Avapro

Diabetic Nephropathies, Hypertensive disease, Treatment Naive + 2 more
Treatment
6 FDA approvals
20 Active Studies for Avapro

What is Avapro

IrbesartanThe Generic name of this drug
Treatment SummaryIrbesartan is a medication used to treat high blood pressure and diabetic kidney disease. It is usually taken in combination with hydrochlorothiazide, and it does not usually cause a dry cough like some other similar medications. Irbesartan was approved by the FDA in 1997.
Avaprois the brand name
image of different drug pills on a surface
Avapro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avapro
Irbesartan
1997
246

Approved as Treatment by the FDA

Irbesartan, also called Avapro, is approved by the FDA for 6 uses such as Diabetic Nephropathies and not adequately controlled with monotherapy .
Diabetic Nephropathies
Helps manage Diabetic Nephropathy
not adequately controlled with monotherapy
Used to treat not adequately controlled with monotherapy in combination with Hydrochlorothiazide
Diabetic Nephropathy
Helps manage Diabetic Nephropathy
multiple antihypertensive drugs likely required
Used to treat multiple antihypertensive drugs likely required in combination with Hydrochlorothiazide
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Treatment Naive
Used to treat Treatment Naive in combination with Hydrochlorothiazide

Effectiveness

How Avapro Affects PatientsIrbesartan is a medication that helps regulate blood pressure and is used to treat high blood pressure and kidney damage related to diabetes. It is usually taken once daily and has a wide safety range, with a low dose of 150mg per day and a high dose of 900mg per day being well tolerated in healthy human subjects.
How Avapro works in the bodyIrbesartan blocks the angiotensin II hormone from binding to certain cells. These cells, like those in the adrenal gland and in the walls of blood vessels, would normally respond to angiotensin II by constricting and increasing the amount of aldosterone released. By blocking the ability of angiotensin II to bind to these cells, irbesartan causes them to relax, reducing blood pressure.

When to interrupt dosage

The proposed measure of Avapro is contingent upon the recognized condition, for example Hypertensive disease, not adequately managed with monotherapy and Diabetic Nephropathy. The quantity of dosage is contingent upon the delivery technique expressed in the table beneath.
Condition
Dosage
Administration
Diabetic Nephropathies
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
not adequately controlled with monotherapy
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
multiple antihypertensive drugs likely required
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Treatment Naive
150.0 mg, 300.0 mg, , 75.0 mg, 1.5 mg/mg, 3.0 mg/mg, 7.5 mg/mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Avapro Contraindications
Condition
Risk Level
Notes
Hypesthesia
Do Not Combine
Dehydration
Do Not Combine
Chronic Kidney Disease
Do Not Combine
Renal Artery Stenosis
Do Not Combine
Type 2 Diabetes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Irbesartan may interact with Pulse Frequency
There are 20 known major drug interactions with Avapro.
Common Avapro Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Irbesartan.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Irbesartan.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Irbesartan.
Amifostine
Major
Irbesartan may increase the hypotensive activities of Amifostine.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Irbesartan.
Avapro Toxicity & Overdose RiskThe lowest toxic dose of this drug in humans is 30mg/kg over a period of six weeks. If someone overdoses on this drug, they may experience low blood pressure and a rapid or slow heartbeat. Treatment for these symptoms includes giving terlipressin, which acts as a substitute for traditional vasopressors if they are not successful in restoring blood pressure.
image of a doctor in a lab doing drug, clinical research

Avapro Novel Uses: Which Conditions Have a Clinical Trial Featuring Avapro?

19 active clinical investigations are currently being conducted to assess the potential of Avapro to ameliorate Diabetic Nephropathy, Hypertensive disease, and the likely requirement of multiple antihypertensive drugs.
Condition
Clinical Trials
Trial Phases
not adequately controlled with monotherapy
0 Actively Recruiting
Treatment Naive
0 Actively Recruiting
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathies
0 Actively Recruiting
multiple antihypertensive drugs likely required
0 Actively Recruiting

Avapro Reviews: What are patients saying about Avapro?

