Baciguent

Empyema, Pink Eye, Pneumonia + 17 more

Treatment

20 Active Studies for Baciguent

Treatment for

Empyema

What is Baciguent

Bacitracin

The Generic name of this drug

Treatment Summary

Bacitracin is a combination of nine different antibiotics. It was discovered in 1945 from a knee scrape of a child named Margaret Tracy. It is mostly composed of bacitracin A and was approved by the FDA in 1948.

Bacitracin

is the brand name

Baciguent Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bacitracin

1948

Effectiveness

How Baciguent Affects Patients

Bacitracin is a combination of proteins that stop bacteria from forming a cell wall and break down DNA. It must be applied to the skin every 3-4 hours like an ointment to be effective. Bacitracin can be dangerous if taken by injection and may cause kidney failure.

How Baciguent works in the body

Bacitracin binds to metal ions like manganese, cobalt, nickel, copper, and zinc. This binding prevents cell wall synthesis by blocking the breakdown of a lipid molecule. It also breaks down DNA for added effect.

When to interrupt dosage

The prescribed dosage of Baciguent is contingent upon the diagnosed condition, such as prophylaxis of infection in slight lacerations, grazes, or burns, Secondary Infection and Skin Ulcer. The measure of dosage is reliant on the method of delivery (e.g. Topical or Cream - Topical) indicated in the table beneath.

Condition

Dosage

Administration

Acne Vulgaris

0.5 [USP'U]/mg, , 0.4 [USP'U]/mg, 0.5 [iU]/mg, 0.4 [iU]/mg, 0.0004 mg/mg, 5000.0 [iU]/mL, 50000.0 [USP'U], 0.4 units/mg, 0.5 units/mg, 400.0 [USP'U], 0.4178 [iU]/mg, 0.6 [USP'U]/mg, 50000.0 units, 1.25 %, 5000.0 [USP'U]/mL, 50000.0 [iU], 0.04 units/mg, 0.0041 mg/mg, 0.0051 mg/mg, 5000.0 units/mL, 0.0486 mg/hour, 400.0 mg/mg, 0.005 [USP'U]/mg, 1.0 mg, 6.0 mg/mL, 400.0 mg/mL, 1.2 [USP'U]/mg, 0.8 [iU]/mg, 0.00048 mg/mg, 0.25 units/mg, 0.065 units/mg, 5.0 units/mg, 500.0 units/mL, 0.05 units/mg

Ointment - Topical, Topical, , Ointment, Ointment - Ophthalmic, Ophthalmic, Liquid - Topical, Liquid, Intramuscular, Injection, powder, for solution - Intramuscular, Injection, powder, for solution, Injection, powder, lyophilized, for solution - Intramuscular, Injection, powder, lyophilized, for solution, Stick - Topical, Powder - Topical, Spray - Topical, Spray, Powder, for solution - Intramuscular; Topical, Intramuscular; Topical, Powder, for solution, Cream, Cream - Topical, Powder, Injection, Injection - Intramuscular, Kit, Kit - Topical, Gel - Topical, Ointment - Ophthalmic; Topical, Stick, Lozenge, Oral, Gel, Swab - Topical, Ophthalmic; Topical, Ointment; Swab - Topical, Oral; Topical, Kit - Oral; Topical, Lozenge - Oral, Swab, Ointment; Swab, Irrigation; Ophthalmic; Respiratory (inhalation); Topical, Kit - Irrigation; Ophthalmic; Topical, Irrigation; Ophthalmic; Topical, Kit - Irrigation; Ophthalmic; Respiratory (inhalation); Topical, Kit - Ophthalmic, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Topical, Kit - Ophthalmic; Respiratory (inhalation); Topical, Electro-osmosis, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Electro-osmosis, Ophthalmic; Respiratory (inhalation); Topical, Cutaneous, Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Irrigation; Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Irrigation; Oral; Respiratory (inhalation); Topical, Patch - Cutaneous, Patch, Kit - Respiratory (inhalation); Topical, Irrigation; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Topical, Ophthalmic; Oral; Topical, Kit - Oral; Respiratory (inhalation); Topical, Oral; Respiratory (inhalation); Topical, Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Pneumonia

Infection

Urinary Tract Infection (UTI)

Wound Infection

Ocular Inflammatory Disease

Bacterial Infections

Keratoconjunctivitis

Blepharoconjunctivitis

prophylaxis of infection in minor cuts, scrapes, or burns

infection in minor cuts, scrapes, or burns

Coinfection

Empyema

Pink Eye

Skin Diseases

Blepharitis

Wound

Eye Infections

Skin Ulcer

Inflammation

Warnings

Baciguent Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Bacitracin may interact with Pulse Frequency

There are 20 known major drug interactions with Baciguent.

Common Baciguent Drug Interactions

Drug Name

Risk Level

Description

Tenofovir

Major

Bacitracin may increase the nephrotoxic activities of Tenofovir.

Tenofovir alafenamide

Major

Bacitracin may increase the nephrotoxic activities of Tenofovir alafenamide.

Tenofovir disoproxil

Major

Bacitracin may increase the nephrotoxic activities of Tenofovir disoproxil.

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Bacitracin.

Abacavir

Minor

Bacitracin may decrease the excretion rate of Abacavir which could result in a higher serum level.

Baciguent Toxicity & Overdose Risk

Tests have found that it would take more than 2000mg/kg of bacitracin for rats to experience toxicity. There is limited information about bacitracin overdoses, but they may cause kidney damage. If a person has overdosed on bacitracin, they should be given supportive care.

image of a doctor in a lab doing drug, clinical research

Baciguent Novel Uses: Which Conditions Have a Clinical Trial Featuring Baciguent?

