Adalat

Anal sphincter hypertonia, Proctalgia, Altitude Sickness + 12 more
Treatment
3 FDA approvals
20 Active Studies for Adalat

What is Adalat

NifedipineThe Generic name of this drug
Treatment SummaryNifedipine (brand name BAY a 1040) is a type of medication used to treat high blood pressure. It belongs to a class of drugs known as calcium channel blockers and is the first of its kind to be developed. Nifedipine works by blocking calcium from entering the cells in the walls of arteries, which reduces tension and widens them. This helps to lower blood pressure and improve blood flow. There are newer, second and third generation versions of nifedipine with slower onset times and longer-lasting effects, such as amlodipine. Nifedipine was approved by
Procardiais the brand name
image of different drug pills on a surface
Adalat Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Procardia
Nifedipine
1981
355

Approved as Treatment by the FDA

Nifedipine, otherwise called Procardia, is approved by the FDA for 3 uses like Failed conventional therapy and Angina, Stable .
Failed conventional therapy
Helps manage Failed conventional therapy
Angina, Stable
Helps manage Chronic Stable Angina Pectoris
Vasospastic Angina
Helps manage Vasospastic Angina

Effectiveness

How Adalat Affects PatientsNifedipine is a medication that helps to lower blood pressure and increase the amount of oxygen that reaches the heart. It needs to be taken three times a day, typically in doses of 10 to 120mg daily. It is important for patients to be aware of the risks associated with taking this medication, such as excessively low blood pressure, chest pain and heart attack.
How Adalat works in the bodyNifedipine helps reduce blood pressure and ease chest pain by blocking the entry of calcium ions into cells. This stops the cells from becoming over-stimulated, allowing blood vessels to relax and provide more oxygen to the heart.

When to interrupt dosage

The suggested dose of Adalat is contingent upon the diagnosed condition, including Achalasia, Ureteral Calculus and Hypertensive disease. The amount of dosage varies, as per the method of delivery (e.g. Tablet, film coated, extended release or Capsule) specified in the table below.
Condition
Dosage
Administration
Fissure;Anal
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Failed conventional therapy
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Hypertensive Emergency
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Pulmonary Edema
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Ureteral Calculi
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Hypertensive disease
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Angina, Stable
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Proctalgia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Altitude Sickness
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Vasospastic Angina
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Raynaud Disease
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Anal sphincter hypertonia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Premature Labour
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Esophageal Achalasia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Pulmonary Hypertension
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Warnings

Adalat has one contraindication, thus its use should be avoided if any of the situations in the table below are present.Adalat Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Nifedipine may interact with Pulse Frequency
There are 20 known major drug interactions with Adalat.
Common Adalat Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Nifedipine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Nifedipine.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Artemether.
Adalat Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats was found to be 1022mg/kg and in mice was 202mg/kg. An overdose on this drug may cause low blood pressure, problems with the heart rate, and rapid heartbeat. Treatment for an overdose should involve monitoring vital signs, raising the patient's extremities, and administering fluids, vasopressors, and calcium.
image of a doctor in a lab doing drug, clinical research

Adalat Novel Uses: Which Conditions Have a Clinical Trial Featuring Adalat?

101 active investigations are exploring the potential of Adalat to mitigate Achalasia, Hypertensive Emergency and Anal Fissures.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
21 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Angina, Stable
1 Actively Recruiting
Not Applicable
Esophageal Achalasia
0 Actively Recruiting
Pulmonary Edema
0 Actively Recruiting
Premature Labour
4 Actively Recruiting
Not Applicable, Phase 2
Altitude Sickness
0 Actively Recruiting
Raynaud Disease
1 Actively Recruiting
Phase 4
Pulmonary Hypertension
23 Actively Recruiting
Phase 4, Phase 2, Not Applicable, Phase 1, Phase 3, Early Phase 1
Proctalgia
0 Actively Recruiting
Hypertensive Emergency
1 Actively Recruiting
Phase 4
Fissure;Anal
0 Actively Recruiting
Vasospastic Angina
1 Actively Recruiting
Phase 2, Phase 3
Anal sphincter hypertonia
0 Actively Recruiting
Ureteral Calculi
0 Actively Recruiting
Failed conventional therapy
0 Actively Recruiting

Adalat Reviews: What are patients saying about Adalat?

5Patient Review
11/13/2007
Adalat for Angina
3Patient Review
1/16/2008
Adalat for Angina
My blood pressure and chest pain are much more manageable now.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about adalat

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is nifedipine and Adalat the same thing?

"Nifedipine is available as an oral tablet in the brand-name drugs Adalat CC, Afeditab CR, and Procardia XL. These are all extended-release tablets, meaning the drug is slowly released into your bloodstream over time."

Answered by AI

When do you give Adalat?

"It is recommended that you take Adalat CC once a day on an empty stomach. Adalat CC is an extended release dosage form, which means you should swallow the tablet whole, without biting or dividing it. In general, you should start with 30 mg once a day, and increase the dosage over a 7-14 day period."

Answered by AI

Is Adalat for blood pressure?

"Nifedipine, sold under the brand name Adalat, is a calcium channel blocker used to lower high blood pressure and treat chest pain. Nifedipine slows the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels, lowers blood pressure, and makes it easier for the heart to pump."

Answered by AI

What is Adalat used for?

"This medication prevents certain types of chest pain by blocking calcium channels. This allows the individual to exercise more and have fewer angina attacks."

Answered by AI

Clinical Trials for Adalat

Have you considered Adalat clinical trials? We made a collection of clinical trials featuring Adalat, we think they might fit your search criteria.
Have you considered Adalat clinical trials? We made a collection of clinical trials featuring Adalat, we think they might fit your search criteria.
Have you considered Adalat clinical trials? We made a collection of clinical trials featuring Adalat, we think they might fit your search criteria.
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