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What is Plavix
ClopidogrelThe Generic name of this drug
Treatment SummaryClopidogrel is a medication used to reduce the risk of heart attack and stroke in people with non-ST elevated acute coronary syndrome, people with ST-elevated myocardial infarction, and people with recent or established peripheral arterial disease. It is more effective than aspirin at reducing cardiovascular outcomes in people with cardiovascular disease and it provides additional benefits for those who are already taking aspirin. Clopidogrel was approved by the FDA in 1997.
Plavixis the brand name
Plavix Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Plavix
Clopidogrel
1900
178
Approved as Treatment by the FDA
Clopidogrel, commonly known as Plavix, is approved by the FDA for 19 uses including elegible for thrombolytic therapy and Peripheral Arterial Disease (PAD) .elegible for thrombolytic therapy
Used to treat elegible for thrombolytic therapy in combination with Acetylsalicylic acid
Peripheral Arterial Disease (PAD)
ST Segment Elevation Myocardial Infarction (STEMI)
Unstable Angina Pectoris
Atrial Fibrillation
Non ST Segment Elevation Myocardial Infarction (NSTEMI)
Acute Myocardial Infarction (AMI)
Used to treat Acute Myocardial Infarction (AMI) in combination with Acetylsalicylic acid
Acute Coronary Syndrome (ACS)
Used to treat Acute Coronary Syndrome (ACS) in combination with Acetylsalicylic acid
Cardiovascular Events
Stroke
prophylaxis of cardiovascular event
Heart Attack
Used to treat Acute Myocardial Infarction (AMI) in combination with Acetylsalicylic acid
Heart Attack
Angina, Unstable
Peripheral Arterial Disease
atherothrombotic events
Used to treat atherothrombotic events in combination with Acetylsalicylic acid
Myocardial Infarction
Atrial Fibrillation
Acute Chest Syndrome
Used to treat Acute Coronary Syndrome (ACS) in combination with Acetylsalicylic acid
Effectiveness
How Plavix Affects PatientsClopidogrel is a medication that helps protect against heart attack and stroke. It is usually taken once a day, and the recommended dose is between 75-300mg. This drug has a long lasting effect and a wide range of safe doses.
How Plavix works in the bodyClopidogrel stops platelets from clumping together. It does this by binding to the ADP receptor on platelets, preventing them from receiving signals to form clumps. This binding is irreversible, so the platelets stay blocked from clumping together.
When to interrupt dosage
The prescribed dosage of Plavix is contingent upon the diagnosed state, including Myocardial Infarction, Cardiovascular Events and Heart Attack. The dose may vary as per the method of delivery (e.g. Tablet - Oral or Tablet, film coated - Oral) indicated in the table below.Condition
Dosage
Administration
Atrial Fibrillation
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Angina, Unstable
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Heart Attack
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
prophylaxis of cardiovascular event
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Peripheral Arterial Disease
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Acute Chest Syndrome
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Stroke
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Cardiovascular Events
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Myocardial Infarction
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Heart Attack
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
elegible for thrombolytic therapy
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
atherothrombotic events
75.0 mg, , 300.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit
Warnings
Plavix ContraindicationsCondition
Risk Level
Notes
Hemorrhage
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Clopidogrel may interact with Pulse Frequency
Common Plavix Drug Interactions
Drug Name
Risk Level
Description
Abrocitinib
Major
The risk or severity of bleeding and thrombocytopenia can be increased when Clopidogrel is combined with Abrocitinib.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Clopidogrel.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Clopidogrel.
Amodiaquine
Major
The metabolism of Amodiaquine can be decreased when combined with Clopidogrel.
Anastrozole
Major
The metabolism of Anastrozole can be decreased when combined with Clopidogrel.
Plavix Toxicity & Overdose RiskClopidogrel is toxic to mice, rats, and baboons in doses of 1500-3000mg/kg. Symptoms of overdose include vomiting, difficulty breathing, gastrointestinal bleeding, and weakness. Clopidogrel binds to platelets and remains there for 11 days, meaning it cannot be removed from the bloodstream. Platelet transfusions may be used to restore the body's ability to clot if an overdose occurs.
Plavix Novel Uses: Which Conditions Have a Clinical Trial Featuring Plavix?
245 active trials are currently underway to explore the potential of Plavix in providing relief from Peripheral Arterial Disease, Acute Chest Syndrome and Heart Attack.Condition
Clinical Trials
Trial Phases
Atrial Fibrillation
90 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Angina, Unstable
2 Actively Recruiting
Not Applicable
Heart Attack
7 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Myocardial Infarction
3 Actively Recruiting
Not Applicable, Phase 4
elegible for thrombolytic therapy
0 Actively Recruiting
Cardiovascular Events
5 Actively Recruiting
Not Applicable
Acute Chest Syndrome
3 Actively Recruiting
Not Applicable, Phase 2
atherothrombotic events
0 Actively Recruiting
Stroke
9 Actively Recruiting
Phase 4, Not Applicable, Phase 1
prophylaxis of cardiovascular event
0 Actively Recruiting
Peripheral Arterial Disease
36 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1, Early Phase 1
Heart Attack
7 Actively Recruiting
Not Applicable, Phase 4, Phase 3
Plavix Reviews: What are patients saying about Plavix?
5Patient Review
2/17/2016 I took this medication for 14 months before I started bleeding from my large intestine. It was a close call, but I required 3 pints of blood and 2 saline solutions to get back to normal. This drug is very dangerous and it nearly killed me.
5Patient Review
1/3/2017 I began this treatment in December 2015 and have since then lost eyebrows and body hair, as well as experiencing thinning hair that doesn't grow back after waxing.
5Patient Review
3/2/2020 I unfortunately had a very negative reaction to Plavix and developed drug-induced Lupus. I constantly feel flu-like, with chills, fatigue, and general malaise.
5Patient Review
12/15/2020 I don't know what color this is, but it really helped me.
5Patient Review
7/5/2017 I felt really fuzzy and confused after taking this medication, and it didn't feel right.
Patient Q&A Section about plavix
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are Plavix side effects?
"Bleeding that takes a long time to stop, nosebleeds, more frequent bruising, fever, muscle pain, confusion, skin rash, or itching may be signs of a problem."
Answered by AI
Is Plavix a blood thinner?
"Plavix, also known as clopidogrel, is a blood thinner that reduces the risk of blood clots. It was first approved by the FDA in 1997 and is prescribed to people who have a higher risk of cardiovascular problems, such as heart attacks or strokes."
Answered by AI
Is Plavix a blood thinner or antiplatelet?
"Clopidogrel is a medication that prevents your platelets from clumping together. By doing this, it lowers the risk of heart attack since most heart attacks are caused by a clot forming in the vessels supplying your heart."
Answered by AI
Is Plavix a strong blood thinner?
"Plavix, also known as clopidogrel, is a blood thinner that was first approved by the FDA in 1997. It is prescribed to people who have a higher risk of cardiovascular problems, such as heart attacks or strokes, in order to reduce the risk of blood clots."
Answered by AI
What is the drug Plavix used for?
"Clopidogrel is used to prevent heart attacks, strokes, and blood circulation disease in people who have heart disease, a recent heart attack, or a recent stroke."
Answered by AI