Prilosec Otc

Zollinger-Ellison Syndrome, Curling Ulcer, Heartburn + 15 more
Treatment
15 FDA approvals
20 Active Studies for Prilosec Otc

What is Prilosec Otc

OmeprazoleThe Generic name of this drug
Treatment SummaryOmeprazole is a medication used to reduce the production of stomach acid in patients with gastrointestinal disorders. It was the first drug approved by the FDA in 1989 for treating gastric-acid related conditions. Omeprazole is typically used to treat gastroesophageal reflux disease (GERD) and peptic ulcer disease. It is considered a safe and effective drug that can be prescribed to both adults and children.
Prilosecis the brand name
image of different drug pills on a surface
Prilosec Otc Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prilosec
Omeprazole
1990
669

Approved as Treatment by the FDA

Omeprazole, otherwise called Prilosec, is approved by the FDA for 15 uses which include Gastro-esophageal Reflux Disease (GERD) and multiple endocrine adenomas .
Gastro-esophageal Reflux Disease (GERD)
multiple endocrine adenomas
Gastric Ulcer
Gastroesophageal Reflux
Healing
Zollinger-Ellison Syndrome
Helps manage Zollinger-Ellison Syndrome
Heartburn
Helps manage Heartburn
Stomach Ulcer
Duodenal Ulcer
Helicobacter Pylori Infection
Used to treat Helicobacter Pylori Infection in combination with Amoxicillin
Heartburn
Helps manage Heartburn
Heartburn
Erosive Esophagitis
Adenoma
Curling Ulcer

Effectiveness

How Prilosec Otc Affects PatientsOmeprazole helps decrease the amount of acid in the stomach. Its effects usually start within one hour of taking it and are strongest after two hours. Taking omeprazole once daily can increase effectiveness over time. It can also raise gastrin levels in the blood, which can lead to false positive results when testing for certain tumors. Studies of over 3,000 people taking omeprazole long-term have not shown any cases of cancer related to the drug. Omeprazole does not seem to have any effects on the nervous system, heart or lungs, and does not affect thyroid, hormone, or other bodily functions.
How Prilosec Otc works in the bodyHydrochloric acid, or stomach acid, is produced by the parietal cells of the stomach and regulated by an enzyme called the H(+)/K(+)-ATPase. Omeprazole, a type of antisecretory drug, stops stomach acid production by blocking the H+/K+ ATPase enzyme system. This effect can last up to 36 hours. Helicobacter pylori is a bacteria that is associated with peptic ulcer disease. Omeprazole can be used as part of the treatment regimen for H. pylori infection. This is because it raises the

When to interrupt dosage

The suggested dosage of Prilosec Otc is contingent upon the established condition, including Stomach Ulcer, Heartburn and Zollinger-Ellison Syndrome. The amount of dosage is contingent upon the method of delivery, as outlined in the table beneath.
Condition
Dosage
Administration
hypersecretory conditions
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Heartburn
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Rheumatoid Arthritis
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Ankylosing Spondylitis
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Heartburn
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Prophylaxis of NSAID gastric ulceration
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Mastocytosis, Systemic
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Gastroesophageal Reflux
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Stomach Ulcer
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Helicobacter Pylori Infection
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Osteoarthritis
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Zollinger-Ellison Syndrome
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Curling Ulcer
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Adenoma
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Erosive Esophagitis
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Stomach Ulcer
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Healing
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral
Peptic Ulcer
40.0 mg, , 10.0 mg, 20.0 mg, 20.6 mg, 2.5 mg
, Oral, Capsule, delayed release pellets, Capsule, delayed release pellets - Oral, Capsule, delayed release, Capsule, delayed release - Oral, Tablet, delayed release, Tablet, delayed release - Oral, Capsule, Capsule - Oral, Kit, Powder, for suspension, Powder, for suspension - Oral, Granule, delayed release, Granule, delayed release - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Delayed Release, Tablet, Delayed Release - Oral, Tablet, orally disintegrating, delayed release, Tablet, orally disintegrating, delayed release - Oral, Tablet, chewable, Tablet, chewable - Oral, Tablet, Tablet - Oral, Kit - Oral, For suspension, For suspension - Oral

