Penicillin G Sodium

Gas Gangrene, Botulism, Anthrax + 20 more

Treatment

20 Active Studies for Penicillin G Sodium

Treatment for

Gas Gangrene

What is Penicillin G Sodium

BenzylpenicillinThe Generic name of this drug

Treatment SummaryPenicillin G (Benzylpenicillin) is a type of antibiotic used to treat bacterial infections. It is usually given intravenously or intramuscularly as it is not easily absorbed orally. Penicillin G is typically used to treat infections caused by certain gram-positive bacteria, such as Streptococcus pneumoniae, Streptococcus agalactiae and Staphylococcus. It can also be used in some cases against gram-negative bacteria such as Neisseria meningitidis and Pasteurella. Penicillin G is not usually used to treat anaerobic infections.

Bicillin L-Ais the brand name

Penicillin G Sodium Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bicillin L-A

Benzylpenicillin

1952

Effectiveness

How Penicillin G Sodium Affects PatientsPenicillin G is an antibiotic used to treat bacterial infections caused by certain types of bacteria. It works by preventing the bacteria from forming their cell walls, which kills them. Penicillin G is effective against both gram-positive and gram-negative bacteria, and is resistant to many types of beta-lactamases that can break down other antibiotics.

How Penicillin G Sodium works in the bodyPenicillin G works by blocking specific proteins inside the bacterial cell wall. This stops the cell from being able to build its wall, causing it to break apart and die. Penicillin G is also believed to interfere with molecules that stop autolysis, which helps the cell wall break down even further.

When to interrupt dosage

The prescribed dose of Penicillin G Sodium is contingent upon the recognized ailment, which includes rat bite fever, Haverhill fever and Actinomycosis. The amount of dosage fluctuates as per the technique of delivery (e.g. Intramuscular; Intravenous or Injection, suspension) featured in the table beneath.

Condition

Dosage

Administration

Diphtheria

, 5000000.0 [iU], 20000000.0 [iU], 5000000.0 [USP'U], 1200000.0 [iU]/mL, 5000000.0 units, 1000000.0 units, 10000000.0 units, 500000.0 units, 600000.0 [iU]/mL, 2400000.0 [iU]/mL, 100000.0 [iU]/mL, 200000.0 [iU]/mL, 300000.0 [iU]/mL, 1000000.0 [iU], 900000.0 [iU]/mL, 500000.0 units/mL, 1200000.0 units/mL, 250000.0 units/mL, 900000.0 units/mL, 300000.0 units/mL

, Intramuscular; Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intramuscular; Intravenous, Injection, suspension, Injection, suspension - Intramuscular, Intramuscular, Intramuscular; Intrapleural; Intrathecal; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intrapleural; Intrathecal; Intravenous, Intravenous, Powder, for solution - Intravenous, Powder, for solution - Intramuscular; Intravenous, Intramuscular; Intravenous; Topical, Powder, for solution - Intramuscular; Intravenous; Topical, Oral, Tablet - Oral, Tablet, Suspension - Intramuscular, Suspension, Suspension - Oral, Powder, for solution - Intramuscular, Injection, solution, Injection, solution - Intravenous, Injection, powder, for solution - Intravenous

Pericarditis

Haverhill fever

Acute Rheumatic Fever

Endocarditis

Gas Gangrene

Botulism

Lockjaw

Bacterial Meningitis

Pneumonia

Syphilis

Endocarditis

Gonorrhea

Actinomycosis

Communicable Diseases

Listeriosis

Fusospirochetosis

rat bite fever

Meningitis, Meningococcal

Gram-Negative Bacterial Infections

Warnings

Penicillin G Sodium has one contraindication and should not be administered together with any of the conditions listed in the below table.Penicillin G Sodium Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Benzylpenicillin may interact with Pulse Frequency

There are 20 known major drug interactions with Penicillin G Sodium.

Common Penicillin G Sodium Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Benzylpenicillin.

Adefovir dipivoxil

Minor

The excretion of Adefovir dipivoxil can be decreased when combined with Benzylpenicillin.

Chlormadinone

Minor

The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Benzylpenicillin.

Cidofovir

Minor

The excretion of Cidofovir can be decreased when combined with Benzylpenicillin.

Cloprostenol

Minor

The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Benzylpenicillin.

Penicillin G Sodium Toxicity & Overdose RiskThe toxic dose of cephalosporin in rats is 8900 mg/kg. Taking too much can lead to seizures, a decrease in white blood cells, and other neurological reactions. If cephalosporin is taken for more than two weeks at high doses, it can also cause a drop in the number of neutrophils in the blood.

Penicillin G Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Penicillin G Sodium?

85 active clinical trials are assessing the potential of Penicillin G Sodium in treating Pneumonia, Acute Rheumatic Fever and Gram-Negative Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Pneumonia

22 Actively Recruiting

Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 1

Lockjaw

1 Actively Recruiting

Phase 4

Bacterial Meningitis

0 Actively Recruiting

Botulism

2 Actively Recruiting

Phase 1, Phase 2

Communicable Diseases

0 Actively Recruiting

Acute Rheumatic Fever

0 Actively Recruiting

Fusospirochetosis

0 Actively Recruiting

Meningitis, Meningococcal

0 Actively Recruiting

Anthrax

1 Actively Recruiting

Phase 2

Gram-Negative Bacterial Infections

1 Actively Recruiting

Phase 2

Gas Gangrene

0 Actively Recruiting

Empyema

0 Actively Recruiting

Listeriosis

0 Actively Recruiting

Actinomycosis

0 Actively Recruiting

Diphtheria

1 Actively Recruiting

Phase 4

rat bite fever

0 Actively Recruiting

Endocarditis

0 Actively Recruiting

Pericarditis

0 Actively Recruiting

Endocarditis

1 Actively Recruiting

Not Applicable

Sepsis

1 Actively Recruiting

Not Applicable

Penicillin G Sodium Reviews: What are patients saying about Penicillin G Sodium?

