Avapro

Diabetic Nephropathies, Hypertensive disease, Treatment Naive + 2 more
Treatment
6 FDA approvals
20 Active Studies for Avapro

What is Avapro

IrbesartanThe Generic name of this drug
Treatment SummaryIrbesartan is a medication used to treat high blood pressure and diabetic kidney disease. It is usually taken in combination with hydrochlorothiazide, and it does not usually cause a dry cough like some other similar medications. Irbesartan was approved by the FDA in 1997.
Avaprois the brand name
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Avapro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avapro
Irbesartan
1997
246

Approved as Treatment by the FDA

Irbesartan, also called Avapro, is approved by the FDA for 6 uses such as multiple antihypertensive drugs likely required and not adequately controlled with monotherapy .
multiple antihypertensive drugs likely required
Used to treat multiple antihypertensive drugs likely required in combination with Hydrochlorothiazide
not adequately controlled with monotherapy
Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide
Diabetic Nephropathies
Helps manage Diabetic Nephropathy
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Treatment Naive
Used to treat Treatment Naive in combination with Hydrochlorothiazide

Effectiveness

How Avapro Affects PatientsIrbesartan is a medication that helps regulate blood pressure and is used to treat high blood pressure and kidney damage related to diabetes. It is usually taken once daily and has a wide safety range, with a low dose of 150mg per day and a high dose of 900mg per day being well tolerated in healthy human subjects.
How Avapro works in the bodyIrbesartan blocks the angiotensin II hormone from binding to certain cells. These cells, like those in the adrenal gland and in the walls of blood vessels, would normally respond to angiotensin II by constricting and increasing the amount of aldosterone released. By blocking the ability of angiotensin II to bind to these cells, irbesartan causes them to relax, reducing blood pressure.

When to interrupt dosage

The proposed measure of Avapro is contingent upon the recognized condition, for example Hypertensive disease, not adequately managed with monotherapy and Diabetic Nephropathy. The quantity of dosage is contingent upon the delivery technique expressed in the table beneath.
Condition
Dosage
Administration
Diabetic Nephropathies
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
not adequately controlled with monotherapy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Avapro Contraindications
Condition
Risk Level
Notes
Hypesthesia
Do Not Combine
Dehydration
Do Not Combine
Chronic Kidney Disease
Do Not Combine
Renal Artery Stenosis
Do Not Combine
Type 2 Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Irbesartan may interact with Pulse Frequency
There are 20 known major drug interactions with Avapro.
Common Avapro Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Irbesartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Irbesartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Irbesartan.
Amifostine
Major
Irbesartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Irbesartan.
Avapro Toxicity & Overdose RiskThe lowest toxic dose of this drug in humans is 30mg/kg over a period of six weeks. If someone overdoses on this drug, they may experience low blood pressure and a rapid or slow heartbeat. Treatment for these symptoms includes giving terlipressin, which acts as a substitute for traditional vasopressors if they are not successful in restoring blood pressure.
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Avapro Novel Uses: Which Conditions Have a Clinical Trial Featuring Avapro?

19 active clinical investigations are currently being conducted to assess the potential of Avapro to ameliorate Diabetic Nephropathy, Hypertensive disease, and the likely requirement of multiple antihypertensive drugs.
Condition
Clinical Trials
Trial Phases
not adequately controlled with monotherapy
0 Actively Recruiting
Treatment Naive
0 Actively Recruiting
Hypertensive disease
22 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathies
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting

Avapro Reviews: What are patients saying about Avapro?

5Patient Review
3/14/2013
Avapro for High Blood Pressure
5Patient Review
4/8/2013
Avapro for High Blood Pressure
5Patient Review
10/27/2013
Avapro for High Blood Pressure
At first, I didn't think this drug had any side effects. However, now I'm not so sure. I seem to feel blue when I'm on it, and when the script ran out I definitely felt happier. But I'm back on it now..
5Patient Review
1/20/2014
Avapro for High Blood Pressure
I've been on a few different blood pressure medications, and this one has by far been the most effective. Within two days of starting it, my numbers were down to 120/70. I have experienced some lightheadedness if I stand up too quickly, but that's the only side effect I've noticed. It's worth it to find a medication that works for you—your health is worth it.
5Patient Review
9/18/2013
Avapro for High Blood Pressure
Avapro is the best blood pressure medication I've tried. Not only does it work well, but I haven't experienced any negative side effects like other drugs in this class have given me (e.g., anxiety, interrupted sleep, decreased energy and libido, a very NASTY dry cough, etc.)
View All Reviews
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Patient Q&A Section about avapro

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Avapro a good blood pressure medicine?

"Irbesartan is an effective blood pressure medication that is especially beneficial for those with diabetes. It has minimal side effects and only needs to be taken once a day."

Answered by AI

What are the side effects for Avapro?

"These are some of the side effects you may experience as your body adjusts to the medication: dizziness, lightheadedness, upset stomach, diarrhea, heartburn, or tiredness."

Answered by AI

What is Avapro 150 mg used for?

"This medication works by blocking a hormone that controls blood vessels.

Irbesartan is used to treat high blood pressure and help protect the kidneys from damage due to diabetes. By blocking a hormone that controls blood vessels, it lowers high blood pressure and prevents strokes, heart attacks, and kidney problems."

Answered by AI

What is the difference between Avapro and irbesartan?

"Ibesartan is a drug used to treat high blood pressure. It is available as a pill that is taken orally. It comes in three different strengths: 75 mg, 150 mg, and 300 mg."

Answered by AI

Clinical Trials for Avapro

Have you considered Avapro clinical trials? We made a collection of clinical trials featuring Avapro, we think they might fit your search criteria.
Have you considered Avapro clinical trials? We made a collection of clinical trials featuring Avapro, we think they might fit your search criteria.
Have you considered Avapro clinical trials? We made a collection of clinical trials featuring Avapro, we think they might fit your search criteria.