Urispas

Suprapubic pain, Urethritis, Dysuria + 17 more
Treatment
10 FDA approvals
20 Active Studies for Urispas

What is Urispas

FlavoxateThe Generic name of this drug
Treatment SummaryDicyclomine is a drug used to treat urinary and abdominal spasms. It works by numbing the area and blocking a certain type of nerve receptor that causes the spasms. It is unclear how effective this drug is and how exactly it works.
Urispasis the brand name
image of different drug pills on a surface
Urispas Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Urispas
Flavoxate
1970
10

Approved as Treatment by the FDA

Flavoxate, otherwise known as Urispas, is approved by the FDA for 10 uses including Urethritis and urethrocystitis .
Urethritis
urethrocystitis
Urethrotrigonitis
Prostatitis
Urinary Tract Infection (UTI)
Prostatitis
Urethritis
Urethritis
Urethritis
Urinary Tract Infections

Effectiveness

How Urispas Affects PatientsFlavoxate is a drug used to treat bladder and urinary issues, such as incontinence, frequent urination, and urgency. It works by blocking a certain type of receptor (muscarinic) that helps control bladder muscle contractions and the production of saliva.
How Urispas works in the bodyFlavoxate is a drug that works by blocking signals sent by nerves that control bladder contractions. This reduces muscle tension in the bladder and leads to fewer trips to the bathroom, fewer episodes of urge incontinence, less urgency and improved bladder control.

When to interrupt dosage

The recommended dosage of Urispas is contingent upon the identified condition, such as Menstrual Distress (Dysmenorrhea), urethrocystitis and Urinary Tract Infection. The measure of dosage shifts, in accordance with the method of delivery (e.g. Oral or Tablet, film coated - Oral) featured in the table beneath.
Condition
Dosage
Administration
cystalgia
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Pelvic Pain
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Urinary Tract Infection (UTI)
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Catheterization
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Neurogenic Urinary Bladder
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Uterine dyskinesia
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Urethritis
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Suprapubic pain
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Urethritis
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Nocturia
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Kidney Stones
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Urinary Tract Infections
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Dysmenorrhea
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Urethritis
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Urinary Incontinence
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Prostatitis
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Cystoscopy
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Cerebellar Diseases
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Urinary Urgency
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral
Dysuria
, 100.0 mg, 200.0 mg
, Tablet, film coated, Tablet, film coated - Oral, Oral, Tablet, Tablet - Oral

Warnings

Urispas is contraindicated in eight cases, and should not be amalgamated with the conditions delineated in the following table.Urispas Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Ileus
Do Not Combine
Pyloric Stenosis
Do Not Combine
obstructive uropathies of the lower urinary tract
Do Not Combine
Gastrointestinal Hemorrhage
Do Not Combine
Intestinal Obstruction
Do Not Combine
Duodenal Obstruction
Do Not Combine
Esophageal Achalasia
Do Not Combine
There are 20 known major drug interactions with Urispas.
Common Urispas Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Flavoxate is combined with Aclidinium.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Flavoxate is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Flavoxate is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Flavoxate is combined with Glycopyrronium.
Ipratropium
Major
The risk or severity of adverse effects can be increased when Flavoxate is combined with Ipratropium.
Urispas Toxicity & Overdose RiskThe amount of flavoxate HCl that is toxic to rats is 4273 mg/kg, and 1837 mg/kg for mice. Signs of an overdose include seizures, decreased sweating, red and warm skin, dry mouth, elevated body temperature, hallucinations, rapid heart rate and high blood pressure, and mental confusion.
image of a doctor in a lab doing drug, clinical research

Urispas Novel Uses: Which Conditions Have a Clinical Trial Featuring Urispas?

