Clariscan
MRI
Treatment
1 FDA approval
17 Active Studies for Clariscan
Treatment for
MRI
What is Clariscan
Gadoteric acid
The Generic name of this drug
Treatment Summary
Gadoteric acid is a contrast agent used in MRI scans to make blood vessels and areas of inflammation or disease more visible. It consists of an organic acid called DOTA and gadolinium, a magnetic element. Gadoteric acid creates a magnetic moment when put in a magnetic field, which then brightens the signal of tissues around it. This drug, sold under the brand name Dotarem, is approved for use in adults and children aged 2 and up for imaging of the brain, spine, and associated tissues. It helps to detect and visualize areas with damaged blood-brain barriers or abnormal blood vessels.
Dotarem
is the brand name
Clariscan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dotarem
Gadoteric acid
2013
9
Approved as Treatment by the FDA
Gadoteric acid, also known as Dotarem, is approved by the FDA for 1 uses including MRI .
MRI
Effectiveness
How Clariscan Affects Patients
Gadoterate changes how protons respond to MRI signals, which is used to create an image. This drug works the same way with different strength magnetic fields used in clinical MRI. It does not cross the blood-brain barrier, so it cannot be used to image normal brain or lesions with an intact blood-brain barrier. However, if the blood-brain barrier is disrupted or there is abnormal vascularity, gadoterate can be distributed in lesions like tumors, abscesses, and infarcts.
How Clariscan works in the body
Gadoterate is a special molecule that reacts to magnetic fields. When placed in a magnetic field, it creates a magnetic moment that makes nearby water molecules relax faster. This increases the signal intensity of nearby tissues, resulting in brighter images when it is used as a contrast agent.
When to interrupt dosage
The endorsed dosage of Clariscan is dependent on the determined condition. The measure of dosage shifts, as per the mode of application (e.g. Injection - Intravenous or Solution - Intravenous) detailed in the table below.
Condition
Dosage
Administration
MRI
, 376.9 mg/mL
, Injection, Injection - Intravenous, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous
Warnings
There are 20 known major drug interactions with Clariscan.
Common Clariscan Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Gadoteric acid may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Acrivastine
Minor
Gadoteric acid may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Gadoteric acid may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Gadoteric acid may decrease the excretion rate of Almasilate which could result in a higher serum level.
Antihemophilic factor (recombinant), PEGylated
Minor
Gadoteric acid may decrease the excretion rate of Antihemophilic factor (recombinant), PEGylated which could result in a higher serum level.
Clariscan Toxicity & Overdose Risk
Common side effects of GBCAs include nausea, headache, pain, coldness, and burning around the injection site. It is also possible to develop Nephrogenic Systemic Fibrosis, especially in those with impaired kidney function.
Clariscan Novel Uses: Which Conditions Have a Clinical Trial Featuring Clariscan?
10 active trials are exploring the potential of Clariscan as a therapeutic agent for Magnetic Resonance Imaging (MRI) scans.
Condition
Clinical Trials
Trial Phases
MRI
17 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Patient Q&A Section about clariscan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the CPT code for Clariscan?
"Gadoterate meglumine injection can be billed using HCPCS code A9575. Guidelines for billing this code can be found on the NC Medicaid website."
Answered by AI
What class is Clariscan?
"Clariscan is a drug that helps create pictures of the inside of your body during an MRI scan. It belongs to a class of drugs called Diagnostic Imaging Agents."
Answered by AI
Are Clariscan and Dotarem the same?
"A new macrocyclic GBCA, Clariscan, has become available in some countries. This GBCA has the same formulation as Dotarem, but has never been included in either clinical or non-clinical studies of Gd retention."
Answered by AI
What is a Clariscan?
"Clariscan is a drug that is injected into a vein and used with MRI scans to help doctors better see and understand areas of the brain where there may be problems with the blood-brain barrier."
Answered by AI