Retisert

Otitis Externa, Uveitis, Perianal erythema + 30 more
Treatment
2 FDA approvals
20 Active Studies for Retisert

What is Retisert

Fluocinolone acetonideThe Generic name of this drug
Treatment SummaryFluocinolone acetonide is a type of corticosteroid that is used in dermatological treatments and to make implantable corticosteroid devices. These devices are made by Taro Pharmaceuticals and have been approved by the FDA since 2016. The formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide makes this drug highly lipophilic, or able to dissolve in fat.
Neo-Synalaris the brand name
Retisert Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Neo-Synalar
Fluocinolone acetonide
1963
93

Approved as Treatment by the FDA

Fluocinolone acetonide, otherwise called Neo-Synalar, is approved by the FDA for 2 uses like Uveitis and Uveitis .
Uveitis
Uveitis

Effectiveness

How Retisert Affects PatientsFluocinolone acetonide is a medication used to reduce inflammation. It comes in a form that can be injected directly into the eye, and has been shown to reduce the recurrence of uveitis flares by two times compared to patients not taking it. However, this medication can cause a slight increase in eye pressure, so it is important to monitor your pressure closely.
How Retisert works in the bodyFluocinolone acetonide is a steroid that reduces inflammation in the body. It works by binding to glucocorticoid receptors in the cell nucleus, which then triggers the production of proteins called lipocortins. These lipocortins stop the release of arachidonic acid, which is the precursor to inflammation-causing substances like prostaglandins and leukotrienes. This process reduces inflammation and prevents further damage.

When to interrupt dosage

The recommended dosage of Retisert is contingent upon the determined condition, including Hemorrhoids, Perianal erythema and Itch. The amount of dosage is contingent upon the method of administration (e.g. Kit or Emulsion - Topical) featured in the table below.
Condition
Dosage
Administration
Skin Diseases
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Postoperative Care
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Pressure Ulcer
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Uveitis
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Purulent Wounds
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Ear structure
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Blisters
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Surgery; Ear
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Hemorrhoids
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Otitis Externa
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Wound Infection
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Anger Management Therapy
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Otitis Media
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Eczema
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Skin Inflammation caused by Bacterial Infections
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Eczema
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Skin
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Diabetic Macular Edema
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Chronic disease
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular
Otitis
, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg
Topical, , Cream, Cream - Topical, Solution, Solution - Topical, Ointment, Ointment - Topical, Kit, Oil, Auricular (otic), Oil - Auricular (otic), Oil - Topical, Kit - Topical, Solution - Auricular (otic), Intravitreal, Implant - Intravitreal, Implant, Shampoo - Topical, Shampoo, Solution / drops, Solution / drops - Auricular (otic), Gel - Topical, Gel, Emulsion, Emulsion - Topical, Intraocular, Implant - Intraocular

Warnings

Retisert has four prohibitions and should not be taken in combination with the ailments listed in the table below.Retisert Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Fluocinolone Acetonide may interact with conjunctiva
Mycoses
Do Not Combine
External auditory canal structure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Fluocinolone Acetonide may interact with conjunctiva
There are 20 known major drug interactions with Retisert.
Common Retisert Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Abatacept.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Fluocinolone acetonide.
Abetimus
Major
The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Abetimus.
Retisert Toxicity & Overdose RiskStudies have not been conducted to determine the cancer-causing effects or the impact on fertility of taking fluocinolone acetonide. However, other corticosteroids have been shown to cause genetic damage, but tests have found that fluocinolone acetonide does not cause genetic damage.

Retisert Novel Uses: Which Conditions Have a Clinical Trial Featuring Retisert?

97 active clinical trials are currently being conducted to assess the utility of Retisert in alleviating Atopic Dermatitis, Otitis Media and Otitis Externa.
Condition
Clinical Trials
Trial Phases
Perianal erythema
0 Actively Recruiting
Otitis
2 Actively Recruiting
Not Applicable
Eczema
0 Actively Recruiting
Otitis Externa
0 Actively Recruiting
Hemorrhoids
0 Actively Recruiting
Psoriasis of the scalp
1 Actively Recruiting
Phase 4
Hemorrhoids
0 Actively Recruiting
Blisters
0 Actively Recruiting
Scab
0 Actively Recruiting
Ear structure
0 Actively Recruiting
Skin
0 Actively Recruiting
Skin Diseases
0 Actively Recruiting
Fissure;Anal
0 Actively Recruiting
Postoperative Care
1 Actively Recruiting
Not Applicable
Wound Infection
0 Actively Recruiting
Skin Inflammation caused by Bacterial Infections
0 Actively Recruiting
Uveitis
5 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3
Purulent Wounds
0 Actively Recruiting
Coinfection
0 Actively Recruiting
Chronic disease
0 Actively Recruiting

Patient Q&A Section about retisert

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does RETISERT work?

"The Retisert implant is a corticosteroid used to treat inflammation within the eye that may be caused by a variety of diseases or infections. The Retisert implant slowly releases the drug into the eye over a period of approximately 30 months. However, Retisert will not treat an eye infection."

Answered by AI

Who makes retisert?

"Two or more intraocular injections of 0.1 mL (8 mcg) of RETISERT [bimatoprost (r-prostaglandin F2 alpha)] were given 91 to 180 days apart in the study eye of 22 uveitis patients.

In a study of 22 uveitis patients, two or more intraocular injections of 0.1 mL (8 mcg) of RETISERT [bimatoprost (r-prostaglandin F2 alpha)] were given 91 to 180 days apart in the study eye."

Answered by AI

What is Yutiq?

"The YUTIQ® (fluocinolone acetonide intravitreal implant) 0.18 mg is a medical device that is used to treat chronic non-infectious uveitis affecting the back of the eye."

Answered by AI

Clinical Trials for Retisert

Have you considered Retisert clinical trials? We made a collection of clinical trials featuring Retisert, we think they might fit your search criteria.
Have you considered Retisert clinical trials? We made a collection of clinical trials featuring Retisert, we think they might fit your search criteria.
Have you considered Retisert clinical trials? We made a collection of clinical trials featuring Retisert, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top