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What is Apresoline
HydralazineThe Generic name of this drug
Treatment SummaryHydralazine is a medication used to treat high blood pressure and heart failure. It was originally developed in the 1950s as a malaria treatment, but was later discovered to reduce hypertension. It is no longer used as a first line treatment for hypertension, as newer medications are available. Hydralazine hydrochloride was approved by the FDA in 1953.
Apresoline hydrochlorideis the brand name
Apresoline Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Apresoline hydrochloride
Hydralazine
1953
300
Approved as Treatment by the FDA
Hydralazine, also called Apresoline hydrochloride, is approved by the FDA for 1 uses which include Hypertensive disease .Hypertensive disease
Helps manage Hypertension, Essential Hypertension
Effectiveness
How Apresoline Affects PatientsHydralazine helps to relax the small muscles of the arteries, which reduces blood pressure. The effects of the drug usually last 2-6 hours. It is generally safe and can be taken in doses of up to 300mg. However, people should be aware of the risk of developing systemic lupus erythematosus syndrome when taking this drug.
How Apresoline works in the bodyHydralazine works to lower blood pressure by blocking calcium from entering cells in vascular smooth muscle. This reduces the resistance in the blood vessels and increases the heart rate, stroke volume, and cardiac output. Hydralazine also prevents a protein called protocollagen prolyl hydroxylase from binding to free iron. This stops the breakdown of HIF-1α, which encourages the growth of new blood vessels and helps them regenerate.
When to interrupt dosage
The proposed measure of Apresoline is contingent upon the specified condition, including Hypertensive crisis, Hypertensive disease and Pregnancy. The quantity of dosage is dependent upon the technique of delivery (e.g. Tablet, coated - Oral or Tablet) detailed in the table beneath.Condition
Dosage
Administration
Hypertensive disease
, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intramuscular; Intravascular
Hypertension
, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intramuscular; Intravascular
Congestive Heart Failure
, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intramuscular; Intravascular
Severe Hypertension
, 20.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 100.0 mg, 37.5 mg
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Injection, Injection - Intramuscular; Intravenous, Intramuscular; Intravascular, Injection, solution - Intramuscular; Intravascular, Intravenous, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intramuscular; Intravascular
Warnings
Apresoline ContraindicationsCondition
Risk Level
Notes
Coronary Disease
Do Not Combine
Rheumatic Heart Disease
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Hydralazine may interact with Pulse Frequency
Common Apresoline Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Hydralazine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Hydralazine.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Hydralazine.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Hydralazine.
Amifostine
Major
Hydralazine may increase the hypotensive activities of Amifostine.
Apresoline Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats is 173-187mg/kg, and the highest known dose an adult human has survived is 10g. Symptoms of an overdose may include low blood pressure, rapid heart rate, headache, redness of the skin, lack of oxygen to the heart, heart attack, abnormal heart rhythm, and shock. Treatment for overdose includes emptying the stomach contents and administering activated charcoal, though this can lead to further arrhythmias and shock. Patients should receive supportive and symptomatic care.
Apresoline Novel Uses: Which Conditions Have a Clinical Trial Featuring Apresoline?
352 active clinical trials are presently exploring the potential of Apresoline to mitigate Hypertensive disease, Congestive Heart Failure and Hypertensive crisis.Condition
Clinical Trials
Trial Phases
Hypertension
0 Actively Recruiting
Congestive Heart Failure
180 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Severe Hypertension
0 Actively Recruiting
Hypertensive disease
3 Actively Recruiting
Not Applicable
Apresoline Reviews: What are patients saying about Apresoline?
4.7Patient Review
1/19/20092Patient Review
8/18/20091.7Patient Review
10/6/2019 Though it did lower my blood pressure, I felt like all of my energy was gone. It's effects were very sudden and severe. I only messed with it for a week because of how bad it made me feel, and I almost lost my job because of it. On top of that, I fractured my elbow while taking it.
1Patient Review
9/30/2009 My sister had a terrible reaction to this medication. It caused lupus and she ended up in the hospital for two weeks as a result. I would not recommend this drug to anyone after seeing what it did to her.
1Patient Review
3/10/2010 The pills are large and bitter, which makes them hard to take.
1Patient Review
11/6/20081Patient Review
8/5/2018 I had an extremely negative reaction to this drug. I felt intense chest pain, dizziness, and a headache that lasted for over 24 hours after taking it. I would never recommend this medication to anyone.
1Patient Review
9/13/2016 The medicine caused some serious side effects for me, including headaches, heart palpitations, loss of appetite and nausea.
Patient Q&A Section about apresoline
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the drug Apresoline used for?
"Hydralazine is used to lower blood pressure, either on its own or with other medications. This reduces the risk of strokes, heart attacks and kidney problems, as hydralazine causes the blood vessels to dilate, improving blood flow around the body."
Answered by AI
What type of drug is Apresoline?
"Apresoline is a prescription medicine used to treat chronic high blood pressure, Hypertensive Crisis, and Congestive heart failure. Apresoline may be used alone or with other medications. Apresoline belongs to a class of drugs called Vasodilators."
Answered by AI
What are side effects for hydralazine?
"You may experience flushing, headache, upset stomach, vomiting, loss of appetite, diarrhea, constipation and eye tearing."
Answered by AI
Is Apresoline a water pill?
"Does hydralazine make you urinate more?
No, hydralazine does not make you urinate more because it is not a water pill. It works by relaxing your blood vessels to lower your blood pressure."
Answered by AI