Tilade

Eye, Asthma, Allergic Conjunctivitis (AC)
Treatment
20 Active Studies for Tilade

What is Tilade

NedocromilThe Generic name of this drug
Treatment SummaryMontelukast is a medication that works to reduce inflammation in cells related to asthma, such as eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. It does this by blocking the activation of these cells.
Tiladeis the brand name
Tilade Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tilade
Nedocromil
1992
3

Effectiveness

How Tilade Affects PatientsNedocromil is a medicine that helps to reduce inflammation in the bronchial airways. It has been shown to decrease symptoms of asthma when triggered by allergens, and can also help to reduce sensitivity in the airways.
How Tilade works in the bodyNedocromil works to reduce inflammation associated with asthma by blocking the release of inflammatory substances like histamine, prostaglandin D2, and leukotrienes c4. It does this by inhibiting the activation of different types of cells in the bronchial tree. Nedocromil also works to block nerve reflexes and the release of sensory neuropeptides, like substance P and neurokinin A, which can cause bronchoconstriction. It does not have any effect on bronchodilators, antihistamines, or corticosteroids.

When to interrupt dosage

The proposed dosage of Tilade is contingent upon the diagnosed condition, such as Asthma, Allergic Conjunctivitis (AC) and Hay Fever. The quantity of dosage is contingent upon the method of delivery (e.g. Liquid or Solution / drops) delineated in the table underneath.
Condition
Dosage
Administration
Eye
20.0 mg/mL, , 2.0 %, 2.0 mg, 2.0 mg/pump actuation, 2.0 mg/dose
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Liquid, Liquid - Ophthalmic, Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Oral, Aerosol, metered - Oral
Asthma
20.0 mg/mL, , 2.0 %, 2.0 mg, 2.0 mg/pump actuation, 2.0 mg/dose
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Liquid, Liquid - Ophthalmic, Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Oral, Aerosol, metered - Oral
Allergic Conjunctivitis (AC)
20.0 mg/mL, , 2.0 %, 2.0 mg, 2.0 mg/pump actuation, 2.0 mg/dose
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Liquid, Liquid - Ophthalmic, Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Oral, Aerosol, metered - Oral

Warnings

There are 20 known major drug interactions with Tilade.
Common Tilade Drug Interactions
Drug Name
Risk Level
Description
Abacavir
Minor
Nedocromil may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Nedocromil may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Nedocromil may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Nedocromil may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Allylestrenol
Minor
Nedocromil may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
Tilade Toxicity & Overdose RiskSide effects of taking this drug may include headaches, blocked nose, burning, irritation or stinging eyes, bad taste, coughing, difficulty breathing, wheezing, pink eye, blurry vision, change in color vision, difficulty seeing in the dark, and increased sensitivity to sunlight.

Tilade Novel Uses: Which Conditions Have a Clinical Trial Featuring Tilade?

154 active clinical trials are investigating the potential of Tilade in alleviating Asthma, Eye Symptoms and Hay Fever conditions.
Condition
Clinical Trials
Trial Phases
Asthma
92 Actively Recruiting
Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3
Allergic Conjunctivitis (AC)
1 Actively Recruiting
Phase 2
Eye
0 Actively Recruiting

Tilade Reviews: What are patients saying about Tilade?

5Patient Review
8/28/2008
Tilade for Asthma
Tilade was a game-changer for me. It made being around people and perfumes, car exhaust, and humidity possible again. I'm on edge now that it's being discontinued.
2Patient Review
6/19/2017
Tilade for Bronchospasm Prevention
Even when I follow the instructions for cleaning my inhaler very carefully, I often end up with no access to the drug because the inhaler is blocked. This is very frustrating!
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about tilade

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is tilade still available?

"The Tilade and Intal Forte inhalers have been discontinued. The supply of Nedocromil and sodium cromoglicate inhalers ran out in late November 2020."

Answered by AI

What is tilade inhaler used for?

"Tilade CFC-Free Inhaler contains the medication nedocromil sodium and is used to treat asthma by preventing asthma attacks."

Answered by AI

Is tilade a steroid?

"The drug Tilade CFC-Free contains nedocromil sodium, a non-steroidal agent with anti-inflammatory properties. When administered topically, it can help to reduce inflammation in the lungs."

Answered by AI

Why was tilade discontinued?

"King Pharmaceuticals has decided to discontinue the manufacturing of Tilade Inhaler (nedocromil sodium inhalation consumol) because they have been unable to find a manufacturer for a chlorofluorocarbon propellant inhaler that meets their standards."

Answered by AI

Clinical Trials for Tilade

Have you considered Tilade clinical trials? We made a collection of clinical trials featuring Tilade, we think they might fit your search criteria.Go to Trials
Image of Allergy Immunology Associates in Mayfield Heights, United States.

