Navane

Schizophrenia
Treatment
1 FDA approval
20 Active Studies for Navane

What is Navane

ThiothixeneThe Generic name of this drug
Treatment SummaryThiothixene is an antipsychotic medication that works similarly to other antipsychotic drugs. It is used to treat mental health conditions such as schizophrenia and bipolar disorder.
Navaneis the brand name
image of different drug pills on a surface
Navane Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Navane
Thiothixene
1967
50

Approved as Treatment by the FDA

Thiothixene, also known as Navane, is approved by the FDA for 1 uses which include Schizophrenia .
Schizophrenia
Helps manage Schizophrenia

Effectiveness

How Navane Affects PatientsThiothixene is an older type of antipsychotic drug that is not used as often today as newer drugs like risperidone. It belongs to a group of drugs called thioxanthene series and shares certain chemical and pharmacological similarities to other antipsychotics. However, it is not as effective as the newer medications.
How Navane works in the bodyThiothixene works by blocking certain receptors in the brain. It works on dopamine receptors to reduce symptoms of psychosis, serotonin receptors to reduce anxiety, depression and aggression, histamine receptors to cause sedation, weight gain and lower blood pressure, alpha receptors to reduce symptoms of Parkinson's and muscarinic receptors to cause dry mouth, blurred vision and difficulty urinating.

When to interrupt dosage

The recommended measure of Navane is contingent upon the confirmed condition. The portion of dosage fluctuates, based on the technique of delivery (e.g. Capsule or Capsule - Oral) featured in the table beneath.
Condition
Dosage
Administration
Schizophrenia
, 1.0 mg, 2.0 mg, 5.0 mg, 10.0 mg, 20.0 mg, 5.0 mg/mL
, Capsule, Oral, Capsule - Oral, Tablet - Oral, Tablet, Solution, concentrate, Solution, concentrate - Oral

Warnings

Navane Contraindications
Condition
Risk Level
Notes
Coma
Do Not Combine
Shock
Do Not Combine
Disease
Do Not Combine
Mental Depression
Do Not Combine
There are 20 known major drug interactions with Navane.
Common Navane Drug Interactions
Drug Name
Risk Level
Description
Amisulpride
Major
Thiothixene may increase the antipsychotic activities of Amisulpride.
Azelastine
Major
Thiothixene may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Deutetrabenazine
Major
The risk or severity of adverse effects can be increased when Thiothixene is combined with Deutetrabenazine.
Ethanol
Major
Thiothixene may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Thiothixene is combined with Hydroxyzine.
Navane Toxicity & Overdose RiskSigns of an overdose on Xanax include confusion, trouble swallowing, dizziness, drowsiness, a tilted head, low blood pressure, muscle twitching, stiff muscles, excessive saliva, shaking, difficulty walking, and weakness.
image of a doctor in a lab doing drug, clinical research

Navane Novel Uses: Which Conditions Have a Clinical Trial Featuring Navane?

Condition
Clinical Trials
Trial Phases
Schizophrenia
98 Actively Recruiting
Phase 3, Not Applicable, Early Phase 1, Phase 4, Phase 1, Phase 2

Navane Reviews: What are patients saying about Navane?

5Patient Review
5/28/2019
Navane for Schizophrenia
Navane has been an absolute godsend. I don't know how I would have lived without it these past 40 years.
5Patient Review
10/26/2007
Navane for Mental Disorder with Loss of Normal Personality & Reality
5Patient Review
1/30/2009
Navane for Mental Disorder with Loss of Normal Personality & Reality
I sleep very well when I take this drug at night. It's also a lot less expensive than some of the newer drugs on the market.
5Patient Review
3/24/2009
Navane for Mental Disorder with Loss of Normal Personality & Reality
I was having a lot of anxiety and struggling to focus, plus crying spells and involuntary muscle movements. This treatment really helped me get those under control.
5Patient Review
10/2/2010
Navane for Mental Disorder with Loss of Normal Personality & Reality
I've been using this medication to treat my bipolar disorder for twenty years. I find it highly effective with few side effects. It's much better than many of the newer psychiatric medications on the market.
5Patient Review
7/11/2010
Navane for Mental Disorder with Loss of Normal Personality & Reality
Missing a dose of this medication would cause my hallucinations to come back, but Risperdal has completely eliminated that problem for me. I'm on the generic brand and it works just as well as its more expensive counterpart.
4.3Patient Review
1/1/2013
Navane for Mental Disorder with Loss of Normal Personality & Reality
This medication was really effective for my bi-polar disorder. However, I did experience some weight gain and increased prolactin levels.
4.3Patient Review
3/12/2011
Navane for Mental Disorder with Loss of Normal Personality & Reality
I've been on Navane for decades now, and it's the only thing that keeps me stable. I know it's not perfect, but it's better than anything else I've tried.
3.7Patient Review
5/4/2010
Navane for Schizophrenia
I've been on Navane for a couple years now. It's not perfect, but it does the job. That said, be careful; this medication caused me to put on a lot of weight. Additionally, you have to be careful about what other medications you take while on Navane because they tend to interact.
2.7Patient Review
7/19/2009
Navane for Schizophrenia
I was given this medication for psychosis. After a few weeks, I had extremely adverse reactions including shaking, loss of all emotion, depression, and suicide thoughts. I was 36 years old at the time. I was put on the drug again at age 50. It was fine for a few weeks but then I had the same problems, with less shaking.
1.3Patient Review
4/8/2010
Navane for Mental Disorder with Loss of Normal Personality & Reality
I've been taking this medication because I can't afford the more expensive option, risperdal.
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Patient Q&A Section about navane

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Navane used for?