126 active clinical trials are assessing the efficacy of Urispas in providing relief from Urinary Incontinence, Cerebellar Diseases and Nocturia.
Condition
Clinical Trials
Trial Phases
Nocturia
3 Actively Recruiting
Phase 4, Not Applicable
Kidney Stones
32 Actively Recruiting
Not Applicable, Early Phase 1, Phase 2
Dysuria
0 Actively Recruiting
Urinary Tract Infection (UTI)
0 Actively Recruiting
Neurogenic Urinary Bladder
9 Actively Recruiting
Phase 3, Phase 2, Early Phase 1, Not Applicable
Catheterization
0 Actively Recruiting
Uterine dyskinesia
0 Actively Recruiting
Dysmenorrhea
1 Actively Recruiting
Not Applicable
Urinary Tract Infections
7 Actively Recruiting
Not Applicable, Phase 4
Urethritis
0 Actively Recruiting
Urethritis
0 Actively Recruiting
Cystoscopy
0 Actively Recruiting
Urinary Urgency
2 Actively Recruiting
Not Applicable
Urinary Incontinence
2 Actively Recruiting
Phase 4, Not Applicable
Suprapubic pain
0 Actively Recruiting
Prostatitis
0 Actively Recruiting
cystalgia
0 Actively Recruiting
Pelvic Pain
13 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3
Urethritis
0 Actively Recruiting
Cerebellar Diseases
2 Actively Recruiting
Not Applicable

Urispas Reviews: What are patients saying about Urispas?

5Patient Review
1/3/2022
Urispas for Urination During the Night
Since I was a baby, I've suffered from water infections. On a trip to India, I went to the doctor again for another infection. He took a urine sample and it tested positive for antibiotics. He prescribed me Urispas and, for three years now, I haven't had a single infection. They've changed my life--I'm 100% better.
5Patient Review
9/2/2021
Urispas for Urinary Tract Irritation
This has been a total game-changer for me. I was given this while I was in India and it really helped me out of a tough spot. I had been struggling with what I later found out were recurring UTIs, and the antibiotics just weren't cutting it anymore. This treatment allowed me to go week after week without any pain or discomfort, and I'm so grateful for that.
5Patient Review
5/24/2010
Urispas for Difficult or Painful Urination
This medication has been such a relief! I've suffered from bladder infections my whole life, and this is the first time I've found something that actually helps. The only downside is that if I take it too close together or on an empty stomach, I get a little nauseous.
3.3Patient Review
6/22/2021
Urispas for Urinary Tract Irritation
This medication only provides temporary relief while it is active in your system. I was recommended this by a pharmacist when I told her about my UTI. The mornings are still the hardest, but once the medication kicks in I can finally empty my bladder. Unfortunately, even after finishing the dosage, the UTI symptoms persist.
2.7Patient Review
7/14/2013
Urispas for Urination During the Night
I have interstitial cystitis and could not afford the other medication, Uribel. So, I decided to give this a try instead. Unfortunately, I felt very shaky and drowsy after taking it. Will not take this again!
2.3Patient Review
4/7/2014
Urispas for Frequent Urination
I've been taking the medication as prescribed, but I haven't noticed any difference in my frequent urination.
1Patient Review
8/23/2022
Urispas for Frequent Urination
I took antibiotics and probiotics to fight an infection, then I started taking urispas. Unfortunately, even after six days of use, there was no change.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about urispas

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Will Urispas help for bladder infection?

"Urispas is not a treatment for bladder infections. Those must be treated with antibiotics. Urispas can also be used for other purposes not mentioned in this medication guide."

Answered by AI

Is Urispas antibiotic?

"Urispas is not a cure for infections, but is available in generic form."

Answered by AI

What is Urispas tablets used for?

"The drug Urispas contains an active ingredient that inhibits muscle contractions in the urinary tract. This effect can help to relieve pain caused by inflammation in the bladder, prostate gland, or urethra. Urispas is typically used to treat muscle spasms that occur in these areas."

Answered by AI

Is Urispas harmful?

"The following side effects may occur: nausea, vomiting, dry mouth, headache, drowsiness, dizziness, blurred vision, and nervousness. If you experience any of these side effects, tell your doctor or pharmacist."

Answered by AI

Clinical Trials for Urispas

Image of UPMC Magee-Womens Hospital in Pittsburgh, United States.

