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What is Cordarone
AmiodaroneThe Generic name of this drug
Treatment SummaryAmiodarone is a medication used to treat irregular or abnormal heart rhythms. It is typically prescribed for life-threatening ventricular arrhythmias, as well as atrial fibrillation. This drug can be very powerful and has the potential to cause serious side effects, so it should only be used to treat its approved indications.
Cordaroneis the brand name
Cordarone Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cordarone
Amiodarone
1985
144
Approved as Treatment by the FDA
Amiodarone, also known as Cordarone, is approved by the FDA for 4 uses like Tachycardia, Ventricular and Ventricular Fibrillation .Tachycardia, Ventricular
Helps manage recurrent hemodynamically unstable Ventricular tachycardia
Ventricular Fibrillation
Helps manage recurrent Ventricular fibrillation
recurrent hemodynamically unstable Ventricular tachycardia
Helps manage recurrent hemodynamically unstable Ventricular tachycardia
recurrent Ventricular fibrillation
Helps manage recurrent Ventricular fibrillation
Effectiveness
How Cordarone Affects PatientsAmiodarone is an anti-arrhythmic drug that helps to prevent and treat irregular heartbeats. When given intravenously, it helps relax the muscles in the walls of the blood vessels, lowers the pressure of the blood, and increases the amount of blood the heart pumps. However, when taken orally, it does not have much of an effect on how much blood is pumped. Taking amiodarone also affects the QRS and QT intervals in the heart, and can cause thyroid problems due to the high levels of iodine in the drug. Controlled clinical trials have not shown that taking amiodarone orally increases
How Cordarone works in the bodyAmiodarone is a type of drug that helps to treat abnormal heart rhythms. It works by blocking potassium currents that help the heart muscle to repolarize after a contraction. This increases the time it takes for the heart to repolarize and prevents abnormal heart rhythms. Amiodarone also affects other parts of the body, such as beta-adrenergic receptors and calcium channels, which can lead to side effects such as low blood pressure, slowed heart rate, and abnormal rhythm in the heart. It can also affect receptors in the liver, leading to fatty changes, and it can bind to the thyroid receptor, potentially leading to
When to interrupt dosage
The proposed dose of Cordarone is contingent upon the diagnosed ailment, including recurrent Ventricular fibrillation, Tachycardia, Ventricular and Cardiothoracic Surgery. The amount of dosage fluctuates as per the administration approach (e.g. Tablet or Injection, solution - Intravenous) specified in the table beneath.Condition
Dosage
Administration
Ventricular Fibrillation
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Atrial Fibrillation
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Tachycardia, Ventricular
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Tachycardia, Supraventricular
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Cardiothoracic Surgery
, 200.0 mg, 50.0 mg/mL, 1.8 mg/mL, 100.0 mg, 400.0 mg, 1.5 mg/mL, 300.0 mg, 150.0 mg/mL, 450.0 mg/mL, 90.0 mg/mL
Oral, Tablet, , Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous
Warnings
Cordarone ContraindicationsCondition
Risk Level
Notes
Shock, Cardiogenic
Do Not Combine
Syncope
Do Not Combine
Atrioventricular Block
Do Not Combine
pathologic fistula
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Amiodarone may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Amiodarone may interact with Pulse Frequency
Common Cordarone Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Amiodarone.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Amiodarone.
3-isobutyl-1-methyl-7H-xanthine
Major
The serum concentration of 3-isobutyl-1-methyl-7H-xanthine can be increased when it is combined with Amiodarone.
5-androstenedione
Major
The metabolism of 5-androstenedione can be decreased when combined with Amiodarone.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be decreased when combined with Amiodarone.
Cordarone Toxicity & Overdose RiskThe highest dose of amiodarone found to be non-toxic in mice and rats is 3,000 mg/kg. Overdosing on amiodarone can be fatal, as it can lead to irregular heartbeat, low blood pressure, shock, slow heartbeat, or damage to the liver. Treatment for an overdose may include fluids, medicines that raise blood pressure, or drugs that increase the strength of the heart's contractions. In some cases, a pacemaker may also be needed. Since amiodarone cannot be removed from the body through dialysis, regular liver function tests are recommended.
Cordarone Novel Uses: Which Conditions Have a Clinical Trial Featuring Cordarone?
161 active clinical trials are currently being conducted to investigate the potential of Cordarone to mitigate recurrent Ventricular fibrillation, Cardiothoracic Surgery and Ventricular Tachycardia.Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
91 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Tachycardia, Ventricular
0 Actively Recruiting
Tachycardia, Supraventricular
1 Actively Recruiting
Not Applicable
Cardiothoracic Surgery
0 Actively Recruiting
Ventricular Fibrillation
0 Actively Recruiting
Cordarone Reviews: What are patients saying about Cordarone?
5Patient Review
9/8/2009 I had been taking Amio for about a year with great results- no episodes of VT. But then I went in for a lung test and found out that the drug was causing my lungs to not work properly. I had to stop taking it immediately, and 30 days later I had an episode of VT which caused my ICD to fire.
4.7Patient Review
7/8/2010 The side effects of this medication are so bad that I'm actually going back to the cardiologist today. I would not recommend it to anyone, even as a last resort.
4.3Patient Review
1/6/2015 In the three months I've been taking this medication, I've only had one short episode of atrial fibrillation.
4.3Patient Review
7/20/2010 I take Amio for post-open heart surgery and it has given me more acid indigestion. I realized that this is because Amio contains HCL, which is basically stomach acid. This has been a problem for me in the past, and now I know why Amio is bothering me. Pepto Bismal tablets help, but I might need something stronger.
3.7Patient Review
9/29/2008 I had a terrible reaction to the sun while taking this medication, so I had to stop. However, it does seem to have gotten rid of my fibrillations.
Patient Q&A Section about cordarone
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Cordarone used for?
"Amiodarone is a drug used to treat and prevent an irregular heartbeat. It slows down nerve activity in the heart and relaxes an overactive heart."
Answered by AI
What are the side effects of Cordarone?
"The following are symptoms: nausea, vomiting, constipation, weight loss, fatigue, pulmonary fibrosis, heart block, and heart failure."
Answered by AI
What type of drug is Cordarone?
"CORDARONE (amiodarone HCl) is a drug used to treat irregular heartbeats, available as a pink, scored tablet. Each tablet contains 200 mg of amiodarone hydrochloride. Other inactive ingredients present are colloidal silicon dioxide, lactose, magnesium stearate, povidone, starch, and FD&C Red 40."
Answered by AI
Does Cordarone affect blood pressure?
"Amiodarone not only prevents irregular heartbeats, but also widens blood vessels. This can lead to lower blood pressure. Since this is also beneficial for patients with congestive heart failure, amiodarone may help these patients as well."
Answered by AI