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What is Lexette
UlobetasolThe Generic name of this drug
Treatment SummaryUlobetasol is a strong steroid medication used to treat severe plaque psoriasis and other skin conditions. It is related to another steroid medication called clobetasol. Ulobetasol was approved by the FDA in 1990.
Halobetasol Propionateis the brand name
Lexette Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Halobetasol Propionate
Ulobetasol
2004
38
Effectiveness
How Lexette Affects PatientsUlobetasol is a type of corticosteroid that helps reduce inflammation. It is usually applied once or twice per day, and patients may need a higher dose than what their body naturally produces. However, it is important to keep in mind that taking corticosteroids can lead to a weakened immune system and increased risk of infections.
How Lexette works in the bodyCorticosteroids reduce inflammation by decreasing the blood flow to the affected area and reducing the number of white blood cells going there. They also block molecules that would normally increase inflammation and promote molecules that reduce it. Low doses of corticosteroid have an anti-inflammatory effect, while higher doses can lower your immune response. Long-term use of high doses of corticosteroids can also cause your body to produce too much salt and not enough potassium.
When to interrupt dosage
The suggested measure of Lexette is contingent upon the diagnosed malady, including Pruritus, corticosteroid responsive, Inflammatory Dermatosis and Plaque Psoriasis. The amount also shifts based on the technique of administration (e.g. Lotion - Topical or Cream) specified in the table below.Condition
Dosage
Administration
corticosteroid responsive, Inflammatory Dermatosis
, 0.0005 mg/mg, 0.05 %, 0.0001 mg/mg, 0.01 %
, Topical, Cream - Topical, Cream, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Kit, Aerosol, foam - Topical, Aerosol, foam, Kit - Topical
Pruritus
, 0.0005 mg/mg, 0.05 %, 0.0001 mg/mg, 0.01 %
, Topical, Cream - Topical, Cream, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Kit, Aerosol, foam - Topical, Aerosol, foam, Kit - Topical
Psoriasis Vulgaris
, 0.0005 mg/mg, 0.05 %, 0.0001 mg/mg, 0.01 %
, Topical, Cream - Topical, Cream, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Kit, Aerosol, foam - Topical, Aerosol, foam, Kit - Topical
Warnings
Lexette has a single contraindication, so it should not be administered alongside the conditions in the following table.Lexette ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Ulobetasol may interact with Pulse Frequency
Common Lexette Drug Interactions
Drug Name
Risk Level
Description
Allogeneic processed thymus tissue
Minor
The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Ulobetasol.
Inebilizumab
Minor
The risk or severity of infection can be increased when Ulobetasol is combined with Inebilizumab.
Vibrio cholerae CVD 103-HgR strain live antigen
Minor
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Ulobetasol.
2,4-thiazolidinedione
Moderate
The risk or severity of hyperglycemia can be increased when Ulobetasol is combined with 2,4-thiazolidinedione.
AICA ribonucleotide
Moderate
The risk or severity of hyperglycemia can be increased when Ulobetasol is combined with AICA ribonucleotide.
Lexette Toxicity & Overdose RiskGlucocorticoid overdose is rare, but long-term use of high doses can cause cataracts, glaucoma, high blood pressure, weight gain, high cholesterol, ulcers, pancreatitis, muscle weakness, mental health issues, skin thinning, allergies, acne, increased body hair, weakened immune system, diabetes, low calcium levels, low phosphate levels, and reduced growth. To treat an overdose, the dose may need to be adjusted or stopped and supportive care should be provided.
Lexette Novel Uses: Which Conditions Have a Clinical Trial Featuring Lexette?
18 active clinical trials are evaluating the potential of Lexette to reduce Pruritus, Plaque Psoriasis and Inflammatory Dermatosis responsive to Corticosteroids.Condition
Clinical Trials
Trial Phases
Psoriasis Vulgaris
23 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 2
corticosteroid responsive, Inflammatory Dermatosis
0 Actively Recruiting
Pruritus
0 Actively Recruiting
Lexette Reviews: What are patients saying about Lexette?
5Patient Review
7/12/2021 I've tried a lot of different treatments for my psoriasis, and this one is by far the most effective. I highly recommend it to anyone else who suffers from this condition.
4.7Patient Review
12/24/2021 This is the only treatment that has worked for me so far. I apply it to my skin and then spread it using the cap, which makes it go a lot further than if I were just using my hand.
2Patient Review
8/1/2020 The foam dispenser stopped working pretty quickly, which was frustrating because I couldn't use the medication. A lot of it went to waste. If you can get it out of the can, it works well though.
Patient Q&A Section about lexette
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Lexette a steroid?
"Lexette is a highly potent steroid that helps reduce inflammation in the body. Lexette is used to treat inflammation and itching caused by plaque psoriasis or skin conditions that respond to steroid medication."
Answered by AI
What is Lexette used for?
"This medication is used to treat certain skin conditions, such as psoriasis. Halobetasol helps reduce the itching, redness, scaling, and swelling that can occur with these conditions. This medication is a very strong corticosteroid."
Answered by AI
What is halobetasol used to treat?
"Halobetasol is a topical cream used to relieve swelling, redness, and itchiness caused by skin conditions like psoriasis. It's a corticosteroid, which is a type of medication that reduces inflammation. You need a prescription from a doctor to get it."
Answered by AI
How long does it take for Lexette to work?
"It has been found in two clinical studies that five times more people who treat their moderate to severe plaque psoriasis with LEXETTE Foam achieve clear or almost clear skin after two weeks, compared to those usingvehicle foam with no active ingredient."
Answered by AI