Lexette

corticosteroid responsive, Inflammatory Dermatosis, Pruritus, Psoriasis Vulgaris
Treatment
20 Active Studies for Lexette

What is Lexette

UlobetasolThe Generic name of this drug
Treatment SummaryUlobetasol is a strong steroid medication used to treat severe plaque psoriasis and other skin conditions. It is related to another steroid medication called clobetasol. Ulobetasol was approved by the FDA in 1990.
Halobetasol Propionateis the brand name
image of different drug pills on a surface
Lexette Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Halobetasol Propionate
Ulobetasol
2004
38

Effectiveness

How Lexette Affects PatientsUlobetasol is a type of corticosteroid that helps reduce inflammation. It is usually applied once or twice per day, and patients may need a higher dose than what their body naturally produces. However, it is important to keep in mind that taking corticosteroids can lead to a weakened immune system and increased risk of infections.
How Lexette works in the bodyCorticosteroids reduce inflammation by decreasing the blood flow to the affected area and reducing the number of white blood cells going there. They also block molecules that would normally increase inflammation and promote molecules that reduce it. Low doses of corticosteroid have an anti-inflammatory effect, while higher doses can lower your immune response. Long-term use of high doses of corticosteroids can also cause your body to produce too much salt and not enough potassium.

When to interrupt dosage

The suggested measure of Lexette is contingent upon the diagnosed malady, including Pruritus, corticosteroid responsive, Inflammatory Dermatosis and Plaque Psoriasis. The amount also shifts based on the technique of administration (e.g. Lotion - Topical or Cream) specified in the table below.
Condition
Dosage
Administration
corticosteroid responsive, Inflammatory Dermatosis
, 0.0005 mg/mg, 0.05 %, 0.0001 mg/mg, 0.01 %
, Cream, Topical, Cream - Topical, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Kit, Aerosol, foam - Topical, Aerosol, foam, Kit - Topical
Pruritus
, 0.0005 mg/mg, 0.05 %, 0.0001 mg/mg, 0.01 %
, Cream, Topical, Cream - Topical, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Kit, Aerosol, foam - Topical, Aerosol, foam, Kit - Topical
Psoriasis Vulgaris
, 0.0005 mg/mg, 0.05 %, 0.0001 mg/mg, 0.01 %
, Cream, Topical, Cream - Topical, Ointment, Ointment - Topical, Lotion, Lotion - Topical, Kit, Aerosol, foam - Topical, Aerosol, foam, Kit - Topical

Warnings

Lexette has a single contraindication, so it should not be administered alongside the conditions in the following table.Lexette Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Ulobetasol may interact with Pulse Frequency
There are 20 known major drug interactions with Lexette.
Common Lexette Drug Interactions
Drug Name
Risk Level
Description
Allogeneic processed thymus tissue
Minor
The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Ulobetasol.
Inebilizumab
Minor
The risk or severity of infection can be increased when Ulobetasol is combined with Inebilizumab.
Vibrio cholerae CVD 103-HgR strain live antigen
Minor
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Ulobetasol.
2,4-thiazolidinedione
Moderate
The risk or severity of hyperglycemia can be increased when Ulobetasol is combined with 2,4-thiazolidinedione.
AICA ribonucleotide
Moderate
The risk or severity of hyperglycemia can be increased when Ulobetasol is combined with AICA ribonucleotide.
Lexette Toxicity & Overdose RiskGlucocorticoid overdose is rare, but long-term use of high doses can cause cataracts, glaucoma, high blood pressure, weight gain, high cholesterol, ulcers, pancreatitis, muscle weakness, mental health issues, skin thinning, allergies, acne, increased body hair, weakened immune system, diabetes, low calcium levels, low phosphate levels, and reduced growth. To treat an overdose, the dose may need to be adjusted or stopped and supportive care should be provided.
image of a doctor in a lab doing drug, clinical research

Lexette Novel Uses: Which Conditions Have a Clinical Trial Featuring Lexette?

18 active clinical trials are evaluating the potential of Lexette to reduce Pruritus, Plaque Psoriasis and Inflammatory Dermatosis responsive to Corticosteroids.
Condition
Clinical Trials
Trial Phases
Psoriasis Vulgaris
23 Actively Recruiting
Early Phase 1, Phase 3, Not Applicable, Phase 2, Phase 4, Phase 1
corticosteroid responsive, Inflammatory Dermatosis
0 Actively Recruiting
Pruritus
0 Actively Recruiting

Lexette Reviews: What are patients saying about Lexette?