Warnings

Prilosec Otc has two contraindications and should not be consumed in conjunction with the conditions noted in the following table.Prilosec Otc Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Omeprazole may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Omeprazole may interact with Pulse Frequency
There are 20 known major drug interactions with Prilosec Otc.
Common Prilosec Otc Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Omeprazole.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Omeprazole.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Omeprazole.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Omeprazole.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Omeprazole.
Prilosec Otc Toxicity & Overdose RiskThe toxic dose of omeprazole for rats is 2210mg/kg and 4000mg/kg in mice. Overdosing can cause confusion, drowsiness, blurred vision, rapid heartbeat, nausea, sweating, flushing, headache, and dry mouth. Long-term use of omeprazole in rats has been linked to an increased risk of gastric cancer and abnormal cell growth. Omeprazole can be found in breast milk, but it is unknown how this may affect an infant. Studies have shown that omeprazole does not have an effect on fertility or reproduction in rats.
image of a doctor in a lab doing drug, clinical research

Prilosec Otc Novel Uses: Which Conditions Have a Clinical Trial Featuring Prilosec Otc?

96 active clinical trials are currently being conducted to assess the potential of Prilosec OTC to combat Rheumatoid Arthritis, Acid-mediated Gastroesophageal Reflux Disease (GERD) and Curling Ulcer.
Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
54 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Heartburn
12 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Gastroesophageal Reflux
0 Actively Recruiting
Prophylaxis of NSAID gastric ulceration
0 Actively Recruiting
Mastocytosis, Systemic
0 Actively Recruiting
hypersecretory conditions
0 Actively Recruiting
Stomach Ulcer
2 Actively Recruiting
Phase 4, Not Applicable
Erosive Esophagitis
2 Actively Recruiting
Phase 2, Phase 3
Helicobacter Pylori Infection
2 Actively Recruiting
Not Applicable, Phase 4
Ankylosing Spondylitis
3 Actively Recruiting
Phase 3, Not Applicable
Stomach Ulcer
0 Actively Recruiting
Heartburn
2 Actively Recruiting
Phase 3, Not Applicable
Zollinger-Ellison Syndrome
0 Actively Recruiting
Osteoarthritis
0 Actively Recruiting
Curling Ulcer
0 Actively Recruiting
Peptic Ulcer
0 Actively Recruiting
Adenoma
0 Actively Recruiting
Healing
0 Actively Recruiting

Prilosec Otc Reviews: What are patients saying about Prilosec Otc?

5Patient Review
11/11/2014
Prilosec Otc for Stomach Ulcer from Aspirin or Ibuprofen-Like Drugs
I had a really severe case of Barret's esophagus, but after eight to ten endoscopies with ablation, I'm now cell-free. I still take the medication twice a day, but I'm wondering if it's safe to do so.
5Patient Review
11/18/2017
Prilosec Otc for Heartburn
I've been taking this for two decades now. It's the only thing that really helps with my indigestion and heartburn. I find it starts working on me within half an hour, which is much quicker than the commercials claim.
5Patient Review
11/28/2013
Prilosec Otc for Treatment to Prevent Heartburn
I have had great success in managing my heartburn by taking two Prilosec pills in the morning and two more in the evening. My doctor says that, on a molecular level, this is equivalent to taking Nexium minus one molecule.
5Patient Review
6/14/2013
Prilosec Otc for Condition in which Stomach Acid is Pushed Into the Esophagus
5Patient Review
11/9/2017
Prilosec Otc for Heartburn
I've been taking this medication for a little under two weeks now for gastritis caused by a stomach flu. There's definitely been slow and gradual improvement, but some days I feel like I'm back at square one. Here's hoping that by the end of the month-long course it prescribed, I'll be feeling much better.
4.7Patient Review
11/26/2018
Prilosec Otc for Inflammation of the Esophagus with Erosion
I've been using this medication for years now, and it has really helped me with my swallowing problem. However, I have recently developed a dry mouth and throat. The manufacturer told me that the 14-day advertised limit is only because that's the extent of its clinical trials. My doctor advises 'permanent' dosing no problem. We'll see, as eliminating swallowing problem is worth some side effects.
4.7Patient Review
10/18/2013
Prilosec Otc for Conditions of Excess Stomach Acid Secretion
This pill has saved me from daily bouts of heartburn, nausea, vomiting. But I have recently been diagnosed with Osteoporosis. I don't know if it is from taking Prilosec as I have been told by a relative, happens when taking the pill.
4Patient Review
2/2/2014
Prilosec Otc for Conditions of Excess Stomach Acid Secretion
I was hospitalized with interstitial nephritis, and this treatment really helped me recover.
3.7Patient Review
10/1/2016
Prilosec Otc for Inflammation of the Esophagus with Erosion
I was taking 20 mg. of Prilosec as needed for the past six months, but my doctor increased it to 40 mg./day. After only two weeks of this dosage, I had a headache every day and felt like there was a lump in my throat. By the end of the two weeks, I felt like someone was choking me and my symptoms got much worse.
3.7Patient Review
1/9/2017
Prilosec Otc for Condition in which Stomach Acid is Pushed Into the Esophagus
I recently developed chronic diarrhea and have been struggling with it for the last six months. In the last month, I've lost fifteen pounds despite having a good appetite. No matter what I eat, it seems to just come right back out.
3.3Patient Review
8/28/2013
Prilosec Otc for Treatment to Prevent Heartburn
2.3Patient Review
7/3/2014
Prilosec Otc for Condition in which Stomach Acid is Pushed Into the Esophagus
I take Prilosec for a chronic cough, which developed into atelectasis. I have a tremor and have difficulty writing. Is there a substitute????
1.7Patient Review
6/23/2020
Prilosec Otc for Excessive Production of Stomach Acid
After using this treatment for ten years, I developed chronic kidney disease. Definitely would not recommend it to others.
1Patient Review
5/9/2015
Prilosec Otc for Treatment to Prevent Heartburn
I've been taking this medication for over five years now, and it doesn't help me at all anymore.
1Patient Review
8/19/2016
Prilosec Otc for Condition in which Stomach Acid is Pushed Into the Esophagus
I'm not sure when the best time to take this medication is.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about prilosec otc

