Phrenilin

Inadequate analgesia, Tension-Type Headache

Treatment

3 FDA approvals

0 Active Studies for Phrenilin

What is Phrenilin

Butalbital

The Generic name of this drug

Treatment Summary

Acetaminophen, also known as Tylenol, is one of the most widely used pain relievers and fever reducers. It is available in different forms like syrup, regular tablets, effervescent tablets, injections, and suppositories. It is also commonly mixed with other drugs in over-the-counter medications such as cold and allergy remedies, sleep aids and pain relievers. It is important to take acetaminophen as directed because taking too much can lead to fatal overdoses or liver failure.

Fiorinal

is the brand name

image of different drug pills on a surface

Phrenilin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Fiorinal

Butalbital

1976

283

Approved as Treatment by the FDA

Butalbital, also known as Fiorinal, is approved by the FDA for 3 uses such as Tension-Type Headache and Tension Headache .

Tension-Type Headache

Used to treat Tension Headache in combination with Acetaminophen

Tension Headache

Used to treat Tension Headache in combination with Acetaminophen

Inadequate analgesia

Used to treat Inadequate analgesia in combination with Acetaminophen

Effectiveness

How Phrenilin Affects Patients

Acetaminophen is a pain and fever reliever that has been proven to work in both animals and humans. Unlike other drugs in its class, acetaminophen does not increase the amount of uric acid in the body or disturb the body's acid-base balance when taken at the recommended dosage. It also does not have any effect on blood clotting or platelet aggregation. Rarely, people may experience an allergic reaction to acetaminophen.

How Phrenilin works in the body

Acetaminophen works to reduce pain, but the exact mechanism is unknown. It is believed to block two types of cyclooxygenase, which are enzymes responsible for producing prostaglandins which cause pain. It does not seem to block these enzymes in peripheral tissues, so it does not have anti-inflammatory effects. Acetaminophen may also block a different type of cyclooxygenase, called COX-3. Its antipyretic actions are thought to be due to direct action on heat-regulating centers in the brain, resulting in increased sweating and reduced body heat.

When to interrupt dosage

The recommended measure of Phrenilin relies upon the identified condition, including Pain, Spasm and Inflammation. The quantity of dosage is contingent upon the technique of administration featured in the table beneath.

Condition

Dosage

Administration

Tension-Type Headache

, 50.0 mg, 5.0 mg/mL, 25.0 mg, 25.0 mg/mg

Capsule, Tablet, , Oral, Tablet - Oral, Capsule - Oral, Syrup, Syrup - Oral, Tablet, coated - Oral, Tablet, coated

Inadequate analgesia

, 50.0 mg, 5.0 mg/mL, 25.0 mg, 25.0 mg/mg

Capsule, Tablet, , Oral, Tablet - Oral, Capsule - Oral, Syrup, Syrup - Oral, Tablet, coated - Oral, Tablet, coated

Warnings

Phrenilin has three contraindications and should be avoided if any of the conditions in the below table are present.

Phrenilin Contraindications

Condition

Risk Level

Notes

Porphyrias

Do Not Combine

Post-Tonsillectomy

Do Not Combine

Porphyrias

Do Not Combine

post-adenoidectomy

Do Not Combine

There are 20 known major drug interactions with Phrenilin.

Common Phrenilin Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Butalbital.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Butalbital.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Butalbital.

Alpelisib

Major

The metabolism of Alpelisib can be increased when combined with Butalbital.

Amiodarone

Major

The metabolism of Amiodarone can be increased when combined with Butalbital.

Phrenilin Toxicity & Overdose Risk

The toxic dose of acetaminophen in mice is 338mg/kg and 1944mg/kg in rats. Overdoses may cause kidney or liver damage, low blood sugar, and a decrease in blood cells. Long-term studies have shown an increased risk of leukemia in female rats, but no similar risk has been found in humans. Acetaminophen has not been found to cause mutations in bacteria, but it has been found to be clastogenic or disrupt chromosomes at very high doses. There have been no studies on its effects on fertility, but it is considered a category C drug in pregnancy and can be found in small amounts

image of a doctor in a lab doing drug, clinical research

Phrenilin Novel Uses: Which Conditions Have a Clinical Trial Featuring Phrenilin?

698 active trials are being conducted to evaluate the potential of Phrenilin in providing relief from Chronic Pain, Rheumatoid Arthritis and Allergies.

Condition

Clinical Trials

Trial Phases

Inadequate analgesia

0 Actively Recruiting

Tension-Type Headache

0 Actively Recruiting

Phrenilin Reviews: What are patients saying about Phrenilin?

5

Patient Review

8/2/2010

Phrenilin for Tension Headache

This medication has been a godsend. For years I've suffered from tension headaches and migraines, but this treatment really helps me get through the day.

5

Patient Review

11/20/2013

Phrenilin for Tension Headache

I have to eat after I swallow the pills or else I become nauseated. Even so, it's a very effective medication that unfortunately happens to be quite expensive.

5

Patient Review

1/14/2013

Phrenilin for Tension Headache

This medication was great for my migraines!

4.7

Patient Review

12/18/2008

Phrenilin for Tension Headache

This is the only medication I've found that helps with my migraines. I need to take it every four hours, but it's worth it for the relief.

4.3

Patient Review

9/26/2007

Phrenilin for Tension Headache

This medication is one of the only kinds that doesn't trigger my allergies, and it does provide some measure of relief from tension headaches and neck pain. That said, it can make me pretty drowsy so I generally avoid taking it when I have to work or be alert.

4

Patient Review

6/11/2009

Phrenilin for Tension Headache

This medication has been a lifesaver for me. I have a combination of tension and migraine headaches, and this is one of the only things that has given me relief. It works quickly and doesn't make me drowsy or unsteady, which is great because I can take it at work.

4

Patient Review

11/9/2008

Phrenilin for Tension Headache

I've been taking this medication for a while now and it's really helped. Not only does it help with my back pain, but I can also take it without feeling nauseous. In my opinion, this is the best option out there.

Patient Q&A Section about phrenilin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Butal make you sleepy?

"Jun 1, 2022 Although barbiturates such as butalbital often cause drowsiness, some children become excited after taking them."

Answered by AI

Is Phrenilin available?

"The Phrenilin drug has been discontinued and is no longer being sold in the United States. If the FDA has approved generic versions of this drug, there may be generic equivalents available from other manufacturers."

Answered by AI

How does butalbital make you feel?

"Butalbital produces a feeling of euphoria that is associated with feeling relaxed and almost as if one is intoxicated on alcohol."

Answered by AI

What is Phrenilin used for?

"This medication is used to treat tension headaches by combining acetaminophen to decrease pain with butalbital, a sedative that decreases anxiety and causes sleepiness and relaxation."

Answered by AI