"Thiothixene, also known as Navane, is an antipsychotic medication used to treat schizophrenia and other conditions with psychotic features, including bipolar disorder. Thiothixene is rarely used today to treat psychosis."

Answered by AI

Is Navane discontinued?

"The Navane brand name has been discontinued in the U.S. However, if generic versions of this product have been approved by the FDA, there may be generic equivalents available."

Answered by AI

Is Navane an atypical antipsychotic?

"The following is a paraphrased version of the text above:

Navane (Thiothixene) is a typical antipsychotic drug. It is used to treat schizophrenia and other psychotic disorders. It works by blocking dopamine receptors in the brain."

Answered by AI

What drug class is Navane?

"These drugs are also called “typical antipsychotics.”

Navane is a member of the class of drugs known as antipsychotics, or first-generation drugs. These drugs are sometimes referred to as "typical antipsychotics.""

Answered by AI

Clinical Trials for Navane

Image of The University of Iowa in Iowa City, United States.

fMRI for Cognitive Flexibility

18 - 35
All Sexes
Iowa City, IA
The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates "context"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control. The primary research questions are: Does the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules? Participants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.
Waitlist Available
Has No Placebo
The University of Iowa
Image of Vanderbilt Psychiatric Hospital in Nashville, United States.

Repetitive Transcranial Magnetic Stimulation for Schizophrenia

18 - 65
All Sexes
Nashville, TN
The central hypothesis is this: DMN connectivity can be modulated with inhibitory cTBS when delivered on an accelerated treatment schedule. This study seeks to provide evidence that accelerated, network-targeted inhibitory stimulation of the DMN leads to both altered network activity and a concomitant behavioral change in cognitive performance in individuals with schizophrenia and schizoaffective disorder. This study will also compare the effect of inhibitory cTBS in healthy individuals, as it may also lead to both altered network activity and a behavioral change in cognitive performance in individuals without schizophrenia or schizoaffective disorder. If successful, this study will have identified a safe, effective, and broadly applicable treatment for cognitive impairment in schizophrenia that has potential for translation into many other psychiatric and neurodevelopmental disorders, such as autism.
Waitlist Available
Has No Placebo
Vanderbilt Psychiatric HospitalHeather Ward, MD
Image of Woodland International Research Group /ID# 275747 in Little Rock, United States.

Emraclidine for Schizophrenia

18 - 65
All Sexes
Little Rock, AR
Schizophrenia is a common and severe psychiatric illness characterized by extreme disturbances of cognition and thought, affecting language, perception and sense of self. This study will assess adverse events, change in disease activity, and how oral emraclidine moves through the body in adult participants with schizophrenia Emraclidine is an investigational drug being developed for the treatment of schizophrenia. Participants are placed in one of two parts, Part A or Part B, where each group will receive a different treatment. Participants will receive either oral emraclidine or placebo. Approximately 258 participants will be enrolled across roughly 32 sites in the United States. Participants in Part A will be assigned to one of multiple ascending doses of emraclidine or placebo administered orally for 14 days or up to 21 days. Participants in Part B will receive Emraclidine or placebo administered orally for up to 42 days. Participants will be followed for 30 days after the last dose of the study drug. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Phase 2
Recruiting
Woodland International Research Group /ID# 275747 (+4 Sites)ABBVIE INC.AbbVie
Have you considered Navane clinical trials? We made a collection of clinical trials featuring Navane, we think they might fit your search criteria.Go to Trials
Have you considered Navane clinical trials? We made a collection of clinical trials featuring Navane, we think they might fit your search criteria.Go to Trials
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Xanomeline/Trospium for Schizophrenia

18 - 40
All Sexes
Richmond, TX
This is an open label study of the treatment satisfaction, efficacy and tolerability of xanomeline/ trospium in a population of 172 participants diagnosed with schizophrenia in the early phase of illness. Participants will be followed for 24 weeks with scheduled assessments conducted by centralized raters, local mental health professionals and self-assessments completed by patients. Recruitment will be based on insufficient efficacy of previous antipsychotic or due to dissatisfaction with treatment as a result of unacceptable side effects on previous antipsychotic/patient choice, with approximately 50% for each enrollment criteria. Participants who present with both insufficient efficacy and unacceptable side effects will be considered as belonging to the insufficient efficacy subgroup. Treatment and assessments will be identical for the 2 groups. Primary outcome for participants enrolled will be improvement in overall treatment satisfaction as measured by the MSQ.
Phase 4
Waitlist Available
Clinical SiteBristol-Myers Squibb
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