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What is Kionex
TolevamerThe Generic name of this drug
Treatment SummarySodium polystyrene sulfonate is a medication used to lower high potassium levels in the body. It can be taken by mouth or as an enema, and it works by trapping potassium in the intestines. It can also be used as a topical microbicide and spermicide, preventing the spread of HIV and other infections through sexual contact.
Kayexalateis the brand name
Kionex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kayexalate
Tolevamer
1958
34
Effectiveness
How Kionex Affects PatientsPolystyrene sulfonate helps balance levels of sodium and potassium in the body. It is used to treat hyperkalemia, which is too much potassium in the blood. It is given orally or rectally, usually in a solution with sorbitol.
How Kionex works in the bodyPolystyrene sulfonate binds to extra potassium in the body and carries it out in the stool. By doing this, it prevents the potassium from entering the bloodstream and lowers the amount of potassium in the body.
When to interrupt dosage
The proposed dosage of Kionex is contingent upon the diagnosed condition. The appropriate dosage can be found in the table underneath, contingent upon the technique of administration.Condition
Dosage
Administration
Hyperkalemia
0.0041 meq/mg, , 1.0 mg/mg, 100.0 %, 1500.0 mg/mL, 250.0 mg/mL, 0.0943 mg/mg, 0.999 mg/mg
, Oral; Rectal, Powder, for suspension, Powder, for suspension - Oral; Rectal, Powder, Oral, Powder - Oral, Powder - Oral; Rectal, Powder, for suspension - Oral, Suspension, Suspension - Oral; Rectal, Powder, for solution, Powder, for solution - Oral; Rectal, Suspension - Oral, Rectal, Suspension - Rectal
Warnings
There are 20 known major drug interactions with Kionex.Common Kionex Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Tolevamer may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Acetyldigitoxin
Moderate
The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Acetyldigitoxin.
Acetyldigoxin
Moderate
The risk or severity of Cardiac Arrhythmia can be increased when Tolevamer is combined with Acetyldigoxin.
Almasilate
Moderate
The risk or severity of adverse effects can be increased when Tolevamer is combined with Almasilate.
Aloglutamol
Moderate
The risk or severity of adverse effects can be increased when Tolevamer is combined with Aloglutamol.
Kionex Toxicity & Overdose RiskSigns of an overdose on this drug may include confusion, irritability, difficulty thinking or focusing, muscle weakness, and difficulty breathing.
Kionex Novel Uses: Which Conditions Have a Clinical Trial Featuring Kionex?
Seven active trials are being conducted to evaluate the potential of Kionex in managing Hyperkalemia.Condition
Clinical Trials
Trial Phases
Hyperkalemia
4 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1
Kionex Reviews: What are patients saying about Kionex?
5Patient Review
8/20/2009 I have no trouble taking this powder. If mixed/stirred with a small amount of liquid at first to dissolve, then adding the rest of the liquid and drinking very quickly, it is very palatable. I find no taste or aftertaste at all...I even take it with water.
4.7Patient Review
8/2/2011 If you mix it with cranberry juice and little water it is palatabel.You have to watch out for constipation, but a good diet in high fiber will take care of it.
4.3Patient Review
8/20/2012 The texture and flavor of this treatment is really unappealing, but I know it's saving my life. I have to be careful about my potassium intake now, which can be difficult, but it's worth it.
4.3Patient Review
6/4/20083.7Patient Review
5/9/2018 It's not the best tasting medication, but it gets the job done. It tastes like mushed bananas to me, which is ironic since it is supposed to reduce potassium found in things like bananas. Yeah, it's gritty, but three sips and it's gone. Follow with your favorite non alcohol beverage and you're done. No bad bathroom side effects for me
3.7Patient Review
7/12/2010 The texture is very gritty and it tastes terrible, but it's effective. It also makes quite a mess when you're mixing it.
3.7Patient Review
8/27/2010 The medication is not palatable - gritty, salty tating and tated like over ripe bananas. It made me very nauseated and had difficulty keeping it down. It also caused duarrhea which was inconvenient. I REALLY wish it could be made into a capsule, caplet or pill of some form which would make it much easier to take; however, even the distasteful liquid by mouth is much better than the alternative administration!
3.7Patient Review
9/15/2015 The taste is unpleasant and it gave me diarrhea, but I only tried it once.
3.3Patient Review
10/5/2015 I'm content with this medication. I am waiting for my potassium levels to go down.
3.3Patient Review
3/11/2014 The after taste is unfortunately quite terrible, but it does work well to lower potassium levels. It also causes diarrhea, which has me wondering how exactly it manages to get rid of potassium in the first place.
3.3Patient Review
5/21/2013 I've never complained about taking pills before, but this medication is really unpleasant. It's not the flavor, but the grittiness makes it tough to take. And the diarrhea it causes is really bad. I won't be able to leave the house while taking this. But I know it's necessary to get rid of the excess potassium in my system.
3Patient Review
7/27/2017 My monthly labwork has shown that this treatment helps to reduce the amount of potassium in my blood, which is a great relief. However, the taste is terrible and it can cause some pretty bad diarrhea. Please create a pill form!
3Patient Review
7/29/2009 I find this medication very unpalatable, as it is quite gritty when mixed with water. I hope the company can improve the formulation in the near future.
2.7Patient Review
9/15/2010 The taste was really bad, but I was able to get it down with some water. Unfortunately, it gave me diarrhea, which I later found out is a common side effect. I'm hoping the treatment is effective so that I don't have to go through that again.
2.7Patient Review
1/5/2013 My son is taking this due to kidney failure and he hates it. The liquid form is hard for him to get down.
1.7Patient Review
7/7/2009 The taste of this drug is so bad that I have trouble swallowing it. The aftertaste burns my throat and mouth no matter how much water or liquid I drink. I wish someone would make this into a capsule or tablet form.
1.7Patient Review
12/24/2017 This caused explosive diarrhea that lasted for eight hours. The taste was so bad that it almost made me gag.
1.3Patient Review
5/31/2014 I took the recommended dosage and saw no results whatsoever. The next day, I doubled the dosage as I was desperate for some relief but still nothing. I'm now on my third day taking this treatment and have yet to see any positive effects.
1.3Patient Review
4/6/2011 This caused me a lot of problems with diarrhea.
Patient Q&A Section about kionex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Who makes Kionex?
"The copyright for this text belongs to Cerner Multum, Inc. and the date of the most recent version is March 25, 2022."
Answered by AI
Is Kionex discontinued?
"CMP Pharma has seen an increase in demand for their products which has led to a shortage of raw materials. This has resulted in Perrigo discontinuing their Kionex suspension and sodium polystyrene sulfonate (sorbitol-free) suspension."
Answered by AI
What is Kionex used for?
"This medication helps to treat a high level of potassium in your blood by helping your body get rid of the excess potassium."
Answered by AI
Is Kionex the same as Kayexalate?
"Sodium polystrene sulfonate is used to treat patients with high potassium levels by binding to the potassium and then excreting the compound."
Answered by AI