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What is Zolmitriptan
ZolmitriptanThe Generic name of this drug
Treatment SummaryZolmitriptan is an oral medication used to treat migraine headaches. It belongs to a group of drugs called triptans and is one of the most commonly prescribed medications for this condition. It is available in tablet and nasal spray form under the brand name Zomig. Zolmitriptan can be taken alone or with an NSAID, such as naproxen, to provide the best relief from migraine pain. It was approved by the FDA in 1997 and is considered the gold standard in treating acute migraine attacks.
Zomigis the brand name
Zolmitriptan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zomig
Zolmitriptan
1998
91
Effectiveness
How Zolmitriptan Affects PatientsZolmitriptan is a type of drug called a triptan, which works by activating certain serotonin receptors in the body. It can help reduce the pain of migraines, but can also cause adverse cardiovascular effects such as heart attack, stroke, or arrhythmia. Other side effects of taking Zolmitriptan include chest/throat/neck/jaw pain, tightness, and/or pressure, as well as the possibility of overusing the medication or having a reaction that affects the body's serotonin levels. People with phenylketonuria should be aware that ZOMIG-ZMT contains
How Zolmitriptan works in the bodyMigraines are severe headaches usually accompanied by nausea, light and sound sensitivity, and irritability. The exact cause is not known, but it is thought to involve both the nerves and blood vessels in the brain. Zolmitriptan is a medication used to treat migraines. It works by targeting certain nerve and blood vessels throughout the brain. This helps calm down the nerves and blood vessels, reducing the pain and other symptoms of migraine.
When to interrupt dosage
The recommended dosage of Zolmitriptan is contingent upon the diagnosed affliction, such as Cluster Headache, Migraine and moderate or extreme hepatic insufficiency. The measure varies as per the method of delivery (e.g. Spray, metered - Nasal or Tablet, multilayer, extended release - Oral) recorded in the table beneath.Condition
Dosage
Administration
Migraine
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Cluster Headache
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Liver
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Migraine Disorders
, 2.5 mg, 5.0 mg, 1.0 mg, 5.0 mg/pump actuation, 2.5 mg/pump actuation
, Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Nasal, Spray, metered, Spray, metered - Nasal, Tablet, film coated, Tablet, film coated - Oral, Spray, Nasal; Oral, Spray - Nasal; Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Spray - Nasal
Warnings
Zolmitriptan has fourteen contraindications and should not be used in tandem with the conditions provided in the subsequent table.Zolmitriptan ContraindicationsCondition
Risk Level
Notes
Coronary Vasospasm
Do Not Combine
cardiac accessory conduction pathway disorders
Do Not Combine
Basilar-Type Migraine
Do Not Combine
Stroke
Do Not Combine
Peripheral Vascular Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Coronary Artery Disease
Do Not Combine
Transient Ischemic Attack
Do Not Combine
Wolff-Parkinson-White Syndrome
Do Not Combine
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
intestinal ischemia
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Zolmitriptan may interact with Pulse Frequency
Common Zolmitriptan Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Zolmitriptan may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Zolmitriptan may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Zolmitriptan may increase the serotonergic activities of Mirtazapine.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Zolmitriptan is combined with Oliceridine.
Zolmitriptan Toxicity & Overdose RiskTaking too much zolmitriptan may lead to serious side effects such as changes to the blood vessels and activation of serotonin receptors. Those who take a single dose of 50 mg may feel drowsy. It is recommended to provide medical support and symptom relief in cases of overdose.
Zolmitriptan Novel Uses: Which Conditions Have a Clinical Trial Featuring Zolmitriptan?
65 clinical trials are in progress to investigate the potential of Zolmitriptan in treating moderate to severe hepatic impairment, Cluster Headache and Migraine Disorders.Condition
Clinical Trials
Trial Phases
Liver
0 Actively Recruiting
Migraine Disorders
0 Actively Recruiting
Migraine
55 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Cluster Headache
3 Actively Recruiting
Phase 1, Phase 2
Zolmitriptan Reviews: What are patients saying about Zolmitriptan?
5Patient Review
3/13/2009 Extremely effective at treating migraines, but be aware that it can cause drowsiness. I find that I fall asleep and wake up without a migraine, but if I need to stay awake, the medicine makes me feel light-headed and dizzy.
4.7Patient Review
11/20/2019 I'm mostly pleased with this product. If I don't take it the second I notice a migraine starting, it's not as effective.
4.3Patient Review
5/13/2008 Zolmitriptan has helped me a lot by taking care of my migraines and their neurological symptoms. However, I do get headaches from the medication itself (although they're manageable), as well as some other side effects that can last around 24 hours. These include hot water making my skin tingle, mild dizziness, and generally feeling out-of-it.
4Patient Review
10/9/2010 This drug has been effective in treating my headaches; however, the problem is that they tend to come back every day.
Patient Q&A Section about zolmitriptan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does zolmitriptan take to work?
"In patients who respond to treatment, Zomig is effective within one hour of taking the medication. Zomig works just as well no matter when it is taken during a migraine attack, but it is best to take it as soon as possible after the migraine begins."
Answered by AI
How does zolmitriptan make you feel?
"Zolmitriptan is a type of medication that is designed to specifically target serotonin receptors. By narrowing the blood vessels around the brain, it is able to effectively stop pain signals from being sent to the brain and also block the release of certain natural substances that can cause a range of symptoms associated with migraines including pain and nausea."
Answered by AI
What is zolmitriptan prescribed for?
"Zolmitriptan is a medication used to treat acute migraine headaches in adults. It is not effective in preventing migraine headaches or treating cluster headaches. Zolmitriptan works by targeting pain receptors in the brain to relieve the pain associated with migraines."
Answered by AI