5Patient Review
3/14/2013
Avapro for High Blood Pressure
5Patient Review
4/8/2013
Avapro for High Blood Pressure
5Patient Review
10/27/2013
Avapro for High Blood Pressure
At first, I didn't think this drug had any side effects. However, now I'm not so sure. I seem to feel blue when I'm on it, and when the script ran out I definitely felt happier. But I'm back on it now..
5Patient Review
1/20/2014
Avapro for High Blood Pressure
I've been on a few different blood pressure medications, and this one has by far been the most effective. Within two days of starting it, my numbers were down to 120/70. I have experienced some lightheadedness if I stand up too quickly, but that's the only side effect I've noticed. It's worth it to find a medication that works for you—your health is worth it.
5Patient Review
9/18/2013
Avapro for High Blood Pressure
Avapro is the best blood pressure medication I've tried. Not only does it work well, but I haven't experienced any negative side effects like other drugs in this class have given me (e.g., anxiety, interrupted sleep, decreased energy and libido, a very NASTY dry cough, etc.)
5Patient Review
2/17/2016
Avapro for High Blood Pressure
Avapro has been really helpful for me in managing my blood pressure, but recently it's become difficult to find in stores. I've tried other medications that just don't work as well, so please make Avapro available again soon!
4.7Patient Review
2/24/2014
Avapro for High Blood Pressure
I was on the medication for over a month when I started feeling awful. I thought maybe I had the flu, but then I realized that it might be the Avapro. Sure enough, after doing some research online, I found that I had nearly all of the listed side effects. As soon as I stopped taking the drug, I felt better almost immediately. However, it took my doctor several days to get me another prescription (during which time I felt terrible). Now I'm on my third medication and experiencing more side effects.
4.7Patient Review
8/26/2014
Avapro for High Blood Pressure
Was put on 150mg, 6 months later, blood pressure tested for routine pre op surgery test and blood pressure was out of control! No one had a clue that it was totally ineffective. Doctor raised (doubled) dosage to 300mg. That solved the problem, and my blood pressure has been good for 1 1/2 years now.
4.3Patient Review
1/28/2013
Avapro for High Blood Pressure
4.3Patient Review
6/8/2015
Avapro for High Blood Pressure
I was on this medication for a few years and it effectively controlled my blood pressure; however, I developed a cough and shortness of breath. My doctor has put me on Avapro 300mg starting 6/9, so we'll see how that goes.
3.7Patient Review
5/24/2015
Avapro for High Blood Pressure
I had high hopes for Avapro to help lower my blood pressure, but unfortunately it didn't work as well as I'd hoped. It did lower my blood pressure some, but not enough. I also experienced some digestive issues while taking this medication.
3Patient Review
4/1/2013
Avapro for High Blood Pressure
3Patient Review
7/2/2020
Avapro for High Blood Pressure
This drug was effective at reducing my blood pressure. However, it also caused a number of side effects like headaches, fatigue, and numbness in my feet. I'm going to try something else after two weeks on this medication.
3Patient Review
7/20/2013
Avapro for High Blood Pressure
About five years ago, I started taking this medication and four weeks in, I developed a chronic lower back problem. An MRI showed nothing, but I suspect it's from the drug. Even so, it does help control my blood pressure.
2.7Patient Review
7/27/2014
Avapro for High Blood Pressure
Avapro worked well for me with no side effects. However, when I was given the generic version (Ibesartan) over a period of 2 years, I developed short bursts of adrenaline which gave me a fast heart rate. It totally cured my high blood pressure. My problem is convincing my cardiologist that this is the cause of my quick heartbeats.
2.3Patient Review
2/7/2014
Avapro for High Blood Pressure
So far this treatment is effective for me, but I want to do more research before continuing.
1.7Patient Review
5/2/2020
Avapro for High Blood Pressure
I was taking the maximum dosage for 9 months and experienced awful side effects the whole time. I constantly felt tired, had to urinate frequently, and got daily cramps in my feet. I wouldn't wish this on anyone.
1.7Patient Review
9/1/2022
Avapro for High Blood Pressure
Out of the ten possible side effects of Avopro, I experienced diarrhea, upset stomach muscle weakness, tiredness and low energy. These were by far the worst of them all. Consequently, I've asked my doctor for a different prescription.
1Patient Review
9/7/2019
Avapro for High Blood Pressure
I was taking 75 mg every day for 7 years ( high blood pressure) and after researching realised that a lot of my health problems were caused by this drug.I could not understand why I was feeling like I did because I did everything right re: lifestyle changes. Have ceased taking it . 2 weeks off it and feel fantastic and back to my old self.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about avapro

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Avapro a good blood pressure medicine?

"Irbesartan is an effective blood pressure medication that is especially beneficial for those with diabetes. It has minimal side effects and only needs to be taken once a day."

Answered by AI

What are the side effects for Avapro?

"These are some of the side effects you may experience as your body adjusts to the medication: dizziness, lightheadedness, upset stomach, diarrhea, heartburn, or tiredness."

Answered by AI

What is Avapro 150 mg used for?

"This medication works by blocking a hormone that controls blood vessels.

Irbesartan is used to treat high blood pressure and help protect the kidneys from damage due to diabetes. By blocking a hormone that controls blood vessels, it lowers high blood pressure and prevents strokes, heart attacks, and kidney problems."

Answered by AI

What is the difference between Avapro and irbesartan?

"Ibesartan is a drug used to treat high blood pressure. It is available as a pill that is taken orally. It comes in three different strengths: 75 mg, 150 mg, and 300 mg."

Answered by AI

Clinical Trials for Avapro

Image of University of Alabama at Birmingham in Birmingham, United States.

Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamPankaj Arora, MD, FAHA
Have you considered Avapro clinical trials? We made a collection of clinical trials featuring Avapro, we think they might fit your search criteria.Go to Trials
Image of Wayne Health Mobile Units in Detroit, United States.

Text Message Reminders for High Blood Pressure

18+
All Sexes
Detroit, MI
This project is part of the ACHIEVE GREATER (Addressing Cardiometabolic Health In Populations Through Early PreVEntion in the GREAT LakEs Region) Center (IRB# 100221MP2A), the purpose of which is to improve cardiometabolic health in two uniquely comparable cities: Detroit, Michigan, and Cleveland, Ohio. The ACHIEVE GREATER Center involves separate but related projects that aim to improve cardiometabolic health outcomes through better risk factor control for three chronic conditions that are of tremendous public health importance, (hypertension (HTN), heart failure, and coronary heart disease), all of which contribute significantly to premature death in Detroit and Cleveland. The present study is the prospective observational cohort component of ACHIEVE P1- EPI (Project 1) of the ACHIEVE GREATER Center and serves to characterize the population of patients with blood pressure (BP) levels above normal attending The Wayne Health Mobile Health Unit (MHU) events to better understand key factors (e.g., social determinants of health) that convey information about baseline BP levels and related clinical outcomes (e.g., follow-up clinic visits, BP control, and cardiovascular events).
Recruiting
Has No Placebo
Wayne Health Mobile UnitsSteven J Korzeniewski, PhD
Have you considered Avapro clinical trials? We made a collection of clinical trials featuring Avapro, we think they might fit your search criteria.Go to Trials
Image of Northern Arizona University in Flagstaff, United States.

CardioCare Quest for High Blood Pressure

18+
All Sexes
Flagstaff, AZ
This project aims to address healthcare disparities among Navaho people diagnosed with hypertension or prehypertension through three main objectives. Firstly, it identifies and shares insights on healthcare access disparities affecting Navaho individuals experiencing nonadherence to hypertension treatment. Secondly, the proposal develops a telehealth solution based on factors identified as knowledge gaps caused by healthcare access disparities in hypertension management; we will use the factors to design a series of engaging minigames that can be incorporated into the larger CardioCare Quest. These minigames will be co-designed with end users and clinicians. Finally, the proposal conducts comprehensive qualitative and quantitative assessments of user experiences, perceptions, and challenges with CardioCare Quest.
Recruiting
Has No Placebo
Northern Arizona University (+1 Sites)Tochukwu Ikwunne, PhD
Image of Tufts University in Boston, United States.

Food as Medicine for Cardiometabolic Health

18+
All Sexes
Boston, MA
Though the Mississippi Delta has a rich agricultural history and some of the nation's most fertile soil, residents have experienced the legacy of slavery and economic exploitation through food insecurity and poverty for generations. This project focuses on Bolivar, Washington, and Sunflower, contiguous counties in the Delta that are designated as health disparity populations. Over 65% of the 100,000 residents are Black/African American and \~30% live at or below the poverty level. Obesity rates are high and the rate of diabetes is almost double the national average. Tufts University received a grant from the National Institute of Minority Health and Health Disparities to develop, test, and evaluate a Food is Medicine program in Mississippi. The Delta Growing a Resilient, Enriching, Equitable, Nourishing food System (GREENS) Food is Medicine (FIM) Project, is a collaborative project in Bolivar, Washington, and Sunflower counties in Mississippi. The intervention involves regularly distributed fruit and vegetable produce boxes as well as nutrition education materials to the intervention group. The control group will receive produce boxes later, after they complete study activities. The project's primary goal is to improve health outcomes by creating a FIM intervention. The Delta GREENS FIM Project aims to become a model for promoting nutrition security and management of chronic conditions in varied communities nationwide.
Recruiting
Has No Placebo
Tufts UniversityChristina D Economos, PhD
Image of Providence College in Providence, United States.

Heat Therapy for High Blood Pressure

18 - 50
All Sexes
Providence, RI
The goal of this clinical trial is to test whether putting a participant's legs in a hot bath after exercise improves blood pressure in people with higher blood pressure. . The main questions it aims to answer are: * Whether exercise alone, hot water leg bath alone, or both treatments together cause blood pressure to be lower during sleep. * If there are any changes in heart rhythm or blood vessel health after exercise, hot water leg bath, or the two treatments together that relate to changes in blood pressure. Participants will complete four different trials: * 30 minutes of walking with a 45-minute lukewarm leg bath after * 30 minutes of walking with a 45-minute hot leg bath after * 45 minutes of a hot leg bath with no exercise * A day with no exercise or leg bath Researchers will look at heart rhythm, blood vessels, and blood pressure after each of these trials to see if there are differences, and if exercise and heat together can improve heart health more than exercise or heat alone.
Recruiting
Has No Placebo
Providence CollegeBrett R Ely, PhD
Have you considered Avapro clinical trials? We made a collection of clinical trials featuring Avapro, we think they might fit your search criteria.Go to Trials
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