Ampicillin And Sulbactam

Bites, Human, Animal bite, Bacterial Infections + 14 more
Treatment
8 FDA approvals
20 Active Studies for Ampicillin And Sulbactam

What is Ampicillin And Sulbactam

SulbactamThe Generic name of this drug
Treatment SummarySulbactam is a medication that is used in combination with other antibiotics to prevent bacteria from destroying the effects of the antibiotic. It works by inhibiting an enzyme called beta-lactamase that is produced by bacteria.
Unasynis the brand name
image of different drug pills on a surface
Ampicillin And Sulbactam Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Unasyn
Sulbactam
1991
92

Approved as Treatment by the FDA

Sulbactam, also known as Unasyn, is approved by the FDA for 8 uses which include Bacterial Infections and Communicable Diseases .
Bacterial Infections
Used to treat Skin and Subcutaneous Tissue Bacterial Infections in combination with Ampicillin
Communicable Diseases
Used to treat Gynaecological infection in combination with Ampicillin
Intraabdominal Infections
Used to treat Intraabdominal Infections in combination with Ampicillin
Skin and Subcutaneous Tissue Bacterial Infections
Used to treat Skin and Subcutaneous Tissue Bacterial Infections in combination with Ampicillin
Abdominal Infection
Used to treat Intraabdominal Infections in combination with Ampicillin
Bacterial Infections
Used to treat Bacterial Infections in combination with Ampicillin
Urinary Tract Infection (UTI)
Used to treat Bacterial Infections in combination with Ampicillin
Gynaecological infection
Used to treat Gynaecological infection in combination with Ampicillin

Effectiveness

How Ampicillin And Sulbactam works in the bodySulbactam stops bacteria from producing an enzyme called beta-lactamase. This enzyme stops certain antibiotics from working, so stopping it from forming allows other antibiotics to work on the bacteria. Sulbactam is often combined with ampicillin, a type of antibiotic that is not effective on its own against certain bacteria. When combined with sulbactam, ampicillin can fight a wide range of bacteria that it would otherwise be unable to.

When to interrupt dosage

The recommended dosage of Ampicillin And Sulbactam is contingent upon the diagnosed condition, such as moderate Bacterial Infections, Bacterial Infections and Nosocomial Pneumonia. The measure of dosage depends upon the appliance of delivery (e.g. Injection, powder, for solution - Intramuscular; Intravenous or Injection, powder, for solution) as listed in the following table.
Condition
Dosage
Administration
Surgical Wound Infection
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Animal bite
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Community Acquired Pneumonia (CAP)
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Bacterial Infections
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Communicable Diseases
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Intraabdominal Infections
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Bacterial Infections
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Bacterial Infections
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Healthcare-Associated Pneumonia
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Sinusitis
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Bacterial Infections
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Bites, Human
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Bacterial Infections
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Catheter-Related Infections
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Urinary Tract Infection (UTI)
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Postoperative Infections
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous
Bacterial Endocarditis
, 1000.0 mg/mL, 500.0 mg/mL, 0.5 mg/mg, 1.0 mg/mg, 125.0 mg/mL, 500.0 mg, 1000.0 mg, 5000.0 mg, 50.0 mg/mL, 100.0 mg/mL
Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, , Intravenous, Injection, powder, for solution - Intravenous, Injection, powder, for suspension, Injection, powder, for suspension - Intramuscular; Intravenous

Warnings

Ampicillin And Sulbactam has one contraindication, so it is not advised to be taken when experiencing the conditions listed in the below table.Ampicillin And Sulbactam Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Ampicillin And Sulbactam.
Common Ampicillin And Sulbactam Drug Interactions
Drug Name
Risk Level
Description
Acrivastine
Minor
Sulbactam may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Sulbactam may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Sulbactam may decrease the excretion rate of Almasilate which could result in a higher serum level.
Antihemophilic factor (recombinant), PEGylated
Minor
Sulbactam may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level.
Antithrombin III human
Minor
Sulbactam may decrease the excretion rate of Antithrombin III human which could result in a higher serum level.
image of a doctor in a lab doing drug, clinical research

Ampicillin And Sulbactam Novel Uses: Which Conditions Have a Clinical Trial Featuring Ampicillin And Sulbactam?