Catheterization Methods for Postpartum Urinary Problems

18+
All Sexes
Pittsburgh, PA
At least ten percent of patients have postpartum urinary retention or difficulty urinating after birth, which can cause incontinence and other urinary problems long-term. After getting an epidural placed, patients should be numb in their pelvic region. This numbness makes it difficult to feel the need to urinate, so patients need a urinary catheter placed to empty the bladder. Some patients have one catheter placed throughout their labor and others have a catheter placed to empty the bladder then removed every few hours. The investigators are studying whether placing a catheter once or catheterizing multiple times affects the rate of postpartum urinary problems and infection.
Waitlist Available
Has No Placebo
UPMC Magee-Womens HospitalAnna Binstock, MD
Image of University of California, San Francisco in San Francisco, United States.

Trimethoprim-Sulfamethoxazole for Urinary Tract Infections

13 - 29
All Sexes
San Francisco, CA
The goal of this clinical trial is to learn if a common antibiotic called trimethoprim-sulfamethoxazole (TMP-SMX) can help prevent urinary tract infections (UTIs) in children and young adults who recently had a kidney transplant. Most people take TMP-SMX for about 6 months after getting a kidney transplant. In this study, researchers want to see what happens if people keep taking it for 6 more months. The main questions this study is asking are: * Does TMP-SMX lower the number of UTIs in the first year after transplant? * What side effects or problems do participants have while taking TMP-SMX? Researchers will compare TMP-SMX to a placebo (a look-alike pill that does not contain any medication) to see if TMP-SMX works to prevent UTIs. Participants will: * Take either TMP-SMX or a placebo pill by mouth every day for 6 months * Have three visits to touch base with the study team about any issues * Complete short monthly online surveys about any symptoms or side effects * Share blood and urine test results from their regular transplant clinic visits
Phase 4
Waitlist Available
University of California, San FranciscoAlexandra Bicki, MD
Have you considered Urispas clinical trials? We made a collection of clinical trials featuring Urispas, we think they might fit your search criteria.Go to Trials
Image of School of Allied Health Professions in Loma Linda, United States.

Seed Cycling for Menstrual Disorder

18 - 45
Female
Loma Linda, CA
The purpose of this research is to investigate the impact of seed cycling on menstrual regularity, cramps, and pre-menstrual symptoms in women with an irregular menstrual cycle and/or dysmenorrhea. The research seeks to provide evidence-based insights into the potential benefits of seed cycling as a holistic approach to women's reproductive health. It is expected that your participation will last 3 months. Procedures and Activities. You will be provided with and asked to consume specific seeds daily. The seeds are to be consumed as follows: follicular phase (the period from the first day of menstruation (day 1) to ovulation (day 14) in a typical 28-day cycle): 1 tablespoon flax seeds and 1 tablespoon pumpkin seeds, and luteal phase (the period between ovulation and the start of the next period; typically days 15-28): 1 tablespoon sunflower seeds and 1 tablespoon sesame seeds. Before the intervention and once monthly for a total of 3 cycles, you will be asked to complete an online menstrual health symptom questionnaire (MHSQ) and keep track of your menstrual cycle days on the built-in health tracking app on your electronic device. Risks. Some of the foreseeable risks or discomforts of your participation include the potential for mild gastrointestinal side effects, the potential for allergic reactions, and the possibility of no significant benefit. Benefits. Possible benefits include the potential for improved menstrual cycle regularity, the potential for a reduction in premenstrual syndrome (PMS) symptoms, and the potential for nutritional benefits. Societal benefits include additional knowledge on seed cycling to help manage menstrual regularity and PMS symptoms.
Waitlist Available
Has No Placebo
School of Allied Health Professions
Image of United States, Alabama University of Alabama at Birmingham in Birmingham, United States.

Oxalate Synthesis for Kidney Stones

18 - 80
All Sexes
Birmingham, AL
The goal of this clinical trial study is to test if patients with idiopathic calcium oxalate kidney stones have an increased production of oxalate by the body, which would lead to increased urinary excretion of oxalate. The study will recruit adult patients with a history of calcium oxalate kidney stones and healthy volunteers without kidney stones. Participants will ingest fixed diets containing low amounts of oxalate for 5 days ingest a soluble form of glycolate and vitamin C collect urine, blood, stool during the dietary and oral dosing portions of the study and also collect breath sample during the oral glycolate test
Recruiting
Has No Placebo
United States, Alabama University of Alabama at Birmingham (+1 Sites)Sonia Fargue, PhD
Image of University of Iowa in Iowa City, United States.