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are side effects of Prilosec OTC?

"or, jaundice (yellowing of the skin or eyes).

You may have a serious reaction to ibuprofen if you experience severe stomach pain, watery or bloody diarrhea, new or unusual pain in your wrist, thigh, hip, or back, or a seizure. Kidney problems can also occur, manifesting as fever, rash, nausea, loss of appetite, joint pain, urinating less than usual, blood in your urine, or weight gain. Jaundice (yellowing of the skin or eyes) is another possible symptom of a serious reaction to ibuprofen."

Answered by AI

Why is Prilosec OTC only 14 days?

"Since Prilosec OTC works by shutting off many of the pumps that produce acid, it is not likely that you will have too little acid.

Prilosec OTC begins working on the first day of treatment, but it may take 1-4 days to reach its full effect. Taking Prilosec OTC every day for 14 days helps keep acid production under control.

Since Prilosec OTC works by shutting off pumps that produce acid, it's unlikely you'll have too little acid."

Answered by AI

Why you should not take Prilosec?

"Prilosec dangers include an increased risk of kidney disease and long-term kidney damage. A study looked at 125,000 PPI users over five years and found kidney problems developed silently in many cases. Half of those who developed chronic kidney damage never had any kidney problems before taking PPIs."

Answered by AI

What is the difference between Prilosec and Prilosec OTC?

"Both prescription Prilosec and Prilosec OTC contain the same active ingredient, omeprazole, which effectively stops acid production. Prescription Prilosec is used to treat diseases that require diagnosis and supervision by a doctor, while Prilosec OTC is only used to treat symptoms of frequent heartburn."

Answered by AI

Clinical Trials for Prilosec Otc

Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Steroids for Rheumatoid Arthritis

18+
All Sexes
Toronto, Canada
People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Our Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What We Think: We believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What We're Doing: We will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing we'll look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. We'll also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: We've already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. We've also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, we need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.
Phase 4
Waitlist Available
Sunnybrook Health Sciences Centre (+4 Sites)
Image of California Clinical Trials Medical Group in Glendale, United States.

NTR-1011 for Lupus and Rheumatoid Arthritis

18 - 75
All Sexes
Glendale, CA
This phase 1a and 1b study is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy of NTR-1011 in healthy adults and in adult patients with systemic lupus erythematosus and rheumatoid arthritis. The main goals of this study are to determine the safety profile of NTR-1011 across subcutaneous and intravenous dose levels, understand how the drug behaves in the body, characterize its biological activity through relevant pharmacodynamic markers, assess the potential for immune responses to treatment, and explore early signals of clinical benefit in autoimmune disease settings. This is a randomized, double blind, placebo controlled study that begins with a single ascending dose evaluation in healthy volunteers followed by a multiple dose assessment in patients. The design is intended to define the highest safe and well tolerated dose, establish a robust PK and PD baseline, and generate initial patient level evidence to support dose selection and advancement into subsequent clinical development.
Phase 1
Recruiting
California Clinical Trials Medical GroupHakop Gevorkyan, MDNeutrolis
Image of Weill Cornell Medical College in New York, United States.