41 active trials are currently exploring the potential of Ampicillin and Sulbactam in providing relief for moderate human bites, bacterial infections and intra-abdominal infections.
Condition
Clinical Trials
Trial Phases
Bites, Human
0 Actively Recruiting
Bacterial Infections
0 Actively Recruiting
Catheter-Related Infections
4 Actively Recruiting
Phase 4, Not Applicable
Bacterial Infections
0 Actively Recruiting
Community Acquired Pneumonia (CAP)
5 Actively Recruiting
Not Applicable, Phase 1, Phase 3
Bacterial Endocarditis
1 Actively Recruiting
Not Applicable
Intraabdominal Infections
1 Actively Recruiting
Not Applicable
Bacterial Infections
0 Actively Recruiting
Animal bite
0 Actively Recruiting
Surgical Wound Infection
24 Actively Recruiting
Not Applicable, Early Phase 1, Phase 4, Phase 2, Phase 3, Phase 1
Sinusitis
0 Actively Recruiting
Urinary Tract Infection (UTI)
6 Actively Recruiting
Phase 1, Phase 3, Phase 4, Phase 2
Bacterial Infections
0 Actively Recruiting
Postoperative Infections
0 Actively Recruiting
Bacterial Infections
0 Actively Recruiting
Healthcare-Associated Pneumonia
0 Actively Recruiting
Communicable Diseases
0 Actively Recruiting

Ampicillin And Sulbactam Reviews: What are patients saying about Ampicillin And Sulbactam?

5Patient Review
10/5/2016
Ampicillin And Sulbactam for Abdominal Cavity Lining Infection caused by Enterobacter
This treatment was lifesaving!
4.3Patient Review
7/12/2008
Ampicillin And Sulbactam for Cat Bite Wound
I got this medication as an IV drip and it cleared up my infection very quickly. However, I developed a yeast infection the next day because of the treatment.
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Patient Q&A Section about ampicillin and sulbactam

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the function of ampicillin?

"Ampicillin is an antibiotic used to treat various infections caused by bacteria. These infections include meningitis, infections of the throat, sinuses, lungs, reproductive organs, urinary tract, and gastrointestinal tract."

Answered by AI

What is ampicillin and sulbactam used for?

"Ampicillin and sulbactam combination is used to treat bacterial infections in many different parts of the body. This antibiotic prevents the growth of bacteria by killing them. It belongs to a group of medicines known as penicillins and beta-lactamase inhibitors."

Answered by AI

What is the ampicillin-sulbactam side effects?

"You may experience diarrhea, a rash, swollen or black tongue, vaginal itching or discharge, or pain at the injection site."

Answered by AI

Clinical Trials for Ampicillin And Sulbactam

Image of The Center for Dermatologic Surgery at Cooper University Health Care in Marlton, United States.

Antibacterial Soap + Ointment for Wound Infection

18+
All Sexes
Marlton, NJ
The goal of this clinical trial is to learn if reducing bacterial load on the skin and nostrils with topical antibacterial soap and ointment, respectively, reduces rate of infection in surgical sites on lower leg wounds left open to heal in adults undergoing skin cancer surgery. The main question it aims to answer is: Does Hibiclens antibacterial skin cleanser and mupirocin antibacterial ointment applied to nostrils prior to surgery lower the number of times participants develop an infection in their open wound on the lower leg? Researchers will compare the treatment group to the standard of care, which involves no treatment prior to surgery, to see if topical antibiotics applied prior to surgery affect infection rates between the two groups. Participants randomized to the treatment group will: Shower with Hibiclens once daily for 5 days prior to the day of surgery and apply mupirocin to the nostrils twice daily for 5 days prior to the day of surgery. They will then send pictures of their surgical site to monitor for signs of infection at 2-week and 4-week post-operation. Participants randomized to the control group (standard of care) will: NOT apply the topical antibacterials prior to the day of surgery. They will then send pictures of their surgical site to monitor for signs of infection at 2-week intervals for 1 month after surgery.
Phase 3
Recruiting
The Center for Dermatologic Surgery at Cooper University Health Care
Have you considered Ampicillin And Sulbactam clinical trials? We made a collection of clinical trials featuring Ampicillin And Sulbactam, we think they might fit your search criteria.Go to Trials
Image of Jack D. Weiler Hospital (Einstein Campus) in The Bronx, United States.

