Behavioural Intervention
Brain Stimulation for Schizophrenia
Recruiting0 awards8 criteria
Sacramento, California
This trial is testing whether a small electrical current to the forehead can help improve thinking skills in people with schizophrenia. The study will see if doing this during tasks or at rest makes a difference, and if targeting the front or back of the head is more effective. It also looks at changes in a brain chemical important for thinking. This method has been shown to enhance cognitive performance in both healthy individuals and patients with schizophrenia.
Behavioral Intervention
Cognitive Behavioral Therapy for Serious Mental Illness-related Chronic Pain
Recruiting1 award7 criteria
Baltimore, Maryland
This trial is testing whether a therapy called CBT-CP, which is used to help manage chronic pain, is feasible and acceptable to Veterans with SMI, and if it is worth examining in a larger clinical trial.
Monoclonal Antibodies
Ocrelizumab for Psychosis
Recruiting1 awardPhase 1 & 2
Houston, Texas
This trial is investigating whether some people diagnosed with schizophrenia or bipolar disorder may actually have a brain disease caused by auto-antibodies. These auto-antibodies attack brain receptors, leading to symptoms
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Trials for Schizoaffective Disorder Patients
Bromocriptine for Schizophrenia and Diabetes-Related Issues
Recruiting5 awardsPhase 4
Pittsburgh, Pennsylvania
This trial is testing whether bromocriptine, a drug that affects dopamine and serotonin levels, is a safe and tolerable way to improve glucose tolerance and insulin resistance in people with schizophrenia who are also taking antipsychotic drugs.
Behavioural Intervention
Visual Perceptual Remediation for Schizophrenia
Recruiting1 award
Rochester, New York
This trial will evaluate the effectiveness of different interventions targeting visual functions that are often impaired in people with schizophrenia. The study will compare the effects of the interventions to a control condition of higher-level cognitive remediation. Outcome measures include multiple aspects of visual functioning, as well as visual cognition and overall community functioning.
Diet and Exercise for Schizophrenia
Recruiting1 award4 criteria
Aurora, Colorado
This trial will study how drugs for schizophrenia can lead to weight gain, and how diet and exercise may help. They will look at how people's brains react to food, and ask about eating habits and symptoms. Some participants may do an exercise or diet intervention.
Trials for First Episode Psychosis Patients
Bromocriptine for Schizophrenia and Diabetes-Related Issues
Recruiting5 awardsPhase 4
Pittsburgh, Pennsylvania
This trial is testing whether bromocriptine, a drug that affects dopamine and serotonin levels, is a safe and tolerable way to improve glucose tolerance and insulin resistance in people with schizophrenia who are also taking antipsychotic drugs.
Diet and Exercise for Schizophrenia
Recruiting1 award4 criteria
Aurora, Colorado
This trial will study how drugs for schizophrenia can lead to weight gain, and how diet and exercise may help. They will look at how people's brains react to food, and ask about eating habits and symptoms. Some participants may do an exercise or diet intervention.
Behavioral Intervention
Mindfulness and CBT for Preventing Severe Mental Illness in Youth
Recruiting1 award
Halifax, Nova Scotia
This trial will test a new intervention to prevent severe mental illness in young people who are at high risk. The intervention will target early preceding factors to severe mental illness, which are often impairing and distressing to the individual but can be improved with self-management skills and parent training. The goal is to intervene early enough in the young person's life that severe mental illness can be prevented.
Phase 3 Trials
Atypical Antipsychotic
Cariprazine for Pediatric Schizophrenia
Recruiting2 awardsPhase 3
Dothan, Alabama
This trial is testing the safety and effectiveness of cariprazine in children and teens with schizophrenia, bipolar I disorder, or autism. The goal is to see if the medication is safe and beneficial for use in these young patients.
KarXT for Schizophrenia
Recruiting1 awardPhase 3
Cerritos, California
This trial tests KarXT, a combination of two drugs, for people who haven't improved with their current treatment. KarXT aims to balance brain functions and reduce side effects. The study will look at improvements in health and daily life. KarXT has shown positive results in earlier tests.
Atypical Antipsychotic
OLZ/SAM for Schizophrenia
Recruiting2 awardsPhase 3
Cincinnati, Ohio
This trial evaluates the safety and tolerability of OLZ/SAM in children and adolescents with schizophrenia or Bipolar I disorder. OLZ/SAM combines olanzapine to manage symptoms and samidorphan to reduce weight gain. Olanzapine is a well-established antipsychotic effective for schizophrenia and bipolar I disorder, but its use is limited by significant weight gain; samidorphan is added to mitigate this side effect.
Trials With No Placebo
Bromocriptine for Schizophrenia and Diabetes-Related Issues
Recruiting5 awardsPhase 4
Pittsburgh, Pennsylvania
This trial is testing whether bromocriptine, a drug that affects dopamine and serotonin levels, is a safe and tolerable way to improve glucose tolerance and insulin resistance in people with schizophrenia who are also taking antipsychotic drugs.
Behavioural Intervention
Visual Perceptual Remediation for Schizophrenia
Recruiting1 award
Rochester, New York
This trial will evaluate the effectiveness of different interventions targeting visual functions that are often impaired in people with schizophrenia. The study will compare the effects of the interventions to a control condition of higher-level cognitive remediation. Outcome measures include multiple aspects of visual functioning, as well as visual cognition and overall community functioning.
Diet and Exercise for Schizophrenia
Recruiting1 award4 criteria
Aurora, Colorado
This trial will study how drugs for schizophrenia can lead to weight gain, and how diet and exercise may help. They will look at how people's brains react to food, and ask about eating habits and symptoms. Some participants may do an exercise or diet intervention.
Behavioral Intervention
Mindfulness and CBT for Preventing Severe Mental Illness in Youth
Recruiting1 award
Halifax, Nova Scotia
This trial will test a new intervention to prevent severe mental illness in young people who are at high risk. The intervention will target early preceding factors to severe mental illness, which are often impairing and distressing to the individual but can be improved with self-management skills and parent training. The goal is to intervene early enough in the young person's life that severe mental illness can be prevented.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.