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Lean Beef for Heart Health and Gut Microbiome

N/A
Recruiting
Led By Jaapna Dhillon, PhD
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Non-smoker >1 year or more
Age: 18-45 years of age
Must not have
Taste or smell disorders
Uncontrolled hypertension and blood pressure ≥ 180/110
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, week 3, week 6
Awards & highlights

Summary

"This trial is looking at how eating lean beef can improve heart health and the balance of good bacteria in the gut."

Who is the study for?
This trial is for adults aged 18-45 with a BMI of 18-35 who are non-smokers, have stable weight and diet, and will follow the study plan. It's not for those using drugs, with taste/smell issues, heart diseases, uncontrolled high blood pressure, food allergies relevant to the study foods, gut problems or recent antibiotic use.
What is being tested?
The study examines how eating lean grass-fed beef or grain-fed beef compares to plant-based meat in affecting heart health and gut bacteria. Participants will consume assigned foods as part of their regular diet.
What are the potential side effects?
Since this is a dietary intervention focusing on lean meats and plant-based alternatives rather than medication or supplements, specific side effects are not listed but could include digestive changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have not smoked for over a year.
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I am between 18 and 45 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have problems with my taste or smell.
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My blood pressure is very high and not under control.
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I have had gastrointestinal disease or bariatric surgery.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, week 3, week 6
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, week 3, week 6 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Gut microbial alpha-diversity
Interleukin-6 concentrations
LDL-C concentrations
Secondary study objectives
24 hour appetite ratings
Acceptance rating of foods
Body mass
+19 more
Other study objectives
Metabolite intensities
Nutrient intakes

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Lean (93%) Grass-Fed BeefExperimental Treatment1 Intervention
The quantity of beef will be adjusted or normalized based on their individual energy requirements. The specified amount will be 4 oz. per day or 28 ounces per week for participants with an energy requirement of 2000 kcal. Participants will consume meals for six weeks.
Group II: Lean (93%) Grain-Fed BeefExperimental Treatment1 Intervention
The quantity of beef will be adjusted or normalized based on their individual energy requirements. The specified amount will be 4 oz. per day or 28 ounces per week for participants with an energy requirement of 2000 kcal. Participants will consume meals for six weeks.
Group III: Plant-Based MeatActive Control1 Intervention
Plant-based meat (beyond meat product) would be macronutrient matched to the same quantities of meat prescribed for a given energy level. Participants will consume meals for six weeks.

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor
376 Previous Clinical Trials
628,571 Total Patients Enrolled
2 Trials studying Diet Intervention
180 Patients Enrolled for Diet Intervention
Jaapna Dhillon, PhDPrincipal InvestigatorUniversity of Missouri-Columbia
3 Previous Clinical Trials
214 Total Patients Enrolled
2 Trials studying Diet Intervention
180 Patients Enrolled for Diet Intervention
~60 spots leftby Dec 2027
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