Health Coaching for Rheumatoid Arthritis

18+
All Sexes
New York, NY
The goal of this clinical trial is to learn if peer coaching works to reduce levels of anxiety and/or depression in adults diagnosed with Rheumatoid Arthritis (RA). The main questions it aims to answer are: Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months from baseline? Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months compared to those in the control arm? Researchers will compare the peer coaching intervention to an active-control arm (where people without RA coach participants on general health and nutrition topics) to see if peer coaching works to reduce anxiety and/or depression. Participants will meet with a coach every week for 9 weeks and complete several surveys before, during and after the intervention
Recruiting
Has No Placebo
Weill Cornell Medical CollegeIris Y Navarro-Millán, MDBristol-Myers Squibb
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Image of Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016) in New York, United States.

Electromagnetic Resonance Therapy for Autoimmune Diseases

Any Age
All Sexes
New York, NY
The ImmuneNet study is a Phase I/II clinical trial sponsored by Truway Health, Inc. It will test whether gentle, low-frequency electromagnetic resonance (LF-EMR) can influence how immune cells communicate and synchronize with each other. The goal is to see if this "quantum-synaptic" signaling effect can help stabilize immune activity and reduce the number of autoimmune flare-ups in people living with conditions such as lupus, rheumatoid arthritis, or multiple sclerosis. Participants will receive either an active or a sham (placebo) LF-EMR session three times per week for twelve weeks. Each session is completely non-invasive. Blood samples will be collected to study cytokines (immune-system messenger molecules), gene-expression patterns, and electrical field coherence among immune cells. A machine-learning system will analyze these data to predict inflammation patterns and guide individualized treatment settings. All participant data will be securely recorded and time-stamped to ensure transparency and privacy. The expected outcome of the study is a measurable reduction in autoimmune flare frequency and symptom severity, along with improved understanding of how electromagnetic signaling might safely regulate immune function.
Phase 1 & 2
Waitlist Available
Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016)Gavin Solomon, President & CEOTruway Health, Inc.
Image of University of California, Irvine - UCI Medical Center in Orange, United States.

Sling-Fiber Preservation vs. Conventional POEM for Achalasia

18+
All Sexes
Orange, CA
Peroral endoscopic myotomy (POEM) is an effective, minimally invasive treatment for achalasia, offering excellent rates of symptom relief. However, a significant drawback is the high incidence of gastroesophageal reflux disease (GERD) following the procedure. One proposed technical modification, the selective preservation of the sling fibers during gastric myotomy (SFP-POEM), may reduce this risk without compromising efficacy as compared to a conventional POEM procedure, which includes myotomy of the sling fibers. In this study, adults with achalasia will be randomly assigned to receive one of the two POEM technical approaches. Researchers will monitor whether preserving sling fibers reduces the rates of reflux esophagitis (classified as Los Angeles Grade B or higher) on follow-up endoscopy. Participants will be followed for up to 1 year after the procedure.
Waitlist Available
Has No Placebo
University of California, Irvine - UCI Medical CenterJason Samarasena, MD, MBA
Image of University of Minnesota Medical School, Division of Rheumatic and Autoimmune Diseases in Minneapolis, United States.

Ultrasound Therapy for Rheumatoid Arthritis

18+
All Sexes
Minneapolis, MN
The At-Home ULTRA Study will evaluate performance of the MINI system as indicated for the treatment of adults with active, moderate to severe rheumatoid arthritis who are inadequate responders or are intolerant to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), biologic DMARDs (bDMARDs), or targeted synthetic DMARDs (tsDMARDs). The non-invasive study device delivers ultrasound stimulation to the spleen to reduce inflammation. The study will enroll at least 60 participants at up to 8 sites. There will be three arms consisting of two active stimulation groups (treatment) and one non-active stimulation group (sham-control). After completing the double-blinded primary endpoint assessment period at Week 12, there will be a one-way crossover of control participants to active stimulation and an additional 12 week follow-up with all participants to evaluate long-term outcomes.
Recruiting
Drug
University of Minnesota Medical School, Division of Rheumatic and Autoimmune DiseasesHubert LimSecondWave Systems Inc.
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Image of Del Sol Research Management, LLC in Tucson, United States.

