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What is Bryhali
UlobetasolThe Generic name of this drug
Treatment SummaryUlobetasol is a strong steroid medication used to treat severe psoriasis and other skin conditions that respond to corticosteroids. It is related to another steroid called clobetasol and was approved by the FDA in 1990.
Halobetasol Propionateis the brand name
Bryhali Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Halobetasol Propionate
Ulobetasol
2004
38
Effectiveness
How Bryhali Affects PatientsCorticosteroids, like ulobetasol, work by blocking certain inflammatory signals and promoting others. It is usually applied once or twice every day. Corticosteroids can also be taken in doses much higher than what the body naturally produces. It is important to inform patients taking corticosteroids of the risk of decreased activity of the body's natural hormones and being more susceptible to illnesses.
How Bryhali works in the bodyCorticosteroids reduce inflammation by decreasing the flow of white blood cells to sites of inflammation and blocking molecules that cause inflammation. They also work in the long term by binding to a receptor that increases sodium levels and lowers potassium levels. Low doses of corticosteroids reduce inflammation while high doses suppress the immune system.
When to interrupt dosage
The proposed dose of Bryhali is contingent upon the diagnosed condition, including Pruritus, corticosteroid responsive, Inflammatory Dermatosis and Plaque Psoriasis. The quantity of dosage varies, depending on the technique of delivery (e.g. Lotion - Topical or Cream) pointed out in the table beneath.Condition
Dosage
Administration
corticosteroid responsive, Inflammatory Dermatosis
, 0.0005 mg/mg, 0.05 %, 0.0001 mg/mg, 0.01 %
, Topical, Cream - Topical, Cream, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Kit, Aerosol, foam - Topical, Aerosol, foam, Kit - Topical
Pruritus
, 0.0005 mg/mg, 0.05 %, 0.0001 mg/mg, 0.01 %
, Topical, Cream - Topical, Cream, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Kit, Aerosol, foam - Topical, Aerosol, foam, Kit - Topical
Psoriasis Vulgaris
, 0.0005 mg/mg, 0.05 %, 0.0001 mg/mg, 0.01 %
, Topical, Cream - Topical, Cream, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Kit, Aerosol, foam - Topical, Aerosol, foam, Kit - Topical
Warnings
Bryhali ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Ulobetasol may interact with Pulse Frequency
Common Bryhali Drug Interactions
Drug Name
Risk Level
Description
Allogeneic processed thymus tissue
Minor
The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Ulobetasol.
Inebilizumab
Minor
The risk or severity of infection can be increased when Ulobetasol is combined with Inebilizumab.
Vibrio cholerae CVD 103-HgR strain live antigen
Minor
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Ulobetasol.
2,4-thiazolidinedione
Moderate
The risk or severity of hyperglycemia can be increased when Ulobetasol is combined with 2,4-thiazolidinedione.
AICA ribonucleotide
Moderate
The risk or severity of hyperglycemia can be increased when Ulobetasol is combined with AICA ribonucleotide.
Bryhali Toxicity & Overdose RiskTaking too much glucocorticoid medication can cause serious long-term health issues such as cataracts, high blood pressure, water retention, ulcers, pancreatitis, muscle weakness, mood changes, skin thinning and hair growth, weakened immune system, diabetes, calcium deficiency, and reduced growth. If someone overdoses on glucocorticoid medication, doctors may reduce the dose or stop it altogether and provide supportive care.
Bryhali Novel Uses: Which Conditions Have a Clinical Trial Featuring Bryhali?
18 active clinical trials are currently in progress to ascertain the suitability of Bryhali in remedying Pruritus, Plaque Psoriasis and Inflammatory Dermatosis amenable to corticosteroid treatment.Condition
Clinical Trials
Trial Phases
corticosteroid responsive, Inflammatory Dermatosis
0 Actively Recruiting
Pruritus
0 Actively Recruiting
Psoriasis Vulgaris
24 Actively Recruiting
Early Phase 1, Phase 4, Phase 3, Not Applicable, Phase 2
Patient Q&A Section about bryhali
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can you use Bryhali for poison ivy?
"This medication helps to relieve swelling, redness, itching, and discomfort on the skin caused by insect bites, poison ivy, mild burns, skin rashes, and sunburn. It can also be used to treat certain skin conditions such as plaque psoriasis."
Answered by AI
Is there a generic for Bryhali?
"Bryhali is only available as a brand name drug, and a generic version is not yet available."
Answered by AI
How long does it take for Bryhali to work?
"In a clinical study of adults with plaque psoriasis, Bryhali was found to be more effective than a placebo at clearing up the condition. 37% to 38% of people using Bryhali reported that their skin was clear or almost clear of psoriasis after 8 weeks of treatment."
Answered by AI
What is the medication Bryhali used for?
"BRYHALI Lotion is for use on the skin only (topical). You should not use BRYHALI Lotion if you are allergic to halobetasol propionate.
BRYHALI is a topical corticosteroid medication used to treat plaque psoriasis in adults. The safety and efficacy of BRYHALI in children under 18 has not been established. Prior to using BRYHALI, you should consult your physician if you are allergic to halobetasol propionate."
Answered by AI