Your session is about to expire
What is Pexeva
ParoxetineThe Generic name of this drug
Treatment SummaryParoxetine, also known as Paxil, is an antidepressant drug used to treat a variety of conditions, including anxiety disorders, depression, post-traumatic stress disorder, and menopausal symptoms. It is part of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs) and works by blocking the absorption of serotonin. Paroxetine is generally well-tolerated but can cause withdrawal effects if stopped abruptly. There is also a controlled release version of paroxetine that is designed to reduce the risk of nausea.
Paxilis the brand name
Pexeva Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Paxil
Paroxetine
1993
429
Approved as Treatment by the FDA
Paroxetine, also known as Paxil, is approved by the FDA for 3 uses which include Vasomotor Symptoms Associated With Menopause and Hot flashes .Vasomotor Symptoms Associated With Menopause
Helps manage Vasomotor Symptoms Associated With Menopause
Hot flashes
Helps manage Menopause
Hot Flashes
Helps manage Vasomotor Symptoms Associated With Menopause
Effectiveness
How Pexeva Affects PatientsParoxetine is a drug used to treat depression, anxiety, post-traumatic stress disorder, obsessive-compulsive disorder, and the hot flashes of menopause. It works by blocking the reuptake of serotonin. The effects of paroxetine are usually seen within 6 weeks. It is not recommended to take paroxetine with certain other medications called monoamine oxidase inhibitors (MAOIs) because it can cause a serious reaction called serotonin syndrome. If you do take MAOIs, it is important to wait 2 weeks before taking paroxetine.
How Pexeva works in the bodyParoxetine works by blocking the reuptake of serotonin into the brain, allowing more serotonin to remain in the gaps between neurons. This boosts serotonin levels in the brain, which helps relieve various symptoms. Paroxetine is more effective at blocking serotonin reuptake than other drugs in its class. We don't know exactly how it works to relieve menopausal symptoms, but it may have something to do with how it affects body temperature. Paroxetine also has a very small effect on other types of receptors in the brain, such as adrenergic and dopamine receptors, as well as serotonin receptors. This drug also has an
When to interrupt dosage
The amount of Pexeva is dependent on the diagnosed condition, such as Post Traumatic Stress Disorder, Depression and Irritable Bowel Syndrome (IBS). The dosage also shifts according to the mode of administration (e.g. Oral or Capsule - Oral) shown in the table beneath.Condition
Dosage
Administration
Generalized Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Irritable Bowel Syndrome
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Depression
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot Flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Premature Ejaculation
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Panic Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Social Anxiety Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Obsessive-Compulsive Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Hot flashes
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Post Traumatic Stress Disorder
, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 12.5 mg, 25.0 mg, 37.5 mg, 7.5 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, extended release - Oral, Tablet, extended release, Capsule, Capsule - Oral, Suspension, Suspension - Oral
Warnings
Pexeva has five contraindications and should not be taken when encountering conditions in the following table.Pexeva ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Serotonin Syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Paroxetine may interact with Pulse Frequency
Common Pexeva Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Paroxetine.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Paroxetine.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Paroxetine.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Paroxetine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Paroxetine is combined with Aclidinium.
Pexeva Toxicity & Overdose RiskThe most toxic dose of paroxetine in mice and rats is 350 mg/kg. The smallest overdose of paroxetine that has ever been fatal is 400 mg. The highest reported paroxetine overdose from which a person has survived is 2,000 mg. Common side effects in an overdose include feeling tired, fever, high blood pressure, fast heartbeat, nausea, vomiting, drowsiness, shaking, dizziness, restlessness, anxiety, headache, sweating, dilated pupils, shaking or twitching muscles, and changes in mental state. There is no specific treatment for a paroxetine overdose.
Pexeva Novel Uses: Which Conditions Have a Clinical Trial Featuring Pexeva?
There are 539 active studies assessing the potential of Pexeva in providing relief from Post Traumatic Stress Disorder, Premature Ejaculation and Menopause symptoms.Condition
Clinical Trials
Trial Phases
Depression
198 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 1, Early Phase 1, Phase 3
Social Anxiety Disorder
18 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Generalized Anxiety Disorder
2 Actively Recruiting
Not Applicable
Obsessive-Compulsive Disorder
17 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 1
Post Traumatic Stress Disorder
237 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1
Panic Disorder
9 Actively Recruiting
Not Applicable, Phase 2
Irritable Bowel Syndrome
8 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Early Phase 1
Hot Flashes
0 Actively Recruiting
Premature Ejaculation
0 Actively Recruiting
Hot flashes
15 Actively Recruiting
Phase 1, Not Applicable, Early Phase 1, Phase 2, Phase 4
Pexeva Reviews: What are patients saying about Pexeva?
5Patient Review
1/28/2011 I'm on a low dose of this medication, but it seems to be working well for me. I haven't experienced any negative side effects and my doctor also has me taking buspar twice daily to help with that.
5Patient Review
4/11/2011 Pexeva has helped me so much that I cannot imagine living without it. It's improved my quality of life to such a degree that I will take it for the rest of my days.
5Patient Review
2/22/2011 I found that taking just a quarter of the pill was perfect for me. I didn't feel drowsy or have any negative emotions. However, twice I forgot to take the pill and felt very bad as a result.
5Patient Review
6/9/2011 Pexeva has been the most effective drug I've taken for my various mental disorders. It doesn't completely cure me, but it makes living with them much more tolerable. I haven't had any negative side effects from this medication, which is in contrast to other drugs I've tried for these conditions.
5Patient Review
4/12/2014 This drug has been effective for me and I am very pleased with the results.
Patient Q&A Section about pexeva
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the difference between Paxil and pexeva?
"Pexeva is used to treat generalize anxiety disorder (GAD), major depressive disorder (MDD), obsessive compulsive disorder (OCD), and panic disorder (PD). Paxil is also used for the same conditions, with the addition of post-traumatic stress disorder (PTSD) and social anxiety disorder."
Answered by AI
What is pexeva used for?
"Paroxetine is a drug used to treat various mental disorders by restoring the balance of serotonin in the brain. Paroxetine is classified as a selective serotonin reuptake inhibitor (SSRI) drug."
Answered by AI
How long does it take pexeva to work?
"It typically takes four to six weeks for paroxetine to take full effect. If you have been prescribed paroxetine to treat depression or anxiety, you may notice some improvements in your energy, appetite, and sleep patterns within the first two weeks of use."
Answered by AI
Does pexeva cause weight gain?
"and fluoxetine (Prozac, Sarafem).
The SSRIs that are most commonly prescribed for depression can cause weight gain if they are used for a long period of time. These SSRIs are paroxetine and fluoxetine."
Answered by AI