Mepilex Ag Dressing for Postpartum Infection

18+
Female
The Bronx, NY
The goal of this clinical trial is to learn whether using a silver-containing antimicrobial foam dressing (Mepilex Ag) can help prevent surgical site infections in patients undergoing cesarean delivery. The main questions it aims to answer are: 1. Does Mepilex Ag reduce the rate of surgical site infections after cesarean delivery? 2. Is Mepilex Ag more effective than standard wound dressings in preventing infection? Researchers will compare those who receive the Mepilex Ag dressing to those who receive the standard dressing to see if the silver impregnated antimicrobial foam dressing lowers infection rate. Participants will: 1. Undergo a routine cesarean delivery as per usual obstetric indication 2. Be randomly assigned to receive either a silver-containing foam dressing or a standard dressing after surgery 3. Be monitored for wound complications and signs of infection during the postpartum period
Waitlist Available
Has No Placebo
Jack D. Weiler Hospital (Einstein Campus)Georgios Doulaveris
Image of Children's Healthcare of Atlanta in Atlanta, United States.

Antibiotic Strategies for Pneumonia in Children

12 - 71
All Sexes
Atlanta, GA
The goal of this clinical trial is to determine if a "watch and wait" antibiotic strategy, called Safety Net Antibiotic Prescribing (SNAP), can safely reduce unnecessary antibiotic use while ensuring that children diagnosed with community-acquired pneumonia get better from their illness. The main aims of this study are: * To compare the effectiveness of SNAP versus immediate antibiotic prescribing in children with mild community-acquired pneumonia (CAP) * To identify which patient groups benefit most from the SNAP strategy * To identify factors that shape implementation of each prescribing strategy. Researchers will compare the SNAP strategy (where parents or guardians are instructed to give antibiotics only if their child is not improving after 72 hours, or sooner if they are worsening) to the immediate antibiotic prescribing strategy (where parents or guardians are instructed to give the antibiotics right after their healthcare visit) to see if one strategy is more effective than the other. Participants will be randomly assigned to either the immediate antibiotic group or the SNAP group at enrollment. Participation lasts 14 days with follow-up surveys at 4, 7, and 14 days after enrollment.
Recruiting
Has No Placebo
Children's Healthcare of Atlanta (+3 Sites)Todd Florin, MD, MSCE
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Image of Harbor UCLA Medical Center - Medicine - Infectious Diseases in Torrance, United States.

Optimized Beta-lactam Dosing for Bacterial Infections

18+
All Sexes
Torrance, CA
The purpose of this study is to evaluate the abilities of Cystatin C (CysC) and CysC-based estimated Glomerular Filtration Rate (eGFR) equations to characterize the pharmacokinetics (PK) profiles of meropenem and cefepime relative to Serum Creatinine (SCR), Serum Creatinine based Equation (SCRE)and iohexol at the population and individual levels in critically ill adult patients with suspected or documented AMR Gram-negative infections. We hypothesize that CysC and CysC-based eGFR equations will characterize the PK profiles of meropenem and cefepime at the population and individual levels with greater accuracy and precision than SCR and SCREs. Iohexol will be administered to patients enrolled in the study and serve as the reference indicator of measured Glomerular Filtration Rate (mGFR), which is the gold standard assessment of kidney function. We hypothesize that the predictive performances of CysC and CysC-based eGFR equations in estimating the PK profiles of meropenem and cefepime at the population and individual levels will be comparable to iohexol. The information obtained in this study will be used to develop PK/pharmacodynamics (PD) optimized meropenem and cefepime dosing schemes based on the renal function biomarker population PK (PopPK) model with the best predictive performance for clinical use in the treatment of critically ill adult patients with suspected or documented AMR Gram-negative infections and varying degrees of renal function. The primary objective of this study is to compare the abilities of renal function biomarkers (CysC, CysC-based eGFR equations, SCR, SCREs) relative to iohexol to characterize the PK profiles of meropenem and cefepime in critically ill adult patients with suspected or documented AMR Gram-negative infections.
Phase 4
Recruiting
Harbor UCLA Medical Center - Medicine - Infectious Diseases (+9 Sites)
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