128 active clinical trials are being conducted to evaluate the potential of Baciguent in treating Bacterial Infections, Keratoconjunctivitis and Wound healing.

Condition

Clinical Trials

Trial Phases

Acne Vulgaris

0 Actively Recruiting

infection in minor cuts, scrapes, or burns

0 Actively Recruiting

Blepharitis

0 Actively Recruiting

prophylaxis of infection in minor cuts, scrapes, or burns

0 Actively Recruiting

Urinary Tract Infection (UTI)

6 Actively Recruiting

Phase 1, Phase 3, Phase 4, Phase 2

Empyema

1 Actively Recruiting

Phase 4

Bacterial Infections

0 Actively Recruiting

Pink Eye

0 Actively Recruiting

Skin Diseases

0 Actively Recruiting

Ocular Inflammatory Disease

0 Actively Recruiting

Pneumonia

16 Actively Recruiting

Not Applicable, Early Phase 1, Phase 2

Keratoconjunctivitis

0 Actively Recruiting

Infection

6 Actively Recruiting

Not Applicable, Phase 1

Blepharoconjunctivitis

0 Actively Recruiting

Inflammation

0 Actively Recruiting

Wound Infection

0 Actively Recruiting

Wound

9 Actively Recruiting

Phase 1, Phase 2, Phase 3, Not Applicable

Skin Ulcer

2 Actively Recruiting

Phase 2, Not Applicable

Eye Infections

0 Actively Recruiting

Coinfection

0 Actively Recruiting

Baciguent Reviews: What are patients saying about Baciguent?

Patient Review

8/20/2009

Baciguent for Minor Skin Infection caused by Bacteria

We've been using Baciquent for about 50 years now and it's definitely worth the effort to get it.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about baciguent

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the brand name of bacitracin?

"Bacitracin is part of the drug class: Aminoglycosides.

What is bacitracin? Bacitracin is an antibiotic used for the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug.

How does bacitracin work? Bacitracin works by killing the bacteria that are causing the infection."

Answered by AI

What is Baciguent used for?

"This medication prevents minor skin infections by stopping the growth of certain bacteria. It is used for small cuts, scrapes, or burns."

Answered by AI

What disease does bacitracin treat?

"Bacitracin is an antibiotic made up of small peptides. It is used to treat bacterial infections of the skin or to prevent infection in minor burns, cuts, or scrapes."

Answered by AI

What is Baciguent ointment?

"Bacitracin ointment is used to treat bacterial infections of the eye. It is a lower-cost generic medication with very few side effects. However, some people may find it difficult or uncomfortable to use."

Answered by AI

Clinical Trials for Baciguent

Image of Children's of Alabama in Birmingham, United States.

Antibiotic Duration for Infections in Children

60 - 17

All Sexes

Birmingham, AL

Infections like pneumonia, skin and soft tissue infection (also called SSTI or cellulitis), and urinary tract infections (UTI) are some of the most common reasons children get admitted to the hospital. All three of these conditions require antibiotics for treatment. Although antibiotics are needed to treat the infection and help children feel better, taking them longer than needed can negatively impact children and their families. Negative impacts include things like the burdens of taking more medications and medication side effects. There are guidelines (instructions) from expert medical organizations that suggest the number of days children need antibiotics, but they give a wide range (between 5 and 14 days). Unfortunately, these guidelines are not based on high-quality studies. National data suggests that doctors often choose on the higher end of this range when writing prescriptions for children in the hospital. Our three caregiver co-investigators, other parents of hospitalized children, doctors, other care providers, and researchers, all believe that additional study is needed to determine the best length of antibiotic treatment that weighs both the benefits and harms of antibiotics. The goal of our study is to understand if 5 total days of antibiotic treatment compared to 10 total days of antibiotic treatment is better for children who have been in the hospital for pneumonia, SSTI, or UTI. We will study this question through a randomized control trial. In other words, half of the children will receive 5-days of antibiotics and the other half will receive 10-days of antibiotics. Children in this study (and their caregivers) will not know how many days of antibiotics they will receive to cure their infection because some children will take a placebo (or a pill without antibiotics in it). Only the pharmacy will know if a child is getting antibiotic or placebo (for days 6-10 of treatment). During the first phase of the trial (feasibility phase), 4 hospitals will enroll children in the study. We plan on enrolling 50 patients during this phase. We are starting with just 4 hospitals, so our study team can create and update our study plans if needed. We will closely review information about how many patients and families agree to participate, and if they have any trouble completing any part of the study. We will also interview families to understand the choice to participate in the study, the choice not to participate in the study, and what it is like to be in the study. During the second study phase, we will enroll 1150 more patients across all 11 hospitals. Families will complete short, daily surveys until the 15th day after they started antibiotics, then a larger survey at day 15, at day 20, and at day 30. These surveys will ask about the child's symptoms and recovery from their illness, how the antibiotics are making them feel, and if they had to go back to their doctor, emergency room, or hospital. The answers to these questions will be combined to measure how well the child did, balancing feeling better and having bad effects from the antibiotics. We will use mathematical tests to determine which antibiotic duration is better for treating these illnesses. We will complete other mathematical tests to see if all children should receive the same length of antibiotics or if certain children should be prescribed shorter courses and others longer courses.

Phase 4

Waitlist Available

New This Month

Children's of Alabama (+9 Sites)

Sunitha V Kaiser, MD, MSc