Linaprazan Glurate vs Lansoprazole for Acid Reflux

18 - 80
All Sexes
Tucson, AZ
The goal of this clinical trial is to find out how well linaprazan glurate can heal erosive esophagitis (EE) caused by gastroesophageal reflux disease (GERD), compared to lansoprazole, a commonly used medication. Researchers will also evaluate whether linaprazan glurate: * Reduces heartburn symptoms more effectively than lansoprazole * Is safe and well tolerated, based on physical exams, blood tests, and vital signs (heart rate, blood pressure, temperature, and breathing rate) * Causes any side effects during treatment * Has different effects depending on how much of the drug is in the blood * Works differently depending on participants' genes Participants must be between 18 to 80 years old and have EE due to GERD confirmed by an endoscopy. Participants cannot join if they have an active Helicobacter pylori (HP) infection or were treated for HP in the past 6 weeks or have taken antibiotics or bismuth-containing drugs in the past 6 weeks. The study is a randomized, double-blind, active comparator-controlled trial lasting up to 4 months. Randomized means that participants are assigned by chance (like flipping a coin) to one of the treatment groups and double-blind means neither the participants nor the study team will know which treatment is given. Participants will be placed into one of three groups (about 167 people in each group): * Linaprazan glurate 50 mg twice a day * Linaprazan glurate 50 mg once a day * Lansoprazole 30 mg once a day Everyone will take 2 tablets and 1 capsule by mouth daily for 8 weeks. Some tablets or capsules will be placebos (look like medicine but contain no active drug). Participants will: * Undergo an endoscopy in the beginning and after 4 weeks of treatment * If healing is not observed, another endoscopy may be done at 8 weeks * During the procedure, doctors will use a thin, flexible tube with a camera to look at the esophagus and take small tissue samples (biopsies) * Have blood and urine tests at clinic visits to check overall health * Receive electrocardiograms (ECGs) to monitor heart function * Complete daily questionnaires on an electronic device about symptoms and experiences
Phase 3
Waitlist Available
Del Sol Research Management, LLC (+24 Sites)Cinclus Pharma Holding AB
Image of St. Lawrence Health in Potsdam, United States.

Primary Care for Rheumatoid Arthritis

18+
All Sexes
Potsdam, NY
Rheumatoid arthritis (RA) is a complex autoimmune disease where the immune system attacks healthy joint tissue; causing pain, swelling, and stiffness of the joints. This disease effects lots of people in the US and can lead to major joint damage if not properly treated. In rural areas like northern NY, these are underserved areas for RA patients, thus many patients struggle to get the appropriate care. This model is testing whether primary care providers (PCP) can safely and effectively provide stable RA patients with the proper treatment rather than send them to a specialist. PCPs were trained through classes, case reviews, and a final exam. Patients will be randomly assigned to either see a trained PCP or their normal rheumatologist at the rheumatology clinic. This study will examine how patients are doing over a year using medical exams and patient feedback. If this model proves to be successful, it will make RA treatment easier and more affordable for patients.
Recruiting
Has No Placebo
St. Lawrence HealthEyal Kedar, MD
Image of Pender Community Health Centre in Vancouver, Canada.

Personalized Outreach for Rheumatic Diseases

18+
All Sexes
Vancouver, Canada
The primary goal of this study is to determine whether providing patient honoraria and/or outreach services can improve the attendance rate of appointments at an inner city rheumatology clinic in Vancouver, British Columbia. The main question it aims to answer are: * Does providing a financial honorarium ($20 for each follow-up appointment with completed bloodwork) improve attendance rate at an inner city rheumatology clinic? * Does providing a personalized outreach service for rheumatic diseases improve attendance rate at an inner city rheumatology clinic? The researchers will compare providing patient honoraria to providing both honoraria and outreach services, and compare each of these to the regular appointment schedule without honoraria or outreach. Participants will: * Undergo randomization to receive honoraria or honoraria and outreach services together * Complete surveys about their health and understanding of their rheumatic disease at baseline, 3-month, and 6-month intervals * Visit the clinic every month for check-ups and monitoring bloodwork if they are started on immunosuppressants for their condition
Waitlist Available
Has No Placebo
Pender Community Health CentreBrent R Ohata, MD
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