4Patient Review

6/12/2009

Penicillin G Sodium for Bacterial Pneumonia caused by Streptococcus

The needle is quite long, but it does the job. I was a bit sore afterward, but nothing too bad.

1Patient Review

10/2/2013

Penicillin G Sodium for Pus in Lungs caused by Bacteria Clostridium Perfringens

This caused me to stop breathing and cough while I was in the hospital.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about penicillin g sodium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is penicillin G sodium used for?

"Penicillin G sodium is an antibiotic used to treat severe infections, such as strep throat, meningitis, anthrax, pneumonia, gonorrhea, and syphilis."

Answered by AI

What does penicillin G contain?

"Penicillin G potassium is a natural penicillin. Its chemical designation is 4-Thia-1- azabicyclo[3.2. 0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-, monopotassium salt, [2S-(2α, 5α, 6β)]. It is crystalline."

Answered by AI

What is penicillin G sodium salt?

"Penicillin G Sodium is the sodium salt form of benzylpenicillin, a broad-spectrum penicillin antibiotic with bactericidal activity. Benzylpenicillin sodium binds to and inactivates penicillin-binding proteins located on the bacterial cell wall."

Answered by AI

What is the difference between penicillin G potassium and penicillin G sodium?

"Penicillin G Sodium is usually given to patients who can't take Penicillin G Potassium (for example, patients with kidney problems). Most patients who need penicillin given by injection can take Penicillin G Potassium, which is not in short supply."

Answered by AI

Clinical Trials for Penicillin G Sodium

Image of Public Health Sexual Health Clinic in Seattle, United States.

Have you considered Penicillin G Sodium clinical trials? We made a collection of clinical trials featuring Penicillin G Sodium, we think they might fit your search criteria.

Image of Ronald Reagan UCLA Medical Center in Los Angeles, United States.

Next Day Clinic for Patient Care

18+

All Sexes

Los Angeles, CA

"This trial is about a new clinic called the Next Day Clinic (NDC) that will be run by UCLA Health starting in July 2024. The clinic aims to improve patient care and safety while

Recruiting

Has No Placebo

Ronald Reagan UCLA Medical Center

Image of Geisinger 65-Forward, Buckhorn in Bloomsburg, United States.

Osteopathic Manipulative Therapy for Respiratory Diseases

65 - 100

All Sexes

Bloomsburg, PA

This trial aims to investigate whether Osteopathic Manipulative Therapy (OMT) can help patients with respiratory illnesses and their symptoms. The study will see if adding OMT to standard care can reduce symptoms

Waitlist Available

Has No Placebo

Geisinger 65-Forward, BuckhornMargaret Moore, DO

Image of Boston Medical Center in Boston, United States.

Recovery Management Checkups for Opioid Use Disorder

18 - 65

All Sexes

Boston, MA

This trial is testing a new version of a treatment program for opioid use disorder (OUD) called Recovery Management Checkups (RMC) that is tailored for people who have been hospitalized with serious injection

Waitlist Available

Has No Placebo

Boston Medical CenterSimeon Kimmel, MD

Antibody Test for Syphilis

Any Age

All Sexes

Ottawa, Canada

"This trial is testing a new syphilis antibody test called the Multiplo Complete Syphilis Antibody Test in an urban STI clinic. They will be using a finger-prick blood sample to

Waitlist Available

Has No Placebo

Sexual Health ClinicPatrick O'Byrne, PhDMedMira Laboratories Inc.

Have you considered Penicillin G Sodium clinical trials? We made a collection of clinical trials featuring Penicillin G Sodium, we think they might fit your search criteria.

Image of Harborview Medical Center in Seattle, United States.

Mobile Clinic Services for Women Who Inject Drugs

18+

All Sexes

Seattle, WA

This trial will set up a pop-up clinic in a van near areas where women who inject drugs gather in north Seattle. The clinic will offer HIV prevention medication, opioid use disorder medication, and testing for

Recruiting

Has No Placebo

Harborview Medical CenterMaria Corcorran, MD, MPH

Image of California Department of Public Health in Richmond, United States.

Botulinum Vaccine for Botulism

18 - 69

All Sexes

Richmond, CA

This trial will test safety, tolerability, and effectiveness of a botulinum vaccine in healthy participants, with a 6-month follow-up.

Phase 2

Waitlist Available

Has No Placebo

California Department of Public Health

Image of University of Utah in Salt Lake City, United States.

Antibiotic Stewardship at Discharge for Pneumonia

18+

All Sexes

Salt Lake City, UT

This trial will test if an antibiotic stewardship approach tailored to a hospital's needs can reduce antibiotic overuse at discharge in hospitalized patients with CAP or UTI.

Waitlist Available

Has No Placebo

University of UtahValerie M Vaughn, MD

Image of University of Michigan in Ann Arbor, United States.

Motivational Interviewing for STI Screening

18+

All Sexes

Ann Arbor, MI

This trial will investigate if gay/bi men w/ HIV are willing to collect & return bacterial STI specimens for testing when combined with live AV conferencing support, to prevent health complications & reduce transmissions.

Waitlist Available

Has No Placebo

University of MichiganAkshay Sharma, PhD

Have you considered Penicillin G Sodium clinical trials? We made a collection of clinical trials featuring Penicillin G Sodium, we think they might fit your search criteria.