Nicotrol
Smoke, nicotine
Treatment
2 FDA approvals
2 Active Studies for Nicotrol
Treatment for
Smoke
What is Nicotrol
Nicotine
The Generic name of this drug
Treatment Summary
Nicotine is a toxic chemical found in tobacco smoke. It acts on the brain by attaching to specific receptors, which causes neurons to become overly stimulated and block brain signals. Nicotine has medical implications as it can cause serious health issues when it is inhaled through smoking.
equate Nicotine
is the brand name
Nicotrol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
equate Nicotine
Nicotine
1990
1005
Approved as Treatment by the FDA
Nicotine, otherwise called equate Nicotine, is approved by the FDA for 2 uses which include Smoke and nicotine .
Smoke
Helps manage Smoking cessation therapy
nicotine
Helps manage Withdrawal Nicotine
Effectiveness
How Nicotrol Affects Patients
Nicotine, found in tobacco products, attaches to certain receptors in the body and brain. This causes a stimulant effect that can lead to increased heart rate and blood pressure. Nicotine is highly addictive, and is used in inhalers and patches to treat people who are trying to quit smoking. Nicotine is classified as a stimulant.
How Nicotrol works in the body
Nicotine is a stimulant that works on two different areas of the body. In the brain, it binds to nicotinic acetylcholine receptors, allowing ions like sodium and calcium to enter the neuron. This causes more dopamine to be released, which gives a sense of euphoria and leads to nicotine addiction. In the adrenal medulla, nicotine binds to nicotinic acetylcholine receptors and triggers the release of epinephrine. This causes vasoconstriction, increased blood pressure, higher heart rate, and increased blood sugar.
When to interrupt dosage
The advised dose of Nicotrol is contingent upon the recognized condition. The quantity of dose fluctuates, contingent upon the technique of delivery featured in the table beneath.
Condition
Dosage
Administration
nicotine
, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg
Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, , Oral, Gum, chewing, Gum, chewing - Oral, Lozenge, Lozenge - Oral, Gum, chewing - Buccal, Buccal, Kit - Transdermal, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Powder - Oral, Liquid, Powder, Patch - Transdermal, Patch, Nasal, Spray, metered - Nasal, Dental; Oral, Patch - Topical, Kit, Liquid - Oral, Spray, metered
Smoke
, 1.4 mg/hour, 14.0 mg, 0.7 mg/hour, 2.1 mg/hour, 7.0 mg, 21.0 mg, 4.0 mg, 2.0 mg, 1.0 mL/mL, 1.0 mg/mg, 114.0 mg, 78.0 mg, 36.0 mg, 10.0 mg/mL, 0.18 mg/mg, 0.15 mg/mg, 0.2 mg/mg, 2.0 mg/hour, 4.0 mg/hour, 8.0 mg, 2.5 mg/hour, 0.06 mg/mg, 0.12 mg/mg, 0.21 mg/mg
Transdermal, Patch, extended release, Patch, extended release - Transdermal, Topical, Patch, extended release - Topical, , Oral, Gum, chewing, Gum, chewing - Oral, Lozenge, Lozenge - Oral, Gum, chewing - Buccal, Buccal, Kit - Transdermal, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Powder - Oral, Liquid, Powder, Patch - Transdermal, Patch, Nasal, Spray, metered - Nasal, Dental; Oral, Patch - Topical, Kit, Liquid - Oral, Spray, metered
Warnings
There are 20 known major drug interactions with Nicotrol.
Common Nicotrol Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Nicotine.
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Nicotine.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Nicotine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Nicotine.
Dalfampridine
Major
The serum concentration of Dalfampridine can be increased when it is combined with Nicotine.
Nicotrol Toxicity & Overdose Risk
Overdosing on this drug can lead to symptoms such as nausea, stomach pain, vomiting, sweating, redness of the skin, dizziness, hearing or vision problems, confusion, weakness, heart palpitations, changes in breathing, and low blood pressure. The lowest toxic dose of this drug in mice has been found to be 24 mg/kg when taken orally.
Nicotrol Novel Uses: Which Conditions Have a Clinical Trial Featuring Nicotrol?
5 active studies are currently in progress to assess the efficacy of Nicotrol in treating nicotine-related conditions.
Condition
Clinical Trials
Trial Phases
Smoke
0 Actively Recruiting
nicotine
2 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Nicotrol Reviews: What are patients saying about Nicotrol?
5
Patient Review
5/11/2008
Nicotrol for Stop Smoking
5
Patient Review
1/4/2010
Nicotrol for Stop Smoking
5
Patient Review
12/14/2010
Nicotrol for Nicotine Addiction
5
Patient Review
1/12/2018
Nicotrol for Stop Smoking
5
Patient Review
6/24/2018
Nicotrol for Stop Smoking
5
Patient Review
9/14/2022
Nicotrol for Stop Smoking
5
Patient Review
4/6/2009
Nicotrol for Stop Smoking
5
Patient Review
9/14/2009
Nicotrol for Stop Smoking
5
Patient Review
3/14/2008
Nicotrol for Stop Smoking
4.3
Patient Review
7/17/2022
Nicotrol for Stop Smoking
4
Patient Review
5/11/2019
Nicotrol for Stop Smoking
3
Patient Review
2/6/2010
Nicotrol for Stop Smoking
2.7
Patient Review
3/9/2011
Nicotrol for Nicotine Addiction
Patient Q&A Section about nicotrol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Can you smoke with Nicotrol inhaler?
"Do not use the NICOTROL Inhaler if you are currently smoking or using any other tobacco products, as this could result in nicotine overdose. Symptoms of overdose include dizziness, headache, weakness, and nausea. If you experience any of these symptoms, call a doctor or Poison Control Center immediately."
Answered by AI
What are the side effects of nicotrol?
"You may experience headache, nausea, mouth or tooth pain, cough, runny or stuffy nose, change in taste, heartburn, hiccups, sweating, or diarrhea."
Answered by AI
How long can you use Nicotrol inhaler?
"A minimum of 4 and a maximum of 20 NICOTROL Inhaler cartridges were used per day. In both studies, the recommended treatment duration was 3 months, but patients were allowed to continue using the product for up to 6 months if they wanted to."
Answered by AI
Do I need a prescription for nicotrol?
"You will need a prescription from a prescribing healthcare provider in order to use the nicotine oral inhaler. The nicotine oral inhaler may resemble a cigarette, but it must be used differently. You do not need to inhale as deeply for the medicine to be effective."
Answered by AI