxycodone and Acetaminophen with Codeine, much like most opioid medications, may exacerbate symptoms of depression in some individuals. If you notice your depression worsening or an increase in suicidal ideation, thoughts or behavior after starting these medications, it is crucial to seek immediate medical attention.
Neither Oxycodone nor Acetaminophen with Codeine should be taken if you are currently taking or have recently stopped taking monoamine oxidase (MAO) inhibitors. Remember to always inform your healthcare provider about all the medications you're on; this includes MAOIs which require around two weeks to clear from your system to prevent dangerous interactions with both Oxycodone and Acetaminophen with Codeine.
How much do Oxycodone and Acetaminophen With Codeine cost?
For the brand name versions of these drugs:
- The price for 100 tablets of Percocet (5 mg Oxycodone/325 mg Acetaminophen) averages around $167, which works out to $1.67/day if taken as a single daily dose. However, dosages can vary widely depending on medical need.
- The cost for 30 tablets of Tylenol with Codeine #3 (300 mg Acetaminophen/30 mg Codeine) is approximately $37–$50, averaging about $1.23 to $1.66 per day.
Thus, if you are taking a lower dosage range for Oxycodone (i.e., less than 10mg/day), then brand-name Tylenol with Codeine may be less expensive on a per-day treatment basis when taken at typical doses. Please note that cost should not be a primary consideration in determining which of these drugs is right for you.
Regarding the generic versions:
- Generic oxycodone-acetaminophen costs significantly less: prices start from as low as $14 for 120 capsules (~$0.12 per day).
- Generic acetaminophen-codeine starts from around $15 for 15 tablets (~$1 per day).
The actual price depends heavily on your location and any insurance coverage you might have.
Popularity of Oxycodone and Acetaminophen With Codeine
Oxycodone, available under various brand names such as Roxicodone and OxyContin, had an estimated 5.2 million prescriptions filled in the United States in 2020. Oxycodone alone accounted for approximately 10% of prescriptions written for opioid analgesics, a group of medications used to treat severe pain.
In contrast, acetaminophen with codeine (also known as Tylenol #3 or Tylenol with Codeine) was prescribed to about 1.2 million people in the USA during that same period. It accounts for just under 2% of all opioid analgesic prescriptions. The use of both oxycodone and acetaminophen with codeine has been declining over recent years due to increasing awareness and concern about dependency risks associated with opioids.
Conclusion
Both Oxycodone and Acetaminophen with Codeine have long-standing records of usage in pain management, and are backed by numerous clinical studies indicating that they are more effective than placebo treatments. In some cases, these drugs may be combined under careful consideration by a physician as they can potentiate each other's effects. Due to their different mechanisms of action - with Oxycodone being a powerful opioid acting on mu-opioid receptors, and Acetaminophen with Codeine acting primarily on the same receptors but at a lower potency - they tend to be prescribed under different circumstances. Oxycodone is considered for severe pain relief where non-opioids don't work whereas Acetaminophen with Codeine would usually be considered for moderate pain.
Both drugs are available in generic form which represents significant cost savings especially for patients who must pay out of pocket. Both Oxycodone and Acetaminophen with Codeine require an adjustment period due to potential dependence development.
The side effect profile is similar between the two drugs; both carry risk of constipation, nausea, dizziness among others but oxycodone has higher addiction potential than acetaminophen-codeine combination due to its higher potency. Patients should closely monitor their condition when starting treatment; any signs of dependency or worsening symptoms should prompt immediate medical attention.
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Refrences
- Pöyhiä, R., Vainio, A., & Kalso, E. (1993, February). A review of oxycodone's clinical pharmacokinetics and pharmacodynamics. Journal of Pain and Symptom Management. Elsevier BV.http://doi.org/10.1016/0885-3924(93)90101-z
- Kalso, E. (2005, May). Oxycodone. Journal of Pain and Symptom Management. Elsevier BV.http://doi.org/10.1016/j.jpainsymman.2005.01.010
- Olkkola, K. T., & Hagelberg, N. M. (2009, August). Oxycodone: new ‘old’ drug. Current Opinion in Anaesthesiology. Ovid Technologies (Wolters Kluwer Health).http://doi.org/10.1097/aco.0b013e32832bc818
- Gatoulis, S. C., Voelker, M., & Fisher, M. (2012, January). Assessment of the Efficacy and Safety Profiles of Aspirin and Acetaminophen With Codeine: Results From 2 Randomized, Controlled Trials in Individuals With Tension-Type Headache and Postoperative Dental Pain. Clinical Therapeutics. Elsevier BV.http://doi.org/10.1016/j.clinthera.2011.11.018
- Schug, S. A. (2006, June 2). Combination analgesia in 2005—a rational approach: focus on paracetamol–tramadol. Clinical Rheumatology. Springer Science and Business Media LLC.http://doi.org/10.1007/s10067-006-0202-9
- Natoli, S., Lazzari, M., Carpenedo, R., Palombo, E., Silvi, M. B., Mammucari, M., & Dauri, M. (2016, May 3). Retrospective Evaluation of a Fixed-Dose Combination of Oxycodone and Acetaminophen to Manage Moderate Pain: The Lower the Better. Advances in Therapy. Springer Science and Business Media LLC.http://doi.org/10.1007/s12325-016-0339-0
- Pereira, V. B. P., Garcia, R., Torricelli, A. A. M., Mukai, A., & Bechara, S. J. (2017, August 17). Codeine Plus Acetaminophen for Pain After Photorefractive Keratectomy: A Randomized, Double-Blind, Placebo-Controlled Add-On Trial. Cornea. Ovid Technologies (Wolters Kluwer Health).http://doi.org/10.1097/ico.0000000000001328
- Birchall, C. L., Maines, J. L., Kunselman, A. R., Stetter, C. M., & Pauli, J. M. (2021, February 28). Opioid use after cesarean: a cohort study comparing combined versus separate oxycodone and acetaminophen regimens. The Journal of Maternal-Fetal & Neonatal Medicine. Informa UK Limited.http://doi.org/10.1080/14767058.2021.1892065