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What is Glucotrol Xl
GlipizideThe Generic name of this drug
Treatment SummaryGlipizide is a medication used to treat type 2 diabetes. It was introduced in 1984 and is available in the U.S. and Canada. Glipizide is a second-generation sulfonylurea drug, which helps control blood sugar levels by reducing the amount of glucose in the body. It is typically used in early-stage type 2 diabetes when pancreatic failure has not occurred. Glipizide is absorbed quickly and has a short duration of action, which helps reduce the risk of long-term hypoglycemia. It is available in extended-release tablets under the brand name Glucotrol,
Glipizideis the brand name
Glucotrol Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Glipizide
Glipizide
1984
471
Approved as Treatment by the FDA
Glipizide, also called Glipizide, is approved by the FDA for 2 uses such as Type 2 Diabetes Mellitus and Type 2 Diabetes .Type 2 Diabetes Mellitus
Helps manage Type 2 Diabetes Mellitus
Type 2 Diabetes
Helps manage Type 2 Diabetes Mellitus
Effectiveness
How Glucotrol Xl Affects PatientsGlipizide is a drug that helps to lower blood sugar. It begins working about 30 minutes after taking it and its effects can last for up to 24 hours. It is known to increase the body's response to insulin and can help with glucose uptake in the muscles and liver. However, it can also lead to low blood sugar and weight gain with long-term use. It may also cause the pancreas to produce less insulin over time, as well as have other effects outside the pancreas. These include decreasing lipolysis in the liver and fat tissue, reducing glucose production in the liver, and increasing glucose uptake and
How Glucotrol Xl works in the bodyGlipizide is a medication used to treat type 2 diabetes. It works by stimulating the release of insulin from cells in the pancreas, which helps lower the amount of glucose in the blood. It does this by binding to the sulfonylurea receptor on the cell surface, and then closing the cell's potassium channels and opening calcium channels. This causes the cell to release insulin granules, which helps lower blood glucose levels. Glipizide also helps to increase the number and sensitivity of insulin receptors, allowing more glucose to be taken up by cells in the liver. In addition to this medication, lifestyle changes such as
When to interrupt dosage
The recommended dosage of Glucotrol Xl is contingent upon the diagnosed condition. The quantity of dosage is contingent upon the method of administration (e.g. Tablet - Oral or Tablet, film coated - Oral) mentioned in the table beneath.Condition
Dosage
Administration
Type 2 Diabetes
2.5 mg, , 5.0 mg, 10.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Glucotrol Xl has seven contraindications and should not be used in concert with the conditions detailed in the following table.Glucotrol Xl ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Acute Coryza
Do Not Combine
Metabolic acidosis
Do Not Combine
Comatose
Do Not Combine
Comatose
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Comatose
Do Not Combine
Common Glucotrol Xl Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Minor
Glipizide may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Minor
Glipizide may increase the anticoagulant activities of (S)-Warfarin.
Abrocitinib
Minor
The metabolism of Abrocitinib can be decreased when combined with Glipizide.
Aclidinium
Minor
Glipizide may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Glipizide may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Glucotrol Xl Toxicity & Overdose RiskIn tests, rats have been found to tolerate a dose of up to 4000 mg/kg when taken orally, and up to 1200 mg/kg when taken through the abdomen. The smallest amount of glipizide to cause toxicity in a child is 379 μg/kg. If an overdose occurs, the patient may experience a coma, seizure, or other neurological issues due to severe hypoglycemia. Immediate treatment with glucagon or intravenous glucose is necessary, and medical attention should be sought for at least 24-48 hours since hypoglycemia may happen again. Mild hypoglycemic symptoms can be treated with oral glucose.
Glucotrol Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Glucotrol Xl?
162 active clinical trials are investigating the potential of Glucotrol Xl in managing Type 2 Diabetes.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
174 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Glucotrol Xl Reviews: What are patients saying about Glucotrol Xl?
5Patient Review
11/28/2008 For me, it took a week or two for this treatment to really start working well, but it was worth the wait!
5Patient Review
1/12/2009 I have found that these pills sometimes give me an upset stomach.
5Patient Review
2/12/2011 Though this medication has the unfortunate side-effect of increasing my appetite, it is otherwise very effective. I'm now on the lookout for a similar pill that doesn't make me constantly hungry.
5Patient Review
1/19/2012 Glipizide XL 10 just doesn't work for me. I think it might not be breaking down in my system the way it's supposed to. The 5XL works better than the ten XL, so I take three of those a day. Plus if I need to bring my insulin level down more, I'll take the regular 5's as well. Right now I'm trying to see another doctor to see if there's something else out there that might work better for me.
5Patient Review
2/15/2008Patient Q&A Section about glucotrol xl
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does Glucotrol XL cause weight gain?
"Weight gain is a common side effect of diabetes medications like insulin and glipizide."
Answered by AI
What is Glucotrol XL used for?
"Glipizide is used in conjunction with a proper diet and exercise regime to help control high blood sugar levels in people with type 2 diabetes. It can also be used alongside other diabetes medications. Managing high blood sugar levels can help reduce the risk of developing kidney damage, blindness, nerve problems, losing limbs and sexual function issues."
Answered by AI
Is Glucotrol the same as metformin?
"Polycystic ovaries and weight gain due to medications used for treating psychoses can also be treated with metformin. The brand names for metformin include Glumetza, Glucophage, and Fortamet. The brand names for glipizide include Glucotrol and Glucotrol XL."
Answered by AI
When should I take Glucotrol XL?
"You should take Glucotrol XL once a day by mouth, either with breakfast or the first big meal of the day. The recommended starting dose is 5 mg. If you're at increased risk for hypoglycemia (for example, if you're elderly or have liver problems), start with 2.5 mg."
Answered by AI