Osteopathic Manipulative Treatment for Asthma

18 - 60
All Sexes
Mayfield Heights, OH
Asthma is a common respiratory condition that can be difficult to control despite the use of medications such as inhalers, oral steroids or even injectable medications. Osteopathic Manipulative Treatment (OMT) is a hands-on technique used to improve the chest structure and function and may help in improving breathing. Previous research showed that OMT in asthma patients, can improve the movement of the ribs and improve the "peak flow" which is the maximum rate at which a person can exhale air after taking a deep breath. However, no studies have evaluated the impact of OMT on lung inflammation. This single-site research study at University Hospitals aims to evaluate whether Osteopathic Manipulative Treatment (OMT) can reduce lung inflammation and improve breathing and lung function in adult patients with asthma. The lung function will be evaluated by Spirometry which is a test that measures how much air you can breathe in and out of your lungs, as well as how quickly and easily you can exhale air. The lung inflammation will be measured using a device that can detect how much you are breathing out Nitric Oxide which is a gas produced by inflamed cells in the lungs, this test is called: Fractional exhaled Nitric Oxide or FeNO. Approximately 100 participants will be enrolled.
Waitlist Available
Has No Placebo
Allergy Immunology AssociatesNancy Wasserbauer-Kingston, DO
Image of DARTNet Institute in Aurora, United States.

Inhaled Corticosteroids + Azithromycin for Asthma

13 - 75
All Sexes
Aurora, CO
While asthma therapy is becoming more individualized based on asthma phenotypes, more research is needed to tailor newer therapies to individuals. Inhaled corticosteroid (ICS) medications are the foundation of care for all individuals with persistent asthma. But ICS use is not without possible long term side effects. This study will compare two currently available approaches to reduce AEX in primary care patients: (1) use of inhaled corticosteroids (ICS) as part of rescue therapy, also known as MART (Maintenance And Reliever Therapy) or PARTICS (Patient Activated Reliever Trigger Inhaled Corticosteriods) therapy - either of these therapies will be called Rescue-Inhaled Corticosteroids or R-ICS pronounced "Ricks," and (2) use of azithromycin (AZ) as a preventive therapy. These treatments will be studied both individually and in combination.
Phase 4
Recruiting
DARTNet Institute (+12 Sites)Wilson D Pace, MD, FAAFP
Image of Medical Place Pharmacy in Ajax, Canada.

Pharmacy Support System for Asthma

Any Age
All Sexes
Ajax, Canada
The goal of this study is to assess the effect of an electronic asthma management system in pharmacies (eAMS-Pharm) on asthma control assessment, asthma medication adjustment, asthma action plan delivery, and prompting for specialist referral in severe asthma. The study assesses the differences on pharmacy processes (affecting both the pharmacy team and patients) and pharmacy-delivered care using an interrupted time-series analysis (six-months before vs. six-months after the introduction of eAMS-Pharm in study pharmacy sites). The eAMS-Pharm uses patient data (asthma control, asthma flare-up risk, and current medications) to provide clinical decision support to pharmacists, empowering them to bridge existing gaps between guideline-recommended asthma care and patient care received.
Waitlist Available
Has No Placebo
Medical Place Pharmacy (+2 Sites)
Have you considered Tilade clinical trials? We made a collection of clinical trials featuring Tilade, we think they might fit your search criteria.Go to Trials
Image of Velocity Clinical Research, Mobile in Mobile, United States.

PF-07275315 for Asthma

18 - 70
All Sexes
Mobile, AL
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 18 to 70 years old * Have had moderate-to-severe asthma for at least 12 months that is not well controlled * Have been taking their regular maintenance treatment(s) for asthma over the last 12 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 12 weeks. We will compare the experiences of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants will be involved in this study for about 9.5 months. During this time, they will have 10 visits at the study clinic.
Phase 2
Recruiting
Velocity Clinical Research, Mobile (+10 Sites)Pfizer CT.gov Call CenterPfizer
Image of St. Joseph's Healthcare Hamilton in Hamilton, Canada.

Corticosteroids for Asthma

18+
All Sexes
Hamilton, Canada
Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of asthma attacks remain unimproved despite conventional inhaled medications. There could be several reasons for this. One possibility is that inhaled medications fail to reach the intended areas within the lungs, due to structural abnormalities within the airways themselves. Much like road conditions or closures can impede the speed and efficiency of vehicle travel, factors such as airway narrowing or mucus blockages, which are common in asthma, can obstruct the passage of inhaled medications through the airways. Our team has now optimized advanced medical imaging techniques, including magnetic resonance imaging (MRI) and computed tomography (CT), required to investigate this. This study will use these imaging methods to visually assess and measure individual patients' airways and determine whether abnormal airway structures impact how well they respond to inhaled and orally delivered medications. We anticipate finding that abnormal airway structures make inhaled medications less effective, but that they do not affect the response to oral medications.
Phase 4
Recruiting
St. Joseph's Healthcare Hamilton (+1 Sites)
Have you considered Tilade clinical trials? We made a collection of clinical trials featuring Tilade, we think they might fit your search criteria.Go to Trials
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