5Patient Review
7/12/2021
Lexette for Plaque Psoriasis
I've tried a lot of different treatments for my psoriasis, and this one is by far the most effective. I highly recommend it to anyone else who suffers from this condition.
4.7Patient Review
12/24/2021
Lexette for Plaque Psoriasis
This is the only treatment that has worked for me so far. I apply it to my skin and then spread it using the cap, which makes it go a lot further than if I were just using my hand.
2Patient Review
8/1/2020
Lexette for Plaque Psoriasis
The foam dispenser stopped working pretty quickly, which was frustrating because I couldn't use the medication. A lot of it went to waste. If you can get it out of the can, it works well though.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lexette

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Lexette a steroid?

"Lexette is a highly potent steroid that helps reduce inflammation in the body. Lexette is used to treat inflammation and itching caused by plaque psoriasis or skin conditions that respond to steroid medication."

Answered by AI

What is Lexette used for?

"This medication is used to treat certain skin conditions, such as psoriasis. Halobetasol helps reduce the itching, redness, scaling, and swelling that can occur with these conditions. This medication is a very strong corticosteroid."

Answered by AI

What is halobetasol used to treat?

"Halobetasol is a topical cream used to relieve swelling, redness, and itchiness caused by skin conditions like psoriasis. It's a corticosteroid, which is a type of medication that reduces inflammation. You need a prescription from a doctor to get it."

Answered by AI

How long does it take for Lexette to work?

"It has been found in two clinical studies that five times more people who treat their moderate to severe plaque psoriasis with LEXETTE Foam achieve clear or almost clear skin after two weeks, compared to those usingvehicle foam with no active ingredient."

Answered by AI

Clinical Trials for Lexette

Have you considered Lexette clinical trials? We made a collection of clinical trials featuring Lexette, we think they might fit your search criteria.Go to Trials
Image of Lynderm Research in Markham, Canada.

ESK-001 for Plaque Psoriasis

18+
All Sexes
Markham, Canada
The objective of the ESK-001-018 long term extension is to evaluate the safety and efficacy of ESK-001 over time. The scientific questions it aims to answer are: * How safe is taking ESK-001 long-term in people with moderate to severe plaque psoriasis? * Does taking ESK-001 long-term reduce the severity of people's plaque psoriasis? Patients will enter the long-term extension study following completion of one of the parent studies (ESK-001-016 or ESK-001-017) and will receive open-label ESK-001 twice daily for 24 weeks. After 24 weeks, the first 200 patients meeting at least PASI-75 clinical response will be randomly assigned to receive ESK-001 or placebo. At any point during this time, the patients losing the initial clinical response may return to the open-label ESK-001 treatment. Patients who complete Week 48 will return to open-label ESK-001 treatment and they will receive ESK-001 until the end of the study or discontinuation. All the remaining patients not meeting the entry criteria for the randomized withdrawal phase will continue to receive open-label ESK-001 for the remainder of the study. Patients taking part in the study must be men or women aged at least 18 years old and have completed a previous (parent) study of ESK-001 in moderate to severe plaque psoriasis. Patients must consent and agree to: * ensure drug daily compliance until end of study or discontinuation. * visit the clinic for checkups and assessments. * provide blood and urine samples.
Phase 3
Recruiting
Quick Reply
Lynderm Research (+35 Sites)Alumis Inc
Image of Not posted in Webster, United States.

IRX4204 for Plaque Psoriasis

18+
All Sexes
Webster, TX
The goal of this clinical trial is to learn if IRX4204 works to treat plaque psoriasis in adults. It will also learn about the safety of IRX4204. The main questions it aims to answer are: * Does IRX4204 treat plaque psoriasis symptoms? * Does IRX4204 treat plaque psoriasis symptoms better than someone who is not being treated? * What medical problems do participants have when taking IRX4204? Researchers will compare IRX4204 to a placebo (a look-alike substance that contains no drug) to see if the drug works to treat mild to moderate plaque psoriasis. Participants will: * Take IRX4204 every day for 28 days * Visit the clinic once every week for checkups and tests * Complete specific assessments about plaque psoriasis and changes to plaques
Phase 2
Waitlist Available
Not postedIo Therapeutics
Have you considered Lexette clinical trials? We made a collection of clinical trials featuring Lexette, we think they might fit your search criteria.Go to Trials
Have you considered Lexette clinical trials? We made a collection of clinical trials featuring Lexette, we think they might fit your search criteria.Go to Trials
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