Genetic Testing for Kidney Stones

18 - 90
All Sexes
Iowa City, IA
Kidney stones continue to affect more and more people in the United States with the most recent estimate being 1 in 9 people will develop a stone in their life. While family history is a known risk factor for stone disease, it remains unclear whether this is related to learned dietary habits or a truly inheritable genetic condition. Known inheritable genetic conditions linked to stone formation are uncommon, and thus, routine genetic testing is not currently recommended by any major urologic organizations. Patients who form calcium phosphate predominant stones, a less common type of stone composition, tend to have alkaline urine pH which suggests that the kidneys are unable to rid the body of acid. Management of such patients for stone prevention can be difficult. The Iowa Institute for Human Genomics is one of only a handful of commercial labs which offers genetic testing for stone disease. The aim of this study is to assess the rate of genetic abnormalities amongst calcium phosphate predominant stone formers with alkaline urine. To this end, the investigators plan to enroll calcium phosphate predominant stone forming patients with alkaline urine on 24 hour urine collection who obtain their health care at UIHC to undergo free genetic testing via blood draw to assess for genetic abnormalities. The investigators will also collect information already available in the subject's chart to assess for other patterns between blood and urine tests and any genetic variants.
Recruiting
Has No Placebo
University of Iowa
Have you considered Urispas clinical trials? We made a collection of clinical trials featuring Urispas, we think they might fit your search criteria.Go to Trials
Image of Endeavor Health in Evanston, United States.

NSAIDs for Menstrual Cramps

18 - 35
Female
Evanston, IL
The goal of this clinical trial is to learn if NSAIDs (i.e. naproxen sodium) can treat menstrual pain and prevent the development of chronic pelvic pain in menstruating adults with painful periods. The main questions it aims to answer are: * Can non-menstrual pelvic pain reduction be predicted by menstrual pain response to NSAIDs? * Will participants with the largest reductions in multi-site sensitivity following NSAID therapy have the largest reductions in non-menstrual pelvic pain? Researchers will compare naproxen sodium to a placebo (a look-alike substance that contains no drug) to see if naproxen sodium works to treat painful periods. Participants will: * Take naproxen sodium or placebo during several days of their menstrual period every month for 1 year. * Complete computer questionnaires and tests from home every 3 months. * Complete at-home urine tests to measure hormones every few days for 1-year. * Use a pin-prick to collect a small spot of blood, and use a pad or tampon to collect a sample of menstrual blood, and bring it to the research site twice over a 1-year period. * Come to the research site twice over a 1-year period to complete sensory assessments and undergo a blood draw. The major goal of the study is to develop a multivariable statistical model (see https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-021.html ) describing the factors that effectiveness of pain medication and risk for chronic pain
Phase 4
Recruiting
Endeavor Health
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Vibrating Pelvic Floor Device for Painful Intercourse

18+
Female
Washington, United States
The goal of this randomized controlled trial is to determine whether the use of a novel vibrating pelvic floor therapeutic device ("Kiwi") improves sexual function in sexually active women aged 18 and older with genito-pelvic pain and penetration disorder (GPPPD) more effectively than traditional vaginal dilators. The main questions it aims to answer are: 1. Does the use of the Kiwi device lead to higher sexual function scores compared to traditional vaginal dilators 2. Does the Kiwi device improve sexual distress, pain, and overall symptom severity more effectively than traditional vaginal dilators? Researchers will compare the Kiwi vibrating device to traditional cylindrical vaginal dilators to assess whether the Kiwi device results in greater improvements in sexual function and symptom relief. Participants will: * Be randomly assigned to use either the Kiwi device or traditional vaginal dilators. * Use the assigned device three times per week for 15 minutes per session over four weeks. * Complete surveys before and after the study, including assessments of sexual function, pain, and overall improvement.
Recruiting
Has No Placebo
MedStar Health (+1 Sites)Cheryl Iglesia, MD
Have you considered Urispas clinical trials? We made a collection of clinical trials featuring Urispas, we think they might fit your search criteria.Go to Trials
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